High performance liquid chromatographic determination of excipients
By using PFP columns and specific mobile combinations in HPLC, the problem of difficulty in separating and quantitatively analyzing multiple excitants in a single run in the prior art is solved, and efficient excitants separation and quantitative analysis effects are achieved.
JP7649441B2Active Publication Date: 2025-03-21SEAGEN INC
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Patent Information
- Application Number
- JP2022532729
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-12-16
- Filing Date
- 2020-12-15
- Publication Date
- 2025-03-21
- Estimated Expiration
- 2040-12-15
AI Technical Summary
Technical Problem
The prior art is difficult to efficiently isolate and quantitatively analyze two or more agents with different physical chemical properties in a single HPLC run.
Method used
Pentafluorophenyl (PFP) high-performance liquid chromatography column was used for HPLC analysis, and the separation and quantification of two or more excipients were achieved through specific mobile phase combinations and detection conditions.
Benefits of technology
Efficient separation and quantitative analysis of multiple excipients in a single HPLC operation is achieved, avoiding the problems of solvent interference and poor station phase retention time and peak shape in traditional methods.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides analytical methods for separating and optionally quantifying two or more buffers or excipients in a sample in a single assay.
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