Methods for delivering islet cells and related methods

The method of delivering stem cell-derived cell clusters, particularly SC-islets, addresses the challenge of treating type 1 diabetes by improving glucose tolerance and reducing insulin dependence, without using scaffolds or devices.

JP2026520439APending Publication Date: 2026-06-23SANA BIOTECHNOLOGY INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
SANA BIOTECHNOLOGY INC
Filing Date
2024-05-21
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

The delivery of therapeutically appropriate numbers of stem cell-derived insulin-producing beta cells for treating type 1 diabetes without the use of additional supports such as scaffolds or devices remains challenging.

Method used

A method for delivering stem cell-derived cell therapy involves administering a cell suspension of SC-derived cells capable of forming aggregated clusters, with controlled cluster sizes and percentages, either as a dissociated or single-cell suspension, intramuscularly without a biological scaffold.

Benefits of technology

This approach enables effective delivery of stem cell-derived cells, particularly SC-islets, to treat type 1 diabetes by improving glucose tolerance, reducing insulin dependence, and stabilizing glucose levels, without the need for additional supports.

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Abstract

This specification provides methods related to the delivery of stem cell-derived cell therapies, including stem cell-derived island cell therapy, as well as related compositions, uses, and products. In certain embodiments, the method relates to the administration of stem cell-derived island cells. In some embodiments, the subject has a beta cell-related disorder, such as diabetes (e.g., type 1 diabetes).
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