Sample measurement device, sample measurement method, and sample measurement program

The sample measuring device addresses the challenge of detecting measurement errors in cell culture analysis by using a configuration that includes voltage application, current measurement, concentration measurement, counter electrode terminal voltage measurement, and error detection, ensuring accurate results by monitoring counter electrode terminal voltage.

JP7653546B2Active Publication Date: 2025-03-28PHC HLDG CORP
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Patent Information

Application Number
JP2023576695
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2022-01-27
Filing Date
2022-12-19
Publication Date
2025-03-28
Estimated Expiration
2042-12-19

AI Technical Summary

Technical Problem

Conventional cell culture analyzing devices face challenges in accurately detecting measurement errors caused by sensor immersion defects or contamination, such as mold adhesion, which can lead to inaccurate results.

Method used

The proposed sample measuring device includes a voltage application section, a current measurement section, a concentration measurement section, a counter electrode terminal voltage measurement section, and a measurement error detection section. This configuration allows for the detection of measurement errors by monitoring the terminal voltage of the counter electrode, which is affected by sensor immersion and contamination.

Benefits of technology

The device effectively detects measurement errors caused by sensor immersion defects or contamination, ensuring accurate measurements and reducing the risk of inaccurate results due to poor sensor immersion or contamination.

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Abstract

A cell culture analysis device (1) comprises a voltage application unit (11a), a current measurement unit (11b), a voltage measurement unit (11c), and an analysis unit (42). The voltage application unit (11a) applies a voltage to a detection unit (31a) of a sensor (30), said detection unit (31a) including a working electrode, a counter electrode, and a reference electrode, while the detection unit (31a) is immersed in a culture medium (X). The current measurement unit (11b) measures the value of the current flowing through the sensor (30) due to the the voltage applied to the detection unit (31a). The analysis unit (42) calculates the concentration of glucose or the like contained in the culture medium on the basis of the measurement result of the current measurement unit (11b). The voltage measurement unit (11c) measures the terminal voltage of the counter electrode in the detection unit (31a) while the voltage application unit (11a) is applying voltage. The analysis unit (42) detects the measurement error on the basis of the terminal voltage of the counter electrode measured by the voltage measurement unit (11c).
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