Computer system for setting adjustable values ​​in a blood treatment device - Patents.com

Abstract

The present invention relates to a computer system (1) for specifying the setpoints of a blood treatment device (100), which has a first input interface (I1), a second input interface (I2) and an output interface, and which also has a computing device (5) and a display device (I3), the computing device (5) being able to, after reading the target value of the renal dose via the blood treatment device (100), display, using the display device (I3), in each case, exactly one setpoint (Q) for the flow rate from the blood pump (101). · 1. Q · 2. Q · 3) and on the other hand exactly one setpoint (D · 1. D · 2. D · The computing device (5) is programmed to display to the user a graph containing a selection range (A) from a plurality of combinations (K1, K2, K3) with the selected combination (K3). The user may adopt the displayed selection range A as a criterion for selecting one of the displayed combinations via the second input interface (I2). The computing device (5) also displays the selected combination (K B The set value (Q · B ) and the setting value (D · B ) via the output interface.

Description

[Technical Field]

[0001] The invention relates to a computer system according to the preamble of claim 1. The invention also relates to a blood treatment device according to the preamble of claim 8 and to a system according to the preamble of claim 10. The invention also relates to a method according to the preamble of claim 11, a digital storage medium according to claim 14, a computer program product according to claim 15 and a computer program according to claim 16, in each case as described in their preambles.

[0002] For purposes of blood treatment, adjustable values ​​for variable treatment parameters are entered by a user, e.g., hospital staff, into a blood treatment device used for this purpose, and the user can change such adjustable values ​​by manual input, e.g., via a screen (touch screen) or other interface.

[0003] To achieve a predetermined therapeutic goal or a predetermined objective, such as a renal dose in dialysis therapy, a user may need to determine or change a series of partially interrelated adjustable values, which is why setting up a blood treatment device can be a demanding and error-prone activity. Summary of the Invention

[0004] The object of the invention can also consist in proposing a computer system that assists a user in setting (or specifying or determining or fixing (hereinafter referred to as setting)) adjustable values ​​of a blood treatment device, as well as a blood treatment device, a system and a method comprising a computer system according to the invention. Furthermore, a digital storage medium, a computer program product and a computer program are proposed.

[0005] The object according to the invention can be achieved by a computer system having the features of claim 1. Furthermore, the object according to the invention can be achieved by a blood treatment device having the features of claim 8, a system having the features of claim 10, and a method having the features of claim 11. Furthermore, the object according to the invention can be achieved by a digital storage medium having the features of claim 14, a computer program product having the features of claim 15, and a computer program having the features of claim 16.

[0006] The computer system of the present invention assists a user (physician, staff, etc.) in setting adjustable values ​​for subsequent use in a blood treatment device, thereby supporting the user. The computer system comprises at least a first input interface, a second input interface, and an output interface. The computer system further comprises, or is connected in signal communication with, a calculation (or computing) device and a display device.

[0007] The computing device is programmed to use the first input interface to read a target value, which may be a target range, illustratively here a renal dose, as a parameter value for subsequent or future treatments of the patient using the blood treatment device.

[0008] Additionally, the computing device is programmed to display the selection ranges calculated by the computing device to the user via the display device, preferably in the form of a graph.

[0009] The selection range is thereby determined by the computing device taking into account the read target value of the renal dose. For example, the selection range can be used to display multiple combinations of exactly one adjustable value for the blood pump flow rate on the one hand and exactly one adjustable value for the dialysate pump flow rate on the other hand. These adjustment ranges, when set in the blood treatment machine, allow the computing device to achieve the target value according to the available information (other things being equal).

[0010] Using the second input interface, the user can select one, preferably any one, of the displayed combinations.

[0011] Accordingly, the computing device is further programmed to present, via the output interface, an adjustable value for the blood pump and an adjustable value for the dialysate pump of the selected combination.

[0012] The blood treatment device according to the present invention is embodied as a dialysis machine including the computer system according to the present invention.

[0013] The system according to the invention comprises or consists of one or several blood treatment devices and a computer system according to the invention.

[0014] Thereby, the blood treatment device is preferably embodied as a dialysis device.

[0015] The one or more blood treatment devices and the computer system are separate from one another. The term "separation" can encompass, for example, spatial, physical separation, and / or separation such that there is no signal communication between the blood treatment device and the computer system.

[0016] A method according to the present invention for setting adjustable values ​​in a blood treatment device (or for example assisting a medical professional in determining or setting appropriate adjustable values) comprises: a. providing a computer system according to the present invention, a blood treatment device according to the present invention, or a system according to the present invention; b. reading target values ​​and / or target ranges for parameter values, e.g. for renal dose, for subsequent treatment of the patient via the blood treatment device, preferably after completion of the method of the present invention, or inputting these parameters via a first input interface, wherein the first input interface may optionally be used as a reading interface; c. displaying the range of adjustable value combinations calculated or determined by the computing device, wherein the displaying is via a display device, e.g., graphically, e.g., diagrammatically; d. selecting one of the combinations displayed by the selection range by a user via a second input interface; e. Presenting the adjustable values ​​for the blood pump and the dialysate pump of the selected combination via an output interface; The method includes the step of:

[0017] Anything mentioned above or below with respect to the computer system according to the invention or its features applies equally to the method according to the invention or its possible embodiments, without being limited thereto, and vice versa. Therefore, to avoid repetition, reference is made to statements and definitions made on the same subject matter or terms elsewhere in this specification.

[0018] A digital storage medium, in particular a non-volatile storage medium, according to the invention, in particular in the form of a machine-readable medium, in particular in the form of a diskette, CD, DVD, EPROM, FRAM® (Ferroelectric RAM) or SSD (Solid-State-Drive), in particular having electronically or optically readable control signals, can be configured or programmed to interact with a programmable computer system, so that the computer system can be programmed, for example, to become the computer system according to the invention when its memory contents are executed on the programmable computer system.

[0019] A computer program product according to the present invention comprises a program code or signal wave stored on a volatile, transitory or machine-readable carrier and is configured to interact with a programmable computer configuration of a computer system, so that the computer system can be reprogrammed to become a computer system according to the present invention. A computer program product may for example be understood according to the present invention as a computer program stored on a carrier, an embedded system which is a comprehensive system comprising a computer program (e.g. an electronic device comprising a computer program), a network of computer-implemented computer programs (e.g. a client / server system, a cloud computing system, etc.), or a computer into which a computer program is loaded, operated, stored, executed or developed.

[0020] The term "machine-readable carrier" as used herein refers, in certain embodiments of the present invention, to a medium containing data or information that can be interpreted by software and / or hardware. The carrier may be, for example, a data carrier such as a diskette, CD, DVD, USB stick, flash card, SD card, and any other storage device or storage medium mentioned herein.

[0021] According to the invention, a computer program product may also be understood to mean, for example, a programmed application (abbreviated as app) in particular for a smartphone, a tablet or any other mobile handheld device.

[0022] The computer program according to the present invention comprises a program code for causing a corresponding computer system to be reprogrammed into a computer system according to the present invention when the computer program is executed on the corresponding computer system. According to the present invention, a computer program can be understood to mean, for example, a physically distributable software product comprising the program.

[0023] In all that follows, the use of expressions such as "may be" or "may have" should be understood as synonymous with "preferably is" or "preferably has", respectively, and is intended to exemplify embodiments according to the present invention.

[0024] Embodiments according to the invention may comprise one or several of the above-mentioned or following features, whereby the features described herein, in any combination, may be the subject of embodiments according to the invention, unless a person skilled in the art recognizes that a particular combination is technically impossible.

[0025] Further embodiments according to the invention are subject matter of the dependent claims.

[0026] Whenever numerical terms are used herein, those skilled in the art will recognize or understand them as indicating lower numerical limits. Unless this would lead the skilled artisan to an obvious contradiction, those skilled in the art will understand, for example, that a designation of "one" encompasses "at least one." This understanding is also equally encompassed by the present invention, as is the interpretation that a numerical term, for example, "one," may alternatively mean "exactly one," whenever this is clearly technically possible for those skilled in the art. Both are encompassed by the present invention and apply to all numerical terms used herein.

[0027] Whenever an application or method step is described herein, the present invention also preferably encompasses suitable apparatus or sections thereof, in particular carrying out the corresponding program or arrangement according to the present invention.

[0028] Whenever an embodiment is described herein, it is an exemplary embodiment according to the present invention.

[0029] References herein to "upper" and "lower" should, in case of doubt, be understood by those skilled in the art as absolute or relative spatial designations of the associated components relative to their intended orientation in use.

[0030] The range of selection may be smaller than the technically possible combinations and / or all combinations displayed in the graph.

[0031] Also, selecting from the combinations displayed by the selection range may be a marking, for example using a computer mouse, and selecting may optionally comprise moving an already marked value or an already marked combination to a new value or new combination.

[0032] The first and / or second input interface may each be a correspondingly embodied touch screen, rotary switch, slider, keyboard, etc.

[0033] The first input interface and the second input interface may be identical, i.e., they may be realized by only one common input interface, or alternatively, they may be different and / or independent from each other.

[0034] The target value or target range can be taken into account when determining or calculating the adjustable value of the selection range, for example based on known algorithms, which may include further parameter values, for example from auxiliary tables, etc. These algorithms and / or further parameter values ​​(as well as the further adjustable values ​​corresponding to the latter) can be stored, for example, in a storage device of the computer system.

[0035] The target value may be input by a user or may be read by the computing device via a first interface, which may for example be an interface to a storage device.

[0036] The target value may be related to the particular patient being treated.

[0037] The renal dose may be established as the quotient of the drainage or filtrate flow rate on the one hand and the patient's body weight on the other hand.

[0038] Depending on the type of therapy, different flow rates (eg, dialysate flow rate, substitution flow rate, calcium flow rate, citrate flow rate, net ultrafiltration rate) may need to be considered when determining the drainage flow rate.

[0039] The renal dose can be, for example, the target renal dose (TRD) or the effective renal dose (RRD).

[0040] The target renal dose (TRD) can be calculated, for example, by using the following formula:

number

[0041] Here the following applies: BF blood flow DF Dialysate flow rate NFRF Net Liquid Removal Flow Rate m Patient weight PostDF Post-dilution flow rate PreDF Predilution flow rate

[0042] The effective renal dose (RRD) can be calculated using the following formula, depending on the treatment period t:

number

[0043] In some embodiments, the computing device of the computer system is programmed to read additional parameter values, e.g., the same or different parameters, and further limit, segment, subdivide, or categorize the range of possible adjustable values ​​based on these parameter values. These additional parameter values ​​can be read in the same manner as the target values.

[0044] In some embodiments, the further parameter or parameter value takes into account desired anticoagulation for or during treatment, particularly citrate-calcium anticoagulation, or desired bicarbonate concentration, for example in serum.

[0045] In some embodiments, the computer system is or comprises a mobile device. The computer system may be or comprise a handheld device, a mobile phone, a smartphone, a tablet, etc.

[0046] In some embodiments, the computer system encompasses computer programs or applications (abbreviated as apps) that may be loaded onto, stored on, executed on, or running on such mobile or other devices.

[0047] In some embodiments, the computing device of the computer system is programmed to display for the user's attention via a display device the adjustable values ​​for the blood pump and the adjustable values ​​for the dialysate pump of the selected combination and / or to present it via an output interface, for example, to a control device or closed-loop control device of the blood treatment machine, which can then read and / or store the transmitted adjustable values.

[0048] The transmitted adjustable settings can be used by the blood treatment device for the next treatment session.

[0049] In some embodiments, the output interface and the display device may be the same, such that output via the output interface may be displayed using the display device, and vice versa.

[0050] In some embodiments, the computer system of the present invention is programmed to present, e.g., via the output interface described above, values ​​indicative of set flow rates and / or renal doses, e.g., target and / or actual renal dose flow rates or adjustable values ​​for pumps described herein, e.g., blood pumps, dialysate pumps, substitution fluid pumps, calcium pumps, citrate pumps, heparin pumps, and / or other pumps.

[0051] The computer system can be programmed to forward these values ​​to, for example, a logistics system and / or an invoicing system. The logistics system and / or invoicing system, which may be external to the computer system but still be part of the system of the present invention, can then be programmed to monitor, record, store, output, invoice, bill, and / or otherwise process delivery flows, orders, consumption, etc. Thus, the logistics system can be configured to use the values ​​transmitted by the computer system to reorder fluids used during a blood treatment session, such as citrate solution, dialysate, etc., and initiate their delivery to the clinic where the blood treatment was performed. The invoicing system can use the values ​​transmitted by the computer system to bill the clinic for services related to the blood treatment session provided. For example, values ​​such as the target value of the renal dose or the heparin flow rate, which reflects the consumption of fluids such as heparin, citrate solution, etc., can be used as a basis for billing patients or payers, such as insurance companies.

[0052] In some embodiments, a computer system according to the present invention is a control device or closed loop control device of a blood treatment apparatus or is in signal communication with such a device.

[0053] According to the present invention, in some embodiments it may also be provided that the computer system according to the present invention is implemented in, for example, a control device or closed-loop control device of a conventional blood treatment apparatus, thereby configuring the blood treatment apparatus into a blood treatment apparatus according to the present invention. In these embodiments, existing input and output interfaces and computing devices of the blood treatment apparatus can advantageously be used to implement the computer system according to the present invention.

[0054] In some embodiments, the computer system may be or comprise a server-based solution, where a user can access a program running on the server, for example, via a website, to perform or initiate steps of the method according to the invention. Thus, the computer system may optionally comprise a server. The computer system may comprise a user interface and / or user device, such as a computer, mobile phone, or tablet, set up to communicate with the server.

[0055] In some embodiments, the control device or closed-loop control device is programmed to control or regulate the blood treatment apparatus based on the adjustable values ​​for the blood pump and the adjustable values ​​for the dialysate pump according to the selected combination, particularly after a selection has been made.

[0056] In some embodiments, the blood treatment device of the present invention is embodied as a hemodialysis device, a hemofiltration device, or a hemodiafiltration device, particularly for long-term renal replacement therapy, acute renal replacement therapy, or continuous renal replacement therapy (CRRT).

[0057] In some embodiments, the method of the present invention further comprises displaying or presenting the adjustable values ​​for the blood pump and the adjustable values ​​for the dialysate pump of the selected combination, optionally via a display device for user attention and / or confirmation.

[0058] The confirmation can simply be an action such as an "OK" button.

[0059] Verification, in some embodiments, does not involve typing, inputting, selecting, etc., an adjustable value from various options, nor does it involve performing mental calculations.

[0060] In some embodiments, the method of the present invention includes as a further step controlling or adjusting, preferably automatically, the blood treatment device based on the selected combination of adjustable values ​​for the blood pump and adjustable values ​​for the dialysate pump.

[0061] This may, for example, immediately follow a selection or confirmation of a selection made by the user.

[0062] In some embodiments, the method of the present invention comprises as a further step loading the selected combination of adjustable values ​​for the blood pump and adjustable values ​​for the dialysis fluid pump into memory (which may be, for example, volatile or permanent), e.g., the blood treatment device, for a subsequent or yet to start treatment or treatment session via the blood treatment device.

[0063] The further parameter value may be or may be related to the acid / base balance of the patient or a component of the patient's blood.

[0064] Whenever "programmed" or "configured" are used herein, it should be understood that these terms are interchangeable.

[0065] Some or all embodiments of the present invention may have one, several, or all of the advantages set forth above and / or the following.

[0066] An advantage of the present invention may be that it facilitates or assists a user, typically a physician, in making a decision as to which adjustable value to select for a blood treatment device pump for the next or current blood treatment so that a predetermined target value can be achieved during the blood treatment using the adjustable value. The desired target value is not simultaneously a target adjustable value for one of the pumps. The present invention significantly reduces the complexity of the physician's decision-making task by taking the target value into account and initially eliminating undesirable combinations from a large number of possible combinations.

[0067] A further advantage of the present invention may be that using the simplifications according to the present invention to change adjustable values ​​may advantageously provide less experienced users with more certainty when making adjustments.

[0068] The present invention significantly reduces the likelihood of making errors when determining the adjustable value, as it eliminates the risk of errors, such as mental calculation steps and / or human errors made by the user.

[0069] This means that, advantageously, patient safety can also be indirectly increased.

[0070] However, the ability and responsibility to determine or change the adjustable values ​​can advantageously remain with the user, so the user receives useful support from the computer system of the present invention without being surprised by unauthorized actions by the computer system.

[0071] If the blood treatment device and computer system remain separate devices, an existing blood treatment device may be combined with a computer system according to the present invention to form a system according to the present invention. Because no intervention is required in the control of the blood treatment device, the blood treatment device does not need to be recertified as a medical device.

[0072] The present invention will now be described, by way of example only, with reference to the accompanying drawings, in which like reference numerals refer to the same or similar elements, and in which: [Brief explanation of the drawings]

[0073] [Figure 1] 1 shows, in a highly simplified representation, a system according to the invention with a blood treatment device next to a computer system according to the invention; [Figure 2] FIG. 1 shows a flow chart of an exemplary embodiment of a method according to the present invention. [Figure 3a] FIG. 2 illustrates a portion of a graph (or graphical representation) that may be displayed to a user via a display device in an exemplary embodiment of a computer system according to the present invention or a method according to the present invention. [Figure 3b] FIG. 3b shows the graph of FIG. 3a with a marked selection range for new adjustable values. [Figure 3c] FIG. 3b shows the graph of FIG. 3b during the setup procedure. DETAILED DESCRIPTION OF THE INVENTION

[0074] FIG. 1 shows, in a highly simplified representation, a blood treatment device 100, optionally connected to an extracorporeal blood circuit 300, as part of a system according to the present invention.

[0075] The extracorporeal blood circuit 300 comprises a first line 301, here in the form of an arterial line section.

[0076] The first line 301 is in fluid connection with a blood treatment device, here illustratively a hemofilter or dialyzer 303. The hemofilter 303 comprises a dialysate chamber 303a and a blood chamber 303b, which are separated from each other by a semipermeable membrane 303c.

[0077] The extracorporeal blood circuit 300 further comprises at least one second line 305, here in the form of a venous line section. Both the first line 301 and the second line 305 may serve to connect to the patient's vascular system (not shown).

[0078] First line 301 is optionally connected to a (first) tubing clamp 302 for isolating or closing line 301. Second line 305 is optionally connected to a (second) tubing clamp 306 for isolating or closing line 305.

[0079] Blood treatment apparatus 100, only some of its devices of which are represented diagrammatically in Figure 1, includes a blood pump 101. During treatment of a patient, blood pump 101 conveys blood through a section of extracorporeal blood circuit 300 toward a blood filter or dialyzer 303, as indicated by the small arrows in each figure that generally indicate the direction of flow.

[0080] Fresh dialysate is pumped from source 200 along dialysate inlet line 104 into dialysate chamber 303a using dialysate pump 121, which may be embodied as a roller pump or any other occluding pump. The dialysate exits dialysate chamber 303a as dialysate, optionally enriched with filtrate, to optional drain bag 400, herein referred to as drain.

[0081] Source 200 can be, for example, a bag or container. Additionally, source 200 can be a fluid line from which online and / or continuously generated or mixed liquids are sourced, such as a hydraulic outlet or port of blood treatment device 100.

[0082] A further source 201 with replacement fluid may optionally be provided, which may correspond to source 200 or may be a separate source.

[0083] A control device or closed-loop control device 150, shown only diagrammatically, may be configured to control or regulate the blood treatment session.

[0084] The location where the drain bag 400 connects to the blood treatment device 100b is shown in the bottom right of FIG.

[0085] In addition to the blood pump 101 described above, the arrangement shown in FIG. 1 further comprises, merely optionally, several other optional pumps: a substituate pump 111, a dialysate pump 121, and a drain pump 131.

[0086] A pump 121 is provided to supply dialysate from a source 200, e.g., a bag, through an optionally available bag heater H2 having a heated bag, and to the hemofilter 303 using the dialysate inlet line 104.

[0087] The dialysate thus delivered can again exit the hemofilter 303 via the dialysate outlet line 102, assisted by an optional pump 131, to waste.

[0088] An optional arterial sensor PS1 is provided upstream of the blood pump 101. It measures the pressure in the arterial line during patient treatment.

[0089] A further optional pressure sensor PS2 is provided downstream of the blood pump 101 but upstream of the hemofilter 303 and, if provided, upstream of the heparin addition point 25. It measures the pressure upstream of the hemofilter 303 ("pre-hemofilter").

[0090] A further pressure sensor may be provided as PS4 downstream of the hemofilter 303 but preferably upstream of the pump 131 in the dialysate outlet line 102, again to measure the filtrate pressure of the hemofilter 303.

[0091] The blood leaving the hemofilter 303 passes through an optional venous blood chamber 29, which may include a ventilation device 31 (also called a vent, degassing or air removal device) and / or a further pressure sensor PS3.

[0092] The control device or closed-loop control device 150 shown in FIG. 1 may be in wired or wireless signal communication with any of the components described herein, particularly or at least with the blood pump 101, to control or regulate the blood treatment apparatus 100.

[0093] An optional pump 111 is provided to supply substitution fluid from an optional source 201, for example a bag, to a second line 305 via an optional available bag heater H1 with a heat bag.

[0094] In some embodiments, citrate solution is dispensed into first line 301 from an optionally provided source for citrate solution, here illustratively embodied as a citrate bag 9, optionally by citrate pump 15. For example, 4% Na3Citrate is added from the citrate solution source.

[0095] An optional dosing device, embodied herein as a calcium pump 12, is provided to supply calcium solution to line 305 from an optional calcium solution source, illustratively embodied in FIG. 1 as a calcium bag 13. For example, a CaCl solution is supplied from the calcium solution source, which may have a calcium concentration of 91 mmol / l, 100 mmol / l, or another suitable calcium concentration.

[0096] 1 illustrates a computer system 1 according to the present invention to the right of the blood treatment apparatus 100, which has a computing device 5 and an optional storage device 7. The computer system has a first input interface I1, a second input interface I2, and an output interface I3.

[0097] The blood treatment device 100 and computer system 1 together represent one embodiment of a system according to the present invention.

[0098] The computer system 1 may be provided on a mobile handheld device, such as a mobile phone or tablet, that is physically separate from the blood treatment apparatus 100. In the embodiment shown in Figure 1, the computer system 1 is not connected in signal communication to the blood treatment apparatus 100.

[0099] The computer system 1 may be or comprise a server-based solution where a user can access a program running on the server, for example, via a website, to perform or initiate steps of the method according to the present invention. Thus, the computer system 1 may comprise a server. The computer system 1 may comprise a user interface and / or user device, such as a computer, mobile phone, or tablet, set up to communicate with the server.

[0100] However, in blood treatment device embodiments other than those shown here, the computer system is connected in signal communication and / or physically to or is part of the blood treatment device 100. In the latter cases, however, the devices so connected are no longer associated with the system of the present invention, but rather with the blood treatment device of the present invention.

[0101] It is also encompassed by the present invention that the computer system 1 is identical to or encompassed by a control device or closed-loop control device 150 other than that shown here.

[0102] FIG. 2 shows a flow chart of an exemplary embodiment of the method according to the invention.

[0103] Thus, method step S1 represents the provision of a computer system 1 according to the invention, a blood treatment device 100 according to the invention, or a system according to the invention.

[0104] In method step S2, target values ​​and / or target ranges for parameter values ​​for the patient's treatment, e.g., for renal dose, are read using the blood treatment device 100 or the parameter values ​​are input via the first input interface I1.

[0105] S3 represents displaying the selection range (see reference A in Figure 3b), calculated by the calculation device (5), for example as described above, via the display device (I3), for example graphically, for example in a diagram.

[0106] In method step S4, one of the displayed combinations is selected by the user using a second input interface I2, which may optionally be identical to the first input interface, as shown in FIG. 3b.

[0107] In method step S5, the adjustable values ​​for the blood pump 101 and the adjustable values ​​for the dialysate pump 121 of the selected combination are presented via the output interface.

[0108] Optionally, in method step S6, the adjustable values ​​for the blood pump 101 and the adjustable values ​​for the dialysis fluid pump 121 of the selected combination are displayed or presented via display device I3 so that the user can notice them.

[0109] S7 represents an optional method step of controlling or regulating the blood treatment device 100 based on the selected combination of adjustable values ​​for the blood pump 101 and adjustable values ​​for the dialysate pump 121.

[0110] FIG. 3a shows the essential parts of a graph or graphical representation that may be displayed to a user via display device I3 in an exemplary embodiment of a computer system or an exemplary embodiment of a method.

[0111] In the graph representation, the vertical axis represents blood flow rate [ml / min] relative to the dialysate flow rate [ml / h] on the horizontal axis.

[0112] Each point in the diagram shown therefore represents, on the one hand, a possible adjustable value Q for the delivery speed of the blood pump. · n and, on the other hand, a possible adjustable value D for the delivery rate of the dialysate pump. · n Therefore, for example, combination K1 corresponds to a combination of a blood pump speed of 100 ml / min (adjustable value Q · 1 = 100 ml / min) and the dialysate pump speed of 2000 ml / min (adjustable value D · However, combination K2 corresponds to a combination with a blood pump speed of 120 ml / min (adjustable value Q · 2=120 ml / min) and the dialysate pump speed of 2000 ml / min (adjustable value D · 2=2000ml / min).

[0113] The possible settings of several such combinations K1, K2, K3, ... of the blood pump and dialysate pump delivery rates mathematically result in a predicted acid-base state (predicted (or expected) bicarbonate concentration in serum).

[0114] The predicted bicarbonate concentration in serum is shown in radial form in the figure for several combinations of blood flow and dialysis fluid flow rates in each case. The illustrated lines are designated B1 to B7. For each of them, the predicted bicarbonate value (in mmol / L) is presented at the edge of the figure for the flow rate combination that lies on the line (the values ​​in the graph in Figure 3a were determined by simulation).

[0115] In this example, it can be seen that a 20% increase in blood flow from K1 to K2 changes the expected serum bicarbonate concentration by approximately 4 mmol / L (from 24 mmol / L to 28 mmol / L, i.e., towards metabolic alkalosis). A 20% increase in dialysate flow (to K3) also compensates for this effect.

[0116] The underlying constant treatment parameters in this example are a citrate dose of 4 mmol per liter of blood, a calcium dose of 1.7 mmol per liter of blood, and a net ultrafiltration rate of 100 ml / h.

[0117] The range of choices available to the user according to the present invention is not shown in Figure 3a for the sake of clarity, but is indicated by the reference character A in Figures 3b and 3c.

[0118] FIG. 3b shows an exemplary graph or graphical representation of FIG. 3a.

[0119] Therefore, all statements made regarding FIG. 3a also apply to FIG. 3b.

[0120] Illustrated here in FIG. 3b is an adjustable value Q for the delivery rate of the blood pump. · n and an adjustable value D for the dialysate pump delivery rate. · n A is a selection range A with an infinite number n of possible combinations.

[0121] Selection range A visually highlights combinations from the n possible combinations in which the associated adjustable values ​​are suitable to be set in blood treatment device 100 to achieve a target value, i.e., a renal dose target value, during or at a procedure performed therewith. Thus, combinations marked by selection range A are selected or determined with the renal dose target value in mind.

[0122] In the example of Fig. 3b, the selection area A is marked by shading. It does not have to be shaded as shown in Fig. 3b, but can be highlighted in other ways. A colored background is also possible. Its shape can, of course, be different from the bar shape shown here.

[0123] By way of example only, in FIG. 3b, a user may mark K by, for example, using a computer mouse. B Suppose we decide on the combination K, which should be exemplified by the circle in selection range A. B An adjustable value Q for the blood pump delivery rate due to · B and D for the dialysate pump delivery rate · B may optionally be displayed to the user, for example in units of ml / min, along with an indication of the precise adjustable value, and may be offered for confirmation by the user before the blood treatment device takes any action thereon.

[0124] However, the adjustable value Q · B , D · B Treatment using this allows for treatment to obtain the desired renal dose, i.e., the target value.

[0125] Selected combination K B The display or highlighting of may correspond to output via an output interface and / or display via a display device.

[0126] However, in contrast to the representation of FIG. 3b, in FIG. 3C the user can select combination K that is outside of selection range A. B The adjustable values ​​of this combination are not suitable for reaching the renal dose target when performing blood treatment with them.

[0127] The user may optionally be made aware of this via a warning, indication, etc. The user may correct the selection and reselect the first selected combination K B into selection range A. The user will have the opportunity to follow the arrows shown in Figure 3c to maintain the desired bicarbonate concentration. The inventions described in the claims of the original application are set forth below. [1] A computer system for setting adjustable values ​​in a blood treatment device, comprising: - a first input interface; - a second input interface; an output interface; a computing device; - Display device and and the computing device - using the first input interface to read a renal dose target value as a parameter value for treatment of a patient using a blood treatment device; - displaying a selected range (A) to the user in a graph via the display device, wherein the selected range (A) is calculated by the calculation device in accordance with the read target value of the renal dose on the one hand and exactly one adjustable value for the flow rate of the blood pump (Q · 1 、Q · 2 、Q · 3 ) and exactly one adjustable value for the flow rate of the dialysate pump (D · 1 、D · 2 、D · 3 ) multiple combinations (K 1 、K 2 、K 3 ) is determined taking into consideration - From the displayed combinations (K1, K2, K3), select the combination (K B a second input interface for the user to select It is programmed to do - the computing device outputs the selected combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B ). [2] The computing device is - further programmed to read further parameter values ​​(B1, B2, B3, B4, B5, B6, B7); - The computer system according to [1], wherein the selection range (A) is further limited by the computing device taking into account the further parameter values ​​(B1 to B7). [3] The computer system of [1] or [2], wherein the further parameter values ​​(B1 to B7) take into account or relate to a desired anticoagulation, in particular a citrate-calcium anticoagulation, or a desired bicarbonate concentration in the serum. [4] The computer system according to any one of [1] to [3], wherein the computer system is a mobile device, a handheld device, a mobile phone, a smartphone, a tablet, etc., or an application suitable for this purpose. [5] The computing device displays the selected combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B The computer system according to any one of [1] to [4], programmed to display or present a [6] The computer system according to any one of [1] to [5], wherein the computer system is a control device or a closed-loop control device of a blood treatment apparatus, or is in signal communication with the blood treatment apparatus. [7] The control device or closed-loop control device is configured to select the combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B ) The computer system according to [6], wherein the computer system is programmed to control or regulate the blood treatment device based on the [8] A blood treatment device embodied as a dialysis device and equipped with the computer system according to any one of [1] to [7]. [9] The blood treatment device according to [8], which is embodied as a hemodialysis device, a hemofiltration device or a hemodiafiltration device, in particular as a device for long-term renal replacement therapy or continuous renal replacement therapy (CRRT).

[10] - one or more blood treatment devices embodied as dialysis machines; - a computer system according to any one of [1] to [7]; comprising or consisting of A system wherein the one or more blood treatment devices and the computer system are separate from one another.

[11] A method for setting an adjustable value in a blood treatment device, comprising: - providing a computer system according to any one of [1] to [7], a blood treatment device according to any one of [8] to [9], or a system according to

[10] ; - reading the target value of the renal dose as a parameter value for the treatment of the patient via the blood treatment device, or inputting the parameter value via the first input interface; - graphically displaying a selection range (A) for the user's attention via the display device, wherein the selection range (A) is determined by the calculation device taking into account the target value of the renal dose and, on the other hand, exactly one adjustable value for the flow rate of the blood pump (Q · 1 、Q · 2 、Q · 3 ) and on the other hand exactly one adjustable value for the flow rate of the dialysate pump (D · 1 、D · 2 、D · 3 ) and displaying multiple combinations of - a combination (K1, K2, K3) of the combinations (K1, K2, K3) displayed by the user via the second input interface B ) and - via the output interface, the selected combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B ) and The method includes the step of:

[12] - for the attention of the user, via the display device, the selected combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B ) displaying or presenting the

[11] The method described in

[11] .

[13] - the selected combination (K B ) for the blood pump. · B ) and the adjustable value for the dialysate pump (D · B and controlling or regulating the blood treatment device based on the measured value of the blood treatment signal. The method according to

[11] or

[12] .

[14] A digital storage medium, particularly in the form of a diskette, CD or DVD, EPROM, FRAM or SSD, having electronically readable control signals configured to interact with a programmable computer system so that the computer system can be programmed to become the computer system described in any one of [1] to [7].

[15] A computer program product having program code stored as a signal wave or on a machine-readable carrier for interacting with a programmable computer system so that the computer system can be programmed to become the computer system described in any one of [1] to [7].

[16] A computer program having program code that, when executed on a computer, enables the computer system to be programmed to become the computer system described in any one of [1] to [7]. [Explanation of symbols]

[0128] 1. Computer system 5...Calculation Device (or Computing Device) 7...Storage device (optional) 9...source for citrate solution, here e.g. citrate bag 12...Calcium pump 13...Source for calcium solution, calcium bag 15...Citrate pump 25...Heparin addition point (optional) 29...Venous blood chamber (optional) 31...Ventilation (or vent, degassing or air removal device) 100...Blood treatment device 101...Blood pump 102...Dialysate outlet line, drainage inlet line 104...Dialysate inlet line 111... Replacement fluid pump 121...Dialysis fluid pump 131...Dialysis fluid or drainage pump in drainage inlet line 150...Control device or closed-loop control device 200…Dialysate supply source 201... Substitution fluid supply source (optional) 300...Extracorporeal blood circuit 301...First line (arterial line section) 302...(first) tube clamp 303...Blood filters or dialysis machines 303a...dialysis fluid chamber 303b...Blood chamber 303c…Semi-permeable membrane 305...Second line (venous line section) 306...(Second) Tube Clamp A...Selection range I1...first input interface I2: Second input interface I3: Display device K1...Combination 1 K2…Combination 2 K3…Combination 3 K B …selected combination B1: Expected (or expected) serum bicarbonate concentration of 30 mmol / l B2: Expected serum bicarbonate concentration of 28 mmol / L B3: Expected serum bicarbonate concentration of 26 mmol / L B4: Expected serum bicarbonate concentration of 24 mmol / L B5: Expected serum bicarbonate concentration of 22 mmol / L B6: Expected serum bicarbonate concentration of 20 mmol / L B7: Expected serum bicarbonate concentration of 18 mmol / L S1...Method step a S2...Method step b S3...Method step c S4...Method step d S5...Method step e S6…Further method steps S7…Further method steps Q ·1. Q · 2. Q · 3. Q · B …adjustable values ​​for blood pumps D · 1. D · 2. D · 3. D · B …adjustable values ​​for dialysate pump

Claims

1. 1. A computer system for setting adjustable values ​​in a blood treatment device, comprising: a first input interface; a second input interface; an output interface; a computing device; - Display devices and and the computing device - using said first input interface to read a target value of renal dose as a parameter value for the treatment of a patient using a blood treatment device; - displaying a selected range (A) to the user in a graph via the display device, wherein the selected range (A) is calculated by the calculation device to correspond to the read target value of the renal dose on the one hand and to exactly one adjustable value for the flow rate of the blood pump (Q ・ １ , Q ・ ２ , Q ・ ３ ) and exactly one adjustable value for the flow rate of the dialysate pump (D ・ １ , D ・ ２ , D ・ ３ ) to reach the read target value of the renal dose (K １ , K. ２ , K. ３ ) and is determined based on - Select the combination (K) from the displayed combinations (K1, K2, K3). Ｂ a second input interface for selecting by the user; It is programmed to do said computing device outputs, via said output interface, said selected combination (K Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ ), the computing device - further programmed to read further parameter values ​​(B1, B2, B3, B4, B5, B6, B7); - said selection range (A) is further limited by said computing device based on said further parameter values ​​(B1 to B7); the further parameter values ​​(B1 to B7) relate to the desired anticoagulation or the desired bicarbonate concentration in the serum; Computer system.

2. The computer system of claim 1, wherein the desired anticoagulation is citrate-calcium anticoagulation.

3. The computer system of claim 1 or 2, wherein the computer system is provided on a mobile device, a handheld device, a mobile phone, a smartphone, or a tablet.

4. The computing device displays the selected combination (K Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ 4. The computer system according to claim 1, programmed to display or present a

5. The computer system of any one of claims 1 to 4, wherein the computer system is a control device or a closed loop control device of a blood treatment apparatus or is in signal communication with the blood treatment apparatus.

6. The control device or closed-loop control device selects the selected combination (K Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ 6. The computer system of claim 5, programmed to control or regulate the blood treatment device based on:

7. A blood treatment device embodied as a dialysis machine and comprising a computer system according to any one of claims 1 to 6.

8. 8. Blood treatment device according to claim 7, embodied as a hemodialysis device, a hemofiltration device or a hemodiafiltration device, in particular as a device for long-term renal replacement therapy or continuous renal replacement therapy (CRRT).

9. one or more blood treatment devices embodied as dialysis machines; a computer system according to any one of claims 1 to 6; comprising or consisting of A system wherein the one or more blood treatment devices and the computer system are separate from one another.

10. A method for setting adjustable values ​​of a blood treatment device, executed by a computer system according to any one of claims 1 to 6, a blood treatment device according to any one of claims 7 to 8, or a system computer according to claim 9, comprising: - reading said renal dose target value as a parameter value for said treatment of the patient via a blood treatment device or inputting said parameter value via said first input interface; - graphically displaying, via the display device, a selection range (A) for the attention of the user, wherein the selection range (A) is determined by the calculation device on the basis of the target value of the renal dose and, on the other hand, on the basis of exactly one adjustable value for the flow rate of the blood pump (Q ・ １ , Q ・ ２ , Q ・ ３ ) and on the other hand exactly one adjustable value for the flow rate of the dialysate pump (D ・ １ , D ・ ２ , D ・ ３ ) and displaying a plurality of combinations (K 1 , K 2 , K 3 ) for reaching the read target value of the renal dose; a combination (K1, K2, K3) of the combinations (K1, K2, K3) displayed by the user via the second input interface; Ｂ ) and via the output interface, the selected combination (K Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ ) and The method includes the step of:

11. - presenting the selected combination (K) to the attention of the user via the display device; Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ and displaying or presenting the image. The method of claim 10.

12. - the selected combination (K Ｂ ) for the blood pump (Q ・ Ｂ ) and the adjustable value for the dialysate pump (D ・ Ｂ and controlling or regulating the blood treatment device based on the measured value of the blood treatment signal.

12. The method according to claim 10 or 11.

13. A digital storage medium, in particular in the form of a diskette, CD or DVD, EPROM, FRAM or SSD, having electronically readable control signals adapted to interact with a programmable computer system so that said computer system can be programmed to become a computer system according to any one of claims 1 to 6.

14. A computer program having a program code which, when the computer program is run on a computer, enables the computer system to be programmed to become a computer system according to any one of claims 1 to 6.

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