Sustained release anesthetic composition and method for preparing same
A one-step lyophilization process forms a lipid-based complex for sustained-release anesthetics, addressing the complexity and cost issues of conventional methods by providing rapid onset and prolonged anesthesia with high drug entrapment efficiency.
JP7770367B2Active Publication Date: 2025-11-14TLC BIOPHARMACEUTICALS INC +1
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Patent Information
- Application Number
- JP2023174172
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2018-03-30
- Filing Date
- 2023-10-06
- Publication Date
- 2025-11-14
- Estimated Expiration
- 2039-03-30
AI Technical Summary
Technical Problem
Conventional lipid-based formulations for sustained-release local anesthetics require tedious procedures and high production costs, lacking a simplified manufacturing process with improved drug entrapment and efficacy.
Method used
A one-step lyophilization process is used to create a lipid cake containing a local anesthetic and a lipid mixture, which is then hydrated with a pH-controlled buffer to form a lipid-based complex, allowing for rapid onset and long duration of local anesthesia with minimal toxicity.
Benefits of technology
The method provides a simple and reliable manufacturing process for sustained-release anesthetic compositions with high drug entrapment efficiency, achieving rapid onset and extended duration of anesthesia with minimal toxicity.
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Abstract
To provide an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof.SOLUTION: An anesthetic composition has a lipid-based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method for preparing an anesthetic composition using what is a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.SELECTED DRAWING: Figure 2B
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