Copper chelating agents, anticancer agents, and agents for preventing or treating Wilson's disease

New copper chelating agents derived from actinomycetes address the limitations of existing agents by offering effective copper chelation for Wilson's disease treatment and anticancer therapy with minimal cellular disruption.

JP7619580B2Active Publication Date: 2025-01-22MURATA MFG CO LTD +1
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Patent Information

Application Number
JP2023531841
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-06-30
Filing Date
2022-06-21
Publication Date
2025-01-22
Estimated Expiration
2042-06-21

AI Technical Summary

Technical Problem

Conventional copper chelating agents used for treating Wilson's disease have strong side effects and inhibit essential cellular processes, while substances with copper chelating effects are also used as anticancer drugs, necessitating the development of new agents with improved safety and efficacy.

Method used

Development of copper chelating agents represented by specific compounds (1), (2), (3), and (4), and their salts or solvates, derived from actinomycetes, which exhibit strong copper chelating effects without significant inhibition of cytochrome C oxidase activity.

Benefits of technology

The new copper chelating agents effectively chelate copper, providing therapeutic benefits for Wilson's disease and anticancer applications with reduced side effects and enhanced safety profiles.

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Abstract

This copper chelator comprises at least one selected from the group consisting of a compound represented by formula (1), a compound represented by formula (2), a compound represented by formula (3), a compound represented by formula (4), salts thereof and solvates of the same.
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Citation Information

Patent Citations

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    JP2003521453A

  • Broad spectrum antibiotic complex produced by a novel micromonospora

    US4440751A