Food tablet manufacturing method

Abstract

To provide a method for manufacturing a food tablet including a food material causing tableting failure.SOLUTION: A method for manufacturing a food tablet includes tableting a tablet raw material containing at least one kind selected from the group consisting of amino acids, a fat-soluble compound, fat-containing algal-derived powder, fat-containing plant-derived powder and saccharide, by a tablet machine with a lubricant applied by spraying to a tableting surface.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a method for producing a highly adhesive food material by tableting. [Background technology]

[0002] Tablet-shaped foods are used in the fields of confectionery, supplements, health foods, etc. Tableting is one method of manufacturing tablets. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 2014-091714 Summary of the Invention [Problem to be solved by the invention]

[0004] Some food ingredients that are desired to be tableted have strong adhesive properties. When raw material powders containing such food ingredients are used for tableting, tableting problems such as sticking (the phenomenon in which the raw material powder adheres to the punch or die) and molding defects such as chipped surfaces of the formed tablets frequently occur, making industrial mass production difficult. To solve this problem, a technique has been reported in which the raw material is mixed with other adsorbent ingredients to suppress adhesion before being compressed into tablets, but the incorporation of such other ingredients is not originally intended. Furthermore, the incorporation of such other ingredients or pretreatment with such ingredients results in additional costs and operations. [Means for solving the problem]

[0005] The present inventors have investigated the possibility of producing highly adhesive tablets containing coenzyme Q10, calcium hydroxymethylbutyrate, etc. by tableting. As a result, they have discovered that by spraying a lubricant such as calcium stearate onto the tableting surface (punches and / or dies) of a tableting machine before tableting, tableting problems are suppressed, poor appearance of the tablets produced is suppressed, and tableting can be continued for a long period of time, thereby completing the present invention.

[0006] The present invention includes, for example, the following aspects. Section 1. A method for producing food tablets, comprising a step of tableting a tableting raw material containing at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars, using a tableting machine whose tableting surface has been sprayed with a lubricant. Section 2. Item 2. The method for producing food tablets according to Item 1, wherein the lubricant is at least one selected from the group consisting of calcium stearate and magnesium stearate. Section 3. Item 3. The method for producing food tablets according to Item 1 or 2, wherein the amino acid is at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine. Section 4. 4. The method for producing a food tablet according to any one of Items 1 to 3, wherein the fat-soluble compound is at least one selected from the group consisting of α-lipoic acid, coenzyme Q10, coenzyme linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, and EPA. Section 5. 5. The method for producing food tablets according to any one of Items 1 to 4, wherein the lipid-containing algae-derived powder is at least one selected from the group consisting of Euglena, Spirulina, and Chlorella. Section 6. 6. The method for producing a food tablet according to any one of Items 1 to 5, wherein the lipid-containing plant-derived powder is at least one selected from the group consisting of Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, and saffron extract powder. Section 7. Item 7. The method for producing food tablets according to any one of Items 1 to 6, wherein the saccharide is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol. Section 8. Item 3. A method for producing a food tablet according to Item 1 or 2, wherein the adhesive component is at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine, and the content of the adhesive component is 30% by mass or more of the mass of the tableting raw materials. Section 9. Item 3. The method for producing food tablets according to Item 1 or 2, wherein the adhesive component is at least one selected from the group consisting of α-lipoic acid, coenzyme Q10, linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, and EPA, and the content of the adhesive component is 10% by mass or more of the mass of the tableting raw materials. Section 10. Item 3. A method for producing a food tablet according to Item 1 or 2, wherein the adhesive component is at least one selected from the group consisting of Euglena, Spirulina, Chlorella, Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, and saffron extract powder, and the content of the adhesive component is 50% by mass or more of the mass of the tableting raw materials. Section 11. Item 3. A method for producing a food tablet according to Item 1 or 2, wherein the adhesive component is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol, and the content of the adhesive component is 50% by mass or more of the mass of the tableting raw materials. Section 12. A food tablet containing at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars, in an amount of 10% by mass or more relative to the tablet mass. Section 13. Item 13. The food tablet according to Item 12, wherein the adhesive component is at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine, and the adhesive component accounts for 30% by mass or more of the tablet mass. Section 14. Item 13. The food tablet according to Item 12, wherein the adhesive component is at least one selected from the group consisting of alpha-lipoic acid, coenzyme Q10, coenzyme Q10, linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, lecithin, plasmalogen, DHA, and EPA. Section 15. Item 13. The food tablet according to Item 12, wherein the adhesive component is at least one selected from the group consisting of Euglena, Salacia extract powder, rice bran extract powder, sesame extract powder, and soybean extract powder, and the adhesive component accounts for 50% by mass or more of the tablet mass. Section 16. Item 13. The food tablet according to Item 12, wherein the adhesive component is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol, and the adhesive component accounts for 50% by mass or more of the tablet mass. [Effects of the Invention]

[0007] The method for producing food tablets of the present invention can suppress tableting problems (such as sticking, peeling of the tablet surface, etc.) when tablets containing highly adhesive food materials are produced by tableting. The food tablet of the present invention contains a highly adhesive food material, and peeling of the tablet surface is suppressed even when it does not contain any other ingredients to suppress the adhesiveness. DETAILED DESCRIPTION OF THE INVENTION

[0008] Unless otherwise specified, the symbols and abbreviations used in this specification should be understood to have the meanings commonly used in the technical field to which the present invention pertains, in accordance with the context of this specification. As used herein, the phrase "comprising" is intended to encompass the phrases "consisting essentially of" and "consisting of."

[0009] Food tablet manufacturing method The method for producing food tablets of the present invention may be a method for producing food tablets by tableting that contain highly adhesive ingredients such as amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars. In this production method, a lubricant is sprayed onto the tableting surface of the tablet press used for tableting, thereby suppressing tableting problems such as sticking and peeling of the tablet surface that are caused by highly adhesive food materials.

[0010] The tableting surface is the surface of a tablet press that comes into contact with the raw material powder when compressing and molding the raw material powder, and is typically the punch and die. The lubricant may be sprayed onto either the punch alone, the die alone, or both the punch and die, with the punch being preferred. The spray application of the lubricant onto the tableting surface can typically be carried out using a commercially available external spray application device.

[0011] Examples of lubricants that can be sprayed onto the tableting surface include calcium stearate and magnesium stearate, with calcium stearate and magnesium stearate being preferred, and calcium stearate being more preferred from the standpoint of food safety. Lubricants can be used singly or in combination of two or more. The amount of lubricant to be sprayed is not particularly limited as long as it can suppress tableting problems. The amount of lubricant to be sprayed can be, for example, 0.01 to 1.5% by mass, 0.01 to 1.0% by mass, etc., and preferably 0.05 to 0.5% by mass relative to the mass of one tablet.

[0012] The tablet press used for tableting is not particularly limited as long as it can mold tablets. Examples of tablet presses include single-punch tablet presses and rotary tablet presses, with rotary tablet presses being preferred from the viewpoints of continuous tableting and good cooperation with an external spray device. The compression pressure during tableting is not particularly limited as long as it allows tablets to be formed. The compression pressure can be, for example, 3 to 20 KN, 3 to 15 KN, etc., and is preferably 3 to 12 KN. The above and other conditions regarding the tablet press and spray application can be set and changed as appropriate depending on the type and amount of raw materials, the shape and amount of tablets to be produced, etc.

[0013] The shape of the food tablets to be produced is not particularly limited, and can be any desired shape depending on the intended use of the food tablets, the specifications of the tablet press, etc.

[0014] The tableting raw material is usually a powder, but is not particularly limited as long as it can be used to form tablets.

[0015] The amino acids may be essential amino acids, non-essential amino acids, free amino acids, etc. Essential amino acids include valine, isoleucine, leucine, methionine, lysine, phenylalanine, tryptophan, threonine, and histidine, with isoleucine, leucine, valine, and tryptophan being preferred. Non-essential amino acids include arginine, glycine, alanine, serine, tyrosine, cysteine, asparagine, glutamine, proline, aspartic acid, and glutamic acid being preferred. Examples of amino acids include essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, carnitine, cystine, 5-aminolevulinic acid, and pyroglutamic acid, with essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine being preferred, essential amino acids, glutamine, citrulline, carnitine, γ-aminobutyric acid, and calcium hydroxymethylbutyrate being more preferred, and glycine, glutamine, citrulline, carnitine, and calcium hydroxymethylbutyrate being particularly preferred. The amino acids can be used alone or in combination of two or more.

[0016] The fat-soluble compound may be, for example, fat-soluble vitamins (vitamin A, vitamin D, vitamin E, vitamin K), α-lipoic acid, coenzyme Q10, linoleic acid, astaxanthin, lutein, carotene, lycopene, lecithin, plasmalogen, DHA, or EPA, and may be, for example, α-lipoic acid, coenzyme Q10, linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, or EPA, with coenzyme Q10, α-lipoic acid, lecithin, or vitamin E being preferred. The fat-soluble compound may be used alone or in combination of two or more.

[0017] The lipid-containing algae-derived powder may be a powder containing lipids obtained from algae, such as a lipid-containing algae powder or a lipid-containing algae extract powder. The lipid-containing algae-derived powder can be used alone or in combination of two or more. The lipid-containing algae powder is, for example, a powder of Euglena, Spirulina, Chlorella, kelp, laver, wakame, etc., with Euglena, kelp, laver, wakame, etc. being preferred, and Euglena, Spirulina, and Chlorella powder being more preferred. The lipid-containing algae extract powder may be, for example, a powder of extract obtained from Euglena, Spirulina, Chlorella, kelp, laver, wakame, etc., preferably a powder of extract obtained from Euglena, kelp, laver, wakame, etc., and more preferably an extract powder obtained from Euglena.

[0018] The lipid-containing plant-derived powder may be a powder containing lipids obtained from plants, but does not include powders containing lipids obtained from algae. Examples of lipid-containing plant-derived powders include lipid-containing plant powders and lipid-containing plant extract powders. The lipid-containing plant-derived powders can be used alone or in combination of two or more. The lipid-containing plant powder is, for example, powder of the genus Eleuthero mushroom, Cordyceps sinensis, or the like. The lipid-containing plant extract powder may be, for example, Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, saffron extract powder, etc., with Salacia extract powder, rice bran extract powder, sesame extract powder, and soybean extract powder being preferred, Salacia extract powder, rice bran extract powder, sesame extract powder, and soybean extract powder being more preferred, and Salacia extract powder and soybean extract powder being even more preferred.

[0019] The sugars may be, for example, glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, erythritol, etc., with glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, and xylitol being preferred, and glucosamine, glucosamine hydrochloride, and isomaltodextrin being more preferred. The sugars can be used alone or in combination of two or more.

[0020] The at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars may be at least one component selected from the group consisting of coenzyme Q10, α-lipoic acid, lecithin, vitamin E, calcium hydroxymethylbutyrate, glutamine, citrulline, glycine, carnitine, glucosamine hydrochloride, Euglena, spirulina, chlorella, Eleuthero mushrooms, Salacia extract powder, and 5-aminolevulinic acid, or may be at least one component selected from the group consisting of coenzyme Q10, α-lipoic acid, lecithin, vitamin E, calcium hydroxymethylbutyrate, glutamine, citrulline, glycine, carnitine, glucosamine hydrochloride, Euglena, spirulina, chlorella, and 5-aminolevulinic acid. As the adhesive component, coenzyme Q10, calcium hydroxymethylbutyrate, Euglena, white bell mushroom, and Salacia extract powder are preferred, coenzyme Q10, calcium hydroxymethylbutyrate, and Euglena are more preferred, and coenzyme Q10 and calcium hydroxymethylbutyrate are more preferred.

[0021] The content ratio of at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars in the tableting raw materials is not particularly limited as long as tableting problems can be suppressed. For example, the content ratio of the adhesive component may be 5 to 98 mass%, 10 to 98 mass%, 15 to 98 mass%, 20 to 98 mass%, 30 to 98 mass%, 40 to 98 mass%, 50 to 98 mass%, 5 to 96 mass%, 10 to 96 mass%, 15 to 96 ...0 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 98 mass%, 50 to 96% by mass, 30-96% by mass, 40-96% by mass, 50-96% by mass, 70-96% by mass, 70-95% by mass, 5-90% by mass, 10-90% by mass, 15-90% by mass, 20-90% by mass, 30-90% by mass, 40-90% by mass %, 50-90% by mass, 70-90% by mass, 10% by mass or more, 30% by mass or more, 50% by mass or more, 10-70% by mass, 15-60% by mass, 20-50% by mass, 50-90% by mass, 50-85% by mass, 50-80% by mass, etc.

[0022] When the adhesive component is at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine, the content of the adhesive component in the tableting raw material can be, for example, 30% by mass or more, 30 to 98% by mass, 50 to 98% by mass, 30 to 96% by mass, 50 to 96% by mass, 70 to 95% by mass, etc., and 70 to 96% by mass is preferred, relative to the mass of the tableting raw material.

[0023] When the adhesive component is at least one selected from the group consisting of α-lipoic acid, coenzyme Q10, coenzyme linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, and EPA, the content of the adhesive component in the tableting raw material can be, for example, 10% by mass or more, 10 to 70% by mass, 15 to 60% by mass, or the like, and 20 to 50% by mass is preferred, relative to the mass of the tableting raw material.

[0024] When the adhesive component is at least one selected from the group consisting of Euglena, Spirulina, Chlorella, Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, and saffron extract powder, the content of the adhesive component in the tableting raw material can be, for example, 50% by mass or more, 50 to 90% by mass, 50 to 85% by mass, 50 to 80% by mass, etc., and 50 to 81% by mass is preferred, relative to the mass of the tableting raw material.

[0025] When the adhesive component is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol, the content of the adhesive component in the tableting raw material can be, for example, 50% by mass or more, 50 to 95% by mass, 50 to 90% by mass, 60 to 90% by mass, or the like, and 70 to 90% by mass is preferred, relative to the mass of the tableting raw material.

[0026] The tableting raw material may contain other ingredients in addition to at least one adhesive ingredient selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars, as needed. The content of the other ingredients in the tableting raw material may be the remainder of the content of the at least one adhesive ingredient selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars. Other ingredients can be a wide variety of raw materials used in tableting food tablets. Other ingredients include excipients, proteins, sugars, other vitamins, minerals, flavonoids, quinones, polyphenols, nucleic acids, essential fatty acids, cooling agents, binders, sweeteners, disintegrants, lubricants, colorants, flavorings, stabilizers, preservatives, sustained-release regulators, surfactants, glossing agents, solubilizers, wetting agents, and fluidizing agents, which can be blended singly or in combination in appropriate amounts. Furthermore, the produced food tablets may be coated with a coating agent (e.g., shellac, sucrose, gelatin, hydroxypropyl cellulose, hydroxypropyl methylcellulose, etc.) or may be coated with one or more layers, if necessary.

[0027] Examples of excipients include maltitol, maltose, lactose, mannitol, glucose, crystalline cellulose, starch, sorbitol, erythritol, xylitol, lactitol, and dextrin. Examples of binders include hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, and polyvinylpyrrolidone. Examples of surfactants include sucrose fatty acid esters, glycerin fatty acid esters, lecithin, and propylene glycol. Examples of sweeteners include maltitol, trehalose, xylitol, sorbitol, erythritol, aspartame, stevia, sucralose, acesulfame potassium, and thaumatin. Examples of disintegrants include agar, carboxymethylcellulose, calcium carboxymethylcellulose, sodium carboxymethylcellulose, calcium cellulose glycolate, and the like. Examples of lubricants include magnesium stearate, calcium stearate, sucrose fatty acid esters, vegetable oils and fats. The fluidizing agent may include fine silicon dioxide, talc, and the like. Examples of proteins include soy whey, milk whey, and gelatin. Examples of sugars include starch, dextrin, monosaccharides, glucose, and fructose. Other vitamins include, for example, B vitamins, vitamin C, vitamin P, niacin, nicotinic acid, pantothenic acid, biotin, inositol, choline, and folic acid. Examples of minerals include calcium, potassium, magnesium, sodium, copper, iron, manganese, zinc, and selenium, and these include inorganic and organic minerals.

[0028] Other preferred ingredients include microcrystalline cellulose, maltitol, and microcrystalline silicon dioxide.

[0029] Food tablets The food tablet of the present invention contains at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars in an amount of 10% by mass or more relative to the tablet mass. The food tablet of the present invention can be produced, for example, by the production method of the present invention. The food tablet of the present invention is

[0030] Unless otherwise specified, the above-mentioned explanation regarding the manufacturing method of the present invention that is applicable to food tablets can be applied to the food tablets of the present invention. For example, when the food tablets contain amino acids, the amino acids explained in the explanation of the manufacturing method of the present invention can be used as the amino acids. The content ratio of at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars, and other components in the food tablets can be the same as the content ratio of those components in the tableting raw materials described in the manufacturing method of the present invention.

[0031] The hardness of the food tablet of the present invention can be, for example, 40 to 300 N, 50 to 200 N, etc., and is preferably 50 to 150 N. According to the production method of the present invention, even when tableting raw materials containing highly adhesive ingredients are used, tableting problems are unlikely to occur, and therefore food tablets with high hardness can be produced despite the presence of highly adhesive ingredients.

[0032] The food tablets of the present invention contain amino acids, fat-soluble compounds, lipid-containing algae-derived powder, lipid-containing plant-derived powder, or sugars, and therefore can be tablets that have physiological activity, taste, color, odor, etc. based on these components. Therefore, based on the physiological activity of these components, they are suitable as tablets for health foods, functional foods, nutritional supplements, supplements, health foods, foods for specified health uses, nutritionally functional foods, and foods with functional claims, and are particularly suitable as tablets for supplements. [Example]

[0033] Hereinafter, one embodiment of the present invention will be described in more detail with reference to examples, but the present invention is not limited to these. The materials, devices, etc. used in the following examples are as follows. Rotary tablet press: AQUARIUS; Kikusui Seisakusho External lubrication spray device: ELS-P1; Kikusui Seisakusho Calcium stearate: Eika Shoji Co., Ltd. Magnesium stearate: Taihei Chemical Co., Ltd. Microcrystalline cellulose 1: VIVAPURE 101; Rettenmeyer Japan Co., Ltd. Microcrystalline cellulose 2: Ceolus UF-F711; Asahi Kasei Corporation Microcrystalline cellulose 3: Ceolus UF-F702; Asahi Kasei Corporation Microcrystalline cellulose 4: Ceolus ST-100; Asahi Kasei Corporation Lactose: LACTOSE 100M; manufactured by GLANBIA Maltose: Sanmaruto Midori; Hayashibara Co., Ltd. Hydroxypropyl cellulose: Celny L; Nippon Soda Co., Ltd. Fine silicon dioxide: Silopage; Fuji Silysia Chemical Ltd. Ascorbic acid: L-ascorbic acid - 100 mesh pass; Santo Luwei Coenzyme Q10: Phyto Q10; PhytoPharma Co., Ltd. Hydroxymethylbutyrate calcium: HMB-Ca; PhytoPharma Co., Ltd. Glycine: Glycine; Showa Denko K.K. L-Citrulline: Fermented Citrulline Kyowa; Kyowa Hakko Bio Co., Ltd. L-Glutamine: L-Glutamine; Kyowa Hakko Bio Co., Ltd. L-Carnitine Fumarate: L-Carnitine Fumarate; PhytoPharma Co., Ltd. Hydroxypropyl cellulose: Cerny SL; Nippon Soda Co., Ltd. Starch: PCS FC-50; Asahi Kasei Corporation Dietary fiber processed products (oat fiber, agar) / tricalcium phosphate: Inageru Fibersat; Ina Food Industry Co., Ltd. Tricalcium phosphate: Tricalcium phosphate: Yoneyama Chemical Industry Co., Ltd. Glucosamine Hydrochloride: Glucosamine (hydrochloride); Nakahara Co., Ltd. Chondroitin sulfate: Salmon-derived chondroitin 40; Nippon Pharmaceutical Co., Ltd. Type II collagen: UC-II UC-250; Ryusendo Co., Ltd. Spirulina: Spirulina Powder ST-F; Hainan DIC Microalgae Co., Ltd. Euglena: Euglena gracilis; Euglena Co., Ltd. Chlorella: Yaeyama Chlorella Powder; Yaeyama Shokusan Co., Ltd. Soy Lecithin: SLP-White; Tsuji Oil Mills Co., Ltd. α-Lipoic acid: R-α Lipoic Acid CD; CycloChem Bio Co., Ltd. d-α-Tocopherol; Mitsubishi Chemical Foods Corporation

[0034] Comparative Example 1: Production of tablets containing coenzyme Q10 by tableting Tablets were manufactured using the raw materials and their blending amounts shown in Table 1. Coenzyme Q10 is a highly adhesive substance. The mass of each tablet was 230 mg. All raw materials (total mass 3 kg) were placed in a bag and mixed well. The mixed raw materials were compressed into tablets using a rotary tablet press. The punches used for tableting were φ8 mm (6.5R), and six of these were installed in the tablet press. The operating parameters of the tablet press were set as follows: preload: 1.6 KN, main pressure: 10 KN, rotary rotation speed: 35 rpm. The target hardness of the tablets was set at a practical 60 N. Three minutes after the tablet press started operation, sticking occurred, with raw material powder adhering to all six upper punches. The tablets produced were defective, with gouged surfaces.

[0035] [Table 1]

[0036] Example 1: Production of tablets containing coenzyme Q10 by tableting Tableting was carried out in the same manner as in Comparative Example 1, while spraying calcium stearate onto the rotary part and punch and die part of the rotary tablet press using an external lubricant spray device. The operating parameters of the external lubricating spray device were spray flow rate: 32 g / hr, upper punch static voltage: 15 KV, lower punch static voltage: 20 KV, and the spray flow rate was adjusted so that 0.1% (0.23 mg) of calcium stearate of the tablet mass was added to each tablet. Tableting was continued for 15 minutes under these conditions, and no sticking or poorly formed tablets were observed, and glossy tablets with the target hardness of 60N were obtained. This indicates that by spraying calcium stearate onto punches and dies using an external lubrication spray device while tableting, it is possible to suppress sticking during the tableting process for a formulation containing 15% coenzyme Q10, making it possible to produce tablets with a smooth appearance.It is also believed that this effect can be achieved by using powdered oils and fats other than calcium stearate, such as magnesium stearate.

[0037] Examples 2 to 5: Production of tablets containing 20 to 50% coenzyme Q10 by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 2. The mass of each tablet was 210 mg. All raw materials (total mass 3 kg) were placed in a bag and mixed well. The mixed raw materials were compressed into tablets using a rotary tablet press. The punches used for tableting were φ8 mm (6.5R), and six of these were installed in the tablet press. The operating parameters of the tablet press were set as follows: preload: 1.6-1.8 KN, main pressure: 4-10 KN, rotary rotation speed: 35 rpm. In addition, calcium stearate was sprayed onto the rotary part and punch and die part of the rotary tablet press, while tableting was carried out in the same manner as in Example 1. The operating parameters of the external lubricant spray device were spray flow rate: 26-130 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and the spray flow rate was adjusted so that the amount of calcium stearate shown in Table 2 was added to each tablet. In Examples 2 and 3, tableting was continued for 15 minutes, but no sticking or poorly formed tablets were observed. In Examples 4 and 5, tableting was continued for 7 minutes, but no sticking or poorly formed tablets were observed. The tablet hardness in each Example was 60 to 70 N, which was at a practical level. There was no prior knowledge demonstrating that raw material powder containing a high concentration of coenzyme Q10 could be tableted, and this was demonstrated for the first time in the Examples of the present application.

[0038] [Table 2]

[0039] Comparative Examples 2 to 5: Production of tablets containing 20 to 50% coenzyme Q10 by tableting Except for not spraying calcium stearate onto the rotary part and punch and die part using an external lubricant spray device, tableting was carried out in the same manner as in Examples 2 to 5. Comparative Examples 2 to 5 correspond to Examples 2 to 5, respectively. Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all six punches. For this reason, by performing tableting while spraying calcium stearate onto the punches and dies using an external lubricant spray device, as in the above example, it was possible to suppress the occurrence of sticking even when tableting using raw material powder with a high concentration of coenzyme Q10, at 50%.

[0040] Comparative Example 6: Preparation of tablets containing hydroxymethylbutyrate calcium (HMB-Ca) by tableting Tableting was carried out in the same manner as in Comparative Example 1, except that the raw materials were changed to those shown in Table 3. The target hardness of the tablets was 120N. Three minutes after the tablet press started operation, sticking occurred, with raw material powder adhering to all six upper punches. The tablets produced were defective, with gouged surfaces.

[0041] [Table 3]

[0042] Example 6: Preparation of tablets containing HMB-Ca by tableting Tableting was carried out in the same manner as in Example 1, except that the raw materials were changed to those shown in Table 3. The target hardness of the tablets was 120N. Tableting was continued for 20 minutes, but no sticking or poorly formed tablets were observed, and glossy tablets with the target hardness of 120N were obtained.

[0043] Example 7 and Comparative Example 7: Preparation of tablets containing HMB-Ca by tableting Tableting was performed in the same manner as in Example 1, except that the raw materials were changed to those shown in Table 3, the spray flow rate was changed to 16 g / hr, and the amount of calcium stearate added was changed to 0.05% (0.115 mg). The target hardness of the tablets was 120 N. Tableting was continued for 20 minutes, but no sticking or poorly formed tablets were observed, and glossy tablets having the target hardness of 120 N were obtained (Example 7). Thereafter, the external lubricant spray device was stopped and tableting was continued. After 5 minutes, tablets with hollowed out surfaces were observed, and sticking had occurred with all punches (Comparative Example 7).

[0044] Examples 8 to 10 and Comparative Example 8: Production of tablets containing 40 to 60% HMB-Ca by tableting Tableting was performed in the same manner as in Example 6, except that the raw materials were changed to those shown in Table 4, the mass per tablet was changed to 200 mg, the preload to 1.5 KN, the main pressure to 4 to 8 KN, the spray flow rate to 26 g / hr, and the amount of calcium stearate added to the tablet was changed to 0.1% (0.20 mg) of the tablet mass. The target hardness of the tablets was set to 120 N. Tableting was continued for 20 minutes, but no sticking or poorly formed tablets were observed, and glossy tablets having the target hardness of 120 N were obtained (Examples 8 to 10). After the tableting in Example 8, the external lubricant spray device was stopped and tableting was continued. After 30 seconds, the surfaces of all tablets were gouged and sticking had occurred in all punches (Comparative Example 8).

[0045] [Table 4]

[0046] Examples 11 to 13 and Comparative Example 9: Production of tablets containing 70 to 90% HMB-Ca by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 5. Because HMB-Ca has poor fluidity and is difficult to handle, it was granulated before use. The weight of each tablet was 200 mg. HMB-Ca was placed in a fluidized bed granulation dryer (FLOW COATER, Freund Corporation), and granulated while spraying a 10% solution of hydroxypropyl cellulose (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated HMB-Ca, crystalline cellulose, maltose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 5, shaken thoroughly, and then compressed into tablets using a rotary tablet press. The punch used was 8 mm in diameter (6.5 R), and the operating parameters of the tablet press were a preload of 1.2-1.4 kN, a main load of 3-4 kN, and a rotary speed of 35 rpm. The operating parameters of the external lubricating spray device were spray flow rate: 26 g / hr, upper punch static voltage: 15 KV, lower punch static voltage: 20 KV, and were adjusted so that 0.1% (0.20 mg) of calcium stearate of the tablet mass was added to each tablet. The rotary tablet press and external spray device were operated, and tablets were produced in the same manner as in Example 6. The target hardness of the tablets was 120N. Tableting was continued for 20 minutes, but no sticking or poorly formed tablets were observed, and glossy tablets having the target hardness of 120 N were obtained (Examples 11 to 13). After the tableting in Example 11, the external lubricant spray device was stopped and tableting was continued. After 30 seconds, tablets with hollowed surfaces were observed, and sticking had occurred in all punches (Comparative Example 9). By using an external lubrication spray device to spray calcium stearate at only 0.1% of the tablet mass while tableting, it was possible to produce tablets with a high HMB-Ca content of 90%.

[0047] [Table 5]

[0048] Example 14 and Comparative Example 10: Preparation of tablets containing 90% glutamine by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 6. The weight of each tablet was 300 mg. Because glutamine has poor fluidity and is difficult to handle, it was granulated in advance. When the total lot weight was 5 kg, glutamine was placed in a stirring granulator (vertical granulator, Powrex) and kneaded with a 3.75% solution of hydroxypropyl cellulose (blade: 300-400 rpm, chopper: 1400-1500 rpm). The glutamine was then dried in a fluidized-bed granulator to granulate the glutamine (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated glutamine, hydroxypropyl cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 6, thoroughly shaken, and then compressed in a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary part and punch and die part of the tablet press using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 142 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.5% (1.5 mg) of calcium stearate of the total tablet weight was added to each tablet. As a result of 30 minutes of continuous tableting, practical tablets with a hardness of 68.2 N were obtained in Example 14, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the nine punches. Tableting was carried out in the same manner as in Example 14, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 10). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This demonstrates that by using an external lubricant spray device to spray calcium stearate onto the punches and dies while tableting, it is possible to prevent sticking even at a high glutamine concentration of 90%.

[0049] [Table 6]

[0050] Example 15 and Comparative Example 11: Production of tablets containing 80% citrulline by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 7. The weight per tablet was 350 mg. Because citrulline has poor fluidity and is difficult to handle, it was granulated in advance. When the total lot weight was 5 kg, citrulline was placed in a stirring granulator (vertical granulator, Powrex), and a 4% solution of hydroxypropyl cellulose was added dropwise (blade: 300-400 rpm, chopper: 1400-1500 rpm). The mixture was then dried in a fluidized bed granulator to granulate citrulline (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated citrulline, hydroxypropyl cellulose, crystalline cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 7, thoroughly shaken, and then compressed into tablets using a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary and punch and die sections using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 165 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.5% (1.75 mg) of calcium stearate was added to each tablet based on the tablet weight. As a result of 30 minutes of continuous tableting, practical tablets with a hardness of 63.7 N were obtained in Example 15, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the nine punches. Tableting was carried out in the same manner as in Example 15, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 11). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This demonstrates that by performing tableting while spraying calcium stearate onto punches and dies using an external lubricant spray device, it is possible to suppress sticking even at a high citrulline concentration of 80%.

[0051] [Table 7]

[0052] Example 16 and Comparative Example 12: Preparation of tablets containing 90% glycine by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 8. The weight of each tablet was 350 mg. Because glycine has poor fluidity and is difficult to handle, it was granulated in advance. When the total lot weight was 5 kg, the glycine was placed in a stirring granulator (vertical granulator, Powrex), and a 4% solution of hydroxypropyl cellulose was added dropwise (blade: 300-400 rpm, chopper: 1400-1500 rpm). The mixture was then dried in a fluidized-bed granulator to granulate the glycine (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated glycine, hydroxypropyl cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 8, thoroughly shaken, and then compressed in a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary and punch and die sections using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 165 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.5% (1.75 mg) of calcium stearate was added to each tablet based on the tablet weight. As a result of 30 minutes of continuous tableting, practical tablets with a hardness of 65.1 N were obtained in Example 16, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the nine punches. Tableting was carried out in the same manner as in Example 16, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 12). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This demonstrates that by performing tableting while spraying calcium stearate onto punches and dies using an external lubricant spray device, it is possible to suppress sticking even at a high glycine concentration of 90%.

[0053] [Table 8]

[0054] Example 17 and Comparative Example 13: Preparation of tablets containing 90% carnitine by tableting Tablets were manufactured using the raw materials and formulations shown in Table 9. The weight of each tablet was 300 mg. Because carnitine has poor fluidity and is difficult to handle, it was prepared in advance. When the total lot weight was 5 kg, the carnitine was placed in a stirring granulator (vertical granulator, Powrex), and a 5% solution of hydroxypropyl cellulose was added dropwise (blade: 300-400 rpm, chopper: 1400-1500 rpm). The carnitine was then dried in a fluidized-bed granulator dryer to granulate the carnitine (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated carnitine, hydroxypropyl cellulose, crystalline cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 9, thoroughly shaken, and then compressed in a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary and punch and die sections using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 99 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.3% (0.9 mg) of calcium stearate was added to each tablet based on the tablet weight. As a result of 30 minutes of continuous tableting, in Example 17, tablets with a hardness of 100N were obtained, no tablets were found to have any dents or hollows on the outside, and no sticking occurred with any of the nine punches. Tableting was carried out in the same manner as in Example 17, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 13). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This demonstrates that by using an external lubricant spray device to spray calcium stearate onto punches and dies while tableting, it is possible to prevent sticking even at a high carnitine concentration of 80%.

[0055] [Table 9]

[0056] Example 18 and Comparative Example 14: Preparation of tablets containing 96% HMB-Ca by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 10. The weight of each tablet was 260 mg. Because HMB-Ca has poor fluidity and is difficult to handle, HMB-Ca was prepared in advance. When the total lot weight was 5 kg, the HMB-Ca was placed in a stirring granulator (vertical granulator, Powrex) and kneaded dropwise with a 3.75% solution of hydroxypropyl cellulose (blade: 300-400 rpm, chopper: 1400-1500 rpm). The HMB-Ca was then dried in a fluidized-bed granulator dryer to granulate the HMB-Ca (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated HMB-Ca, hydroxypropyl cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 10, thoroughly shaken, and then compressed in a rotary tablet press. The punch used was φ8 mm (6.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary and punch and die sections using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 155 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.5% (1.3 mg) of calcium stearate was added to each tablet based on the tablet weight. As a result of 30 minutes of continuous tableting, practical tablets with a hardness of 178.4 N were obtained in Example 18, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the nine punches. Tableting was carried out in the same manner as in Example 18, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 14). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This demonstrates that by using an external lubricant spray device to spray calcium stearate onto the punches and dies while tableting, it is possible to prevent sticking even at a high concentration of 96% HMB-Ca. The results of Examples 6 to 18 revealed that when the raw material powder contains amino acids that are prone to sticking, sticking can be prevented by spraying a lubricant onto the tableting surface while tableting. Amino acids are thought to be adhesive due to the high surface free energy of the amino group. For this reason, this tableting method is thought to be effective in preventing sticking even when other amino acids, such as essential amino acids, non-essential amino acids, γ-aminobutyric acid, theanine, 5-aminolevulinic acid, etc., are used.

[0057] [Table 10]

[0058] Example 19 and Comparative Example 15: Preparation of tablets containing 50% coenzyme Q10 by tableting Tablets were manufactured using the raw materials and formulations shown in Table 11. The mass of each tablet was 270 mg. The total lot weight was 5 kg, and according to the formulation shown in Table 11, coenzyme Q10, starch, processed dietary fiber (oat fiber, agar), tricalcium phosphate, tricalcium phosphate, crystalline cellulose, fine silicon dioxide, and calcium stearate were placed in a bag, shaken well, and then compressed into tablets using a rotary tablet press. The punch used was φ9 mm (8.0 R), and the operating parameters of the tablet press were the same as those of Examples 11 to 13. The tablet press was operated while calcium stearate was sprayed onto the rotary and punch / die sections using an external lubricant spray device. The operating parameters of the external lubricating spray device were spray flow rate: 135 g / hr, upper punch static voltage: 15 KV, lower punch static voltage: 20 KV, and were adjusted so that 0.5% (1.35 mg) of calcium stearate was added to each tablet by weight. As a result of 10 minutes of continuous tableting, practical tablets with a hardness of 50.3 N were obtained in Example 19, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the 19 punches. Tableting was carried out in the same manner as in Example 19, except that calcium stearate was not sprayed onto the rotary part and punch and die part using an external lubricant spray device (Comparative Example 15). Immediately after the start of tableting, tablets with hollowed out surfaces were observed, and sticking was observed with all nine punches. This, as in Example 5, revealed that by performing tableting while spraying calcium stearate onto the punches and dies using an external lubricant spray device, it is possible to suppress the occurrence of sticking even at a high concentration of coenzyme Q10 of 50%.

[0059] [Table 11]

[0060] Example 20: Preparation of tablets containing 89% glucosamine hydrochloride by tableting Tablets were manufactured using the raw materials and formulations shown in Table 12. The weight of each tablet was 420 mg. Because glucosamine hydrochloride has poor fluidity and is difficult to handle, it was prepared in advance. When the total lot weight was 5 kg, a mixture of glucosamine hydrochloride and hydroxypropyl cellulose was placed in a stirring granulator (vertical granulator, Powrex), and 90% alcohol was added dropwise at 24% weight of the mixture. The mixture was kneaded (blade: 300-400 rpm, chopper: 1400-1500 rpm), and dried in a fluidized-bed granulator dryer to produce glucosamine hydrochloride granules (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated glucosamine hydrochloride, hydroxypropyl cellulose, chondroitin sulfate, type II collagen, and calcium stearate were then placed in a bag according to the formulation shown in Table 12, thoroughly shaken, and then compressed in a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary and punch and die sections using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 122 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.3% (1.29 mg) of calcium stearate was added to each tablet based on the tablet weight. As a result of 20 minutes of continuous tableting, practical tablets with a hardness of 96N were obtained in Example 20, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the nine punches. This demonstrates that high-content tablets with a glucosamine hydrochloride content of 89% can be prepared without sticking by using an external lubrication spray device to spray calcium stearate onto punches and dies while tableting. Compounds with a sugar chain skeleton, such as glucosamine, have high surface free energy, which is thought to cause stickiness. Other sugars commonly used in foods, such as xylitol, erythritol, sorbitol, glucose, and isomaltodextrin, also have similar properties. Therefore, even when these compounds are used, this tableting method, in which tablets are formed while spraying a lubricant, is thought to be effective in preventing sticking.

[0061] [Table 12]

[0062] Example 21: Preparation of tablets containing 50% fat-soluble compound by tableting Tablets were manufactured using the raw materials and formulations shown in Table 13. These tablets contained 55% of α-lipoic acid, soybean lecithin, and vitamin E as fat-soluble compounds. The weight of each tablet was 300 mg. Because these fat-soluble compounds have poor fluidity and are difficult to handle, the fat-soluble compounds were prepared in advance. When the total lot weight was 5 kg, α-lipoic acid, soybean lecithin, vitamin E, and maltitol were mixed and placed in a fluidized-bed granulator dryer, where they were granulated while spraying with water (inlet air temperature: 90°C, exhaust air temperature: 40-60°C). The granulated fat-soluble compounds, starch, crystalline cellulose, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 13, thoroughly shaken, and then compressed into tablets using a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary part and punch and die part of the tablet press using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 122 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.3% (1.3 mg) of calcium stearate of the tablet weight was added to each tablet. As a result of 20 minutes of continuous tableting, practical tablets with a hardness of 55.4 N were obtained in Example 21, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the 19 punches. This demonstrates that by using an external lubricant spray device to spray calcium stearate onto punches and dies while tableting, it is possible to prepare high-content tablets with a total fat-soluble compound content of 55% without sticking.

[0063] [Table 13]

[0064] Example 22: Preparation of tablets containing 80% lipid-containing algae-derived powder by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 14. These tablets contained 80% Euglena, Spirulina, and Chlorella as lipid-containing algae-derived powder. The weight of each tablet was 300 mg. Because these lipid-containing algae-derived powders have poor flowability and are difficult to handle, lipid-containing algae-derived powders were prepared in advance. When the total lot weight was 5 kg, the lipid-containing algae-derived powder and maltitol were mixed and placed in a fluidized-bed granulation dryer, where they were granulated while spraying water (inlet air temperature: 25°C, exhaust air temperature: 20-40°C). The granulated lipid-containing algae-derived powder, crystalline cellulose, maltitol, fine silicon dioxide, and calcium stearate were then placed in a bag according to the formulation shown in Table 14, shaken thoroughly, and then compressed into tablets using a rotary tablet press. The punch used was φ9 mm (7.5R), and the operating parameters of the tablet press were the same as in Examples 11 to 13. The tablet press was operated while spraying calcium stearate onto the rotary part and punch and die part of the tablet press using an external lubricant spray device. The operating parameters of the external lubricant spray device were spray flow rate: 122 g / hr, upper punch static voltage: 15 KV, and lower punch static voltage: 20 KV, and were adjusted so that 0.3% (1.3 mg) of calcium stearate of the tablet weight was added to each tablet. As a result of 20 minutes of continuous tableting, practical tablets with a hardness of 54.2 N were obtained in Example 22, no tablets were found to have dents or hollows on the outside, and no sticking occurred with any of the 19 punches. This demonstrates that by using an external lubrication spray device to spray calcium stearate onto punches and dies while tableting, high-content tablets containing 80% lipid-containing algae-derived powder and lipid-containing plant-derived powder can be prepared without sticking.

[0065] [Table 14]

[0066] Example 23: Preparation of tablets containing 81% lipid-containing algae-derived powder by tableting Tablets were manufactured using the raw materials and blending amounts shown in Table 15. These tablets contained 81% Euglena as lipid-containing algae-derived powder. The mass of each tablet was 310 mg. When the total lot weight was 5 kg, all raw materials were placed in a bag, shaken well, and then compressed into tablets using a rotary tablet press. The punch used was φ9.5 mm (two-stage R), and the operating parameters of the tablet press were the same as those of Examples 11 to 13. Calcium stearate was sprayed onto the rotary and punch and die parts of the tablet press using an external lubricant spray device while it was operating. The operating parameters of the external lubricant spray device were spray flow rate: 30 to 272 g / hr, upper punch static voltage: 15 KV, lower punch static voltage: 20 KV, and 0.1 to 0.9% (of the tablet weight) of the tablet was sprayed onto each tablet. 0.3 The amount of calcium stearate added was adjusted to about 2.8 mg. After 20 minutes of continuous tableting, tablets with a practical hardness (52.3 N) were obtained for all spray amounts, no tablets were found to have dents or holes on their exterior, and no sticking occurred with any of the six punches. This demonstrates that high-content tablets containing 81% Euglena can be prepared without sticking by using an external lubricant spray device to spray calcium stearate onto punches and dies while tableting.

[0067] From the results of the investigations in Examples 1 to 5, 19, and 21 to 23, it was found that algae containing fat-soluble compounds or lipids that tend to cause sticking Derived powderIt has been revealed that when the raw material powder contains a lubricant, sticking can be prevented by spraying a lubricant onto the tableting surface while tableting. Generally, during tableting, frictional heat, compression heat, and mechanical driving heat accumulate in the punch and die, causing the temperature to rise, which causes the lipids to melt and makes the raw material powder sticky. For this reason, it is believed that this tableting method is also effective in preventing sticking when using plant-derived powders containing lipids, such as gardenia extract powder, saffron extract powder, salacia extract powder, rice bran extract powder, sesame extract powder, and soy extract powder.

[0068] [Table 15]

Claims

1. A method for producing food tablets having a hardness of 40 to 150 N and a radius of curvature of 6.5 mm, 7.5 mm, or 8.0 mm, comprising a step of tableting a tableting raw material containing at least one adhesive component selected from the group consisting of amino acids, fat-soluble compounds, lipid-containing algae-derived powders, lipid-containing plant-derived powders, and sugars, using a tableting machine on which a lubricant is sprayed onto tableting surfaces having a radius of curvature of 6.5 mm, 7.5 mm, or 8.0 mm at a spray flow rate of 26 to 130 g / h.

2. 2. The method for producing food tablets according to claim 1, wherein the lubricant is at least one selected from the group consisting of calcium stearate and magnesium stearate.

3. The method for producing food tablets according to claim 1 or 2, wherein the amino acids are at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine.

4. The method for producing food tablets according to claim 1 or 2, wherein the fat-soluble compound is at least one selected from the group consisting of α-lipoic acid, coenzyme Q10, coenzyme linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, and EPA.

5. 3. The method for producing food tablets according to claim 1, wherein the lipid-containing algae-derived powder is at least one selected from the group consisting of Euglena, Spirulina, and Chlorella.

6. 3. The method for producing food tablets according to claim 1 or 2, wherein the lipid-containing plant-derived powder is at least one selected from the group consisting of Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, and saffron extract powder.

7. The method for producing food tablets according to claim 1 or 2, wherein the saccharide is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol.

8. 3. The method for producing food tablets according to claim 1 or 2, wherein the adhesive component is at least one selected from the group consisting of essential amino acids, non-essential amino acids, ornithine, citrulline, γ-aminobutyric acid, theanine, calcium hydroxymethylbutyrate, 5-aminolevulinic acid, and carnitine, and the content of the adhesive component is 30% by mass or more relative to the mass of the tableting raw materials.

9. 3. The method for producing food tablets according to claim 1 or 2, wherein the adhesive component is at least one selected from the group consisting of α-lipoic acid, coenzyme Q10, linoleic acid, astaxanthin, lutein, carotene, lycopene, vitamin A, vitamin E, lecithin, plasmalogen, DHA, and EPA, and the content of the adhesive component is 10% by mass or more relative to the mass of the tableting raw materials.

10. 3. A method for producing food tablets as described in claim 1 or 2, wherein the adhesive component is at least one selected from the group consisting of Euglena, Spirulina, Chlorella, Salacia extract powder, rice bran extract powder, sesame extract powder, soybean extract powder, gardenia extract powder, and saffron extract powder, and the content of the adhesive component is 50% by mass or more relative to the mass of the tableting raw materials.

11. 3. The method for producing food tablets according to claim 1 or 2, wherein the adhesive component is at least one selected from the group consisting of glucosamine, glucosamine hydrochloride, N-acetylglucosamine, isomaltodextrin, glucose, xylitol, sorbitol, and erythritol, and the content of the adhesive component is 50% by mass or more relative to the mass of the tableting raw materials.

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