Anticancer agents, cancer inhibitors, and life-extending agents containing novel compounds with mTORC1 inhibitory activity.

Compounds with mTORC1 inhibitory activity address the limitations of existing mTOR inhibitors by specifically targeting cancer cells and promoting apoptosis, offering both cancer treatment and life extension benefits.

JP7847761B2Active Publication Date: 2026-04-20宫武 秀行 +2
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Patent Information

Application Number
JP2022552065
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-09-25
Filing Date
2021-09-24
Publication Date
2026-04-20
Estimated Expiration
2041-09-24

AI Technical Summary

Technical Problem

Current mTOR inhibitors, such as rapamycin, are effective anticancer agents but lack specificity for cancer cells and have immunosuppressive side effects, while smaller compounds with similar mTORC1 inhibitory activity are unknown, and mTORC1 inhibitors are needed for both cancer treatment and life extension.

Method used

Development of compounds with specific mTORC1 inhibitory activity, represented by substructures (I), (II), and (III), which can be administered to suppress cancer and extend lifespan by targeting the mTORC1 pathway.

Benefits of technology

The compounds effectively inhibit cancer cell proliferation, induce apoptosis, and extend lifespan by suppressing mTORC1 activity, showing stronger cytotoxicity and specificity for cancer cells compared to rapamycin, with minimal side effects.

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Abstract

A carcinostatic agent, a carcinogenesis inhibitor and / or a life-prolonging agent each comprising a compound with mTORC1 inhibitory effect, said compound having partial structures (I), (II) and (III), or a pharmacologically acceptable salt thereof. (In the formulae: R1, R2, R3 and R4 are the same or different and represent an H, a lower alkyl, a lower haloalkyl, a lower alkoxy, a lower alkylamino, an OH, a protected OH, an amino, a protected amino, a carboxy, a protected carboxy or a halogen atom; R5 and R6 are the same or different and represent an H or a protecting group of an OH, or R5 and R6 form together a methylene or dimethylmethylene group; and A represents O or S.)
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