Oral components

Abstract

To provide a composition for oral cavity which has high versatility, and can preferably exert actual feeling of use such as coating feel after use.SOLUTION: Provided is a composition for oral cavity that contains: (A) at least one kind of palmitic acid 2-ethylhexyl and stearic acid 2-ethylhexyl; and (B) at least one kind of surfactant selected from the group consisting of (B-1) anionic surfactant such as acylamino acid salt and acyltaurine salt, (B-2) fatty acid ester nonionic surfactant such as polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether, and polyoxyethylene polyoxypropylene, and (B-3) amphoteric surfactant such as betaine-type amphoteric surfactant.SELECTED DRAWING: None

Description

Technical Field

[0004] , , , , , ,

[0001] The present invention relates to an oral composition.

Background Art

[0002] When a functional component such as a bactericide is blended in an oral composition, it is required in terms of continuous use and effect manifestation that the user can sufficiently feel the effect. For example, in Patent Document 1, an oral composition containing glycerophosphoric acid or its salt, cetylpyridinium chloride, and benzethonium chloride exhibits an inhibitory effect on oral biofilm by glycerophosphoric acids, and by blending cetylpyridinium chloride and benzethonium chloride, a high coating feeling can be given to the user. Further, in Patent Document 2, a liquid oral composition containing sodium chondroitin sulfate, dextranase, and polyoxyethylene alkyl ether exhibits an inhibitory effect on dental plaque formation by blending dextranase, and by blending dextranase, a high coating feeling can be given to the user, and it is described that the preservability is improved by blending polyoxyethylene alkyl ether.

Prior Art Documents

Patent Documents

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in Patent Document 1, the disinfectant acts as a coating agent, which limits its versatility. Furthermore, polyoxyalkylene ethers in Patent Document 2 and surfactants optionally included in Patent Document 1 can cause discomfort such as irritation and dryness of the teeth and gums after use. Despite surfactants being commonly used ingredients in oral compositions, no technology is known that can sufficiently suppress the occurrence of such discomfort.

[0005] The present invention aims to provide an oral composition that is highly versatile and exhibits excellent user experience, such as a coated feeling and moisturizing effect after use. [Means for solving the problem]

[0006] The present invention provides the following: [1] (A) At least one of 2-ethylhexyl palmitate and 2-ethylhexyl stearate, (B) At least one surfactant selected from the group consisting of (B-1) anionic surfactants, (B-2) nonionic surfactants, and (B-3) amphoteric surfactants. An oral composition containing [a specific ingredient]. [2] The oral composition according to [1], wherein the ratio (A / B) of the content of component (A) to the content of component (B) is 0.000001 to 400. [3] The oral composition according to [1] or [2], wherein (B-1) comprises at least one of acyl amino acid salts and acyl taurine salts. [4] The oral composition according to any one of [1] to [3], wherein (B-2) comprises at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyoxyethylene polyoxypropylene fatty acid ester. [5] An oral composition according to any one of [1] to [4], wherein (B-3) contains a betaine-type amphoteric surfactant. [6] An oral composition according to any one of items [1] to [5], which is a toothpaste or mouthwash. [Effects of the Invention]

[0007] The present invention provides an oral composition that is highly versatile and exhibits excellent user experience, such as a coated feeling and moisturizing effect after use. [Modes for carrying out the invention]

[0008] [(A): Ethylhexyl compound] Component (A) is an ethylhexyl compound, specifically 2-ethylhexyl palmitate, 2-ethylhexyl stearate, or a combination thereof. By including component (A), together with component (B), the coating sensation on the tooth surface and gums can be enhanced, and a moisturizing sensation can be provided, resulting in a pleasant user experience.

[0009] 2-ethylhexyl palmitate is represented by the following chemical formula and is an ester of palmitic acid and 2-ethylhexyl alcohol (molecular weight 368.64). [ka]

[0010] Ethylhexyl stearate is represented by the following chemical formula and is an ester of stearic acid and 2-ethylhexyl alcohol (molecular weight 396.69). [ka]

[0011] (A) If component contains 2-ethylhexyl stearate, its content is preferably 0.000008% by mass or more, more preferably 0.00008% by mass or more, even more preferably 0.008% by mass or more, and even more preferably 0.02% by mass or more, based on the total oral composition (100% by mass). This can further enhance the coating sensation on the tooth surface and gums, and furthermore, it can efficiently provide and sustain a feeling of moisture. The upper limit is preferably 8.0% by mass or less, more preferably 4.0% by mass or less, even more preferably 1.0% by mass or less, and even more preferably 0.8% by mass or less. This allows for obtaining effects commensurate with the content. Therefore, the content of 2-ethylhexyl stearate is preferably 0.000008 to 8.0% by mass, more preferably 0.00008 to 4.0% by mass, even more preferably 0.008 to 1.0% by mass, and even more preferably 0.02 to 0.8% by mass.

[0012] (A) If component contains 2-ethylhexyl palmitate, its content is preferably 0.000004% by mass or more, more preferably 0.00004% by mass or more, even more preferably 0.004% by mass or more, and even more preferably 0.01% by mass or more, based on the total oral composition (100% by mass). This enhances the coating sensation on the tooth surface and gums, and also efficiently provides and sustains a moisturizing sensation, resulting in a good user experience. The upper limit is preferably 4.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, and even more preferably 0.4% by mass or less. This allows for obtaining effects commensurate with the content. Therefore, the content of 2-ethylhexyl palmitate is preferably 0.000004 to 4.0% by mass, more preferably 0.00004 to 2.0% by mass, even more preferably 0.004 to 1.0% by mass, and even more preferably 0.01 to 0.4% by mass.

[0013] The content of component (A) is preferably 0.000004% by mass or more, more preferably 0.00004% by mass or more, and even more preferably 0.004% by mass or more, based on the total oral composition (100% by mass). The upper limit is preferably 12.0% by mass or less, more preferably 6.0% by mass or less, and even more preferably 2.0% by mass or less. Therefore, the content of component (A) is preferably 0.000004 to 12.0% by mass, more preferably 0.00004 to 6.0% by mass, and even more preferably 0.004 to 2.0% by mass.

[0014] [(B): Surfactants] Component (B) is a surfactant. By including component (B), a coating sensation can be provided to the tooth surface and gums, and together with component (A), a moisturizing sensation can be provided. Component (B) is usually one or more selected from the group consisting of (B-1) anionic surfactants, (B-2) nonionic surfactants, and (B-3) amphoteric surfactants. When the composition is a mouthwash, component (B) preferably contains at least component (B-2), and more preferably is component (B-2).

[0015] [(B-1) Anionic surfactants] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and typically have 10 to 20 carbon atoms, preferably 12 to 18, and more preferably 12 to 14. The salt can be selected from pharmacokinetically acceptable salts. Examples of pharmacokinetically acceptable salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and amino acid salts such as arginine salts, lysine salts, and histidine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0016] Examples of the alkyl sulfate include lauryl sulfate and myristoyl sulfate. Examples of the acyl amino acid salt include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; lauroyl glutamate; acyl glutamate salts such as myristoyl glutamate, palmitoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of the acyl taurine salt include lauroyl methyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of the α-olefin sulfonate include α-olefin sulfonates having 12 to 18 carbon atoms such as tetradecene sulfonate. Other examples of the anionic surfactant include sodium hydrogenated coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate. As the anionic surfactant, acyl amino acid salt and acyl taurine salt are preferred, and lauryl sulfate (for example, sodium lauryl sulfate), lauroyl sarcosine salt (for example, sodium lauroyl sarcosine), and lauroyl methyl taurine salt (sodium lauroyl methyl taurine) are more preferred. The component (B-1) may be a single anionic surfactant or a combination of two or more thereof.

[0017] [(B-2) Nonionic surfactant] Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ethers is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 moles. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 20 to 60 moles when the composition is a dentifrice, and preferably 40 to 100 moles when the composition is a mouthwash. The number of carbon atoms in the fatty acid of sorbitan fatty acid esters is usually 12 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid esters is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of alkylolamides is usually 12 to 14. Preferred nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers (e.g., polyoxyethylene stearyl ether, polyoxyethylene cetyl ether), and polyoxyethylene polyoxypropylene fatty acid esters. When the composition is a dentifrice, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ethers are more preferred. Component (B-2) may be a single nonionic surfactant or a combination of two or more. In the case of a combination of two or more, a combination of polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether (e.g., polyoxyethylene cetyl ether) is preferred.

[0018] [(B-3) Amphoteric surfactants] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine) and fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine, fatty acid amidopropyl dimethylaminoacetic acid betaine, lauric acid amidopropyl betaine); N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine); and imidazoline-type amphoteric surfactants such as coconut oil fatty acid imidazolinium betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. The number of carbon atoms in the alkyl and acyl groups is preferably 8 to 18. Of these, betaine-type amphoteric surfactants are preferred, fatty acid amidopropyl betaine is more preferred, and coconut oil fatty acid amidopropyl betaine is even more preferred. Component (B-3) may be a single amphoteric surfactant or a combination of two or more.

[0019] The content of component (B) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more, based on the total oral composition (100% by mass). This allows the surfactant to exert its inherent effect and, together with component (A), provides a coating sensation, resulting in a good user experience. The upper limit is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 3.5% by mass or less or 3.0% by mass or less. If the composition is a toothpaste, it is even more preferably 2.0% by mass or less or 1.0% by mass or less. This allows for an effect commensurate with the content and suppresses the occurrence of discomfort such as irritation and dryness after use. Therefore, the content of component (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, and even more preferably 0.1 to 3.5% by mass or 0.1 to 3.0% by mass. If the composition is a toothpaste, 0.1 to 2.0% by mass or 0.1 to 1.0% by mass is even more preferable.

[0020] [A / B] The ratio of the content of component (A) to the content of component (B) (A / B) is preferably 0.000001 or more, more preferably 0.0001 or 0.0003 or more, and even more preferably 0.001 or more. The upper limit is preferably 400 or less, more preferably 40 or less, and even more preferably 10 or less. Therefore, A / B is preferably 0.000001 to 400, more preferably 0.0001 to 40 or 0.0003 to 40, and even more preferably 0.001 to 10. In the case of toothpaste, it is further preferably 0.0003 or more, more preferably 0.001 or more, and even more preferably 0.008 or more. The upper limit is preferably 40 or less, more preferably 10 or less, and even more preferably 5 or less. Therefore, for toothpaste, 0.000001 to 40 is preferred, 0.0003 to 40 is more preferred, 0.001 to 10 is even more preferred, and 0.008 to 5 is even more preferred. For mouthwash, 0.00001 or more is preferred, 0.0001 or more is more preferred, 0.0005 or more is even more preferred, and 0.001 or more is even more preferred. The upper limit is preferably 400 or less, more preferably 40 or less, even more preferably 20 or less, and even more preferably 10 or less. Therefore, for mouthwash, 0.00001 to 400 is preferred, 0.0001 to 40 is more preferred, 0.0005 to 20 is even more preferred, and 0.001 to 10 is even more preferred. By being within the above range, a better user experience can be achieved.

[0021] [Optional ingredients] The oral composition of the present invention may contain any components other than components (A) and (B), as long as they do not impair the effects of the present invention.

[0022] Any optional component other than components (A) and (B) is acceptable, and examples include abrasives, surfactants, humectants, medicinal ingredients, fragrances, sweeteners, oily components, preservatives, binders, pH adjusters, colorants (pigments), and solvents. A detailed explanation follows below.

[0023] -Abrasive- The abrasive may be either an inorganic or organic abrasive. Examples of inorganic abrasives include: abrasive silica such as anhydrous silicic acid, zeolite, precipitated silica, aluminosilicate, zirconosilicate, crystalline zirconium silicate, titanium-bonded silica, and silica gel; calcium phosphate compounds such as dicalcium phosphate dihydrate or anhydrous, monocalcium phosphate, dicalcium phosphate dihydrate or anhydrous, insoluble calcium metaphosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, and calcium pyrophosphate; and carbon such as calcium carbonate (light and heavy). Examples of abrasives include calcium oxide-based abrasives; aluminum-based materials such as aluminum oxide, aluminum hydroxide, and alumina; calcium-based abrasives such as calcium hydroxide, calcium sulfate, and calcium oxide; silicate-based abrasives such as anhydrous silicic acid, zeolite, and zirconium silicate; magnesium-based abrasives such as magnesium carbonate and trimagnesium phosphate; apatite-based abrasives such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; titanium-based materials such as titanium dioxide, titanium mica, and titanium oxide; and minerals such as bentonite. Examples of organic abrasives include polymethyl methacrylate and synthetic resin-based abrasives. Inorganic abrasives are preferred, polishable silica is more preferred, and anhydrous silicic acid is even more preferred.

[0024] The abrasive silica is preferably abrasive particles with an average particle size of 1 to 40 μm, and the BET specific surface area of ​​the abrasive silica is preferably 80 to 250 square meters per gram. Here, the average particle size of the abrasive silica is the volume-based median diameter (D50) measured by laser diffraction-scattering.

[0025] There are no particular restrictions on the preferred RDA (Radioactive Dentine Abrasion Value) of the abrasive, but it is usually 50 or higher, and particularly preferably between 50 and 200. The abrasive may also be in the form of granules. Examples of such granules include particles obtained by granulating a water-insoluble powder (e.g., silica gel). When granulating into granules, any conventionally known and suitable binder may be used.

[0026] Abrasives may be used individually or in combination of two or more types.

[0027] The abrasive content is typically 70% by mass or less, preferably 50% by mass or less, and more preferably 8-50% by mass, based on the total oral composition (100% by mass).

[0028] -Wetting agent- As a wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sorbitol, erythritol, maltitol, lactitol, xylitol, and reduced starch syrups; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. As a sugar alcohol, sorbitol is preferred, and as a polyhydric alcohol, propylene glycol is preferred. As a wetting agent, sugar alcohols and glycerin are preferred, and sorbitol and glycerin are more preferred. The wetting agent may be used alone or in combination of two or more.

[0029] The humectant content is usually 40% by mass or less, and preferably 1 to 35% by mass, relative to the total oral composition (100% by mass).

[0030] -Medicinal ingredients- Other medicinal ingredients besides components (A) and (B) include, for example, bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Litec enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhizinate (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid, glycyrrhetinate (e.g., stearyl glycyrrhetinate), azulene, allantoin chlorohydroxyaluminum, and dihydro Examples of medicinal ingredients include anti-inflammatory agents such as cholesterol; metal salts such as zinc, copper salts, and tin salts; tartar preventatives such as condensed phosphates and ethane hydroxydiphosphonate; blood flow promoters such as vitamin E (e.g., tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salts) and lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventatives, amino acids such as alanine, glycine, proline, and pyrrolidone carboxylic acid (salt), plant extracts such as Phellodendron amurense, thyme, Scutellaria baicalensis, clove, and witch hazel; caropeptides and polyvinylpyrrolidone. Of these, fluorides are preferred, and sodium fluoride is more preferred. The medicinal ingredients may be used individually or in combination of two or more. The effective amount of the above medicinal ingredients can be appropriately determined according to conventional methods.

[0031] -Fragrance- As for fragrances, for example, peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pi Natural essential oils such as menthol oil, cinnamon leaf oil, perilla oil, wintergreen oil; fragrances contained in the above natural essential oils such as menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyl linalool, vanillin, etc. Ingredients: Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, etc. Fragrance ingredients: N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropyl Examples of cooling agents include pan-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamide)ethyl acetate, 2-isopropyl-N, 2,3-trimethylbutylamide, and (1R,2S,5R)-N-(4-(cyanomethyl)phenyl)menthylcarboxamide, as well as various blended flavors such as mint, fruit, and herb, which are made by combining several fragrance components and natural essential oils. As for the fragrance, one of the above-example fragrances may be used alone, or two or more may be used in combination.

[0032] -Sweetener- Examples of sweeteners include saccharin, sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, glycyrrhizin, thaumatin, and aspartylphenylalanine methyl ester. Of these, sodium saccharin is preferred. The sweeteners listed above may be used individually or in combination of two or more.

[0033] -Oily components- Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used individually or in combination of two or more of the above examples.

[0034] - Preservatives - Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. Preservatives may be used individually or in combination of two or more.

[0035] - Binding agent - The binder may be either an organic or inorganic binder. Examples of organic binders include polysaccharides, cellulosic binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate), and salts thereof. Polysaccharide thickeners are preferred, and xanthan gum is more preferred. Examples of inorganic binders include thickening silica, silicates, and anhydrous silicic acid, with thickening silica being preferred. The binder may be used alone or in combination of two or more types.

[0036] The content of the organic binder is preferably 0 to 5% by mass, and more preferably 0.1 to 4% by mass, based on the total mass of the oral composition. The content of the inorganic binder is preferably 0 to 10% by mass, and more preferably 0.5 to 8% by mass.

[0037] - pH adjuster - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (sodium citrate); inorganic acids such as phosphoric acid (orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

[0038] The pH adjusting agent content can typically be set to an amount that results in a pH of 5 to 9, preferably 6 to 8.5, of the oral composition after addition.

[0039] In this specification, the pH value usually refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0040] -Colorants- Examples of colorants include natural pigments such as safflower red, gardenia yellow, gardenia blue, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment; legally approved colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin; and titanium dioxide. Colorants may be used individually or in combination of two or more.

[0041] If the oral composition contains a coloring agent, its content is preferably 0.00001 to 3% by mass relative to the total oral composition (100% by mass).

[0042] -solvent- Examples of solvents include water (purified water) and ethanol, with water being preferred. The solvent may be used alone or in combination of two or more.

[0043] -Other optional components- Examples of optional components other than those mentioned above include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention.

[0044] [Dosage forms and uses of oral compositions] The oral composition of the present invention can be in the form of an oral preparation such as a toothpaste, mouthwash, spray, ointment, patch, or oral dissolving agent, with toothpaste and mouthwash being preferred.

[0045] The dosage form of the oral composition can be appropriately selected depending on the intended use and is not particularly limited. For example, the dosage form can be paste, liquid, etc., and in the case of toothpaste, it can be prepared as a paste, liquid toothpaste, liquid toothpaste, or moistened toothpaste.

[0046] [Method for manufacturing the composition] The method for manufacturing oral compositions is not particularly limited and can be prepared by conventional methods depending on the dosage form. For example, when used as a toothpaste, one method involves preparing the components that dissolve in a solvent, then mixing in other insoluble components, and performing defoaming (e.g., by reducing pressure) as needed. The resulting toothpaste can be contained in a container to make a product. The shape and material of the container are not particularly limited and containers commonly used for toothpaste compositions can be used, such as laminated tubes made of plastics such as polyethylene, polypropylene, polyethylene terephthalate, and nylon. [Examples]

[0047] Examples 1-48 and Comparative Examples 1-11 Toothpaste compositions (toothpaste: Examples 1-24 and Comparative Examples 1-6) and mouthwash compositions (Examples 25-48, Comparative Examples 7-11) with the compositions shown in Tables 3-10 were prepared by conventional methods (using the raw materials shown in Table 11). These were used as samples and evaluated by the methods described below (Tables 1-11).

[0048] <Evaluation of user experience with toothpaste> Eight subjects were given a questionnaire about their various experiences using toothpaste compositions with the compositions shown in Tables 3-6 (Table 1). Scores (1-4 points) were assigned based on the scoring criteria shown in Table 1, and the average value was calculated. Furthermore, the average of the calculated scores was evaluated based on the following evaluation criteria. The term "coating sensation" refers to the feeling that the tooth surface is smooth and that the gums are protected (covered).

[0049] For tooth brushing, each subject applied approximately 1g of the toothpaste composition to a toothbrush and brushed for 3 minutes.

[0050] [Table 1]

[0051] [Evaluation Criteria] ◎: Average score of 3.5 or higher ○: Average score of 3.0 or higher but less than 3.5 △: Average score between 2.0 and 3.0 ×: Average score less than 2.0

[0052] <Evaluation of user experience with mouthwash> Eight subjects were given a questionnaire about their various experiences using the mouthwash compositions listed in Tables 7-10 (Table 2). They were assigned scores (1-4 points) based on the scoring criteria shown in Table 2, and the average score was calculated. The average score was then used to evaluate the degree of oral sensation based on the following evaluation criteria. The term "coating sensation" refers to the feeling that the tooth surface is smooth and that the gums are protected (covered).

[0053] For the mouthwash, participants rinsed their mouths with 20 mL of mouthwash for 20 seconds, and then the evaluation was conducted (no rinsing with water after spitting out).

[0054] [Table 2]

[0055] [Evaluation Criteria] ◎: Average score of 3.5 or higher ○: Average score of 3.0 or higher but less than 3.5 △: Average score between 2.0 and 3.0 ×: Average score less than 2.0

[0056] [Table 3]

[0057] [Table 4]

[0058] [Table 5]

[0059] [Table 6]

[0060] [Table 7]

[0061] [Table 8]

[0062] [Table 9]

[0063] [Table 10]

[0064] [Table 11]

[0065] [Footnotes to the table] In the compositions listed in Tables 1-10, blank spaces indicate that no additives were used. For raw materials not listed in Table 11 (optional components), raw materials conforming to standards such as the Japanese Standards for External Raw Materials were used.

[0066] In the comparative examples, none possessed a satisfactory coating sensation on the tooth surface and gums, nor a moisturizing sensation immediately after use and 5 minutes later. In contrast, the examples received favorable evaluations in each of these areas. This result indicates that the oral composition of the present invention can effectively provide a good user experience, including a coating sensation and moisturizing sensation after use.

Claims

1. (A) At least one of 2-ethylhexyl palmitate and 2-ethylhexyl stearate, (B)(B-1) Anionic surfactant comprising at least one selected from the group consisting of alkyl sulfates, α-olefin sulfonates, acyl amino acid salts and acyl taurine salts, (B-2) A nonionic surfactant comprising at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene fatty acid ester, and polyoxyethylene polyoxypropylene copolymer, and (B-3) Betaine-type amphoteric surfactant at least one surfactant selected from the group consisting of the following It contains, (A) The content of component is 0.00004 to 6.0% by mass. (B) The content of component is 0.001 to 10% by mass. The ratio (A / B) of the content of component (A) to the content of component (B) is between 0.0001 and 400. Oral composition.

2. The oral composition according to claim 1, wherein the ratio (A / B) of the content of component (A) to the content of component (B) is 0.0003 to 400.

3. (B-1) is, Alkyl sulfates in which the number of carbon atoms in the alkyl group is 10 to 20, Alpha-olefin sulfonates having 10 to 20 carbon atoms in the alkyl group, Acyl amino acid salts having 10 to 20 carbon atoms in the acyl group, and Acyl taurine salts in which the acyl group has 10 to 20 carbon atoms. The oral composition according to claim 1 or 2, comprising at least one selected from the group consisting of the following.

4. (B-2) is, Polyoxyethylene hydrogenated castor oil having an average number of ethylene oxide addition moles of 20 to 100 moles, Polyoxyethylene alkyl ethers having 14 to 18 carbon atoms in the alkyl chain and an average number of ethylene oxide addition moles of 15 to 30 moles, Polyoxyethylene polyoxypropylene fatty acid ester, and Polyoxyethylene polyoxypropylene copolymer The oral composition according to claim 1 or 2, comprising at least one selected from the group consisting of the following.

5. (B-3) is, Alkyldimethylaminoacetic acid betaine having 8 to 18 carbon atoms in the alkyl group, and Fatty acid amidopropyl betaine with acyl group having 8 to 18 carbon atoms. The oral composition according to claim 1 or 2, comprising at least one selected from the group consisting of the following.

6. An oral composition according to claim 1 or 2, which is a toothpaste or mouthwash.

Images