Composition containing an antimicrobial (bio)-alkanediol for product protection

Abstract

The present invention relates to a composition comprising or consisting of a synergistic combination of an effective amount of an antimicrobial component and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol, or a specific alkanediol or a mixture of two or more different specific alkanediols. Furthermore, the present invention relates to a food, cosmetic, or pharmaceutical preparation comprising said composition. Furthermore, the present invention refers to the use of said composition for suppressing or inhibiting microbial growth in food, cosmetic, or pharmaceutical preparations, or home care products. Furthermore, the present invention relates to the use of an effective amount of 1,2-heptanediol and / or 2,3-heptanediol, or a specific alkanediol, or a mixture of two or more different specific alkanediols to enhance the efficacy of an antimicrobial active component. Finally, the present invention relates to a method for suppressing or inhibiting microbial growth in food, cosmetic, or pharmaceutical preparations, or home care products.

Description

[Technical Field]

[0001] The present invention relates to a composition comprising, or consisting of, an effective amount of an antimicrobial component, and a synergistic combination of an effective amount of 1,2-heptanediol and / or 2,3-heptanediol, or a specific alkanediol, or a mixture of two or more different specific alkanediols. Furthermore, the present invention relates to a food, cosmetic or pharmaceutical preparation, or home care product comprising the said composition. Furthermore, the present invention relates to the use of the said composition for inhibiting or suppressing microbial growth in food, cosmetic or pharmaceutical, or home care products. Furthermore, the present invention relates to the use in effective amounts of 1,2-heptanediol, or a specific alkanediol, or a mixture of two or more different specific alkanediols, to enhance the efficacy of the antimicrobial component. Finally, the present invention relates to a method for inhibiting or suppressing microbial growth in food, cosmetic or pharmaceutical, or home care products. [Background technology]

[0002] Food, cosmetics, pharmaceuticals, or home care products contain a culture medium with proteins, sugars, vitamins, oils, and water—all essential for microbial growth. Cosmetic or pharmaceutical formulations with high moisture content and / or large surface areas, such as emulsions or wet wipes, or formulations containing naturally occurring ingredients that are inherently contaminated with bacteria, are particularly susceptible to microbial growth. Storage in a bathroom with a neutral pH and warm, high humidity contributes to an ideal environment for bacteria and mold. Many microorganisms enter products through hands and mouths. Products may already be contaminated during the production process, for example, from contaminated raw materials. Most microorganisms are harmless to consumers. However, microbial contaminants can cause dangerous infections. Furthermore, some molds and bacteria produce toxins that can cause allergic reactions and skin irritation.

[0003] Preservatives are used to minimize microbial contamination. Preservatives are essential in cosmetic production because they kill or inhibit the growth of microorganisms. If not stored properly, this can lead to the deterioration of the product, which can manifest as changes in odor, discoloration, mold growth, gas formation, emulsion separation, or viscosity, making the product unacceptable to consumers.

[0004] Preservatives are therefore crucial for keeping cosmetics from spoiling and inhibiting the growth of potentially dangerous microorganisms. However, not all substances that can be used as preservatives are harmless to consumers. Parabens, for example, have hormonal effects; benzoic acid can cause pseudoallergic reactions. German cosmetic regulations list all preservatives permitted in cosmetics.

[0005] Furthermore, several natural materials exist that are said to possess antimicrobial effects. These include, for example, propolis, cinnamon bark, clove oil, allspice oil, nutmeg oil, ylang-ylang, rose oil, and thyme. However, these substances have not been sufficiently researched for use as preservatives in the cosmetics industry.

[0006] Currently, there are no legally binding limits on the amount of pathogens that can be contained in cosmetics. According to the recommendations of the Scientific Committee on Consumer Safety of the European Commission, cosmetics should not contain more than 100 or 1,000 colony-forming units per gram, depending on the type of product. Certain pathogens, such as Staphylococcus or E. coli, would not be detectable at all.

[0007] Therefore, in the cosmetics, pharmaceutical, and home care product industries, as well as in the food industry, there continues to be a need for agents with antimicrobial properties for product protection.

[0008] While it is true that numerous antimicrobial compounds are already in use in the field, there is a continuing need for substitutes to enable the performance of targeted specific treatments and / or to reduce side effects. However, in this situation, when investigating substitutes with antimicrobial activity, particularly antiseptic activity, Substances used in the cosmetics, pharmaceuticals and / or food sectors • Toxicologically acceptable, • It is well tolerated by the skin, • Stable (especially in conventional cosmetic and / or pharmaceutical formulations), • It is substantially, preferably completely odorless, and It must be considered that the preparation must be inexpensive (i.e., using standard methods and / or starting from standard precursors), and that it must be of natural origin or based on green synthesis.

[0009] On the one hand, there is no clear dependence between the chemical structure of a substance and, on the other hand, its biological activity and stability against specific microorganisms (pathogens). Furthermore, the investigation of suitable (active) substances possessing one or more of the aforementioned properties to a sufficient extent is difficult for those skilled in the art. Moreover, there is no predictable relationship between antimicrobial activity on the skin, toxicological tolerance, tolerability, and the stability of a substance.

[0010] Furthermore, antimicrobial components should possess antimicrobial activity properties that meet a variety of criteria. These are, • Possesses broad antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts, molds, and fungi. • Shows particularly strong activity against Candida and Aspergillus, and • It should be active in different cosmetic or pharmaceutical formulations, particularly at different pH values.

[0011] The addition of biocides in accordance with biocide regulations, particularly old preservatives such as formaldehyde donors, is becoming increasingly undesirable, especially in natural cosmetics.

[0012] Sterilization of pharmaceutical formulations is not particularly desirable because heat treatment can decompose the formulation components, and this results in additional processing costs.

[0013] Therefore, there remains a continuing need to develop novel compositions that are safe with respect to microorganisms and stable with respect to microorganisms during their shelf life. The cosmetics and pharmaceutical industries are constantly searching for ingredients that can improve this aspect. In particular, there is a continuing interest in the market to improve both the potency and efficiency range of such antimicrobial agents by achieving higher performance with the same amount of antimicrobial agent, or conversely, by achieving the same performance with a smaller amount of antimicrobial agent, so that the overall content of antimicrobial agents in ready-to-use formulations can be reduced.

[0014] Therefore, an object of the present invention is to provide a composition that exhibits a synergistic effect against numerous bacteria, yeasts, molds, and fungi, particularly in cosmetic or pharmaceutical preparations or home care products, and to provide a use thereof that can suppress or inhibit the activity or growth of microorganisms in cosmetic or pharmaceutical preparations or home care products.

[0015] Furthermore, an object of the present invention is to provide a food, cosmetic or pharmaceutical preparation, or home care product containing the above composition.

[0016] Furthermore, an object of the present invention is to provide a substance that can enhance the antimicrobial efficacy of antimicrobial components.

[0017] Furthermore, an object of the present invention is to provide a method for suppressing or inhibiting the growth of microorganisms in food, cosmetics, pharmaceuticals, or home care products.

[0018] The present invention is based on the surprising finding that the combined use of an effective amount of 1,2-heptanediol or 2,3-heptanediol, or a mixture containing 1,2-heptanediol and 2,3-heptanediol, or certain alkanediols, or a mixture of two or more different specific alkanediols with an antimicrobial component results in a synergistic antimicrobial effect against a number of microorganisms, such as bacteria, yeasts, molds and fungi. The use of such compositions in food, cosmetic or pharmaceutical preparations, or home care products subsequently results in a stable formulation of the microorganisms, which can be preserved. Surprisingly, the synergistic antimicrobial effect is also directed against species of the genus Candida, such as Candida albicans, and species of the genus Aspergillus, such as Aspergillus brasiliensis, which are known to be addressed only with great difficulty in any case.

Summary of the Invention

[0019] To address the above problems, in a first aspect, the present invention provides (a1) an effective amount of 1,2-heptanediol, (b1) an effective amount of at least one antimicrobial component, and (c1) optionally, at least one agent and / or additive for food, cosmetic or pharmaceutical compositions, or home care products, or (a2) an effective amount of 2,3-heptanediol, (b2) an effective amount of at least one antimicrobial component, and (c2) optionally, at least one agent and / or additive for food, cosmetic or pharmaceutical compositions, or home care products, or (a3) a mixture containing an effective amount of 1,2-heptanediol and 2,3-heptanediol, (b3) an effective amount of at least one antimicrobial component, and (c3) Optionally, provide a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition, or home care product.

[0020] In a second aspect, the present invention is (a) A mixture comprising at least one linear alkanediol having an effective amount of a carbon chain of 5 to 14 carbon atoms, or at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms different from that of the first linear alkanediol, (b) an effective amount of at least one antimicrobial component, and (c) Optionally, provide a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic, or pharmaceutical composition, or a home care product.

[0021] In a further embodiment, the present invention provides a food, cosmetic or pharmaceutical preparation or home care product comprising the composition according to the present invention.

[0022] In a further embodiment, the present invention provides the use of the compositions according to the present invention for inhibiting or suppressing the growth of microorganisms in food, cosmetic or pharmaceutical preparations, or home care products.

[0023] In further embodiments, the present invention provides the use of 1,2-heptanediol or 2,3-heptanediol, or a mixture comprising 1,2-heptanediol and 2,3-heptanediol, or at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, for enhancing the efficacy of antimicrobial components. In the final aspect, the present invention provides a method for inhibiting or suppressing the growth of microorganisms in food, cosmetic or pharmaceutical preparations, or home care products. [Brief explanation of the drawing]

[0024] [Figure 1] This diagram visualizes the synergistic antimicrobial efficacy of 1,2-heptanediol and 1,2-octanediol against Aspergillus brasiliensis. [Figure 2] This diagram visualizes the synergistic antimicrobial efficacy of 1,2-heptanediol and 1,2-octanediol against Candida albicans. [Figure 3] This diagram visualizes the antimicrobial efficacy of 0.2% EDTA disodium against bacteria. [Figure 4] This diagram visualizes the antimicrobial efficacy of 0.2% 1,2-heptanediol against bacteria. [Figure 5] This diagram visualizes the synergistic antimicrobial efficacy of 0.1% EDTA disodium and 0.1% 1,2-heptanediol against bacteria. [Figure 6] This diagram visualizes the synergistic antimicrobial efficacy of 1,2-heptanediol and 2,3-heptanediol against Candida albicans. [Modes for carrying out the invention]

[0025] The present invention is described in the appended claims. However, the present invention itself, preferred variations thereof, other purposes and advantages will also be apparent from the following detailed description, along with the accompanying embodiments and figures.

[0026] In the first aspect, the present invention is: (a1) Effective amount of 1,2-heptanediol, (b1) an effective amount of at least one antimicrobial component, and (c1) optionally relating to a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product.

[0027] Alternatively, in a first aspect of the present invention: (a2) Effective amount of 2,3-heptanediol, (b2) an effective amount of at least one antimicrobial component, and (c2) optionally relating to a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product.

[0028] In a further substitute, the present invention, in its first aspect, is: (a3) an effective amount of mixture containing 1,2-heptanediol and 2,3-heptanediol, (b3) an effective amount of at least one antimicrobial component, and (c3) optionally relating to a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product.

[0029] In a preferred variation of the first aspect of the present invention, component (b) is different from component (a).

[0030] In a second aspect, the present invention is: (a) A mixture comprising an effective amount of at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols different from the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, (b) an effective amount of at least one antimicrobial component, and (c) optionally relating to a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product.

[0031] In a preferred variation of the second aspect of the present invention, component (b) is different from component (a).

[0032] In a more preferred variation of the second embodiment, the present invention: (a') An effective amount of mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, wherein the number of carbon atoms of the first and second alkanediols is the same or different. (b') an effective amount of at least one antimicrobial component, and (c') optionally relating to a composition comprising or consisting of at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product.

[0033] The term "contains" means that the specified components in the composition are essential, but other components may be added and are further included in the present invention.

[0034] As used in accordance with the present invention, the term "consisting of" means that the total amount of components (a) to (c) is 100% by weight of the total weight of the composition, and the subject matter is closed-ended and may only include the expressly stated limitations.

[0035] Whenever "contains" is mentioned, its meaning can be either "contains" or "consists of," unless the context otherwise indicates otherwise, and it is intended to cover both meanings as options.

[0036] The phrase "at least one..." means that the compositions according to the present invention may contain one, two, three, four, five, six, or more different mixtures of each of the constituent components that follow the aforementioned term.

[0037] The term "optional" means that the following components may be present in the composition but are not required to be present, and the description includes variations that include the compound or variations that do not include the compound.

[0038] The term "synergistic effect" refers to an effect achieved when the interaction of two different chemical substances or biological structures results in an overall cumulative effect that exceeds the sum of the individual effects of either of them. In this invention, synergistic effect refers to synergistic antimicrobial effects.

[0039] The antimicrobial effect associated with this invention means that the number of living microorganisms is reduced, or even inhibited, due to decreased or inhibited microbial growth.

[0040] Alkanediols are a type of organic compound belonging to the glycol family, i.e., the alcohol family; in a glycol molecule, two hydroxyl (-OH) groups are attached to different carbon atoms in the carbon chain.

[0041] In a composition according to a first aspect of the present invention, component (a) is 1,2-heptanediol (a1) or 2,3-heptanediol (a2), or both heptanediols, i.e., a mixture (a3) ​​containing 1,2-heptanediol in addition to 2,3-heptanediol.

[0042] 1,2-Heptanediol belongs to the category of alkanediols, and its general formula is: [ka] It is a linear alkanediol. It has a carbon chain with 7 carbon atoms, and the two functional OH groups of the alkanediol are located at the alpha and beta positions and are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain.

[0043] 2,3-Heptanediol belongs to the category of alkanediols, and its general formula is: [ka] It is a linear alkanediol. It has a carbon chain with seven carbon atoms, and the two functional OH groups of the alkanediol are located in the beta and gamma positions, chemically bonded to the C2 and C3 carbon atoms in the alkanediol chain.

[0044] Linear 1,2-alkanediols have been used for over 15 years as multifunctional active ingredients. Short-chain 1,2-alkanediols are amphiphilic compounds and are therefore soluble in both water and cosmetic oils, like 1,2-pentanediol and 1,2-hexanediol. In contrast, 1,2-octanediol is a solid and tends to precipitate or recrystallize at ≥0.5% in oily solutions as well as water. On the other hand, 1,2-decanediol is a solid and soluble only in cosmetic oils. Apart from moisturizing, some 1,2-alkanediols are used as viscosity modifiers.

[0045] In the composition according to the second aspect of the present invention, component (a) is, in the first option, at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms.

[0046] Furthermore, in a second option of this second embodiment, component (a) may comprise a first linear alkanediol combined with a second linear alkanediol, preferably having a carbon chain of 5 to 14 carbon atoms, at least one first linear alkanediol, and at least one second linear alkanediol having a carbon chain of 5 to 14 carbon atoms. Thus, the present invention also includes mixtures of the first and second alkanediols described herein.

[0047] The first linear alkanediol of the present invention may be selected from the same list and types of compounds as the linear alkanediol according to the first option of the second embodiment below, and therefore when referring to a linear alkanediol in general, this may also be the first linear alkanediol. In mixtures of the first and second linear alkanediols, the specific terms “first” and “second” are used to distinguish the two alkanediol components if they are specifically different.

[0048] The phrases “at least one linear alkanediol” or “at least one first linear alkanediol” as used in this document mean that the composition may contain one linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or more than one linear alkanediol, or more than one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, i.e., two, three, four or more different linear alkanediols, or a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms.

[0049] A linear alkanediol, or a first linear alkanediol, consists of a chain of 5 to 14 carbon atoms linked together by a single covalent bond, with two OH functional groups attached to two different carbon atoms in the chain.

[0050] In a composition according to a second aspect of the present invention, the at least one linear alkanediol, or at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, is preferably selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol, tetradecanediol, and mixtures thereof.

[0051] In a preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, and tridecanediol.

[0052] In a more preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is an octanediol.

[0053] In a more preferred variation, at least one linear alkanediol or at least one first linear alkanediol is selected from the group consisting of alkanediols having an odd number of carbon atoms from 5 to 13, namely pentanediols, heptanediols, nonanediols, undecanediols, tridecanediols, and mixtures thereof.

[0054] In a more preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is selected from the group consisting of alkanediols having an odd number of carbon atoms of 7, 9, 11, and 13, i.e., heptanediol, nonanediol, undecanediol, and tridecanediol; or selected from the group consisting of alkanediols having an odd number of carbon atoms of 9 and 11, i.e., nonanediol and undecanediol; or selected from the group consisting of alkanediols having an odd number of carbon atoms of 9 and 13, i.e., nonanediol and tridecanediol; or selected from the group consisting of alkanediols having an odd number of carbon atoms of 11 and 13, i.e., undecanediol and tridecanediol.

[0055] In a more preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is pentanediol, hexanediol, heptanediol, octanediol, or nonanediol.

[0056] In the most preferred variation, at least one linear alkanediol, or at least the first linear alkanediol, is a heptanediol or a nonanediol.

[0057] In the options, a composition according to a second aspect of the present invention comprises a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols different from the first linear alkanediol, each having a carbon chain of 5 to 14 carbon atoms.

[0058] This means that the alkanediol mixture is a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, i.e., two, three, four or more. In this option, the first linear alkanediol may be any of the alkanediols described herein in general for linear alkanediols, and in particular for the first option of the second embodiment.

[0059] For example, a mixture may contain one first linear alkanediol and one, two, three or more second linear alkanediols; or a mixture may contain two first linear alkanediols together with one, two, three or more second linear alkanediols, etc., provided that in each mixture the first linear alkanediol and the second linear alkanediols are different from each other.

[0060] The phrase "different from each other" means that the first linear alkanediol and the second linear alkanediol in the mixture differ in terms of the length of the carbon chain, i.e., the number of carbon atoms, and / or in terms of their structural isomerism or stereoisomerism.

[0061] Similarly, the number of carbon atoms in the first linear alkanediol and the second linear alkanediol in the mixture may be the same. For example, the first linear alkanediol and the second linear alkanediol may have a carbon chain of seven carbon atoms, but they may differ in terms of their structural isomerism or their stereoisomerism.

[0062] The second linear alkanediol preferably consists of a chain of 5 to 14 carbon atoms linked together by a single covalent bond, with two OH functional groups attached to two different carbon atoms in the chain.

[0063] In a composition according to a second aspect of the present invention, at least one second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol, and tetradecanediol.

[0064] In a preferred variation, at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, and tridecanediol. If both the first and second alkanediols are, for example, heptanediols, then the heptanediol of the second linear alkanediol is a different structural or stereoisomer from the first linear alkanediol.

[0065] In a more preferred variation, at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, and nonanediol, most preferably octanediol and nonanediol.

[0066] The term "alkanediol" in the context of this invention also includes its structural isomers or positional isomers. Structural isomers are compounds with the same molecular formula and different bonding identities. Positional isomers, a specific form of structural isomerism, are structural isomers that can be seen as differing only in the position of the functional group in the parent structure, in this case the position being the position of two alcohol functional groups.

[0067] Depending on the number of carbon atoms in the carbon chain of an alkanediol, various positional isomers of the alkanediol exist: (x,x+1) structural isomer; (x,x+2) structural isomer; (x,x+3) structural isomer; etc. Furthermore, if the alcohol functional group is at the end of the carbon chain, alpha and omega structural isomers exist, where x represents the number of carbon atoms to which the OH group of the alkanediol is chemically bonded in the alkanediol chain. For example, if x is 1, two OH groups of the alkanediol are chemically bonded to carbon atoms C1 and C2 in the alkanediol chain; if x is 2, two OH groups of the alkanediol are chemically bonded to carbon atoms C2 and C3 in the alkanediol chain.

[0068] In the (x,x+1) structural isomer, the two OH functional groups are vicinal, attached to two different adjacent carbon atoms in the chain. In the (x,x+2) structural isomer, the two OH functional groups are attached to two different carbon atoms in the chain, where the two carbon atoms are separated by one carbon atom. In the (x,x+3) structural isomer, the two OH functional groups are attached to two different carbon atoms in the chain, where the two carbon atoms are separated by two carbon atoms. In the alpha and omega structural isomers, the two functional groups are attached to the first carbon atom and the terminal carbon atom.

[0069] In a preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1)diol selected from the group consisting of 1,2-diols, 2,3-diols, 3,4-diols, 4,5-diols, further (x,x+1)diols and mixtures thereof, and is preferably an alpha,beta 1,2 structural isomer.

[0070] In a preferred variation of the composition according to a second aspect of the present invention, the first linear alkanediol and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1)diol selected from the group consisting of 1,2-diols, 2,3-diols, 3,4-diols, 4,5-diols, further (x,x+1)diols and mixtures thereof, and is preferably an alpha,beta 1,2 structural isomer.

[0071] In a further preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a non-proximal (x,x+2)diol selected from the group consisting of 1,3-diols, 2,4-diols, 3,5-diols, further (x,x+2)diols and mixtures thereof, and is preferably an alpha,gamma 1,3 structural isomer.

[0072] In a preferred variation of the composition according to a second aspect of the present invention, the first linear alkanediol and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a non-proximal (x,x+2)diol selected from the group consisting of 1,3-diols, 2,4-diols, 3,5-diols, 4,6-diols, further (x,x+2)diols and mixtures thereof, and is preferably an alpha,gamma 1,3-structural isomer.

[0073] In a further preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a non-proximal (x,x+3)diol selected from the group consisting of 1,4-diols, 2,5-diols, further (x,x+3)diols and mixtures thereof, and is preferably an alpha,delta 1,4 structural isomer.

[0074] In a preferred variation of the composition according to a second aspect of the present invention, the first linear alkanediol and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a non-proximal (x,x+3)diol selected from the group consisting of 1,4-diols, 2,5-diols, further (x,x+3)diols and mixtures thereof, and is preferably an alpha,delta 1,4 structural isomer.

[0075] In a preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol and / or the second linear alkanediol, is preferably an alpha,omegaalkanediol, more preferably 1,7-heptanediol or 1,8-octanediol.

[0076] The nearest (x,x+1) diol according to the present invention is most preferably an alpha, beta or beta, gamma or gamma, delta.

[0077] In a more preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol, particularly the first linear alkanediol and / or the second linear alkanediol, is a 1,2-alkanediol, a 2,3-alkanediol, a 3,4-alkanediol, or a mixture thereof, with 2,3-alkanediol being more preferred.

[0078] Linear alkanediols, particularly a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, may preferably be represented by the following formula: 1,2-pentanediol [ka] 1,2-Hexanediol [ka] 1,2-Heptanediol [ka] 1,2-Octanediol [ka] 1,2-nonanediol [ka] 1,2-Decanediol [ka] 1,2-Undecanediol [ka] 1,2-Dodecanediol [ka] 1,2-Tridecanediol [ka] 1,2-Tetradecanediol [ka]

[0079] The linear alkanediols of the present invention, particularly the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, may preferably be represented by the following formula: 2,3-pentanediol [ka] 2,3-Hexanediol [ka] 2,3-Heptanediol [ka] 2,3-Octanediol [ka] 2,3-nonanediol [ka] 2,3-Decanediol [ka] 2,3-Undecanediol [ka] 2,3-Dodecanediol [ka] 2,3-Tridecanediol [ka] 2,3-Tetradecanediol [ka]

[0080] The 3,4-alkanediols of linear alkanediols, preferably a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, may preferably be represented by the following formula: 3,4-Hexanediol [ka] 3,4-Heptanediol [ka] 3,4-Octanediol [ka] 3,4-nonanediol [ka] 3,4-decanediol [ka] 3,4-Undecanediol [ka] 3,4-Dodecanediol [ka] 3,4-Tridecanediol [ka] 3,4-Tetradecanediol [ka]

[0081] In a preferred variation, a composition according to a second aspect of the present invention comprises at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, wherein the first and second alkanediols have the same or different numbers of carbon atoms.

[0082] When both the first and second alkanediols have the same number of carbon atoms, such a combination of alkanediols is also referred to herein as a “homoalkanediol mixture” or “homocombination.” For example, the first linear alkanediol and the second linear alkanediol have a carbon chain of seven carbon atoms, but they differ in terms of their structural isomerism or their stereoisomerism.

[0083] When the first and second alkanediols have different numbers of carbon atoms, such a combination of alkanediols is also referred to herein as a “heteroalkanediol mixture” or “heterocombination.” For example, the first linear alkanediol has a carbon chain of seven carbon atoms, and the second linear alkanediol has a carbon chain of eight carbon atoms. However, in addition, the first and second linear alkanediols may differ in terms of their structural isomerism or their stereoisomerism.

[0084] In a preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 3,4-Hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-Undecanediol, 2,3-Undecanediol, 3,4-Undecanediol, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, The selection is made from the group consisting of 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0085] Of the aforementioned linear alkanediols, or the first linear alkanediol, alpha,beta structural isomers are preferred: 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol. The alkanediol is liquid with a purity of 90 to 99%.

[0086] Of the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, or mixtures of the aforementioned liquid alkanediols are particularly preferred. The aforementioned alkanediols can be more readily incorporated into semi-finished or final products.

[0087] In a more preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms from 5 to 13, namely 1,2-pentanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol and mixtures thereof.

[0088] In a more preferred variation, the linear alkanediol or the first linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 7, 9, 11, and 13, i.e., 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, or 1,2-tridecanediol; or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 11, i.e., 1,2-nonanediol and 1,2-undecanediol; or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 13, i.e., 1,2-nonanediol and 1,2-tridecanediol; or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 11 and 13, i.e., 1,2-undecanediol and 1,2-tridecanediol.

[0089] In a more preferred variation, at least one linear alkanediol, or at least one first linear alkanediol, is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms from 5 to 13, namely 2,3-pentanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol and mixtures thereof.

[0090] In a more preferred variation, the linear alkanediol or the first linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 7, 9, 11, and 13, i.e., 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, or 2,3-tridecanediol; or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 9 and 11, i.e., 2,3-nonanediol and 2,3-undecanediol; or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 9 and 13, i.e., 2,3-nonanediol and 2,3-tridecanediol; or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 11 and 13, i.e., 2,3-undecanediol and 2,3-tridecanediol.

[0091] In a further preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 3,-4-Hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, The selection is made from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures thereof.

[0092] In a more preferred composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is selected from the group consisting of 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol and mixtures thereof, or from the group consisting of 1,2-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol and mixtures thereof. However, the linear alkanediol or the first linear alkanediol may also preferably be selected from the group consisting of 1,2-octanediol, 2,3-octanediol, 3,4-octanediol and mixtures thereof.

[0093] In compositions according to a second aspect of the present invention, the linear alkanediol or first linear alkanediol is more preferably alpha, beta or beta,gammadiol as 1,2-heptanediol, 2,3-heptanediol, or a mixture thereof. However, the linear alkanediol or first linear alkanediol may also preferably be alpha, beta or beta,gammadiol as 1,2-octanediol, 2,3-octanediol, or a mixture thereof. A mixture containing 1,2-heptanediol and 1,2-octanediol, or a mixture of 1,2-heptanediol and 2,3-octanediol, or a mixture of 1,2-octanediol and 2,3-heptanediol is also conceivable.

[0094] The most preferred linear alkanediol or first linear alkanediol is 1,2-heptanediol or 1,2-octanediol.

[0095] Similarly, in a further preferred variation of the composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is: 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, The substance is selected from the group consisting of 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, and mixtures thereof.

[0096] In a more preferred composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is selected from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol and mixtures thereof, or preferably selected from the group consisting of 1,2-decanediol, 2,3-decanediol, 3,4-decanediol and mixtures thereof, or preferably selected from the group consisting of 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol and mixtures thereof.

[0097] In a more preferable composition according to a second aspect of the present invention, the linear alkanediol or the first linear alkanediol is alpha, beta or beta, gammadiol as 1,2-nonanediol, 2,3-nonanediol, or a mixture thereof. However, the linear alkanediol or the first linear alkanediol may also preferably be 1,2-decanediol, 2,3-decanediol, or a mixture thereof.

[0098] Furthermore, the linear alkanediol or the first linear alkanediol may preferably be 1,2-undecanediol, 2,3-undecanediol, or a mixture thereof. A mixture of 1,2-nonanediol and / or 2,3-decanediol and / or 2,3-undecanediol, or a mixture of 1,2-decanediol and / or 2,3-nonanediol and / or 2,3-undecanediol, or a mixture of 1,2-undecanediol and / or 2,3-nonanediol and 2,3-decanediol is also conceivable.

[0099] In a preferred variation of the composition according to a second aspect of the present invention, the second linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 3,4-Hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-Undecanediol, 2,3-Undecanediol, 3,4-Undecanediol, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, The selection is made from the group consisting of 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol, and mixtures thereof.

[0100] Of the aforementioned second alkanediols, the following (x,x+1) structural isomers are particularly preferred: 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol. The alkanediol is liquid with a purity of 90 to 99%.

[0101] Of the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, or mixtures of the aforementioned liquid alkanediols are particularly preferred. The aforementioned alkanediols can be more readily incorporated into semi-finished or final products.

[0102] In a more preferred variation, the second linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms from 5 to 13, namely 1,2-pentanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol and mixtures thereof.

[0103] In a more preferred variation, the second linear alkanediol is selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 7, 9, 11, and 13, i.e., 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol, and 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 11, i.e., 1,2-nonanediol and 1,2-undecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 9 and 13, i.e., 1,2-nonanediol and 1,2-tridecanediol, or selected from the group consisting of 1,2-alkanediols having an odd number of carbon atoms of 11 and 13, i.e., 1,2-undecanediol and 1,2-tridecanediol.

[0104] In a more preferred variation, the second linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms from 5 to 13, namely 2,3-pentanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol, and mixtures thereof.

[0105] In a more preferred variation, the second linear alkanediol is selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 7, 9, 11, and 13, namely 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 9 and 11, namely 2,3-nonanediol and 2,3-undecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 9 and 13, namely 2,3-nonanediol and 2,3-tridecanediol, or selected from the group consisting of 2,3-alkanediols having an odd number of carbon atoms of 11 and 13, namely 2,3-undecanediol and 2,3-tridecanediol.

[0106] In a more preferred variation of the composition according to a second aspect of the present invention, the second linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 3,4-Hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, The selection is made from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures thereof.

[0107] In a more preferred composition according to a second aspect of the present invention, the second linear alkanediol is selected from the group consisting of 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, and mixtures thereof. However, the second linear alkanediol may also be selected from the group consisting of 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, and mixtures thereof, or preferably from the group consisting of 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, and mixtures thereof.

[0108] In a more preferred composition according to a second aspect of the present invention, the second linear alkanediol is alpha, beta or beta, gammadiol as 1,2-pentanediol, 2,3-pentanediol, or a mixture thereof. However, the second linear alkanediol may also preferably be 1,2-hexanediol, 2,3-hexanediol, or a mixture thereof. A mixture of 1,2-pentanediol and 2,3-hexanediol, or a mixture containing 2,3-pentanediol and 1,2-hexanediol, is also conceivable.

[0109] The most preferred second linear alkanediol is 1,2-pentanediol or 2,3-pentanediol, or 1,2-hexanediol or 2,3-hexanediol, or 1,2-heptanediol or 2,3-heptanediol, or 2,3-octanediol, or 2,3-nonanediol.

[0110] In a particularly preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, comprises any one of the following mixtures / combinations: • A mixture containing 1,2-pentanediol and 2,3-pentanediol, • A mixture containing 1,2-hexanediol and 2,3-hexanediol, • A mixture containing 1,2-heptanediol and 2,3-heptanediol, • A mixture containing 1,2-octanediol and 2,3-octanediol, • A mixture containing 1,2-nonanediol and 2,3-nonanediol, • A mixture containing 1,2-decanediol and 2,3-decanediol, • A mixture containing 1,2-undecanediol and 2,3-undecanediol, • A mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or A mixture containing 1,2-tridecanediol and 2,3-tridecanediol.

[0111] In the homoalkanediol mixture, the first linear alkanediol and the second linear alkanediol have the same number of carbon atoms.

[0112] Particularly advantageous are combinations containing 1,2-heptanediol in combination with 2,3-heptanediol and / or 3,4-heptanediol, or mixtures containing 1,2-octanediol in combination with 2,3-octanediol and / or 3,4-octanediol.

[0113] The homoalkanediol mixture described above according to a second aspect of the present invention, comprising 1,2-alkanediols and 2,3-alkanediols having the same number of carbon atoms, when used in combination with antimicrobial components, is characterized by synergistic antimicrobial efficacy against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds, compared to each single alkanediol substance, as demonstrated by preservation efficacy tests (PET) in the following examples. Surprisingly, the synergistic antimicrobial effect can even be demonstrated against Candida species, such as Candida albicans, and Aspergillus species, such as Aspergillus brasiliensis, both of which are known to be difficult to combat.

[0114] The aforementioned synergistic antimicrobial effect or action is found in homomixtures containing 1,2-pentanediol and 2,3-pentanediol combined with antimicrobial components.

[0115] The aforementioned synergistic antimicrobial effect is also observed in homomixtures containing 1,2-hexanediol and 2,3-hexanediol combined with antimicrobial components.

[0116] Homo-compounds containing 1,2-heptanediol and 2,3-heptanediol in combination with antimicrobial components are particularly beneficial because they exhibit specific and remarkable synergistic antimicrobial effects.

[0117] Alkanediol mixtures containing 1,2-octanediol and 2,3-octanediol combined with antimicrobial components, or alkanediol mixtures containing 1,2-nonanediol and 2,3-nonanediol combined with antimicrobial components, are particularly advantageous.

[0118] Furthermore, alkanediol mixtures containing 1,2-decanediol and 2,3-decanediol, or alkanediol mixtures containing 1,2-undecanediol and 2,3-undecanediol, synergistically reduce microbial load when used in combination with different antimicrobial agents.

[0119] The synergistic effect also applies to alkanediol mixtures containing 1,2-dodecanediol and 2,3-dodecanediol, or alkanediol mixtures containing 1,2-tridecanediol and 2,3-tridecanediol, when combined with antimicrobial components.

[0120] The aforementioned homoalkanediol mixtures, including 1,2-alkanediols and their corresponding 2,3-alkanediols, act synergistically against the microorganisms described herein when used in combination with antimicrobial components.

[0121] The previously mentioned synergistically enhanced antimicrobial effect is particularly pronounced in homomixtures containing 1,2-nonanediol and 2,3-nonanediol, or homomixtures containing 1,2-undecanediol and 2,3-undecanediol, compared to the corresponding individual 1,2-alkanediol or 2,3-alkanediol substances.

[0122] The use of the alkanediol mixture described above, comprising 1,2-alkanediol and the corresponding 2,3-alkanediol in combination with an antimicrobial component, can significantly inhibit microbial growth in food, cosmetic or pharmaceutical compositions, or home care products, and consequently, reduce the microbial load in such formulations.

[0123] The antimicrobial efficacy of mixtures containing 1,2-alkanediols and their corresponding 2,3-alkanediols, as described above, can significantly reduce the microbial load in food, cosmetic or pharmaceutical compositions, or home care products.

[0124] Therefore, the storage stability of such formulations can be considerably improved, and consequently, their shelf life can be extended. Furthermore, the risk of deterioration during use by individual users is significantly reduced.

[0125] Furthermore, even in small amounts, the corresponding liquid 2,3-alkanediol can be dissolved by miscible mixing with solid 1,2-alkanediols, such as 1,2-octanediol and 1,2-nonanediol, to obtain a liquid alkanediol mixture. The 2,3-alkanediol functions as a solvent for the solid 1,2-alkanediol. Such a liquid mixture has the advantages of, firstly, improved availability of the solid 1,2-alkanediol in the mixture, and secondly, facilitated incorporation of the solid 1,2-alkanediol into semi-finished or final products. This effect is particularly advantageous for emulsions in which lipid-soluble 1,2-alkanediols with carbon chains of eight or more carbon atoms tend to migrate into the oil phase when used alone. By miscible mixing with the corresponding liquid 2,3-alkanediol, the 1,2-alkanediol remains in the aqueous phase, where microbial contamination usually occurs. This is particularly beneficial for the expression of the antimicrobial effect of 1,2-alkanediols in the aqueous phase.

[0126] The availability of strongly antimicrobial 1,2-octanediol, 1,2-nonanediol, or 1,2-undecanediol substances can also be improved in end use by solutions of solid 1,2-octanediol in liquid 2,3-octanediol, solid 1,2-nonanediol in liquid 2,3-nonanediol, or solid 1,2-undecanediol in liquid 2,3-undecanediol.

[0127] Furthermore, the above alkanediol mixture, which includes 1,2-alkanediol and the corresponding 2,3-alkanediol, enables the low-temperature preparation of cosmetic or pharmaceutical formulations, meaning that heating during preparation is no longer necessary.

[0128] Therefore, the aforementioned properties of the alkanediol mixtures, including 1,2-alkanediols and their respective 2,3-alkanediols, can improve the processability of the formulations.

[0129] Therefore, a good balance can be achieved when active antimicrobial agent mixtures are combined in such a way as to improve processability in the formulation while maintaining antimicrobial effect. The above-mentioned combinations of 1,2-alkanediols and their corresponding 2,3-alkanediols solve this balance problem better than the 1,2-alkanediol or 2,3-alkanediol substances alone. This is well achieved by combinations including, for example, 1,2-pentanediol and 2,3-pentanediol, and also 1,2-hexanediol and 2,3-hexanediol. Combinations including, for example, 1,2-heptanediol and 2,3-heptanediol, and also 1,2-octanediol and 2,3-octanediol, also exhibit this effect. The same is true, in particular, for 1,2-nonanediol combined with 2,3-nonanediol, and for 1,2-undecanediol combined with 2,3-undecanediol.

[0130] The aforementioned homoalkanediol mixtures, containing 1,2-alkanediols and their corresponding 2,3-alkanediols combined with antimicrobial components, exhibit remarkably synergistic activity, clearly superior to the individual, corresponding 1,2-alkanediols or 2,3-alkanediols at the same concentration.

[0131] In a particularly preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, thus comprises any one of the following mixtures / combinations: 1,2-pentanediol in combination with one of the following: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-hexanediol in combination with one of the following: 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-Heptanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-Octanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-nonanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-decanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-undecanediol in combination with one of these compounds; 1,2-Pentanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, or 1,2-Dodecanediol in combination with one of these 1,2-Tridecanediols; 1,2-Tridecanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-doedecanediol; 2,3-pentanediol in combination with one of the following: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-hexanediol in combination with one of the following: 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-heptanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-octanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-nonanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-decanediols in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol; 2,3-undecanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol; 2,3-dodecanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-tridecanediol; or 2,3-tridecanediol in combination with one of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol; 2,3-pentanediol in combination with one of the following: 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-Heptanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, 2,3-Dodecanediol, or 2,3-Tridecanediol combined with 2,3-Hexanediol; 2,3-Heptanediol in combination with one of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-Octanediol in combination with one of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-nonanediol in combination with one of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-decanediol in combination with one of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-dodecanediol, or 2,3-undecanediol in combination with one of these 2,3-tridecanediols; 2,3-Pentanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, or 2,3-Tridecanediol combined with 2,3-Dodecanediol; or 2,3-Tridecanediol in combination with one of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, or 2,3-dodecanediol.

[0132] Furthermore, mixtures or combinations of alkanediols containing 1,2-hexanediol and 1,2-octanediol are particularly advantageous.

[0133] In a detailed preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, may therefore include any of the following mixtures / combinations: • A mixture containing 1,2-heptanediol and 1,2-pentanediol, or • A mixture containing 1,2-heptanediol and 1,2-hexanediol, or • A mixture containing 1,2-heptanediol and 1,2-octanediol, or • A mixture containing 1,2-heptanediol and 1,2-nonanediol, or • A mixture containing 1,2-heptanediol and 1,2-decanediol, or A mixture containing 1,2-heptanediol and 1,2-undecanediol, or • A mixture containing 1,2-heptanediol and 1,2-dodecanediol, or A mixture containing 1,2-heptanediol and 1,2-tridecanediol.

[0134] In a detailed preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, may therefore include any of the following mixtures / combinations: • A mixture containing 1,2-heptanediol and 2,3-heptanediol, or • A mixture containing 1,2-heptanediol and 2,3-pentanediol, or A mixture containing 1,2-heptanediol and 2,3-hexanediol, or • A mixture containing 1,2-heptanediol and 2,3-nonanediol, or • A mixture containing 1,2-heptanediol and 2,3-decanediol, or A mixture containing 1,2-heptanediol and 2,3-undecanediol, or • A mixture containing 1,2-heptanediol and 2,3-dodecanediol, or A mixture containing 1,2-heptanediol and 2,3-tridecanediol.

[0135] In a detailed preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, may therefore include any of the following mixtures / combinations: • A mixture containing 1,2-pentanediol and 2,3-pentanediol, • A mixture containing 1,2-pentanediol and 2,3-hexanediol, • A mixture containing 1,2-pentanediol and 2,3-heptanediol, • A mixture containing 1,2-pentanediol and 2,3-octanediol, • A mixture containing 1,2-pentanediol and 2,3-nonanediol, • A mixture containing 1,2-pentanediol and 2,3-decanediol, • A mixture containing 1,2-pentanediol and 2,3-undecanediol, • A mixture containing 1,2-pentanediol and 2,3-dodecanediol, • A mixture containing 1,2-pentanediol and 2,3-tridecanediol, • A mixture containing 1,2-hexanediol and 2,3-pentanediol, • A mixture containing 1,2-hexanediol and 2,3-hexanediol, • A mixture containing 1,2-hexanediol and 2,3-heptanediol, • A mixture containing 1,2-hexanediol and 2,3-octanediol, • A mixture containing 1,2-hexanediol and 2,3-nonanediol, • A mixture containing 1,2-hexanediol and 2,3-decanediol, • A mixture containing 1,2-hexanediol and 2,3-undecanediol, • A mixture containing 1,2-hexanediol and 2,3-dodecanediol, • A mixture containing 1,2-hexanediol and 2,3-tridecanediol, • A mixture containing 1,2-heptanediol and 2,3-pentanediol, • A mixture containing 1,2-heptanediol and 2,3-hexanediol, • A mixture containing 1,2-heptanediol and 2,3-heptanediol, • A mixture containing 1,2-heptanediol and 2,3-octanediol, • A mixture containing 1,2-heptanediol and 2,3-nonanediol, • A mixture containing 1,2-heptanediol and 2,3-decanediol, • A mixture containing 1,2-heptanediol and 2,3-undecanediol, • A mixture containing 1,2-heptanediol and 2,3-dodecanediol, • 1,2-heptanediol and 2,3-tridecanediol, • A mixture containing 1,2-octanediol and 2,3-pentanediol, • A mixture containing 1,2-octanediol and 2,3-hexanediol, • A mixture containing 1,2-octanediol and 2,3-heptanediol, • A mixture containing 1,2-octanediol and 2,3-octanediol, • A mixture containing 1,2-octanediol and 2,3-nonanediol, • A mixture containing 1,2-octanediol and 2,3-decanediol, • A mixture containing 1,2-octanediol and 2,3-undecanediol, • A mixture containing 1,2-octanediol and 2,3-dodecanediol, • A mixture containing 1,2-octanediol and 2,3-tridecanediol, • A mixture containing 1,2-nonanediol and 2,3-pentanediol, • A mixture containing 1,2-nonanediol and 2,3-hexanediol, • A mixture containing 1,2-nonanediol and 2,3-heptanediol, • A mixture containing 1,2-nonanediol and 2,3-octanediol, • A mixture containing 1,2-nonanediol and 2,3-nonanediol, • A mixture containing 1,2-nonanediol and 2,3-decanediol, • A mixture containing 1,2-nonanediol and 2,3-undecanediol, • A mixture containing 1,2-nonanediol and 2,3-dodecanediol, • A mixture containing 1,2-nonanediol and 2,3-tridecanediol, • A mixture containing 1,2-decanediol and 2,3-pentanediol, • A mixture containing 1,2-decanediol and 2,3-hexanediol, • A mixture containing 1,2-decanediol and 2,3-heptanediol, • A mixture containing 1,2-decanediol and 2,3-octanediol, • A mixture containing 1,2-decanediol and 2,3-nonanediol, • A mixture containing 1,2-decanediol and 2,3-decanediol, • A mixture containing 1,2-decanediol and 2,3-undecanediol, • A mixture containing 1,2-decanediol and 2,3-dodecanediol, • A mixture containing 1,2-decanediol and 2,3-tridecanediol, • A mixture containing 1,2-undecanediol and 2,3-pentanediol, • A mixture containing 1,2-undecanediol and 2,3-hexanediol, • A mixture containing 1,2-undecanediol and 2,3-heptanediol, • A mixture containing 1,2-undecanediol and 2,3-octanediol, • A mixture containing 1,2-undecanediol and 2,3-nonanediol, • A mixture containing 1,2-undecanediol and 2,3-decanediol, • A mixture containing 1,2-undecanediol and 2,3-undecanediol, • A mixture containing 1,2-undecanediol and r 2,3-dodecanediol, • A mixture containing 1,2-undecanediol and 2,3-tridecanediol, • A mixture containing 1,2-dodecanediol and 2,3-pentanediol, • A mixture containing 1,2-dodecanediol and 2,3-hexanediol, • A mixture containing 1,2-dodecanediol and 2,3-heptanediol, • A mixture containing 1,2-dodecanediol and 2,3-octanediol, • A mixture containing 1,2-dodecanediol and 2,3-nonanediol, • A mixture containing 1,2-dodecanediol and 2,3-decanediol, • A mixture containing 1,2-dodecanediol and 2,3-undecanediol, • A mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or A mixture containing 1,2-dodecanediol and 2,3-tridecanediol.

[0136] In a detailed preferred variation, a composition according to a second aspect of the present invention, comprising a mixture or combination of at least one first linear alkanediol and one or more second linear alkanediols, may therefore include any of the following mixtures / combinations: • A mixture containing 2,3-pentanediol and 2,3-hexanediol, • A mixture containing 2,3-pentanediol and 2,3-heptanediol, • A mixture containing 2,3-pentanediol and 2,3-octanediol, • A mixture containing 2,3-pentanediol and 2,3-nonanediol, • A mixture containing 2,3-pentanediol and 2,3-decanediol, • A mixture containing 2,3-pentanediol and 2,3-undecanediol, • A mixture containing 2,3-pentanediol and 2,3-dodecanediol, • A mixture containing 2,3-pentanediol and 2,3-tridecanediol, • A mixture containing 2,3-hexanediol and 2,3-pentanediol, • A mixture containing 2,3-hexanediol and 2,3-heptanediol, • A mixture containing 2,3-hexanediol and 2,3-octanediol, • A mixture containing 2,3-hexanediol and 2,3-nonanediol, • A mixture containing 2,3-hexanediol and 2,3-decanediol, • A mixture containing 2,3-hexanediol and 2,3-undecanediol, • A mixture containing 2,3-hexanediol and 2,3-dodecanediol, • A mixture containing 2,3-hexanediol and 2,3-tridecanediol, • A mixture containing 2,3-heptanediol and 2,3-pentanediol, • A mixture containing 2,3-heptanediol and 2,3-hexanediol, • A mixture containing 2,3-heptanediol and 2,3-octanediol, • A mixture containing 2,3-heptanediol and 2,3-nonanediol, • A mixture containing 2,3-heptanediol and 2,3-decanediol, • A mixture containing 2,3-heptanediol and 2,3-undecanediol, • A mixture containing 2,3-heptanediol and 2,3-dodecanediol, • A mixture containing 2,3-heptanediol and 2,3-tridecanediol, • A mixture containing 2,3-octanediol and 2,3-pentanediol, • A mixture containing 2,3-octanediol and 2,3-hexanediol, • A mixture containing 2,3-octanediol and 2,3-heptanediol, • A mixture containing 2,3-octanediol and 2,3-nonanediol, • A mixture containing 2,3-octanediol and 2,3-decanediol, • A mixture containing 2,3-octanediol and 2,3-undecanediol, • A mixture containing 2,3-octanediol and 2,3-dodecanediol, • A mixture containing 2,3-octanediol and 2,3-tridecanediol, • A mixture containing 2,3-nonanediol and 2,3-pentanediol, • A mixture containing 2,3-nonanediol and 2,3-hexanediol, • A mixture containing 2,3-nonanediol and 2,3-heptanediol, • A mixture containing 2,3-nonanediol and 2,3-octanediol, • A mixture containing 2,3-nonanediol and 2,3-decanediol, • A mixture containing 2,3-nonanediol and 2,3-undecanediol, • A mixture containing 2,3-nonanediol and 2,3-dodecanediol, • A mixture containing 2,3-nonanediol and 2,3-tridecanediol, • A mixture containing 2,3-decanediol and 2,3-pentanediol, • A mixture containing 2,3-decanediol and 2,3-hexanediol, • A mixture containing 2,3-decanediol and 2,3-heptanediol, • A mixture containing 2,3-decanediol and 2,3-octanediol, • A mixture containing 2,3-decanediol and 2,3-nonanediol, • A mixture containing 2,3-decanediol and 2,3-undecanediol, • A mixture containing 2,3-decanediol and 2,3-dodecanediol, • A mixture containing 2,3-decanediol and 2,3-tridecanediol, • A mixture containing 2,3-undecanediol and 2,3-pentanediol, • A mixture containing 2,3-undecanediol and 2,3-hexanediol, • A mixture containing 2,3-undecanediol and 2,3-heptanediol, • A mixture containing 2,3-undecanediol and 2,3-octanediol, • A mixture containing 2,3-undecanediol and 2,3-nonanediol, • A mixture containing 2,3-undecanediol and 2,3-decanediol, • A mixture containing 2,3-undecanediol and 2,3-dodecanediol, • A mixture containing 2,3-undecanediol and 2,3-tridecanediol, • A mixture containing 2,3-dodecanediol and 2,3-pentanediol, • A mixture containing 2,3-dodecanediol and 2,3-hexanediol, • A mixture containing 2,3-dodecanediol and 2,3-heptanediol, • A mixture containing 2,3-dodecanediol and 2,3-octanediol, • A mixture containing 2,3-dodecanediol and 2,3-nonanediol, • A mixture containing 2,3-dodecanediol and 2,3-decanediol, • A mixture containing 2,3-dodecanediol and 2,3-undecanediol, A mixture containing 2,3-dodecanediol and 2,3-tridecanediol.

[0137] Particularly advantageous are mixtures or combinations containing 2,3 - hexanediol and 2,3 - heptanediol, or mixtures containing 2,3 - hexanediol and 2,3 - octanediol, or mixtures containing 2,3 - heptanediol and 2,3 - octanediol.

[0138] In previously described heteroalkanediol mixtures, the first linear alkanediol and the second linear alkanediol have different numbers of carbon atoms.

[0139] When the above - mentioned heteroalkanediol mixture according to the second aspect of the invention, which contains at least one first linear alkanediol and one or more second linear alkanediols, is used in combination with an antimicrobial component, as demonstrated in the following examples, it is characterized by a synergistic antimicrobial efficacy against a wide range of microorganisms, i.e., bacteria, yeasts, and fungi / molds, compared to each individual alkanediol substance. Surprisingly, the synergistic antimicrobial effect can even be demonstrated in Candida, such as Candida albicans, and Aspergillus, such as Aspergillus brasiliensis, which are known to be difficult to deal with in any case.

[0140] Among the above - mentioned alkanediol mixtures, particularly advantageous are heteroalkanediol mixtures containing 1,2 - hexanediol and 2,3 - octanediol, or heteroalkanediol mixtures containing 1,2 - octanediol and 2,3 - hexanediol, or heteroalkanediol mixtures containing 1,2 - octanediol and 2,3 - heptanediol, which exhibit a synergistic antimicrobial effect compared to the corresponding single 1,2 - alkanediol or 2,3 - alkanediol substances, i.e., 1,2 - hexanediol, or 1,2 - octanediol, or 2,3 - octanediol, or 2,3 - hexanediol, or 2,3 - heptanediol.

[0141] The aforementioned synergistic antimicrobial effect or action is found in heteromixtures containing 1,2-hexanediol and 2,3-octanediol when used in combination with an antimicrobial substance.

[0142] The aforementioned synergistic antimicrobial effect is also observed in heteromixtures containing 1,2-octanediol and 2,3-hexanediol combined with an antimicrobial substance.

[0143] Heteromixtures containing 1,2-octanediol and 2,3-heptanediol in combination with antimicrobial agents are particularly beneficial because they exhibit specific and remarkable synergistic antimicrobial effects.

[0144] Furthermore, the unique antimicrobial effect against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds, may also be observed when used in combination with the antimicrobial components, with the alkanediol mixtures described below, namely, mixtures of alkanediols containing 1,2-pentanediol and 2,3-hexanediol, or mixtures containing 1,2-pentanediol and 1,2-heptanediol, or mixtures containing 1,2-pentanediol and 2,3-heptanediol, or mixtures containing 1,2-pentanediol and 2,3-octanediol, or mixtures containing 1,2-pentanediol and 1,2-nonanediol, or mixtures containing 1,2-pentanediol and 2,3-nonanediol.

[0145] The heteroalkanediol mixture described above, comprising at least one first linear alkanediol and one or more second alkanediols, exhibits synergistic activity by inhibiting microbial growth when used in combination with antimicrobial components.

[0146] Heteromixtures containing 1,2-pentanediol and 2,3-hexanediol are particularly beneficial because, when used in combination with antimicrobial components, they exhibit a specific and remarkable synergistic antimicrobial effect.

[0147] Alkanediol mixtures containing 1,2-pentanediol and 1,2-heptanediol, or alkanediol mixtures containing 1,2-pentanediol and 2,3-heptanediol, are particularly advantageous.

[0148] Similarly, synergistic antimicrobial effects or actions are found in heteromixtures containing 1,2-pentanediol and 2,3-octanediol when used in combination with antimicrobial components.

[0149] Furthermore, alkanediol mixtures containing 1,2-pentanediol and 1,2-nonanediol, or alkanediol mixtures containing 1,2-pentanediol and 2,3-nonanediol, synergistically reduce microbial load when used in combination with antimicrobial agents.

[0150] Furthermore, the unique antimicrobial effect against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds, may also be observed when used in combination with the antimicrobial components, with the alkanediol mixtures described below, namely mixtures of alkanediols containing 1,2-heptanediol and 1,2-octanediol, or mixtures of alkanediols containing 1,2-heptanediol and 2,3-octanediol, or mixtures of alkanediols containing 1,2-heptanediol and 1,2-nonanediol, or mixtures or combinations of alkanediols containing 1,2-heptanediol and 2,3-nonanediol.

[0151] Alkanediol mixtures containing 1,2-heptanediol and 1,2-octanediol, or 1,2-heptanediol and 2,3-octanediol, are particularly advantageous when used in combination with antimicrobial components.

[0152] Furthermore, alkanediol mixtures containing 1,2-heptanediol and 1,2-nonanediol, or alkanediol mixtures containing 1,2-heptanediol and 2,3-nonanediol, synergistically reduce microbial load when used in combination with different antimicrobial agents.

[0153] The use of alkanediol mixtures in combination with previously described antimicrobial components inhibits microbial growth, resulting in improved, or synergistic, antimicrobial effects against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds, compared to the use of the corresponding single alkanediol substance.

[0154] The use of the above-described alkanediol mixture, comprising a first linear alkanediol and a second linear alkanediol in combination with an antimicrobial component, can significantly inhibit microbial growth in food, cosmetic or pharmaceutical compositions, or home care products, and consequently reduce the microbial load in such formulations.

[0155] Therefore, the storage stability of such formulations can be considerably improved, and consequently, their shelf life can be extended. Furthermore, the risk of deterioration during use by individual users is significantly reduced.

[0156] In a preferred variation according to a second aspect of the present invention, the linear alkanediol in the composition is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.

[0157] In a preferred variant according to the second aspect of the present invention in cosmetics, pharmaceutical compositions or home care products, the linear alkanediol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.

[0158] In a more preferred variant of a cosmetic, pharmaceutical composition or home care product according to the second aspect of the present invention, the linear alkanediol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures thereof.

[0159] Surprisingly, the use of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol and 2,3-tridecanediol in combination with an antimicrobial component results in an improved, i.e., synergistic antimicrobial effect by inhibiting the growth of microorganisms as described herein.

[0160] As a result, the storage stability of such formulations can be considerably improved, and thus the shelf life can be extended. Furthermore, the risk of deterioration during use by individual users is significantly reduced.

[0161]

[0162] Furthermore, the above-mentioned 2,3-alkanediol has the advantage of being liquid, which can facilitate its incorporation into semi-finished or final products. Furthermore, due to its excellent solubility, higher concentrations of 2,3-alkanediol can be obtained in the final formulation.

[0163] Therefore, a good balance can be achieved when active antimicrobial agent mixtures are combined in such a way as to improve processability in the formulation while maintaining antimicrobial effect. The 2,3-alkanediols mentioned above solve this balance problem better than solid 1,2-alkanediol substances.

[0164] The enhanced antimicrobial effects of the alkanediols or alkanediol mixtures described above have the added advantage of being required at low concentrations of antimicrobial components to reduce or even inhibit microbial growth in food, cosmetic or pharmaceutical compositions, or home care products.

[0165] In a particularly advantageous modification according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol, is a liquid alkanediol.

[0166] In the context of this invention, the term "liquid alkanediol" means an alkanediol component that is liquid at room temperature or ambient temperature and under normal pressure, i.e., standard RTP conditions.

[0167] In a highly preferred variation according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol, is a liquid alkanediol selected from the group consisting of 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and mixtures thereof.

[0168] Of the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, or mixtures thereof are most preferred.

[0169] In a more particularly advantageous variation according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol, is characterized by a maximum water solubility of 10% by weight or less. In a preferred variation, the maximum water solubility of the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol is 10% by weight or less and 1.2% by weight or more. A more preferred maximum water solubility of the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol is 5% by weight or less and 1.4% by weight or more.

[0170] Preferably, the alkanediol having the water solubility is selected from the group consisting of 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, and mixtures thereof.

[0171] The water solubility of a substance is the saturation mass concentration of the substance in water at a given temperature. The determination of water solubility pertains to substances that are stable in water, non-volatile, and essentially pure. The determination of water solubility of alkanediols is further described in Example 2 below.

[0172] In the context of this invention, the term "alkanediol" also includes its stereoisomers. Stereoisomers are molecules that have the same molecular formula but differ only in the way in which their atoms are arranged in three-dimensional space. According to the above definition, the linear alkanediols of this invention, and the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, particularly include the following stereoisomers, as described above:

[0173] 1,2-Alkanediol stereoisomers: (2S)-pentane-1,2-diol, (2S)-hexane-1,2-diol, (2S)-heptane-1,2-diol, (2S)-octane-1,2-diol, (2S)-nonane-1,2-diol, (2S)-decane-1,2-diol, (2S)-Undecane-1,2-diol (2S)-dodecane-1,2-diol, (2S)-tridecane-1,2-diol, (2S)-tetradecane-1,2-diol, (2R)-Pentane-1,2-diol, (2R)-hexane-1,2-diol, (2R) -Heptane-1,2-diol, (2R)-Octane-1,2-diol, (2R) - Nonan - 1, 2 - Diol, (2R)-Decan-1,2-Diol, (2R) - Undecane-1,2-Diol, (2R)-Dodecane-1,2-Diol, (2R) - Tridecane-1,2-diol, (2R)-Tetradecane-1,2-diol,

[0174] 2,3-Alkanediol stereoisomers: (2S,3S)-pentane-2,3-diol, (2S,3S)-hexane-2,3-diol, (2S,3S)-heptane-2,3-diol, (2S,3S)-octane-2,3-diol, (2S,3S)-nonane-2,3-diol, (2S,3S)-decane-2,3-diol, (2S,3S)-Undecane-2,3-Diol (2S,3S)-dodecane-2,3-diol, (2S,3S)-tridecane-2,3-diol, (2S,3S)-tetradecane-2,3-diol, (2R,3R)-pentane-2,3-diol, (2R,3R)-hexane-2,3-diol, (2R,3R)-heptane-2,3-diol, (2R,3R)-Octane-2,3-diol, (2R,3R)-Nonan-2,3-Diol, (2R,3R)-Decane-2,3-Diol, (2R,3R)-Undecane-2,3-Diol, (2R,3R)-Dodecane-2,3-Diol, (2R,3R)-Tridecane-2,3-diol, (2R,3R)-tetradecane-2,3-diol, (2S,3R)-pentane-2,3-diol, (2S,3R)-hexane-2,3-diol, (2S,3R)-heptane-2,3-diol, (2S,3R)-octane-2,3-diol, (2S,3R)-nonane-2,3-diol, (2S,3R)-decane-2,3-diol, (2S,3R)-Undecane-2,3-Diol, (2S,3R)-dodecane-2,3-diol, (2S,3R)-tridecane-2,3-diol, (2S,3R)-tetradecane-2,3-diol, (2R,3S)-pentane-2,3-diol, (2R,3S)-hexane-2,3-diol, (2R,3S)-heptane-2,3-diol, (2R,3S)-Octane-2,3-diol, (2R,3S)-Nonane-2,3-Diol, (2R,3S)-decane-2,3-diol, (2R,3S)-Undecane-2,3-Diol, (2R,3S)-Dodecane-2,3-Diol, (2R,3S)-tridecane-2,3-diol, and (2R,3S)-tetradecane-2,3-diol.

[0175] 3,4-Alkanediol stereoisomers: (3R,4R)-hexane-3,4-diol, (3R,4R)-heptane-3,4-diol, (3R,4R)-Octane-3,4-diol, (3R,4R)-Nonan-3,4-Diol, (3R,4R)-Decane-3,4-Diol, (3R,4R)-Undecane-3,4-Diol, (3R,4R)-Dodecane-3,4-Diol, (3R,4R)-Tridecane-3,4-diol, (3R,4R)-tetradecane-3,4-diol, (3S,4S)-hexane-3,4-diol, (3S,4S)-heptane-3,4-diol, (3S,4S)-octane-3,4-diol, (3S,4S)-nonane-3,4-diol, (3S,4S)-decane-3,4-diol, (3S,4S)-Undecane-3,4-Diol, (3S,4S)-dodecane-3,4-diol, (3S,4S)-tridecane-3,4-diol, (3S,4S)-tetradecane-3,4-diol, (3R,4S)-hexane-3,4-diol, (3R,4S)-heptane-3,4-diol, (3R,4S)-octane-3,4-diol, (3R,4S)-Nonane-3,4-Diol, (3R,4S)-decane-3,4-diol, (3R,4S)-Undecane-3,4-Diol, (3R,4S)-dodecane-3,4-diol, (3R,4S)-Tridecane-3,4-diol, (3R,4S)-tetradecane-3,4-diol, (3S,4R)-hexane-3,4-diol, (3S,4R)-heptane-3,4-diol, (3S,4R)-octane-3,4-diol, (3S,4R)-nonane-3,4-diol, (3S,4R)-decane-3,4-diol, (3S,4R)-Undecane-3,4-Diol, (3S,4R)-dodecane-3,4-diol, (3S,4R)-tridecane-3,4-diol, and (3S,4R)-tetradecane-3,4-diol.

[0176] In relation to this text, the terms “1,2-diol,” “2,3-diol,” or “3,4-diol” include both the corresponding S- and R-enantiomers, as well as any mixtures of these S- and R-enantiomers, i.e., mixtures of racemic compounds of each diol.

[0177] The alkanediol mixture of the composition according to the first aspect of the present invention contains 1,2-heptanediol and 2,3-heptanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0178] In a composition according to a first aspect of the present invention used in a cosmetic or pharmaceutical composition, 1,2-heptanediol and 2,3-heptanediol are preferably included in the alkanediol mixture in a ratio ranging from 98:2 to 99.9:0.1.

[0179] In a composition according to a first aspect of the present invention used in home care products, 1,2-heptanediol and 2,3-heptanediol are preferably included in the alkanediol mixture in a ratio ranging from 95:5 to 99.9:0.1.

[0180] Preferably, 1,2-heptanediol and 2,3-heptanediol are included in the alkanediol mixture of the composition according to the first embodiment of the present invention in a ratio of ≥95:≤5, more preferably ≥96:≤4, even more preferably ≥97:≤3, and most preferably ≥98:≤2.

[0181] The majority of all alkanediol mixtures of compositions according to the first aspect of the present invention contain 1,2-heptanediol and 2,3-heptanediol in a ratio of ≥95:≤5, and include ratios of ≥95.5:≤4.5; ≥96:≤4; ≥96.5:≤3.5; ≥97:≤3; ≥97.5:2.5 and ≥98.0:≤2.0.

[0182] A more preferred alkanediol mixture of compositions according to the first embodiment of the present invention contains 1,2-heptanediol and 2,3-heptanediol in a ratio of ≥98:≤2, with ≥98.1:≤1.9; ≥98.2:≤1.8; ≥98.3:≤1.7; ≥98.4:≤1.6; ≥98.5:≤1.5; ≥98.6:≤1.4; ≥9 This includes the ratios 8.7:≦1.3;≧98.8:≦1.2;≧98.9:≦1.1;≧99:≦1.0;≧99.1:≦0.9;≧99.2:≦0.8;≧99.3:≦0.7;≧99.4:≦0.6;≧99.5:≦0.5;≧99.6:≦0.4;≧99.7:≦0.3;≧99.8:≦0.2 and ≧99.9:≦0.1.

[0183] The first linear alkanediol and the second linear alkanediol, as defined in detail above, are present in the alkanediol mixture of the composition according to the second aspect of the present invention in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0184] In a composition according to a second aspect of the present invention used in cosmetics or pharmaceutical compositions, the first linear alkanediol and the second linear alkanediol are preferably included in the alkanediol mixture in a ratio ranging from 98:2 to 99.9:0.1.

[0185] In a composition according to a second embodiment of the present invention used in home care products, the first linear alkanediol and the second alkanediol are preferably included in the alkanediol mixture in a ratio ranging from 95:5 to 99.9:0.1.

[0186] Preferably, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture of the composition according to the second aspect of the present invention in a ratio of ≥95:≤5, more preferably ≥96:≤4; even more preferably ≥97:≤3; and most preferably ≥98:≤2.

[0187] The majority of all alkanediol mixtures of compositions according to the second aspect of the present invention contain a first linear alkanediol and a second linear alkanediol in a ratio of ≥95:≤5, and include ratios of ≥95.5:≤4.5; ≥96:≤4; ≥96.5:≤3.5; ≥97:≤3; ≥97.5:2.5 and ≥98.0:≤2.0.

[0188] A more preferable alkanediol mixture of compositions according to a second aspect of the present invention comprises a first linear alkanediol and a second alkanediol in a ratio of ≥98:≤2, with ≥98.1:≤1.9; ≥98.2:≤1.8; ≥98.3:≤1.7; ≥98.4:≤1.6; ≥98.5:≤1.5; ≥98.6:≤1.4; ≥9 This includes the ratios 8.7:≦1.3;≧98.8:≦1.2;≧98.9:≦1.1;≧99:≦1.0;≧99.1:≦0.9;≧99.2:≦0.8;≧99.3:≦0.7;≧99.4:≦0.6;≧99.5:≦0.5;≧99.6:≦0.4;≧99.7:≦0.3;≧99.8:≦0.2 and ≧99.9:≦0.1.

[0189] Alternatively, the range of the ratios for the first and second alkanediols may be adjusted so that the second alkanediol is the main component and the first alkanediol is a minor component.

[0190] In an advantageous modification according to a second aspect of the present invention, the mixture comprises, as a first linear alkanediol, a 1,2-alkanediol, such as 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, and as a second linear alkanediol, the corresponding 2,3-alkanediol, for example The mixture contains 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0191] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0192] In further modifications, according to a second aspect of the present invention, the mixture comprises, as a first linear alkanediol, a 2,3-alkanediol, such as 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, and as a second linear alkanediol, the corresponding 1,2-alkanediol, e.g. For example, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol are included in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0193] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0194] A more advantageous variation according to a second aspect of the present invention includes a mixture comprising a combination of a 1,2-alkanediol as a first linear alkanediol and a corresponding 2,3-alkanediol as a second linear alkanediol, for example 1,2-pentanediol and 2,3-pentanediol, or 1,2-Hexanediol and 2,3-Hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,2-decanediol, or 1,2-Undecanediol and 2,3-Undecanediol, or 1,2-dodecanediol and 2,3-dodecanediol, or In 1,2-tridecanediol and 2,3-tridecanediol, The first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0195] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0196] These mixing ratios, when used in combination with antimicrobial components, result in the aforementioned mixtures exhibiting synergistic antimicrobial efficacy compared directly to the corresponding individual substances, as described and demonstrated in the experimental section.

[0197] A more advantageous modification according to a second aspect of the present invention is a mixture comprising a 2,3-alkanediol as the first linear alkanediol and a corresponding 1,2-alkanediol as the second linear alkanediol, for example 2,3-pentanediol and 1,2-pentanediol, or 2,3-hexanediol and 1,2-hexanediol, or 2,3-heptanediol and 1,2-heptanediol, or 2,3-octanediol and 1,2-octanediol, or 2,3-nonanediol and 1,2-nonanediol, or 2,3-decanediol and 1,2-decanediol, or 2,3-Undecanediol and 1,2-Undecenaediol, or 2,3-dodecanediol and 1,2-dodecanediol, or In a mixture containing 2,3-tridecanediol and 1,2-tridecanediol, The first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0198] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0199] These mixing ratios result in the aforementioned mixtures exhibiting improved solubility of lipid-soluble active substances compared directly to the corresponding individual substances, as described and demonstrated in the experimental section.

[0200] A preferred variation according to a second aspect of the present invention also includes a mixture comprising 1,2-hexanediol as the first linear alkanediol and 2,3-octanediol as the second linear alkanediol, or a mixture comprising 1,2-octanediol as the first linear alkanediol and 2,3-hexanediol as the second linear alkanediol, or a mixture comprising 1,2-octanediol as the first linear alkanediol and 2,3-heptanediol as the second linear alkanediol, wherein the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0201] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0202] These mixing ratios, when used in combination with antimicrobial components, result in the aforementioned mixtures exhibiting synergistic antimicrobial efficacy compared directly to the corresponding individual substances, as described and demonstrated in the experimental section.

[0203] In a further beneficial modification according to a second aspect of the present invention, the mixture comprises a first linear alkanediol and a second linear alkanediol, for example 1,2-pentanediol and 2,3-hexanediol, or 1,2-pentanediol and 1,2-heptanediol, or 1,2-pentanediol and 2,3-heptanediol, or 1,2-pentanediol and 2,3-octanediol, or 1,2-pentanediol and 1,2-nonanediol, or It contains a mixture comprising 1,2-pentanediol and 2,3-nonanediol, The first linear alkanediol and the second linear alkanediol exist in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5.

[0204] The same ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0205] These mixing ratios, when used in combination with antimicrobial components, result in the aforementioned mixtures exhibiting synergistic antimicrobial efficacy compared directly to the corresponding individual substances, as described and demonstrated in the experimental section.

[0206] A particularly preferred variation according to a second aspect of the present invention is a mixture comprising 1,2-heptanediol as the first linear alkanediol and 1,2-octanediol as the second linear alkanediol, or a mixture comprising 1,2-heptanediol as the first linear alkanediol and 2,3-octanediol as the second linear alkanediol, or a mixture comprising 1,2-heptanediol as the first linear alkanediol and 1,2-nonane as the second linear alkanediol. The mixture also includes a diol, or a mixture containing 1,2-heptanediol as the first linear alkanediol and 2,3-nonanediol as the second linear alkanediol, wherein the first linear alkanediol and the second linear alkanediol are present in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, or even more preferably in a ratio ranging from 90:10 to 95:5.

[0207] Similarly, the ratio of the first linear alkanediol to the second alkanediol, or the range of the above ratios, applies to the aforementioned mixture as well.

[0208] These mixing ratios, when used in combination with antimicrobial components, result in the aforementioned mixtures exhibiting synergistic antimicrobial efficacy compared directly to the corresponding individual substances, as described and demonstrated in the experimental section.

[0209] Alkanediols can be obtained from petrochemical or other fossil fuel sources by known methods, such as bishydroxylation of olefins, hydrolysis from epoxides, or various chemical transformations; from bio-derived raw materials by fermentation; or by catalytic synthesis from bio-based natural and renewable raw materials, such as biomass, as described in US2019 / 0241491A1 and US2020 / 0189995A1. The alkanediols used in accordance with the present invention include those derived from petrochemicals as well as those derived from bio-based natural and renewable raw materials. Preferably, the alkanediols are from bio-based sources and are therefore bio-alkanediols.

[0210] Compound (b) of a composition according to a first or second aspect of the present invention relates to an antimicrobial component commonly used in many cosmetic preparations, particularly in skin care, hair care, or body care, or in pharmaceuticals.

[0211] In relation to this invention, the term "antimicrobial component" refers to a group of substances, particularly agents that kill or inhibit the growth of microorganisms. Antimicrobial agents can be grouped according to the microorganisms they primarily act on. For example, antibiotics are used against bacteria, antifungal agents against fungi, antiprotozoa are used against protozoa, and antiviral agents against viruses. These can also be classified according to their function. Agents that kill microorganisms are biocidal or microbiotoxic, while those that only inhibit their growth are called bacteriostatic.

[0212] The antimicrobial components according to the present invention act primarily against microorganisms, particularly bacteria, yeasts, and / or fungi. The microorganisms described are mesophilic aerobic bacteria, yeasts, or fungi that are undesirable in cosmetics and are recognized as potentially harmful to human health, skin pathogens, or indicating sanitary deficiencies in the manufacturing process. The microorganisms designated according to the present invention are those of the genera Pseudomonas (bacteria), Staphylococcus (bacteria), Escherichia (bacteria), Candida (yeast), and Aspergillus (fungi), and combinations thereof.

[0213] More preferably, the microorganism is selected from the group consisting of Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus brasiliensis, as well as combinations thereof.

[0214] A composition according to the first or second aspect of the present invention is caprylhydroxamic acid, o-cymen-5-ol, isopropylparaben, capryloyl glycine, phenylpropanol, tropolone, cocoyl arginine ethyl PCA, 2-methyl 5-cyclohexylpentanol, phenoxyethanol, disodium EDTA, methylparaben and its salts, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, sodium methylparaben, methylchloroisothiazolinone, Methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, dehydroacetic acid, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, undecylenoyl glycine, thymol, 4-hydroxyacetophenone, lactic acid, sodium lactate, dicarboxymethylalanine Trisodium nitrite, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,It comprises 3-nonanediol and at least one antimicrobial active component selected from the group consisting of two or more mixtures of the aforementioned antimicrobial components.

[0215] In the preferred variant, the antimicrobial active components are caprylhydroxamic acid, o-cymen-5-ol, isopropylparaben, capryloyl glycine, phenylpropanol, tropolone, cocoyl arginine ethyl PCA, 2-methyl 5-cyclohexylpentanol, phenoxyethanol, disodium EDTA, methylparaben and its salts, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, sodium methylparaben, methylchloroisothiazolinone, methylisothiazolinone Ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, dehydroacetic acid, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA lycylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, undecylenoyl glycine, thymol, 4-hydroxyacetophenone, lactic acid, sodium lactate, trisodium dicarboxymethylalanine, Frambinoline, xylitol caprylate, 3-Hydrobenzoate Selected from the group consisting of roxypropyl ester, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components.

[0216] In a preferred variation, the antimicrobial components of the composition of the present invention include dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, and Selected from the group consisting of trisodium ethylenediamine disuccinate, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components.

[0217] In a particularly preferred variation, the microbially active components of the composition of the present invention are phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-hydroxy The antimicrobial agent is selected from the group consisting of acetophenone, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components.

[0218] In a more preferred variation, the antimicrobial component in the composition according to the first or second aspect of the present invention is selected from the group consisting of 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more of the aforementioned antimicrobial components. If the antimicrobial component (b) of the composition according to the first and second aspects of the present invention is a previously identified alkanediol, the antimicrobial alkanediol component (b) is different from the alkanediol component (a).

[0219] The aforementioned antimicrobial components may be used as single components or in combination with one or more further antimicrobial components. To improve the antimicrobial effect and to cover a broader range of antimicrobial effects, combinations of two or more antimicrobial components are preferably used.

[0220] In a preferred advantageous modification, a composition according to the first or second aspect of the present invention comprises one of the following combinations of components (a) and (b): • 1,2-Pentanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Hexanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, diacetic acid glutamate Tetrasodium, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Decanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, diacetic acid glutamate Tetrasodium, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Undecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Dodecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Tridecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-pentanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 2,3-Hexanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, diacetic acid glutamate Tetrasodium, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Decanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, diacetic acid glutamate Tetrasodium, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 2,3-Undecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Dodecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Tridecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, divine Glutamate Tetrasodium acid, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-pentanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-hexanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-nonanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, Tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-decanediol combined with 2,3-decanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, Tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinoline, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-undecanediol combined with 2,3-undecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbita caprylate N, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-dodecanediol combined with 2,3-dodecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-tridecanediol combined with 2,3-tridecanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbita caprylate N, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol in combination with one or more of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, diglucon Chlorhexidine acid, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol in combination with one or more of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, and one or more of the following antimicrobial components: dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts Chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Hexanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 1,2-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 1,2-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Heptanediol combined with 1,2-octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Heptanediol combined with 1,2-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid, iodide propynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate Tan, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, lactic acid, sodium lactate, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components.

[0221] A more preferred combination of components (a) and (b) in a composition according to the first or second aspect of the present invention is as follows: · 1,2-Pentanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Hexanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Heptanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Decanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Undecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole , 4-hydroxyacetophenone, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-Dodecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 1,2-Tridecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole , 4-hydroxyacetophenone, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Pentanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 2,3-Hexanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Heptanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 2,3-decanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Undecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole , 4-hydroxyacetophenone, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or · 2,3-Dodecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-Hydroxyacetophenone, Frambinon, xylitol caprylate, 3-Hydroxypropyl benzoate, 3-Hydroxypropyl anisate, 3-Hydroxypropyl 2-Hydroxybenzoate, 1,3-Propanediol, 1,2-Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2-Nonanediol, 2,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol, 1,2-Decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or • 2,3-Tridecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole , 4-hydroxyacetophenone, Frambinon, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-pentanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-hexanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-nonanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate , Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol or a mixture of two or more of the aforementioned antimicrobial components; 1,2-decanediol, or 1,2-decanediol combined with 2,3-decanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate , Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol or a mixture of two or more of the aforementioned antimicrobial components; 1,2-decanediol, or 1,2-undecanediol combined with 2,3-undecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,3-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; 1,2-decanediol, or 1,2-dodecanediol combined with 2,3-dodecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Tridecanediol combined with 2,3-Tridecanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or · 1,2-heptanediol in combination with one or more of the following: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or 1,2-tridecanediol, and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyethanol Cyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol in combination with one or more of the following: 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyethanol Cyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate, crimbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Hexanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-hexanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Pentanediol combined with 1,2-Heptanediol and one or more of the following antimicrobial components: Phenoxyethanol, Disodium EDTA, Methylparaben, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM ​​Hydantoin, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-heptanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Pentanediol combined with 1,2-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate , Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate , Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Heptanediol combined with 1,2-Octanediol and one or more of the following antimicrobial components: Phenoxyethanol, Disodium EDTA, Methylparaben, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM ​​Hydantoin, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-octanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate L, Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Heptanediol combined with 1,2-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate , Crinbazole, 4-hydroxyacetophenone, Frambino, xylitol caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 3-hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol combined with 2,3-nonanediol and one or more of the following antimicrobial components: phenoxyethanol, disodium EDTA, methylparaben, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid, Octopirox, propanediol caprylate 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, 1,2-decanediol, or a mixture of two or more of the aforementioned antimicrobial components.

[0222] Of the above alkanediol / antibiotic combinations, excellent synergistic antimicrobial efficacy can be obtained by combining 1,2-heptanediol or 2,3-alkanediol, particularly 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and 2,3-undecanediol, or a mixture containing a first linear alkanediol and a second alkanediol. This effect is demonstrated by preservation efficacy tests (PET) in the following examples.

[0223] Therefore, a detailed preferred antimicrobial combination of alkanediol / component (a) and (b) in a composition according to the first or second aspect of the present invention is: · 1,2-heptanediol and 4-hydroxyacetophenone, or · 1,2-heptanediol and o-cymen-5-ol (SymOcide C), or · 1,2-heptanediol and propanediol caprylate (Crinipan PMC Green), or · 1,2-heptanediol and crinbazole (Crinipan AD), or · 1,2-heptanediol and 2-methyl5-cyclohexylpentanol (SymDeo B125), or · 1,2-heptanediol and ethylhexylglycerin (Sensiva SC50), or · 1,2-heptanediol and sodium benzoate, or · 1,2-heptanediol and farnesol, or · 1,2-heptanediol and benzyl alcohol, or · 1,2-heptanediol and phenoxyethanol, or · 1,2-heptanediol and glyceryl caprylate (Symlite G8), or · 1,2-heptanediol and potassium sorbate, or • 1,2-heptanediol and isopropylparaben, or • 1,2-heptanediol and sodium methylparaben, or · 1,2-heptanediol and DMDM ​​hydantoin, or • 1,2-heptanediol and methylchloroisothiazolinone, or • 1,2-heptanediol and methylisothiazolinone, or • 1,2-heptanediol and caprylhydroxamic acid, or · 1,2-octanediol and 2,3-octanediol, or · 1,2-nonanediol and 4-hydroxyacetophenone, or · 2,3-heptanediol and 4-hydroxyacetophenone, or · 2,3-heptanediol and potassium sorbate, or · 2,3-heptanediol and phenoxyethanol, or • 2,3-heptanediol and benzyl alcohol, or • 2,3-heptanediol and lactic acid, or • 2,3-heptanediol and benzyl salicylate, or • 2,3-heptanediol and disodium EDTA, or • 2,3-heptanediol and caprylhydroxamic acid, or • 2,3-heptanediol and phytic acid, or · 2,3-heptanediol and ethylhexylglycerin, or • 2,3-heptanediol and glyceryl caprylate, or · 2,3-octanediol and 4-hydroxyacetophenone, or • 2,3-octanediol and potassium sorbate, or • 2,3-octanediol and phenoxyethanol, or • 2,3-octanediol and benzyl alcohol, or • 2,3-octanediol and lactic acid, • 2,3-octanediol and benzyl salicylate, or • 2,3-octanediol and disodium EDTA, or • 2,3-octanediol and caprylhydroxamic acid, or • 2,3-octanediol and phytic acid, • 2,3-octanediol and ethylhexylglycerin, • 2,3-octanediol and glyceryl caprylate, · 2,3-nonanediol and 4-hydroxyacetophenone, or · 2,3-nonanediol and potassium sorbate, or · 2,3-nonanediol and phenoxyethanol, or • 2,3-nonanediol and benzyl alcohol, or • 2,3-nonanediol and lactic acid, or • 2,3-nonanediol and benzyl salicylate, or • 2,3-nonanediol and disodium EDTA, or • 2,3-nonanediol and caprylhydroxamic acid, or • 2,3-nonanediol and phytic acid, or • 2,3-nonanediol and ethylhexylglycerin, or These are 2,3-nonanediol and glyceryl caprylate.

[0224] In a more preferable alkanediol / antibiotic combination according to the first or second aspect of the present invention, component (a) is a mixture of two different alkanediols combined with an antimicrobial component: · 1,2-pentanediol and 2,3-pentanediol, and 4-hydroxyacetophenone, or · 1,2-pentanediol and 2,3-pentanediol, as well as potassium sorbate, or · 1,2-pentanediol and 2,3-pentanediol, and phenoxyethanol, or · 1,2-pentanediol and 2,3-pentanediol, as well as benzyl alcohol, · 1,2-pentanediol and 2,3-pentanediol, as well as lactic acid, or · 1,2-pentanediol and 2,3-pentanediol, as well as benzyl salicylate, · 1,2-pentanediol and 2,3-pentanediol, and disodium EDTA, or · 1,2-pentanediol and 2,3-pentanediol, as well as caprylhydroxamic acid, · 1,2-pentanediol and 2,3-pentanediol, as well as phytic acid, or • 1,2-pentanediol and 2,3-pentanediol, as well as ethylhexylglycerin, or · 1,2-pentanediol and 2,3-pentanediol, as well as glyceryl caprylate, · 1,2-Hexanediol and 2,3-Hexanediol, and 4-Hydroxyacetophenone, or · 1,2-Hexanediol and 2,3-Hexanediol, as well as potassium sorbate, · 1,2-Hexanediol and 2,3-Hexanediol, and phenoxyethanol, or · 1,2-Hexanediol and 2,3-Hexanediol, as well as benzyl alcohol, · 1,2-Hexanediol and 2,3-Hexanediol, as well as lactic acid, or · 1,2-Hexanediol and 2,3-Hexanediol, as well as benzyl salicylate, · 1,2-Hexanediol and 2,3-Hexanediol, as well as disodium EDTA, or · 1,2-Hexanediol and 2,3-Hexanediol, as well as caprylhydroxamic acid, · 1,2-Hexanediol and 2,3-Hexanediol, as well as phytic acid, · 1,2-Hexanediol and 2,3-Hexanediol, as well as ethylhexylglycerin, or · 1,2-Hexanediol and 2,3-Hexanediol, as well as glyceryl caprylate, · 1,2-heptanediol and 2,3-heptanediol, and 4-hydroxyacetophenone, or · 1,2-heptanediol and 2,3-heptanediol, as well as potassium sorbate, or · 1,2-heptanediol and 2,3-heptanediol, and phenoxyethanol, or · 1,2-heptanediol and 2,3-heptanediol, as well as benzyl alcohol, · 1,2-heptanediol and 2,3-heptanediol, as well as lactic acid, or · 1,2-heptanediol and 2,3-heptanediol, as well as benzyl salicylate, · 1,2-heptanediol and 2,3-heptanediol, and disodium EDTA, or · 1,2-heptanediol and 2,3-heptanediol, as well as caprylhydroxamic acid, · 1,2-heptanediol and 2,3-heptanediol, as well as phytic acid, • 1,2-heptanediol and 2,3-heptanediol, and ethylhexylglycerin, or · 1,2-heptanediol and 2,3-heptanediol, as well as glyceryl caprylate, · 1,2-octanediol and 2,3-octanediol, and 4-hydroxyacetophenone, or • 1,2-octanediol and 2,3-octanediol, as well as potassium sorbate, or · 1,2-octanediol and 2,3-octanediol, as well as phenoxyethanol, or · 1,2-octanediol and 2,3-octanediol, as well as benzyl alcohol, • 1,2-octanediol and 2,3-octanediol, as well as lactic acid, or • 1,2-octanediol and 2,3-octanediol, as well as benzyl salicylate, · 1,2-octanediol and 2,3-octanediol, and disodium EDTA, or · 1,2-octanediol and 2,3-octanediol, as well as caprylhydroxamic acid, • 1,2-octanediol and 2,3-octanediol, as well as phytic acid, • 1,2-octanediol and 2,3-octanediol, as well as ethylhexylglycerin, or • 1,2-octanediol and 2,3-octanediol, as well as glyceryl caprylate, or · 1,2-nonanediol and 2,3-nonanediol, and 4-hydroxyacetophenone, or • 1,2-nonanediol and 2,3-nonanediol, as well as potassium sorbate, · 1,2-nonanediol and 2,3-nonanediol, as well as phenoxyethanol, or · 1,2-nonanediol and 2,3-nonanediol, as well as benzyl alcohol, · 1,2-nonanediol and 2,3-nonanediol, as well as lactic acid, or · 1,2-nonanediol and 2,3-nonanediol, as well as benzyl salicylate, · 1,2-nonanediol and 2,3-nonanediol, as well as disodium EDTA, or · 1,2-nonanediol and 2,3-nonanediol, as well as caprylhydroxamic acid, · 1,2-nonanediol and 2,3-nonanediol, as well as phytic acid, • 1,2-nonanediol and 2,3-nonanediol, as well as ethylhexylglycerin, or · 1,2-nonanediol and 2,3-nonanediol, as well as glyceryl caprylate, · 1,2-decanediol and 2,3-decanediol, and 4-hydroxyacetophenone, or · 1,2-decanediol and 2,3-decanediol, as well as potassium sorbate, or · 1,2-decanediol and 2,3-decanediol, as well as phenoxyethanol, or · 1,2-decanediol and 2,3-decanediol, as well as benzyl alcohol, · 1,2-decanediol and 2,3-decanediol, as well as lactic acid, or · 1,2-decanediol and 2,3-decanediol, as well as benzyl salicylate, · 1,2-decanediol and 2,3-decanediol, as well as disodium EDTA, or · 1,2-decanediol and 2,3-decanediol, as well as caprylhydroxamic acid, · 1,2-decanediol and 2,3-decanediol, as well as phytic acid, or · 1,2-decanediol and 2,3-decanediol, as well as ethylhexylglycerin, or · 1,2-decanediol and 2,3-decanediol, as well as glyceryl caprylate, or · 1,2-Undecanediol and 2,3-Undecanediol, and 4-hydroxyacetophenone, or · 1,2-Undecanediol and 2,3-Undecanediol, as well as potassium sorbate, or · 1,2-Undecanediol and 2,3-Undecanediol, and phenoxyethanol, or · 1,2-Undecanediol and 2,3-Undecanediol, as well as benzyl alcohol, · 1,2-Undecanediol and 2,3-Undecanediol, as well as lactic acid, or · 1,2-Undecanediol and 2,3-Undecanediol, as well as benzyl salicylate, · 1,2-Undecanediol and 2,3-Undecanediol, and disodium EDTA, or · 1,2-Undecanediol and 2,3-Undecanediol, as well as caprylhydroxamic acid, · 1,2-Undecanediol and 2,3-Undecanediol, as well as phytic acid, or · 1,2-Undecanediol and 2,3-Undecanediol, as well as ethylhexylglycerin, or • Contains 1,2-undecanediol and 2,3-undecanediol, as well as glyceryl caprylate.

[0225] The aforementioned combination achieves synergistic antimicrobial efficacy against bacteria, yeasts, and fungi / molds as described in the following examples.

[0226] The most preferred antimicrobial combination of alkanediol / component (a) and (b) in a composition according to the first or second aspect of the present invention is: • 1,2-heptanediol and 1,2-decylene glycol • 1,2-heptanediol and anisic acid • 1,2-heptanediol and tropolone • 1,2-heptanediol and disodium EDTA • 1,2-heptanediol and 2,3-heptanediol • 1,2-heptanediol and hydroxyethoxyphenylbutanone • 1,2-heptanediol and phytic acid • 1,2-heptanediol and levulinic acid and its esters and / or ketals • 1,2-heptanediol and 1,3-propanediol • 1,2-Heptanediol and tetrasodium glutamate diacetate (Dissolvine GL47 S) • 1,2-heptanediol and thymol • 1,2-Heptanediol and Dragosantol 100 (Bisabolol) • 1,2-heptanediol and methylparaben • 1,2-heptanediol and ethylparaben • 1,2-heptanediol and benzyl salicylate • 1,2-heptanediol and hydroxyethoxyphenylbutanol • 1,2-heptanediol and 1,2-octanediol These are 1,2-heptanediol and sodium lactate.

[0227] 1,2-heptanediol, when combined with 1,2-decylene glycol, anisic acid, or tropolone, exhibits synergistic antimicrobial effects against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds. Surprisingly, this synergistic antimicrobial effect was also demonstrated against Candida species, such as Candida albicans, and Aspergillus species, such as Aspergillus brasiliensis, both of which are known to be difficult to control.

[0228] On the other hand, 1,2-heptanediol combined with EDTA, 2,3-heptanediol, or hydroxyethoxyphenylbutanone exhibits synergistic antimicrobial effects against bacteria and yeast.

[0229] Furthermore, synergistic antimicrobial effects against bacteria were also achieved with 1,2-heptanediol in combination with phytic acid, levulinic acid, 1,3-propanediol, tetrasodium glutamate diacetate (Dissolvine GL47S), thymol, Dragosantol 100 (bisabolol), methylparaben, ethylparaben, benzyl salicylate, or hydroxyethoxyphenylbutanol.

[0230] The specific combinations defined above can be combined with one or more additional components described later.

[0231] In a preferred advantageous modification, a composition according to the first or second aspect of the present invention comprises one of the following antimicrobial combinations of alkane / component (a) and (b), wherein antimicrobial component (b) is a 2,3-alkanediol: · 1,2-pentanediol and 2,3-pentanediol, or · 1,2-hexanediol and 2,3-hexanediol, or · 1,2-heptanediol and 2,3-heptanediol, or • 1,2-octanediol and 2,3-octanediol, or · 1,2-nonanediol and 2,3-nonanediol, or · 1,2-decanediol and 2,3-decanediol, or · 1,2-Undecanediol and 2,3-Undecanediol, or These are 1,2-dodecanediol and 2,3-dodecanediol.

[0232] In the particular alkanediol / antibiotic combination, the antimicrobial component (b) is different from the alkanediol component (a) of the composition according to the second aspect of the present invention.

[0233] Such alkanediol / antibiotic combinations, as demonstrated in the following examples, exhibit synergistic antimicrobial efficacy against a wide range of microorganisms, namely bacteria, yeasts, and fungi / molds, particularly compared to each single alkanediol substance.

[0234] To further enhance antimicrobial efficacy, the compositions defined herein are advantageously combined with at least one additional antimicrobial agent different from component (b) of the compositions according to the present invention. Combinations with additional antimicrobial agents provide reliable protection against microbial degradation and deterioration of the preparations, particularly during storage. Furthermore, even more different antimicrobial agents provide reliable protection against other microorganisms, such as Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Malassezia, Peptoniphilus, Streptococcus, Lactobacillus, Gardnerella, Fannyhessea, Epidermophyton, Trichophyton, and Cutibacterium, as described above. Thus, combinations with even more different antimicrobial agents enable antimicrobial protection against different groups of microorganisms, and even a wider range of microorganisms. Furthermore, with even more different antimicrobial agents, preferably antimicrobial agents for skin protection, the compositions according to the present invention may also exhibit different antimicrobial targets.

[0235] Further different antimicrobial agents related to the present invention include, preferably, 2-benzylheptanol, alkyl(C12-22)trimethylammonium bromide and chloride, ascorbic acid and its salts, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharate, benzethonium chloride, benzoic acid, camphor, cetylpyridinium chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol, cyclohexylglycerin, dimethylphenylbutanol, dimethylphenylpropanol, ethanol, and ethyl lauryl Il-arginate HCl, ethyl lauroyl-arginate laurate, eucalyptol, gluconic acid and its salts, glycerin, hexamidine, hexamidine diisethionate, hexylglycerin, iodide-propynyl butylcarbamate, jasmol, lauryl alcohol, levulinic acid and its esters and / or ketal, mannitol, menthol, methyl salicylate, octenidine HCl, polyarginine, polyglyceryl-10 laurate, polyglyceryl-2 caprate, polyglyceryl-3 caprylate, polylysine, Salvia Selected from the group consisting of Officinalis (sage) oil, silver chloride, silver citrate, sodium caproyl lactylate, sodium caproyl / lauroyl lactylate, sodium lauroyl lactylate, sorbic acid, sorbitol, tetracermis extract, triclocarban, triclosan, triethyl citrate, xylitol sesquicaprylate, zinc citrate, zinc pyrithione, zinc ricinoleate, and mixtures of two or more of the aforementioned antimicrobial agents.

[0236] In a more preferred variation, further different antimicrobial agents are selected from the group consisting of 2-benzylheptanol, benzoic acid, dimethylphenylbutanol, dimethylphenylpropanol, ethyl lauroyl alginate HCl, ethyl lauroyl alginate laurate, gluconic acid and its salts, glyceryl laurate, jasmol, lauryl alcohol, levulinic acid and its esters and / or ketal, mannitol, octenidine HCl, polyglyceryl-10 laurate, polyglyceryl-2 caprate, polyglyceryl-3 caprylate, Salvia Officinalis (sage) oil, sodium caproyl lactylate, sodium caproyl / lauroyl lactylate, sodium lauroyl lactylate, sorbic acid, sorbitol, tetraselmis extract, triclosan, triethyl citrate, xylitol sesquicaprylate, zinc ricinoleate, and mixtures of two or more of the aforementioned antimicrobial agents.

[0237] Within the context of the present invention, compositions according to the first or second aspect of the present invention may also be combined with other conventional active agents, adjuvants, or additives, which is advantageous in some cases.

[0238] Optionally, other conventional active agents, adjuvants, or additives habitually used in food, cosmetic, or pharmaceutical compositions, or home care products, as further described below, may be added as component (c) to obtain ready-to-use preparations or formulations, such as food, cosmetic, or pharmaceutical preparations, animal feed preparations, or home care products.

[0239] The compositions according to the present invention may be advantageously combined with other surfactants and / or adjuvants and / or additives or auxiliary agents, which are commonly used, for example, in foods, cosmetics or pharmaceutical preparations, animal feed preparations, or home care products, such as abrasives, anti-acne agents, anti-aging agents for skin, anti-cellulitis agents, anti-dandruff agents, anti-inflammatory agents, anti-irritants, irritation inhibitors, antioxidants, astringents, odor absorbers, sweat inhibitors, disinfectants, antistatic agents, binders, buffers, carrier materials, chelating agents, cell stimulants, cleansing agents, depilators, surfactants, deodorants, and antiperspirants. Agents, softeners, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibers, film-forming agents, fixing agents, foam-forming agents, foam stabilizers, anti-foaming substances, foam enhancers, gelling agents, gel-forming agents, hair care agents, hair styling agents, hair straightening agents, moisture donors, moisturizing substances, water-retaining substances, bleaching agents, enhancers, color removers, optical whitening agents, impregnating agents, anti-fouling agents, pigments, friction reducers, lubricants, moisturizing creams, ointments, opacifying agents, plasticizers, coating agents, polishing agents, preservatives, glossing agents, green and synthetic polymers, powders, proteins, re-oil-retaining agents, abrasives, silicones, skin-soothing agents. (agents), skin cleansing agents, skincare agents, skin healing agents, whitening agents, skin protectants, skin softeners, hair growth stimulants, cooling agents, skin cooling agents, warming agents, skin warming agents, stabilizers, surfactants, UV absorbers, UV filters, primary sunscreen factors, secondary sunscreen factors, detergents, fabric conditioning agents, suspensions, skin tanning agents, active substances that modulate skin or hair pigment, matrix-metalloproteinase inhibitors, skin moisturizers, glycosaminoglycan stimulants, TRPV1 antagonists Desquamating agents, anti-cellulite agents or fat enhancers, hair growth activators or inhibitors, thickeners, rheological additives, vitamins, oils, waxes, pearlescent waxes, fats, phospholipids, saturated fatty acids, monounsaturated or polyunsaturated fatty acids, alpha-hydroxy acids, polyhydroxy fatty acids, liquefaction agents, dyes, color protectants, pigments, rust inhibitors, fragrances or scented oils, fragrances, flavoring substances, scenting substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as further described below.

[0240] Of the above-mentioned cosmetic or pharmaceutical activators and / or adjuvants and / or additives or auxiliary agents for skin aging, antioxidants, chelating agents, emulsifiers, surfactants, green and synthetic polymers, skin coolants, rheological additives, oils, fragrances or scented oils, and polyols are particularly preferred for the preparation of cosmetic and pharmaceutical compositions.

[0241] Cosmetic or medicinal activators and / or adjuvants and / or additives, in some cases, provide one or more benefits or operate through one or more modes of action.

[0242] Since skin lesions or diseases are often associated with dry skin, wounded skin, skin lesions, or further inflammation, compositions according to the present invention advantageously preferably contain anti-inflammatory agents, antibacterial or antifungal substances, substances having redness-reducing or itchiness-reducing effects, analgesic substances, moisturizers and / or coolants, osmolites, keratolytic substances, growth-promoting substances, anti-inflammatory agents, antibacterial or antifungal substances, substances having redness-reducing or itchiness-reducing effects, analgesic substances, anti-dandruff substances or other active compounds, such as solvents, fragrances, antioxidants, preservatives, (metal) chelating agents, permeability enhancers, or mixtures of two or more of the previously mentioned agents, which are further described below.

[0243] Anti-aging active substances: The compositions according to the present invention are preferably combined with one or more anti-aging active substances. In relation to the present invention, anti-aging or biogenic agents include, for example, antioxidants, matrix-metalloproteinase inhibitors (MMPIs), skin moisturizers, glycosaminoglycan stimulants, anti-inflammatory agents, TRPV1 antagonists, and plant extracts.

[0244] Antioxidants: The compositions according to the present invention are preferably combined with one or more antioxidants. Suitable antioxidants include amino acids (preferably glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (preferably urocanic acid) and their derivatives, peptides, preferably D,L-carnosine, D-carnosine, L-carnosine and its derivatives (preferably anserine), carnitine, creatine, matricine peptides (preferably lysyl-threonyl-threonyl-lysyl-serine) and palmitoylated pentapeptides, carotenoids, carotenes (preferably alpha-carotene, ve Carotene (lycopene), its derivatives, lipoic acid and its derivatives (preferably dihydrolipoic acid), gold thioglucose, propylthiouracil and other thiols (preferably thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl, glyceryl and its oligoglyceryl esters) and their salts, dilauryl thiodipropionate, distea Lylthiodipropionate, thiodipropionic acid and its derivatives (preferably esters, ethers, peptides, lipids, nucleotides, nucleosides and salts), as well as sulfoximine compounds (preferably butionine sulfoximine, homocysteine ​​sulfoximine, butionine sulfone, penta-, hexa-, heptahionine sulfoximine) in very low tolerance levels (e.g., pmol to μmol / kg), and (metal) chelating agents (preferably alpha-hydroxy fatty acids, palmitic acid, phytic acid, lactate). Ferin, alpha-hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, tannins, bilirubin, biliverdin, EDTA, EGTA and their derivatives), unsaturated fatty acids and their derivatives (preferably gamma-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and its derivatives, ubiquinol and its derivatives, vitamin C and its derivatives (preferably ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate, ascorbyl glucoside),Tocopherol and derivatives (preferably vitamin E acetate), vitamin A and derivatives (vitamin A palmitate), and benzoic acid resins such as coniferyl benzoate, rutinic acid and its derivatives, flavonoids and their glycosylation precursors, particularly quercetin and its derivatives, preferably alpha-glucosylrutin, rosmarinic acid, carnosol, carnosolic acid, resveratrol, caffeic acid and its derivatives, sinapic acid and its derivatives, ferulic acid and its derivatives, curcuminoids, chlorogenic acid and its derivatives, retinoids, preferably retinyl palmitate, retinol or tretinoin, ursolic acid, levulinic acid and its esters and / or ketals, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiac acid , ordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (preferably ZnO, ZnSO4), selenium and its derivatives (preferably seleniummethionine), superoxide dismutase, stilbene and its derivatives (preferably stilbene oxide, trans-stilbene oxide), and derivatives of these cited active ingredients (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides, and lipids) which are suitable according to the present invention, or plants having antioxidant effects, preferably green tea, rooibos, honeybush, grape, rosemary, sage, melissa, thyme, lavender, olive, oat, cocoa, ginkgo, ginseng, licorice, honeysuckle, sophora, pueraria, pine, citrus, Phyllanthus emblica or St. John's wort, grape seeds, wheat germ, Phyllanthus The extract or fraction of emblica, coenzymes, preferably coenzyme Q10, plastoquinone, and menaquinone are included. Preferred antioxidants are selected from the group consisting of vitamin A and derivatives, vitamin C and derivatives, tocopherol and derivatives, preferably tocopherol acetate, and ubiquinone. Vitamin E and / or its derivatives are also included.When used as an antioxidant(s), it is advantageous to select a concentration in the range of approximately 0.001 to approximately 10% by weight relative to the total weight of the composition. When vitamin A or vitamin A derivatives, or carotene or its derivatives, are used as antioxidants(s), it is advantageous to select a concentration in the range of approximately 0.001 to approximately 10% by weight relative to the total weight of the composition.

[0245] Matrix-metalloproteinase inhibitors (MMPIs): The compositions according to the present invention are preferably combined with one or more matrix-metalloproteinase inhibitors, in particular those that inhibit matrix-metalloproteinases that enzymatically cleave collagen, and these include ursolic acid, retinyl palmitate, propyl gallate, precosene, 6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran, 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran, benzamidine hydrochloride, and the cysteine ​​proteinase inhibitor N-ethylmalemide (N-ethylma Epsilon-amino-n-caproic acid (lemide) and serine protease inhibitors: phenylmethylsufonylfluoride, colhibin (Pentapharm; INCI: hydrolyzed rice protein), oenotherol (Soliance; INCI: PG, water, evening primrose root extract, ellagic acid and ellagitannin, e.g., from pomegranate), phosphoramidone hinokitiol, EDTA, MGDA (trisodium dicarboxymethylalanine), galarzin, EquiStat (Collaborative Group; apple fruit extract, soybean seed extract, ursolic acid, soy isoflavones and soy protein), sage extract, MDI (Atrium; INCI: mucopolysaccharide), Fermiskin (Silab / Mawi; INCI: water and shiitake mushroom extract), actimp 1.9.The following substances are selected from the group consisting of 3 (Expanscience / Rahn; INCI: hydrolyzed lupine protein), lipoversoyaglycone (Mibelle; INCI: ethanol, polysorbate 80, lecithin, and soy isoflavones), extracts from green tea and black tea, and further plant extracts, proteins or glycoproteins from soybeans, hydrolyzed proteins from rice, peas, or lupine, plant extracts that inhibit MMPs, preferably extracts from the mushroom shiitake, extracts from the leaves of the Rosaceae and Rosaceae families, and in particular, extracts from blackberry leaves such as SymMatrix (Symrise; INCI: maltodextrin, Rubus parvifolius leaf extract). Preferred active substances are selected from the group consisting of retinyl palmitate, ursolic acid, extracts from the leaves of the Rosaceae and Rosaceae families, genistein, and daidzein.

[0246] Skin moisturizers: A preferred composition according to the present invention comprises one or more skin moisturizers. Preferred skin moisturizers are alkanediols or alkanetriols containing 3 to 12 carbon atoms, preferably C3-C3. 10 - Alkanediols and C3~C 10 - Selected from the group consisting of alkanetriols. More preferably, the skin moisturizer is selected from the group consisting of glycerol, 1,2-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol.

[0247] Glycosaminoglycan stimulants: Preferred compositions according to the present invention include one or more substances that stimulate glycosaminoglycan synthesis, which include hyaluronic acid and its derivatives or salts, Subliskin (Sederma, INCI: Sinorhizobium Meliloti Ferment Filtrate, Cetyl Hydroxyethylcellulose, Lecithin), Hyalufix (BASF, INCI: Water, BG, Alpinia galanga leaf extract, Xanthan gum, Caprylic / Capric Triglyceride), Stimulhyal (Soliance, INCI: Calcium Ketogluconate), Syn-Glycan (DSM, INCI: Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate) Selected from the group consisting of Trifluoroacetate, Glycerin, Magnesium Chloride, Kalpariane (Biotech Marine), DC Upregulexx (Distinctive Cosmetic Ingredients, INCI: Water, Butylene Glycol, Phospholipids, Hydrolyzed Sericin), Glucosamine, N-Acetylglucosamine, Retinoids, preferably Retinol and Vitamin A, Arctium lappa Fruit Extract, Eriobotrya japonica Extract, Genkwanin, N-Methyl-L-Serine, (-)-Alpha-Bisabolol or Synthetic Alpha-Bisabolol, e.g. Dragosantol and Dragosantol 100 from Symrise, Oat Glucan, Echinacea purpurea Extract and Soy Protein Hydrolysate.Preferred active substances are selected from the group consisting of hyaluronic acid and its derivatives or salts, retinol and its derivatives, (-)-alpha-bisabolol or synthetic alpha-bisabolol, e.g., Dragosantol and Dragosantol 100 from Symrise, oat glucan, Echinacea purpurea extract, Sinorhizobium meliloti fermentation filtrate, calcium ketogluconate, Alpinia galanga leaf extract, and tetradecylaminobutyroyl valylaminobutyric acid urea trifluoroacetate.

[0248] TRPV1 Antagonists: Preferred compositions according to the present invention include one or more TRPV1 antagonists. Preferred TRPV1 antagonists that suppress cutaneous nerve hypersensitivity based on their action include, for example, trans-4-tert-butylcyclohexanol, or indirect regulators of TRPV1 by activation of μ-receptors, such as acetyltetrapeptide-15.

[0249] Plant Extracts: Preferred compositions according to the present invention include one or more plant extracts. Plant extracts, particularly highly active plant extract fractions, and highly pure active substances isolated from plant extracts may also be used in compositions according to the present invention. Extracts, fractions, and active substances from chamomile, aloe vera, Commiphora species, Rubia species, willow, red flower, ginger, marigold, arnica, Glycyrrhiza species, Echinacea species, and Rubus species, as well as pure substances, such as bisabolol, apigenin, apigenin-7-glucoside, gingerol, as an example [6]-gingerol, paradol, as an example [6]-paradol, boswellic acid, plant sterols, glycyrrhizin, glabridin, or licochalcone A are particularly preferred.

[0250] Anti-inflammatory agents: The compositions according to the present invention are preferably combined with anti-inflammatory agents and / or components that relieve redness and / or itching, particularly corticosteroid-type steroid substances selected from the group consisting of hydrocortisone, dexamethasone, dexamethasone phosphate, methylprednisolone, or cortisone, which are advantageously used as anti-inflammatory active components or active components that reduce redness and itching, and this enumeration can be expanded by adding other steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs may also be used. More particularly: (i) Adrenocortical steroid-type steroidal anti-inflammatory substances, especially hydrocortisone, hydrocortisone derivatives, such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone, or cortisone. (ii) Nonsteroidal anti-inflammatory substances, especially oxicams, e.g., piroxicam or tenoxicam; salicylates, e.g., aspirin, disalside, sorbyrin or fendosal; acetic acid derivatives, e.g., diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; fenametes, e.g., mefenamic, meclofenamic, flufenamic or niflumic; propionic acid derivatives, e.g., ibuprofen, naproxen or benoxaprofen; pyrazoles, e.g., phenylbutazone, oxyphenylbutazone, febrazone or azapropazone. (iii) Natural or naturally occurring anti-inflammatory substances or substances that relieve redness and / or itchiness, especially chamomile, aloe vera, Commiphora species, Rubia species, willow, red flower, oat, calendula, arnica, St. John's wort, honeysuckle, rosemary, Passiflora incarnata, witch hazel, ginger or echinacea, or extracts or fractions from any single active compound thereof. (iv) Histamine receptor antagonists, serine protease inhibitors (e.g., soy extracts), TRPV1 antagonists (e.g., 4-t-butylcyclohexanol), NK1 antagonists (e.g., aprepitant, hydroxyphenylpropamide benzoate), cannabinoid receptor agonists (e.g., palmitoylethanolamine), and TRPV3 antagonists.

[0251] Examples that may be cited herein are oxicams, e.g., piroxicam or tenoxicam; salicylates, e.g., aspirin, disalside, sorbyline or fendosal; acetic acid derivatives, e.g., diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; phenamates, e.g., mefenamic, meclofenac, flufenamic or niflumic; propionic acid derivatives, e.g., ibuprofen, naproxen, benoxaprofen or pyrazoles, e.g., phenylbutazone, oxyphenylbutazone, febrazone or azapropazone. Anthranilic acid derivatives are preferred antipruritic components in compositions according to the present invention.

[0252] Substances or mixtures of substances that relieve redness and / or itching, particularly extracts or fractions from chamomile, aloe vera, Commiphora species, Rubia species, willow, red flower, oat, calendula, arnica, St. John's wort, honeysuckle, rosemary, Passiflora incarnata, witch hazel, ginger or echinacea; preferably chamomile, aloe vera, oat, calendula, arnica, honeysuckle, rosemary, witch hazel, ginger or echinacea, and / or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glucoside, gingerol, shogaol, shogadiol, dehydrogingerdione, paradol, natural, or from the group consisting of extracts or fractions from naturally occurring avenanthramides, preferably tranilast, avenanthramide A, avenanthramide B, avenanthramide C, non-natural or naturally occurring avenanthramides, preferably dihydroavennanthramide D, dihydroavennanthramide E, avenanthramide D, avenanthramide E, avenanthramide F, boswellic acid, plant sterols, glycyrrhizin, glabridin, and licochalcone A. Natural or naturally occurring anti-inflammatory mixtures selected from the group consisting of alpha-bisabolol, natural avenanthramides, non-natural avenanthramides, preferably dihydroavennanthramide D (as described in WO2004047833A1), boswellic acid, plant sterols, glycyrrhizin, and licochalcone A, and / or allantoin, panthenol, lanolin, (pseudo)ceramides [preferably ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glyceryl methoxypropyl myristamide, N-(1-hexadecanoyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethyl palmityloxyhydroxypropyl palmitamide], glycosphingolipids, plant sterols, chitosan, mannose, lactose, and β-glucans, particularly 1,3->1,4-β-glucans from oats, are also useful.

[0253] When bisabolol is used in connection with the present invention, it may be of natural or synthetic origin, and is preferably "alpha-bisabolol". Preferably, the bisabolol used is synthetically prepared or natural (-)-alpha-bisabolol and / or synthetic mixed-isomer alpha-bisabolol. When natural (-)-alpha-bisabolol is used, it may also be used as a component of essential oils or plant extracts or fractions thereof, for example, as a component of oils or extracts (fractions thereof) of chamomile or vanillosmopsis (especially Vanillosmopsis erythropappa or Vanillosmopsis arborea). Synthetic alpha-bisabolol is available, for example, from Symrise under the name "Dragosantol".

[0254] In cases where ginger extract is used in connection with the present invention, extracts of fresh or dried ginger root are preferably used, which are prepared by extraction with methanol, ethanol, isopropanol, acetone, ethyl acetate, carbon dioxide (CO2), hexane, methylene chloride, chloroform, or other solvents or solvent mixtures of equivalent polarity. The extract is characterized by the presence of components in amounts that reduce active skin irritation, such as gingerol, shogaol, shogadiol, dehydrogingerdione and / or paradol.

[0255] Physiological Coolants: The compositions according to the present invention may be combined particularly advantageously with one or more physiological coolants. The use of coolants may relieve itching. Individual coolants preferred for use within the framework of the present invention are listed below. Those skilled in the art may add many other coolants to this list; the listed coolants may be used in combination with each other: these are preferably selected herein from the following list: menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, isomenthol, neoisomenthol, neomenthol), methyl ethers (e.g., (I-menthoxy)-1,2-propanediol, (l-menthoxy)-2-methyl-1,2-propanediol, l-menthyl-methyl ether), menthyl glycoside acetals, menthyl glycoside ketals or mixtures of both, menthyl esters (e.g., menthyl formiate, menthyl acetate, menthyl isobutyrate, menthyl hydroxyisobutyrate, menthyl lactate) (L-menthyl-L-lactate, L-menthyl-D-lactic acid, menthyl-(2-methoxy)acetate, menthyl-(2-methoxyethoxy)acetate, menthyl pyroglutamate), menthyl carbonate (e.g., menthylpropylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glycerol carbonate or mixtures thereof), menthol and dicarboxylic acid or its derivatives semi-esters (e.g., mono-menthyl succinate, mono-menthyl glutarate, mono-menthyl malonate, O-menthyl succinate ester-N,N-(dimethyl)amide, O-menthyl succinate ester amide), menthane carboxylic acid amide (in this case, preferably menthane carboxylic acid-N-ethylamide [WS3] or N αSynthesis containing -(menthanecarbonyl)glycine ethyl ester [WS5], menthanecarboxylic acid-N-(4-cyanophenyl)amide or menthanecarboxylic acid-N-(4-cyanomethylphenyl)amide, menthanecarboxylic acid-N-(alkoxyalkyl)amide), menthone and menthone derivatives (e.g., L-menthingglycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyrate derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyrate-N-methylamide [WS23]), isopuregol or its esters (I-(-)-isopulegol, I-(-)-isopulegol acetate), menthane derivatives (e.g., p-menthane-3,8-diol), cubebol or cubebol is also included. or natural mixtures, pyrrolidone derivatives of cycloalkyldione derivatives (e.g., 3-methyl-2(1-pyrrolidinyl)-2-cyclopenten-1-one) or tetrahydropyrimidine-2-one (e.g., iciline or related compounds as described in WO2004 / 026840), further carboxamides (e.g., N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide or related compounds), (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-isopropyl)cyclohexane-carboxamide [WS12], oxamate and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]2-(ethylamino)-2-oxoacetate (X Cool). Preferred coolants for specific synergistic effects include l-menthol, d-menthol, racemic menthol, menthol glycerol acetal (trade name: Frescolat® MGA), menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)), substituted menthyl-3-carboxamide (e.g., menthyl-3-carboxylic acid N-ethylamide), 2-isopropyl-N-2,3-trimethylbutanamide, substituted cyclohexanecarboxamide, 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate, 2-hydroxypropyl menthyl carbonate, and isopuregol.Particularly preferred coolants are l-menthol, racemic menthol, menthol acetal (trade name: Frescolat® MGA), menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)), 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate, and 2-hydroxypropyl menthyl carbonate. Extremely preferred coolants are l-menthol, menthol acetal (trade name: Frescolat® MGA), and menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)).

[0256] Moisturizing and / or water-retaining substances: Itching occurs with a certain intensity when the skin is dry. The use of skin moisturizing and / or water-retaining substances can significantly alleviate itching. The compositions according to the present invention may therefore also advantageously contain one or more of the following moisturizing and / or water-retaining substances: sodium lactate, urea, urea derivatives, alcohols, glycerol, diols, e.g., propylene glycol, hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipate, petrolatum, urocanic acid, lecithin, panthenol, phytantriol, lycopene, (pseudo)ceramides, sphingoglycolipids, cholesterol, plant sterols, chitosan, chondroitin sulfate, lanolin, lanolin esters, amino acids, alpha-hydroxy acids (e.g., citric acid, lactic acid, malic acid) and their derivatives, mono-, di- and oligosaccharides, e.g., glucose, galactose, fructose, mannose, fructose and lactose, polysaccharides, e.g., R-glucans, especially 1,3-1,4-β-glucans from oats, alpha-hydroxy fatty acids, triterpenic acids, e.g., betulinic acid or ursolic acid, and algal extracts.

[0257] Analgesic substances: The compositions according to the present invention may also advantageously contain one or more analgesic substances, any analgesic substance suitable or conventional for cosmetic or pharmaceutical use, such as alpha-bisabolol, azulene, guaiazulene, 18-beta-glycyrrhetinic acid, allantoin, aloe vera juice or gel, Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, chamomile, Arnica monatana, Glycyrrhiza species, algae, seaweed and Calendula officinalis extracts, as well as vegetable oils, such as sweet almond oil, baobab oil, olive oil, and panthenol, laureth-9, trideceth-9, and 4-t-butylcyclohexanol.

[0258] Antimicrobial or Antifungal Substances: In addition to the antimicrobial agents described herein, antimicrobial or antifungal substances may also be used, particularly advantageously, in compositions according to the present invention, and any antimicrobial or antifungal substance suitable or conventional for cosmetic or pharmaceutical, particularly dermatological applications may be used. In addition to the large group of conventional antibiotics, other products advantageous herein include those relevant to cosmetics, such as triclosan, crimbazole, octoxyglycerin, Octopirox® (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone 2-aminoethanol salt), chitosan, farnesol, glyceryl monolaurate, or combinations thereof.

[0259] Desquamating agent: The composition according to the present invention preferably contains one or more desquamating agents. The expression "desquamating agent" means: - Any compound capable of directly acting on desquamation by promoting peeling, such as β-hydroxy acids, especially salicylic acid and its derivatives (including 5-n-octanoylsalicylic acid); α-hydroxy acids, such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; urea; gentisic acid; oligofucose; cinnamic acid; extract of Sophora japonica; resveratrol and some derivatives of jasmonic acid; - Or, it is understood to mean any compound capable of acting on enzymes involved in the desquamation or degradation of corneodesmosomes, glycosidases, stratum corneum chymotrypsinase (SCCE), or other proteases (trypsin, chymotrypsin-like). Chelating agents for inorganic salts: EDTA; N-acyl-N,N',N'-ethylenediaminetriacetic acid; aminosulfonic acid compounds, especially (N-2-hydroxyethylpiperazine-N-2-ethane)sulfonic acid (HEPES); derivatives of 2-oxothiazolidine-4-carboxylic acid (procysteine); derivatives of glycine-type alpha-amino acids (as described in EP-0852 949, and sodium methylglycine diacetate marketed by BASF under the trade name TRILON M); honey; sugar derivatives, e.g., O-octanoyl-6-D-maltose and N-acetylglucosamine; chestnut extract, e.g., marketed by SILAB under the name Recoverine®; prickly pear extract, e.g., marketed by SILAB under the name Exfolactive®; or Phytosphingosine marketed by Degussa. SLC (registered trademark) (phytosphingosine grafted with salicylic acid) may be mentioned.

[0260] Suitable desquamating agents for the present invention may be selected from the group comprising, in particular, sulfonic acids, calcium chelating agents, α-hydroxy acids, such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid, or mandelic acid; ascorbic acid and its derivatives, such as ascorbyl glucoside and magnesium ascorbyl phosphate; nicotinamide; urea; (N-2-hydroxyethylpiperazine-N-2-ethane)sulfonic acid (HEPES), β-hydroxy acids, such as salicylic acid and its derivatives, retinoids, such as retinol and its esters, retinol, retinoic acid and its derivatives, particularly chestnut or prickly pear extracts marketed by SILAB; and reducing compounds, such as cysteine ​​or cysteine ​​precursors. Other desquamating agents that may be used include nicotinic acid and its esters, also known as vitamin B3 or vitamin PP, as well as nicotinamide and ascorbic acid and its precursors.

[0261] Anti-dandruff substances: Furthermore, the compositions according to the present invention may be advantageously used in combination with one or more anti-dandruff substances comprising triclosan, crimbazole, octoxyglycerin, Octopirox® (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone 2-aminoethanol salt), chitosan, farnesol, glyceryl monolaurate, propanediol monocaprylate, or a combination of the said substances, which are used, in particular, against dandruff.

[0262] Further preferred anti-dandruff agents include piroctone olamine (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridinone monoethanolamine salt), Baypival® (Crinbazole), Ketoconazol® (4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1H-imidazole-1-ylmethyl)-1,3-dioxirane-c-4-ylmethoxyphenyl}-piperazine, ketoconazole, and Elvi. These are ol, selenid sulfide, colloidal sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate, sulfur tar fraction, salicylic acid (or in combination with hexachlorophene), undecylenic acid, monoethanolamide sulfosuccinate sodium salt, Lamepon® UD (protein / undecylenic acid condensate), zinc pyrithione, aluminum pyrithione, and magnesium pyrithione / dipyrithione magnesium sulfate.

[0263] (Metal) chelating agents: Combinations with one or more (metal) chelating agents may also be advantageously used in the compositions according to the present invention, and any metal chelating agent suitable or conventional for cosmetic or pharmaceutical applications may be used. Preferred (metal) chelating agents include α-hydroxy fatty acids, phytic acid, lactoferrin, α-hydroxy acids, such as gluconic acid, glyceric acid, glycolic acid, isocitric acid, citric acid, lactic acid, malic acid, mandelic acid, tartaric acid, as well as humic acid, bile acids, bile extracts, bilirubin, biliverdin, or EDTA, EGTA, MGDA (trisodium dicarboxymethylalanine), and their derivatives. The use of one or more chelating agents improves the stability of the compositions according to the present invention.

[0264] Emulsifier: Furthermore, the compositions according to the present invention may, advantageously, include, for example: - Linear C2 of 2 to 30 mol ethylene oxide and / or 0 to 5 mol propylene oxide 8~22 Aliphatic alcohols, C 12~22Addition products to fatty acids and to alkylphenols containing 8 to 15 carbon atoms in the alkyl group; - Addition product of 1 to 30 mol of ethylene oxide to glycerol 12 / 18 Fatty acid monoesters and diesters; - Glycerol mono- and diesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms, as well as sorbitan mono- and diesters, and their ethylene oxide addition products; - Addition products of 15 to 60 mol ethylene oxide to castor oil and / or hydrogenated castor oil; - Polyol esters, and especially polyglycerol esters, such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate, or polyglycerol dimerate isostearate. Mixtures of compounds from some of these classifications are also preferred; - Addition products of 2 to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil; - Linear, branched, unsaturated, or saturated C 6 / 22 Partial esters based on fatty acids, ricinoleic acid and 12-hydroxystearic acid, and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g., sorbitol), alkyl glucosides (e.g., methyl glucoside, butyl glucoside, lauryl glucoside), and polyglucosides (e.g., cellulose); - Mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts; - Wool wax alcohol; - Polysiloxane / polyalkyl polyether copolymers and their corresponding derivatives; - Pentaerythritol, mixed esters of fatty acids, citrate and aliphatic alcohols, and / or C 6~22 Fatty acids, methyl glucose and polyols, preferably mixed esters of glycerol or polyglycerol, - a polyalkylene glycol, and - may also contain one or more emulsifiers including glycerol carbonate.

[0265] Addition products of ethylene oxide and / or propylene oxide to aliphatic alcohols, fatty acids, alkylphenols, glycerol mono- and diesters of fatty acids and sorbitan mono- and diesters, or to castor oil, are known commercially available products. These are homologous mixtures whose average degree of alkoxylation corresponds to the ratio between the amount of ethylene oxide and / or propylene oxide and the substrate to which the addition reaction is carried out. The C of the addition product of ethylene oxide to glycerol 12 / 18 Fatty acid monoesters and diesters are known as lipid layer enhancers for cosmetic formulations. Preferred emulsifiers are described in more detail as follows:

[0266] Partial glycerides: Typical examples of suitable partial glycerides are monoglyceryl hydroxystearate, diglyceryl hydroxystearate, monoglyceryl isostearate, diglyceryl isostearate, monoglyceryl oleate, diglyceryl oleate, monoglyceryl ricinoleate, diglyceryl ricinoleate, monoglyceryl linoleate, diglyceryl linoleate, monoglyceryl linolenate, diglyceryl linolenate, monoglyceryl erucate, diglyceryl erucate, monoglyceryl tartrate, diglyceryl tartrate, monoglyceryl citrate, diglyceryl citrate, monoglyceryl malate, diglyceryl malate, and technical mixtures thereof which may still contain small amounts of triglycerides from the production process. Also suitable are addition products of 1 to 30, preferably 5 to 10 mol of ethylene oxide to partial glycerides which have been mentioned.

[0267] Sorbitan esters: Suitable sorbitan esters include sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sorbitan sesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sesquiricinoleate, sorbitan diricinoleate, and sorbitan triricinoleate. These include sorbitan, sorbitan monohydroxystearate, sorbitan sesquihydroxystearate, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate, and technical mixtures thereof. Addition products of 1 to 30 and preferably 5 to 10 mol of ethylene oxide to sorbitan esters, as mentioned, are also suitable.

[0268] Polyglycerol esters: Typical examples of suitable polyglycerol esters include polyglyceryl-2 dipolyhydroxystearate (Dehymuls® PGPH), polyglycerin-3-diisostearate (Lameform® TGI), polyglyceryl-4 isostearate (Isolan® GI 34), polyglyceryl-3 oleate, diisostearyl polyglyceryl-3 diisostearate (Isolan® PDI), polyglyceryl-3 methyl glucose distearate (Tego Care® 450), polyglyceryl-3 beeswax (Cera Bellina®), polyglyceryl-4 caprate (polyglycerol caprate T2010 / 90), polyglyceryl-3 cetyl ether (Chimexane® NL), and polyglyceryl-3 distearate (Cremophor® GS 32) and polyglyceryl polyricinoleates (Admul® WOL 1403), polyglyceryl dimerate isostearates, and mixtures thereof. Other suitable examples of polyol esters are mono-, di-, and triesters of lauric acid, coco fatty acids, beef tallow fatty acids, palmitic acid, stearic acid, oleic acid, and behenic acid, obtained by reacting trimethylolpropane or pentaerythritol with 1 to 30 mol of ethylene oxide, as well as other polyol esters.

[0269] Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12 to C22 fatty acids, such as palmitic acid, stearic acid, or behenic acid, and C12 to C22 dicarboxylic acids, such as azelaic acid or sebacic acid.

[0270] Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric or amphoteric surfactants. Amphoteric surfactants are surface-active compounds containing at least one quaternary ammonium group, at least one carboxylate, and one sulfonate group in their molecule. Particularly preferred amphoteric surfactants are so-called betaines, for example, N-alkyl-N,N-dimethylammonium glycinates containing 8 to 18 carbon atoms in the alkyl or acyl group, e.g., cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinate, e.g., cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3-carboxymethyl-3-hydroxyethylimidazoline, and cocoacylaminoethylhydroxyethylcarboxymethylglycinate. Fatty acid amide derivatives known by the CTFA name cocamidopropyl betaine are particularly preferred. Amphoteric surfactants are also suitable emulsifiers. Amphoteric surfactants are C 8 / 18 These are surface-active compounds that contain at least one free amino group and at least one -COOH- or -SO3H- group in addition to an alkyl or acyl group, and are capable of forming an intramolecular salt. Examples of preferred amphoteric surfactants include N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N-alkylsarcosine, 2-alkylaminopropionic acid, and alkylaminoacetic acid, which contain approximately 8 to 18 carbon atoms in the alkyl group. Particularly preferred amphoteric surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate, and C 12 / 18 It is acylsarcosine.

[0271] Surfactants: The compositions according to the present invention preferably comprise one or more anionic and / or amphoteric or amphoteric surfactants. Typical examples include: almondamidopropylamine oxide, almondamidopropyl betaine, aminopropyl lauryl glutamine, ammonium C12-15 alkyl sulfate, ammonium C12-16 alkyl sulfate, ammonium capryleth sulfate, ammonium cocomonoglyceride sulfate, ammonium coco-sulfate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, ammonium C12-15 pareth sulfate, ammonium C9-10 peroroalkylsulfonate Perfluoroalkylsulfonate, dinonylammonium sulfosuccinate, ammonium dodecylbenzenesulfonate, ammonium isostearate, ammonium laureth-6 carboxylate, ammonium laureth-8 carboxylate, ammonium laureth sulfate, ammonium laureth-5 sulfate, ammonium laureth-7 sulfate, ammonium laureth-9 sulfate, ammonium laureth-12 sulfate, ammonium lauroyl sarcosinate, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myristyl sulfate, ammonium nonoxynol-4 sulfate, ammonium nonoxynol-30 sulfate, ammonium oleate, ammonium palm kernel sulfate, ammonium stearate, ammonium talate, AMPD-isostearoyl hydrolyzed collagenCollagen, AMPD-Rosin Hydrolyzed Collagen, AMP-Isostearoyl Hydrolyzed Collagen, AMP-Isostearoyl Hydrolyzed Keratin, AMP-Isostearoyl Hydrolyzed Soy Protein, AMP-Isostearoyl Hydrolyzed Wheat Protein, Apricot Amidopropyl Betaine, Arachidic Acid, Hexyldecyl Phosphate Arginine, Avocado Amidopropyl Betaine, Avocado Oil Glycereth-8 Ester, Babassu Acid, Babassu Amidopropyl Amine Oxide, Babassu Amidopropyl Betaine, Beeswax Acid, Behenamidopropyl Betaine, Behenamine Oxide, Beheneth-25, Beheneth-30, Behenic Acid, Behenyl Betaine, Bis-Butyl Dimethicone Polyglyceryl-3 Butoxynol-5 carboxylic acid, Butoxynol-19 carboxylic acid, Butyldimonium hydroxypropyl butyl glucoside chloride, Butyldimonium hydroxypropyl lauryl glucoside chloride, Butyl glucoside, Butyl glucoside caprate, Butyl glucoside hydroxypropyltrimonium chloride, Butyl octanoic acid, C18-36 acid, C20-40 acid, C30-50 acid, C16-22 acid amide MEA, Calcium dodecylbenzenesulfonate, Calcium lauroyl taurate, C9-16 alkane / cycloalkane, C10-14 alkylbenzenesulfonic acid, C12-14 alkyldiaminoethylglycine HCl, C9-15 alkyl phosphate, Candida Bombicola / glucose / rapeseed oil fatty acid methyl ferment, canolamidopropyl betaine, capric acid, caproic acid, caproyl ethyl glucoside, (capryl / capramido)propyl betaine, capryleth-4 carboxylic acid, capryleth-6 carboxylic acid, capryleth-9 carboxylic acid, caprylic acid, capryloyl collagen amino acids, capryloyl glycine, capryloyl hydrolyzed collagen, capryloyl hydrolyzed keratin, capryloyl keratin amino acids, capryloyl silk amino acids, caprylyl / capryl glucoside, caprylyl / capryl wheat bran / straw glycoside, caprylyl glucoside, caprylyl glyceryl ether, caprylylpyrrolidone, carnitine, Ceteareth-20, Ceteareth-23, Ceteareth-24, Ceteareth-25, Ceteareth-27, Ceteareth-28, Ceteareth-29, Ceteareth-30, Ceteareth-33, Ceteareth-34, Ceteareth-40, Ceteareth-50, Ceteareth-55, Ceteareth-60, Ceteareth-80, Ceteareth-100, Ceteareth-25 Carboxylic Acid, Ceteareth-2 Phosphate, Ceteareth-2 Theareth-4 phosphate, Ceteareth-5 phosphate, Ceteareth-10 phosphate, Ceteth-20, Ceteth-23, Ceteth-24, Ceteth-25, Ceteth-30, Ceteth-40, Ceteth-45, Ceteth-150, Ceteth-8 phosphate, Ceteth-10 phosphate, Ceteth-20 phosphate, Cetreth-22, Cetreth-24, Cetreth-25, Cetreth-30, Cetylbetaine, Chrysanthemum Sinense flower extract, C12-14 hydroxyalkyl hydroxyethyl beta-alanine, C12-14 hydroxyalkyl hydroxyethyl sarcosine, cocamidoethyl betaine, cocamidopropylamine oxide, cocamidopropyl betaineamide MEA chloride, cocamidopropyl betaine, cocamidopropyl hydroxysultaine, oxidized cocamine, cocaminobutyric acid, cocaminopropionic acid, coceth-7 carboxylic acid, coceth-4 glucoside, cocoamphodipropionic acid, cocobetaineamide amphopropionate, coco-betaine, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein Protein, coco-glucoside, coco-glucoside hydroxypropyltrimonium chloride, coco-hydroxysultaine, coco-morpholine oxide, coconut fatty acid, coconut oil glycereth-8 ester, coco / oleamidopropyl betaine, coco-sultaine, coco / sunflower amidopropyl betaine, cocoyl choline methosulfate, cocoyl glutamic acid, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, cocoyl hydrolyzed oat protein, cocoyl hydrolyzed rice protein, cocoyl hydrolyzed silk, cocoyl hydrolyzed soy protein, cocoyl hydrolyzed wheat protein, cocoyl sarcosine, corn acid, cottonseed acid, cottonseed oil glycereth-8 ester, C10-16 pareth-1, C10-16 pareth-2,C11-13 Palace-6, C11-13 Palace-9, C11-13 Palace-10, C11-15 Palace-30, C11-15 Palace-40, C12-13 Palace-1, C12-13 Palace-23, C12-14 Palace-5, C12-14 Palace-9, C13-15 Palace-21, C14-15 Palace-8, C20-22 Palace-30, C20-40 Palace-40, C20-40 Palace-95, C22-24 Palace-33, C30-50 Palace-40, C9-11 Palace-6 Cal C12-13 Pareth-5 carboxylic acid, C9-11 Pareth-8 carboxylic acid, C11-15 Pareth-7 carboxylic acid, C12-13 Pareth-8 carboxylic acid, C12-13 Pareth-12 carboxylic acid, C12-15 Pareth-7 carboxylic acid, C12-15 Pareth-8 carboxylic acid, C12-15 Pareth-12 carboxylic acid, C14-15 Pareth-8 carboxylic acid, C6-10 Pareth-4 phosphate, C12-13 Pareth-2 phosphate, C12-13 Pareth- 10-phosphate, C12-15 pareth-6 phosphate, C12-15 pareth-8 phosphate, C12-15 pareth-10 phosphate, C12-16 pareth-6 phosphate, C4-18 perfluoroalkylethylthiohydroxypropyltrimonium chloride, cupuacuamidopropyl betaine, DEA-C12-13 alkyl sulfate, DEA-C12-15 alkyl sulfate, DEA-ceteareth-2 phosphate, DEA-cetyl sulfate, DEA-cocoamphodipropionate DEA-C12-13 Pareth-3 Sulfate, DEA-Cyclocarboxypropyl Oleate, DEA-Dodecylbenzene Sulfonate, DEA-Isostearate, DEA-Laureth Sulfate, DEA-Lauryl Sulfate, DEA-Linoleate, DEA-Methyl Myristate Sulfonate, DEA-Myreth Sulfate, DEA-Myristate, DEA-Myristyl Sulfate, DEA-Oleth-5 Phosphate, DEA-Oleth-20 Phosphate, DEA PG-Oleate, Deceth-7 Carboxylic Acid, Deceth-7 Glucoside, Deceth-9 Phosphate, Decylamine oxide, decylbetaine, decyl glucoside, decyltetradeceth-30, decyltetradecylamine oxide, diammonium lauramide-MEA sulfosuccinate, diammonium lauryl sulfosuccinate, diammonium oleamide PEG-2 sulfosuccinate, dibutoxymethane, di-C12-15 pareth-2 phosphate (Di-CI 2-15 Pareth-2 Phosphate, di-C12-15 pareth-4 phosphate, di-C12-15 pareth-6 phosphate, di-C12-15 pareth-8 phosphate, di-C12-15 pareth-10 phosphate, didodecyl butanetetracarboxylate, diethylamine laureth sulfate, sodium diethylhexyl sulfosuccinate, dihydroxyethyl C8-10 alkoxypropylamine oxide, dihydroxyethyl C9-11 alkoxypropylamine oxide, dihydroxyethyl C12-15 alkoxypropylamine oxide, dihydroxyethyl cocamine oxide, dihydroxyethyl lauramine oxide, dihydroxyethyl stearamine oxide, dihydroxyethyl beef tallowamine oxide, dimethicone PEG-7 phosphate, dimethicone PEG-10 phosphate, dimethicone PEG / PPG-7 / 4 phosphate, dimethicone PEG / PPG-12 / 4 phosphate Acid, Dimethicone / Polyglycerin-3 Crosslinked Polymer, Dimethicone Propyl PG-Betaine, Dimyristyl Phosphate, Dioleilamidoethyl Hydroxyethylmonium Methosulfate, Hydrogenated Coconut Fatty Acid DIPA, Lanolin Fatty Acid DIPA, Myristate DIPA, Dipotassium Capryloyl Glutamate, Dipotassium Lauryl Sulfosuccinate, Dipotassium Undecinoyl Glutamate, Babassuamide MEA-Disodium Sulfosuccinate, Disodium Caproamphodiacetate, Disodium Caproamphodipropionate, Disodium Capryloamphodiacetate, Disodium Capryloamphodipropionate, Disodium Capryloyl Glutamate, Disodium Cetearyl Sulfosuccinate, Disodium Cetyl Phenyl Ether Disulfonate, Disodium Cetyl Sulfosuccinate, Cocamide MEA-Disodium Sulfosuccinate, Cocamide MIPADisodium PEG-4 sulfosuccinate, disodium cocamide MIPA sulfosuccinate, disodium cocamide PEG-3 sulfosuccinate, disodium coceth-3 sulfosuccinate, disodium cocoamphocarboxyethyl hydroxypropyl sulfonate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, disodium coco-glucoside sulfosuccinate, disodium coco-sulfosuccinate, disodium cocoyl butylgluceth-10 sulfosuccinate, disodium cocoyl glutamate, disodium C12-14 pareth-1 sulfosuccinate, disodium C12-14 pareth-2 sulfosuccinate, disodium C12-15 pareth sulfosuccinate, disodium C12-14 Sec-pareth-3 sulfosuccinate, disodium C12-14 Sec-pareth-5 sulfosuccinate, C12-14 Sec-Pareth-7 disodium sulfosuccinate, C12-14 Sec-Pareth-9 disodium sulfosuccinate, C12-14 Sec-Pareth-12 disodium sulfosuccinate, Disodium Deceth-5 Sulfosuccinate, Disodium Deceth-6 Sulfosuccinate, Disodium Decylphenyl Ether Disulfonate, Disodium Dihydroxethyl Sulfosuccinyl Undecylenate, Disodium Ethylene Dicocamide PEG-15 Disulfate, Disodium Hydrogenated Cottonseed Glyceride Sulfosuccinate, Disodium Hydrogenated Beef Tallow Glutamate, Disodium Hydroxydecyl Sorbitol Citrate, Disodium Isodecyl Sulfosuccinate, Disodium Isostearamide MEA-Sulfosuccinate, Disodium Isostearamide MIPA-Sulfosuccinate Disodium succinate, disodium isostearoamphodiacetate, disodium isostearoamphodipropionate, disodium isostearyl sulfosuccinate, disodium laureth-5 sulfosuccinate, disodium lauramide MEA sulfosuccinate, disodium lauramide MIPA glycol sulfosuccinate, disodium lauramide PEG-2 sulfosuccinate, disodium lauramide PEG-5 sulfosuccinate, disodium laureth-5 carboxyamphodiacetate, disodium laureth-7 citrate, disodium laureth sulfosuccinate Sodium, disodium laureth-6 sulfosuccinate, disodium laureth-9 sulfosuccinate, disodium laureth-12 sulfosuccinate, disodium lauriminobishydroxypropylsulfonate, disodium lauriminodiacetate, disodium lauriminodipropionate, disodium lauriminodipropionate tocopheryl phosphate, disodium lauroamphodiacetate, disodium lauroamphodipropionate, disodium N-lauroyl aspartate, disodium lauroyl glutamate, laurylphenyl ether Disodium sulfonate, disodium lauryl sulfosuccinate, myristamide MEA-disodium sulfosuccinate, nonoxynol-10 disodium sulfosuccinate, oleamide MEA-disodium sulfosuccinate, oleamide MIPA-disodium sulfosuccinate, oleamide PEG-2 disodium sulfosuccinate, disodium oleoamphodipropionate, oleth-3 disodium sulfosuccinate, disodium oleyl phosphate, disodium oleyl sulfosuccinate, palmitamide PEG-2 disodium sulfosuccinate,Palmitoreamide PEG-2 disodium sulfosuccinate, PEG-4 cocamide MIPA disodium sulfosuccinate, PEG-12 dimethicone disodium sulfosuccinate, PEG-8 palm glyceride disodium sulfosuccinate, PPG-2-isodeceth-7 disodium carboxyamphodiacetate, ricinoleamide MEA disodium sulfosuccinate, citostereth-14 disodium sulfosuccinate, soybean disodium amphodiacetate, stearamide MEA disodium sulfosuccinate, steariminodipropionate disodium, stearoamphodiacetate disodium, stearoyl glutamate Disodium sodium sodium stearyl sulfosuccinate, disodium stearyl sulfosuccinate, disodium 2-sulfolauryl acid, disodium 2-sulfopalmitate, disodium beef tallow amide MEA-sulfosuccinate, disodium beef tallow amide MEA-sulfosuccinate, disodium beef tallow amphodiacetate, disodium beef tallow iminodipropionate, disodium beef tallow sulfosuccinate, disodium tridecyl sulfosuccinate, disodium undecylenamide MEA-sulfosuccinate, disodium undecylenamide PEG-2 sulfosuccinate, disodium undecylenoyl glutamate, Wheat germ amide MEA-sulfosuccinate disodium, wheat germ amide PEG-2 sulfosuccinate disodium, wheat germ amphodiacetate disodium, di-TEA-cocamide diacetate, di-TEA-oleamide PEG-2 sulfosuccinate, di-TEA-palmitoyl asparate, ditridecyl sodium sulfosuccinate, dodecylbenzenesulfonic acid, ercamidopropyl hydroxysultaine, ethylhexeth-3 carboxylic acid, ethyl PEG-15 cocamine sulfate, glyceryl capryl ether, hexyldecanoic acid, hydrogenated coconut fatty acid, hydrogenated lanes-25, hydrogenated menhedic acid, hydrogenated palm oil fatty acid, hydrogenated palm kernel amine oxide, hydrogenated beef tallow acid, hydrogenated beef tallow amine oxide, hydrogenated beef tallow betaine, hydrogenated tarowes-25, hydrogenated taro oil glutamic acid, hydrolyzed Candida Bombicola extract, hydroxyceteth-60, hydroxyethylacetomonium PG-dimethicone, hydroxyethylbutylamine laureth sulfate, hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl hydroxypropyl C12-15 alkoxypropylamine oxide, hydroxylauryl / hydroxymyristyl betaine, hydroxystearic acid, hydroxysuccinimidyl C10-40 isoalkyl acidate, hydroxysuccinimidyl C21-22 isoalkyl acidate, hydroxysultaine, IPDI / PEG-15 soy amine oxide copolymer, IPDI / PEG-15 soyethonium ethosulfate copolymer, IP DI / PEG-15 soybean glycinate copolymer, isoceteth-30, isolaureth-4 phosphate, isopolyglyceryl-3 dimethicone, isopolyglyceryl-3 dimethiconol, isopropanolamine lanolate, isopropylamine dodecylbenzenesulfonate, isostearamidopropylamine oxide, isostearamidopropyl betaine, isostearamidopropyl morpholine oxide, isosteareth-8, isosteareth-16, isosteareth-22, isosteareth-25, isosteareth-50, isostearic acid, isostearoyl hydrolyzed collagen, jojoba oil PEG-150 ester, jojoba wax PEG-80 ester, jojoba wax PEG-120 ester,Laneth-20, Laneth-25, Laneth-40, Laneth-50, Laneth-60, Laneth-75, Lanolinic Acid, Lauramidopropylamine Oxide, Lauramidopropyl Betaine, Lauramidopropyl Hydroxysultaine, Lauramine Oxide, Lauraminopropionic Acid, Laurdimonium Hydroxypropyl Decyl Glucoside Chloride, Laurdimonium Hydroxypropyl Lauryl Glucoside Chloride, Laureth-16, Laureth-20, Laureth-21, Laureth-23, Laureth-25, Laureth-30, Laureth-38, Laureth-4 0, Laureth-3 carboxylic acid, Laureth-4 carboxylic acid, Laureth-5 carboxylic acid, Laureth-6 carboxylic acid, Laureth-8 carboxylic acid, Laureth-10 carboxylic acid, Laureth-11 carboxylic acid, Laureth-12 carboxylic acid, Laureth-13 carboxylic acid, Laureth-14 carboxylic acid, Laureth-17 carboxylic acid, Laureth-6 citric acid, Laureth-7 citric acid, Laureth-1 phosphate, Laureth-2 phosphate, Laureth-3 phosphate, Laureth-4 phosphate, Laureth-7 phosphate, Laureth-8 phosphate, Laureth-7 tartaric acid, Laury acid, Lauriminobispropanediol, Lauriminodipropionic acid, Lauroamphodipropionic acid, lauroyl beta-alanine, lauroyl collagen amino acids, lauroyl ethyltrimonium methosulfate, lauroyl hydrolyzed collagen, lauroyl hydrolyzed elastin, lauroyl methylglucamide, lauroyl sarcosine, lauroyl silk amino acids, lauryl betaine, lauryl dimethicone / polyglycerin-3 crosslinked polymer, lauryldimonium hydroxypropyl coco-glucoside chloride, lauryl glucoside, lauryl glucoside hydroxypropyltrimonium chloride, lauryl glycol hydroxypropyl ether, lauryl hydroxysultaine, lauryl maramide, lauryl methylglucamide, lauryl / myristyl glycol hydroxypropyl ether, lauryl / myristyl wheat bran / straw glycoside, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone Laurylpyrrolidone, lauryl sultaine, linoleic acid, linolenic acid, flaxseed fatty acid, coconut fatty acid lysine, macadamia seed oil glycereth-8 ester, coceth sulfate magnesium, coco-sulfate magnesium, isododecylbenzenesulfonate magnesium, laureth-11 carboxylate magnesium, laureth sulfate magnesium, laureth-5 sulfate magnesium, laureth-8 sulfate magnesium, laureth-16 sulfate magnesium, laureth-3 sulfosuccinate magnesium, lauryl hydroxypropyl sulfonate magnesium, lauryl sulfate magnesium, cocoyl methyl taurate magnesium, mireth sulfate magnesium, oleth sulfate magnesium, coco-alkyl sulfate (Mg / TEA), manicuric acid clay, MEA-cocoate, MEA-laureth-6 carboxylate, MEA-laureth sulfate, MEA-lauryl sulfate, MEAPPG-6 Laureth-7 Carboxylate, MEA-PPG-8 Steareth-7 Carboxylate, MEA-Undecylenate, Meloxapole 108, Meloxapole 174, Meloxapole 178, Meloxapole 254, Meloxapole 255, Meloxapole 258, Meloxapole 314, MethoxyPEG-450 Amidoglutaloyl Succinimide, MethoxyPEG-450 Amidohydroxysuccinimidyl Succinate, MethoxyPEG-450 Maleimide, Methylmorpholine Oxide, Milk Amidopropylamine Oxide, Milk Amidopropyl Betaine, Mink Amidopropylamine Oxide, Mink Amidopropyl Betaine, MIPAC12-15 pareth sulfate, MIPA-dodecylbenzenesulfonate, MIPA-laureth sulfate, MIPA-lauryl sulfate, mixed isopropanolamine lanolate, mixed isopropanolamine lauryl sulfate, mixed isopropanolamine myristate, morpholine oleate, morpholine stearate, myreth-3 carboxylic acid, myreth-5 carboxylic acid, myristalkonium chloride, myristamidopropylamine oxide, myristamidopropyl betaine, myristamidopropyl dimethylamine phosphate, myristamidopropyl hydroxysultaine, myristamidopropyl PG-dimonium chloride phosphate, myristamine oxide, myristaminopropionic acid, myristic acid, myristoylethyltrimonium methosulfate, myris Toyl glutamic acid, myristoyl hydrolyzed collagen, myristoyl sarcosine, myristyl betaine, myristyl / cetylamine oxide, myristyldimonium hydroxypropyl coco-glucoside chloride, myristyl glucoside, myristyl phosphate, nonoxynol-20, nonoxynol-23, nonoxynol-25, nonoxynol-30, nonoxynol-35, nonoxynol-40, nonoxynol-44, nonoxynol-50, nonoxynol-100, nonoxynol-120, nonoxynol-5 carboxylic acid, nonoxynol-8 carboxylic acid, nonoxynol-10 carboxylic acid, nonoxynol-3 phosphate, nonoxynol-4 phosphate, nonoxynol-6 phosphate, nonoxynol-9 phosphate, nonoxynol-10 phosphate, Nonylnonoxynol-30, Nonylnonoxynol-49, Nonylnonoxynol-100, Nonylnonoxynol-150, Nonylnonoxynol-7 phosphate, Nonylnonoxynol-8 phosphate, Nonylnonoxynol-9 phosphate, Nonylnonoxynol-10 phosphate, Nonylnonoxynol-11 phosphate, Nonylnonoxynol-15 phosphate, Nonylnonoxynol-24 phosphate, Oatmeal Amidopropyl Betaine, Octoxynol-16, Octoxynol-25, Octoxynol-30, O Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-20 carboxylic acid, Octyldodeceth-20, Octyldodeceth-25, Octyldodeceth-30, Oleamidopropylamine oxide, Oleamidopropyl betaine, Oleamidopropyl hydroxysultaine, Oleamine oxide, Oleic acid, Oleoyl hydrolyzed collagen, Oleoyl sarcosine, Oleth-20, Oleth-23, Oleth-24, Oleth-25, Oleth-30, Oleth-35, Oleth-40, Oleth-44, Oleth-50, Oleth-3 Carboxylic acid, oleth-6 carboxylic acid, oleth-10 carboxylic acid, oleyl betaine, olibamidopropylamine oxide, olibamidopropyl betaine, olive oil fatty acid, hydrolyzed wheat protein, Ophiopogon extract stearate, ozonated oleth-10, ozonated oleate PEG-10, ozonated oleate PEG-14, ozonated polysorbate 80, palm oil fatty acid, palmamidopropyl betaine, palmes-2 phosphate, palmitamidopropylamine oxide, palmitamidopropyl betaine, palmitamine Hoxide, palmitic acid, palmitoyl collagen amino acids, palmitoyl glycine, palmitoyl hydrolyzed collagen, palmitoyl hydrolyzed milk protein, palmitoyl hydrolyzed wheat protein, palmitoyl keratin amino acids, palmitoyl oligopeptide, palmitoyl silk amino acids, palm kernel fatty acids, palm kernel amidopropyl betaine, peach kernel oil glycereth-8 ester, peanut oil fatty acids, PEG-10 castor oil, PEG-40 castor oil, PEG-44 castor oil, PEG-50 castor oil, PEG-54 castor oil, PEG-55 castor oil,PEG-60 castor oil, PEG-80 castor oil, PEG-100 castor oil, PEG-200 castor oil, PEG-11 cocamide, PEG-6 cocamide phosphate, PEG-4 cocamine, PEG-8 cocamine, PEG-12 cocamine, PEG-150 dibehenate, PEG-90 diisostearate, PEG-75 dilaurate, PEG-150 dilaurate, PEG-75 dioleate, PEG-150 dioleate, PEG-75 distearate, PEG-120 distearate, PEG-150 distearate, PEG-175 Distearate, PEG-190 distearate, PEG-250 distearate, PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-30 glyceryl isostearate, PEG-40 glyceryl isostearate, PEG-50 glyceryl isostearate, PEG-60 glyceryl isostearate, PEG-90 glyceryl isostearate, PEG-23 glyceryl laurate, PEG-30 glyceryl laurate, PEG-25 Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl Soyate, PEG-25 Glyceryl Stearate, PEG-30 Glyceryl Stearate, PEG-40 Glyceryl Stearate, PEG-120 Glyceryl Stearate, PEG-200 Glyceryl Stearate, PEG-28 Beef Tallow Fatty Acid Glyceryl, PEG-80 Beef Tallow Fatty Acid Glyceryl, PEG-82 Beef Tallow Fatty Acid Glyceryl, PEG-130 Beef Tallow Fatty Acid Glyceryl, PEG-200 Beef Tallow Fatty Acid Glyceryl, PEG-45 Hydrogenated Castor Oil, PEG- PEG-50 Hydrogenated Castor Oil, PEG-54 Hydrogenated Castor Oil, PEG-55 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, PEG-80 Hydrogenated Castor Oil, PEG-100 Hydrogenated Castor Oil, PEG-200 Hydrogenated Castor Oil, PEG-30 Hydrogenated Lanolin, PEG-70 Hydrogenated Lanolin, PEG-50 Hydrogenated Palmamide, PEG-2 Isostearate, PEG-3 Isostearate, PEG-4 Isostearate, PEG-6 Isostearate, PEG-8 Isostearate, PEG-10 Isostearate, PEG-12 Isostearate, PEG-20 Isostearate, Iso PEG-30 Thearate, PEG-40 Isostearate, PEG-26 Jojoba Fatty Acid, PEG-40 Jojoba Fatty Acid, PEG-15 Jojoba Alcohol, PEG-26 Jojoba Alcohol, PEG-40 Jojoba Alcohol, PEG-35 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-55 Lanolin, PEG-60 Lanolin, PEG-70 Lanolin, PEG-75 Lanolin, PEG-85 Lanolin, PEG-100 Lanolin, PEG-150 Lanolin, PEG-75 Lanolin Oil, PEG-2 Lauramide, PEG-3 Lauramine Oxide, PEG-20 Laurate, PEG-32 Laurate, PEG-75 Laurate, PEG-150 Laurate, PEG-70 Mango Glyceride, PEG-20 Mannitane Laurate, PEG-8 Methyl Ether Dimethicone, PEG-120 Methyl Glucose Dioleate, PEG-80 Methyl Glucose Laurate, PEG-120 Methyl Glucose Trioleate, PEG-4 Montanoate, PEG-30 Oleamine, PEG-20 Oleate, PEG-23 Oleate, PEG-32 Oleate, PEG-36 Oleate, PEG-75 Oleate,PEG-150 Oleate, PEG-20 Palmitate, PEG-150 Polyglyceryl-2 Tristearate, PEG / PPG-28 / 21 Dimethicone Acetate, PEG / PPG-24 / 18 Butyl Ether Dimethicone, PEG / PPG-3 / 17 Copolymer, PEG / PPG-5 / 35 Copolymer, PEG / PPG-8 / 55 Copolymer, PEG / PPG-10 / 30 Copolymer, PEG / PPG-10 / 65 Copolymer, PEG / PPG-12 / 35 Copolymer, PEG / PPG-16 / 17 Copolymer, PEG / PPG-20 / 9 Copolymer, PEG / PPG-20 / 20 Copolymer, PEG / PPG-20 / 60 Copolymer, PEG / PPG-20 / 65 Copolymer, P EG / PPG-22 / 25 copolymer, PEG / PPG-28 / 30 copolymer, PEG / PPG-30-35 copolymer, PEG / PPG-30 / 55 copolymer, PEG / PPG-35 / 40 copolymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copolymer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copolymer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copolymer, PEG / PPG-20 / 22 methyl ether dimethicone, PEG-26-PPG-30 phosphate, PEG / PPG-4 / 2 propylheptyl ether, PEG / PPG-6 / 2 propylheptyl ether, PEG-7 / PPG-2 propylheptyl ether, PEG / PPG-8 / 2 propylheptyl ether, PEG / PPG-10 / 2 propylheptyl ether, PEG / PPG-14 / 2 propylheptyl ether, PEG / PPG-40 / 2 propylheptyl ether, PEG / PPG-10 / 2 ricinoleate, PEG / PPG-32 / 3 ricinoleate, PEG-55 propylene glycol oleate, PEG-25 propylene glycol stearate, PEG-75 propylene glycol stearate, PEG-120 propylene glycol sorbitan laurate, PEG-5 rapeseed sterol, PEG-10 rapeseed sterol, PEG-40 ricinolamide, PEG-75 shea butter glyceride, PEG-75 Shorea butter glyceride, PEG-20 sorbitan cocoate, PEG-20 sorbitan isostearate, PEG-40 sorbitan lanolinate, PEG-75 sorbitan lanolinate, PEG-10 sorbitan laurate, PEG-40 sorbitan laurate, PEG-44 sorbitan laurate, PEG-75 sorbitan laurate, PEG-80 sorbitan laurate, PEG-20 sorbitan oleate, PEG-80 sorbitan palmitate, PEG-40 sorbitan stearate, PEG-60 sorbitan stearate, PEG-160 sorbitan triisostearate, PEG-40 soybean sterols, PEG-2 stearamide carboxylic acid, PEG-9 stearamide carboxylic acid, PEG-20 stearate, PEG-23 stearate, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate, PEG-35 stearate, PEG-36 stearate, PEG-40 stearate, PEG-45 stearate, PEG-50 stearate, PEG-55 stearate, PEG-75 stearate, PEG-90 stearate, PEG-100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 stearate phosphate, PEG-20 talate, PEG-50 beef tallow amide, PEG-2 beef tallow amide DEA, PEG-20 talauate, PEG-66 trihydroxystearin, PEG-200 trihydroxystearin, PEG-60 glyceride of camellia oil fatty acid, pelargonic acid,Pentadoxynol-200, Fenes-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer 217, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 288, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamine 908, Poloxamine 1508, Polydimethylsiloxane PEG / PPG-24 / 19 Butyl Ether Silsesquioxane, Polydimethylsiloxane PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-6 Caprate, Polyglyceryl-10 Dilaurate, Heptacap Polyglyceryl-20 lylate, polyglyceryl-20 hexacaprylate, polyglyceryl-2 lauryl ether, polyglyceryl-10 lauryl ether, polyglyceryl-20 octaisononanoate, polyglyceryl-6 pentacaprylate, polyglyceryl-10 pentacaprylate, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-6 tetracaprylate, polyglyceryl-10 tetralaurate, polyglyceryl-6 tricaprylate, polyglyceryl-10 trilaurate, polyquaternium-77, polyquaternium-78, polyquaternium-79, polyquaternium-80, polyquaternium-81, polyquaternium-82, Pomaderris Kumerahou flower / leaf extract, Poria Cocos extract, potassium abietoyl hydrolyzed collagen, potassium babasate, Potassium behenate, potassium C9-15 alkyl phosphate, potassium C11-15 alkyl phosphate, potassium C12-13 alkyl phosphate, potassium C12-14 alkyl phosphate, potassium caprylate, potassium capryloyl glutamate, potassium capryloyl hydrolyzed rice protein, potassium castor oil fatty acid, potassium coconut fatty acid, potassium cocoyl glutamate, potassium cocoyl glycine, potassium cocoyl hydrolyzed casein, potassium cocoyl hydrolyzed collagen, potassium cocoyl hydrolyzed corn protein, potassium cocoyl hydrolyzed keratin, potassium cocoyl hydrolyzed oat protein, potassium cocoyl hydrolyzed potato protein, potassium cocoyl hydrolyzed rice bran protein, potassium cocoyl hydrolyzed rice protein, potassium cocoyl hydrolyzed silk, potassium cocoyl hydrolyzed soy protein, potassium cocoyl hydrolyzed wheat protein, potassium cocoyl hydrolyzed yeast protein, potassium cocoyl PCA, potassium cocoyl sarcosinate, potassium cocoyl taurate, potassium cornate, potassium cyclocarboxypropyl Oleate, potassium dihydroxyethyl cocamine oxide phosphate, potassium dimethicone PEG-7 phosphate, potassium dodecylbenzenesulfonate, potassium hemp seed ate, potassium hydrogenated coconut fatty acid, partially hydrogenated palm oil fatty acid, partially hydrogenated beef tallow fatty acid, potassium hydroxystearate, potassium isostearate, potassium lanolin fatty acid, potassium laurate, potassium laureth-3 carboxylate, potassium laureth-4 carboxylate, potassium laureth-5 carboxylate, potassium laureth-6 carboxylate, potassium laureth-10 carboxylate, potassium laureth phosphate, potassium lauroyl collagen amino acids, potassium lauroyl glutamate, potassium lauroyl hydrolyzed collagen, potassium lauroyl hydrolyzed pea protein, potassium lauroyl hydrolyzed soy protein, potassium lauroyl PCA, potassium lauroyl pea amino acids, potassium lauroyl sarcosinate, potassium lauroyl silk amino acids, potassium lauroyl wheat amino acids, potassium lauryl phosphate, potassium lauryl sulfate, potassium linoleate, potassium metaphosphate,Potassium cocoyl methyl taurate, potassium myristate, potassium myristoyl glutamate, potassium myristoyl hydrolyzed collagen, potassium octoxynol-12 phosphate, potassium oleate, potassium oleoyl hydrolyzed collagen, potassium olive oil fatty acid, potassium olive oil fatty acid hydrolyzed oat protein, potassium olive oil fatty acid hydrolyzed wheat protein, (olive oil fatty acid / lauroyl) wheat amino acid potassium, potassium olive oil fatty acid PCA, potassium palm fatty acid, potassium palmitate, potassium palmitoyl hydrolyzed corn protein, potassium palmitoyl hydrolyzed oat protein, potassium palmitoyl hydrolyzed rice protein, potassium palmitoyl hydrolyzed sweet almond protein, potassium palmitoyl hydrolyzed wheat protein, potassium palm kernel fatty acid, potassium peanut oil fatty acid, potassium rapeseed oil fatty acid, lysi Potassium nolate, potassium safflower oil fatty acid, potassium soybean oil fatty acid, potassium stearate, potassium stearoyl hydrolyzed collagen potassium, potassium tolate, potassium beef tallow fatty acid, potassium taurate, potassium taurine laurate, potassium trideceth-3 carboxylate, potassium trideceth-3 carboxylate, potassium trideceth-4 carboxylate, potassium trideceth-7 carboxylate, potassium trideceth-15 carboxylate, potassium trideceth-19 carboxylate, potassium trideceth-6 phosphate, potassium trideceth-7 phosphate, potassium camellia fatty acid, potassium undecylenate, potassium undecylenol hydrolyzed collagen, potassium undecylenol hydrolyzed rice protein, PPG-30-buteth-30, PPG-36-buteth-36, PPG-38-buteth-37, PPG-30-capryleth-4 phosphate, PPG-10 cetyl ether phosphate, PPG-2 C9-11 Pareth-8, PPG-1-Deceth-5, PPG-3-Deceth-2 Carboxylic Acid, PPG-30 Ethylhexeth-4 Phosphate, PPG-20-Glycereth-30, PPG-2 Hydroxyethyl Coco / Isostealamide, PPG-2-Isodeceth-8, PPG-2-Isodeceth-10, PPG-2-Isodeceth-18, PPG-2-Isodeceth-25, PPG-4-Isodeceth-10,Propyltrimonium hydrolyzed collagen, quaternium-24, quaternium-52, quaternium-87, rapeseed oil fatty acid, rice bran oil fatty acid, rice oil glycereth-8 ester, ricinoleamidopropyl betaine, ricinoleic acid, ricinoleth-40, safflower oil fatty acid, Sapindus Oahuensis fruit extract, Saponaria Officinalis root powder, saponin, potassium soap, potassium-containing soap base, soap base, potassium soap base, sesame oil glycereth-8 ester, sesamidopropylamine oxide, sesamidopropyl betaine, shea butter amidopropyl betaine, shea butter glycereth-8 ester, sodium arachidonic acid, sodium argan amphoacetate, sodium astrocaryum murumuru fatty acid, sodium avocado oil fatty acid, sodium babassu amphoacetate, sodium babassu oil fatty acid, sodium babassu sulfate, sodium behenate, sodium bisglycol ricinosulfosuccinate, sodium bis-hydroxyethylglycinate coco-glucoside crosslinked polymer, sodium bis-hydroxyethylglycinate trauryl-glucoside crosslinked polymer, boradiamidopropyl PG dimonium chloride phosphate sodium, butoxynol-12 sulfate sodium, butyl glucoside hydroxypropyl phosphate sodium, (C13-17) Sodium canesulfonate, (C14-18) sodium alkanesulfonate, sodium C12-15 alkoxypropyl iminodipropionate, C10-16 sodium alkyl sulfate, C11-15 sodium alkyl sulfate, C12-13 sodium alkyl sulfate, C12-15 sodium alkyl sulfate, C12-18 sodium alkyl sulfate, C16-20 sodium alkyl sulfate, C9-22 sodium alkylsec sulfonate, C14-17 sodium alkylsec sulfonate, sodium caprate, sodium caproamphoacetate, sodium caproamphohydroxypropyl sulfonate, sodium caproamphopropionate, sodium caproylmethyltaurate, sodium caprylate, sodium capryleth-2 carboxylate, sodium capryleth-9 carboxylate, sodium capryloamphoacetate, sodium capryloamphohydroxypropyl sulfonate, sodium capryloamphopropionate,Sodium capryloyl glutamate, sodium capryloyl hydrolyzed wheat protein, sodium caprylyl PG-sulfonate, sodium caprylyl sulfonate, sodium castor fatty acid, sodium ceteareth-13 carboxylate, sodium cetearyl sulfate, sodium ceteth-13 carboxylate, sodium cetyl sulfate, sodium cocamidopropyl PG-dimonium chloride phosphate, sodium cocaminopropionate, sodium coceth sulfate, sodium coceth-30 sulfate, sodium cocoa butter amphoacetate, sodium cocoa butter fatty acid, sodium cocoamphoacetate, sodium cocoamphohydroxypropyl sulfonate, sodium cocoamphopropionate, sodium coconut fatty acid, sodium cocoa / babassu / angina Babassu sulfate, sodium coco / babassu sulfate, sodium coco-glucoside hydroxypropyl phosphate, sodium coco-glucoside hydroxypropyl sulfonate, sodium coco-glucoside tartrate, sodium coco-glyceryl ether sulfonate, sodium coco / hydrogenated beef tallow sulfate, sodium cocoimino diacetate, coco-glyceryl sulfate, sodium coco-monoglyceride sulfate, sodium coco-monoglyceride sulfonate, sodium coco-PG-dimonium chloride phosphate, sodium coco-sulfate, sodium coco-sulfate, sodium coco-sulfoacetate, sodium cocoyl alaninate, sodium cocoyl amino acid, sodium cocoyl collagen amino acid, sodium cocoyl glutamate, sodium cocoyl glutamine, Sodium cocoyl glycinate, (coconut fatty acid / hydrogenated beef tallow fatty acid) sodium glutamate, sodium cocoyl hydrolyzed collagen, sodium cocoyl hydrolyzed keratin, sodium cocoyl hydrolyzed rice protein, sodium cocoyl hydrolyzed silk, sodium cocoyl hydrolyzed soy protein, sodium cocoyl hydrolyzed sweet almond protein, sodium cocoyl hydrolyzed wheat protein, sodium cocoyl hydrolyzed wheat protein glutamate, sodium cocoyl isethionate, sodium cocoyl methylaminopropionate, sodium cocoyl oat amino acid, (coconut fatty acid / palm fatty acid / sunflower fatty acid) sodium glutamate, sodium cocoyl proline, sodium cocoyl sarcosinate, sodium cocoyl taurate, sodium cocoyl threonine, Thorium cocoyl wheat amino acids, sodium olefin (C12-14) sulfonate, sodium olefin (C14-16) sulfonate, sodium olefin (C14-18) sulfonate, sodium olefin (C16-18) sulfonate, sodium corn amphopropionate, sodium cottonseed amphoacetate, sodium C13-15 pareth-8 butyl phosphate, sodium C9-11 pareth-6 carboxylate, sodium C11-15 pareth-7 carboxylate, sodium C12-13 pareth-5 carboxylate, sodium C12-13 pareth-8 carboxylate, sodium C12-13 pareth-12 carboxylate, sodium C12-15 pareth-6 carboxylate, sodium C12-15 pareth-7 carboxylate, sodium C12-15 pareth-8 carboxylate, sodium C14-15 pareth-8 carboxylate, C12-14 Sodium Sec-Pareth-8 Carboxylate, Sodium C14-15 Pareth-PG Sulfonate, Sodium C12-13 Pareth-2 Phosphate, Sodium C13-15 Pareth-8 Phosphate, Sodium C9-15 Pareth-3 Sulfate, Sodium C10-15 Pareth Sulfate, Sodium C10-16 Pareth-2 Sulfate, Sodium C12-13 Pareth Sulfate, Sodium C12-15 Pareth Sulfate, Sodium C12-15 Pareth-3 Sulfate, Sodium C13-15 Pareth-3 Sulfate, Sodium C12-14Sec-Pareth-3 Sodium Sulfate, C12-15 Pareth-3 Sodium Sulfonate, C12-15 Pareth-7 Sodium Sulfonate, C12-15 Pareth-15 Sodium Sulfonate, Deceth-2 Carboxylate Sodium, Deceth Sulfate Sodium, Decylbenzenesulfonate Sodium, Decyl Glucoside Hydroxypropyl Phosphate Sodium, Decyl Glucoside Hydroxypropyl Sulfonate Sodium, Dilaureth-7 Citrate Sodium, Dilaureth-10 Phosphate Sodium, Sodium Dilinoleamidopropyl PG-Dimonium Chloride Phosphate, Sodium Dilinoleate, Dioleth-8 Sodium Phosphate, Dodecylbenzenesulfonate Sodium, Ethyl 2-Sulfolauryl Sodium, Sodium Glyceryl Oleate Phosphate, Sodium Grape Seed Amphoacetate PG-Dimonium Chloride Phosphate, Grape Seed Amphoacetate Sodium, Grape Seed Oil Fatty Acid Sodium, Hemp Seed Amphoacetate Sodium, Sodium Hexeth- 4 Carboxylate, Sodium Hydrogenated Cocoate, Sodium Hydrogenated Cocoyl Methyl Isethionate, Sodium Partially Hydrogenated Palm Oil Fatty Acid, Sodium Partially Hydrogenated Beef Tallow Fatty Acid, Sodium Hydroxylauryldimonium Ethyl Phosphate, Sodium Hydroxypropyl Carnelate Sulfonate, Sodium Hydroxypropyl Phosphate Decyl Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Phosphate Lauryl Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Sulfonate Coco Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Sulfonate Decyl Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Sulfonate Lauryl Glucoside Crosslinked Polymer, Sodium Hydroxystearate, Sodium Isostearate, Sodium Isosteareth-6 Carboxylate, Sodium Isosteareth-11 Carboxylate, Sodium Isostearoamphoacetate, Sodium Isostearoamphopropionate, Sodium N-isostearylmethyl taurate, sodium lanol sulfate, sodium lanolin fatty acid, sodium lardate (Sodium Sodium lauramide diacetate, sodium lauraminopropionate, sodium lauryl sulfate, sodium laureth-3 carboxylate, sodium laureth-4 carboxylate, sodium laureth-5 carboxylate, sodium laureth-6 carboxylate, sodium laureth-8 carboxylate, sodium laureth-11 carboxylate, sodium laureth-12 carboxylate, sodium laureth-13 carboxylate, sodium laureth-14 carboxylate, sodium laureth-16 carboxylate, sodium laureth-17 carboxylate, sodium laureth sulfate, sodium laureth-5 sulfate, sodium laureth-7 sulfate, sodium laureth-8 sulfate, sodium laureth-12 sulfate, sodium laureth-40 sulfate, sodium laureth-7 tartrate, sodium lauriminodipropionate, sodium lauroamphoacetate, sodium lauroamphohydroxypropylsulfonate, sodium lauroampho-PG-acetate phosphate, sodium lauroamphopropionate, sodium lauroyl aspartate, lauroyl Sodium lauroyl glycine propionate, sodium lauroyl hydrolyzed collagen, sodium lauroyl hydrolyzed silk, sodium lauroyl hydroxypropyl sulfonate, sodium lauroyl isethionate, sodium lauroyl methylaminopropionate, sodium lauroyl methyl isethionate, sodium lauroyl millet amino acids, sodium lauroyl / myristoyl asparaginate, sodium lauroyl oat amino acids, sodium lauroyl sarcosinate, sodium lauroyl silk amino acids, sodium lauroyl taurate, sodium lauroyl wheat amino acids, sodium lauryl diethylenediaminoglycinate, sodium lauryl glucose carboxylate, sodium lauryl glucoside hydroxypropyl phosphate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauryl glycol carboxylate, sodium lauryl hydroxyacetate sulfate, sodium lauryl phosphate, sodium lauryl sulfate,Sodium lauryl sulfoacetate, sodium linoleate, sodium macadamia seed oil fatty acid, sodium mango amphoacetate, sodium mango seed oil fatty acid, sodium / MEA laureth-2 sulfosuccinate, sodium methoxyPPG-2 acetate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, sodium oleoyl methyl taurate, sodium palmitoyl methyl taurate, sodium stearoyl methyl taurate, sodium methyl-2-sulfolaurylate, sodium methyl-2-sulfopalmitate, sodium methyl taurate isopalmitamide, sodium methyl taurate cocoyl methyl taurate, sodium myris sulfate, sodium myristate, sodium myristoamphoacetate, sodium myristoyl glutamate, sodium myristoyl hydrolyzed collagen, sodium myristoyl isethionate, sodium myristoyl sarcosinate, myris Sodium tyl sulfate, sodium nonoxynol-6 phosphate, sodium nonoxynol-9 phosphate, sodium nonoxynol-1 sulfate, sodium nonoxynol-3 sulfate, sodium nonoxynol-4 sulfate, sodium nonoxynol-6 sulfate, sodium nonoxynol-8 sulfate, sodium nonoxynol-10 sulfate, sodium nonoxynol-25 sulfate, sodium octoxynol-2 ethanesulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, sodium octoxynol-9 sulfate, sodium oleate, sodium oleoamphoacetate, sodium oleohydroxypropyl sulfonate, sodium oleoamphopropionate, sodium oleyl hydrolyzed collagen, sodium oleoyl isethionate, sodium oleyl sulfate, sodium oleyl methyl isethionate, sodium oleyl sulfate, sodium olive amphoacetate, sodium olive fatty acid, sodium olive oil fatty acid glutamate, Sodium palm amphoacetate, sodium palm fatty acid, sodium palm glyceryl sulfonate, sodium palmitate, sodium palmitoyl hydrolyzed collagen, sodium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosinate, sodium palm kernel fatty acid, sodium palm carnelyl isethionate, sodium palm fatty acid glutamate, sodium Passiflora Edulis seed oil fatty acid, sodium peanut amphoacetate, sodium peanut oil fatty acid, sodium PEG-6 cocamide carboxylate, sodium PEG-8 cocamide carboxylate, sodium PEG-4 cocamide sulfate, sodium PEG-3 lauramidocarboxylate, sodium PEG-4 lauramidocarboxylate, sodium PEG-8 palm glyceride carboxylate, sodium pentaerythrityl hydroxypropyl lminodiacetate dendrimer Dendrimer, sodium propoxy PPG-2 acetate, sodium rapeseed oil fatty acid, sodium rice bran amphoacetate, sodium ricinoleate, sodium ricinoleoamphoacetate, sodium rosehip amphoacetate, sodium rosinate, sodium safflower oil fatty acid, sodium safflower hydrolyzed soy protein, sodium sesame seed oil fatty acid, sodium sesame amphoacetate, sodium shea butter amphoacetate, sodium soy oil fatty acid, sodium soy hydrolyzed collagen, sodium stearate, sodium stearoamphoacetate, sodium stearoamphohydroxypropyl Sulfonates, sodium stearoamphopropionate, sodium stearoyl caseinate, sodium stearoyl glutamate, sodium stearoyl hyaluronate, sodium stearoyl hydrolyzed collagen, sodium stearoyl hydrolyzed corn protein, sodium stearoyl hydrolyzed silk, sodium stearoyl hydrolyzed soy protein, sodium stearoyl hydrolyzed wheat protein, sodium stearoyl lactalbumin, sodium stearoyl methyl isethionate, sodium stearoyl oat protein, sodium stearoyl pea protein,Stearoyl soy protein sodium, sodium stearyl dimethylglycine, sodium stearyl sulfate, sunflower seed sodium amphoacetate, surfactin sodium, sweet almond sodium amphoacetate, sweet almond oil fatty acid sodium, sodium tol amphopropionate, sodium talate, sodium taro amphoacetate, beef tallow fatty acid sodium, sodium taro sulfate, tamanu seed oil fatty acid sodium, sodium taurate, cocoyl methyl taurine sodium, laurate taurine sodium, na Thorium / TEA-lauroyl collagen amino acids, sodium / TEA-lauroyl hydrolyzed collagen, sodium / TEA-lauroyl hydrolyzed keratin, sodium / TEA-lauroyl keratin amino acids, sodium / TEA-undecylenoyl collagen amino acids, sodium / TEA-undecylenoyl hydrolyzed collagen, sodium / TEA-undecylenoyl hydrolyzed corn protein, sodium / TEA-undecylenoyl hydrolyzed soy protein, sodium / TEA-undecylenoyl hydrolyzed wheat protein, Theobroma Sodium Grandiflorum Seed Oil Fatty Acid, Sodium Trideceth-3 Carboxylate, Sodium Trideceth-4 Carboxylate, Sodium Trideceth-6 Carboxylate, Sodium Trideceth-7 Carboxylate, Sodium Trideceth-8 Carboxylate, Sodium Trideceth-12 Carboxylate, Sodium Trideceth-15 Carboxylate, Sodium Trideceth-19 Carboxylate, Sodium Trideceth Sulfate, Sodium Tridecylbenzenesulfonate, Sodium Tridecyl Sulfate, Sodium Trimethylolpropane Hydroxypropyl Iminodiacetate Dendrimer, Sodium Undeceth-5 Carboxylate, Sodium Undecylenate, Sodium Undecylen Amphoacetate, Sodium Undecylen Amphopropionate, Sodium Undecinoyl Glutamate, Sodium Wheat Germ Amphoacetate, Sorbet-160 Stearate, Soybean oil fatty acids, soybean amidopropylamine oxide, soybean amidopropyl betaine, soybean oil glycereth-8 ester, stearamidopropylamine oxide, stearamidopropyl betaine, stearamine oxide, steareth-15, steareth-16, steareth-20, steareth-21, steareth-25, steareth-27, steareth-30, steareth-40, steareth-50, steareth-80, steareth-100, steareth-2 phosphate, steareth-3 phosphate, stearic acid, stearoxypropyltrimonium chloride, stearoyl glutamic acid, stearoyl sarcosine, stearyl betaine, stearyldimonium hydroxypropyl butyl glucoside chloride, stearyldimonium hydroxypropyl decyl glucoside chloride, stearyldimonium hydroxypropyl lauryl glucoside chloride Lido, sulfated castor oil, sulfated coconut oil, sulfated glyceryl oleate, sulfated olive oil, sulfated peanut oil, sunflower amide MEA, sunflower seed oil fatty acid, sunflower seed amide hydroxyethyldimonium chloride, sunflower seed oil glycereth-8 ester, tall acid, beef tallow fatty acid, beef tallow amide propylamine oxide, beef tallow amide propyl betaine, beef tallow amide propyl hydroxysultaine, beef tallow amine oxide, beef tallow betaine, beef tallow dihydroxyethyl betaine, tallow oil ethyl glucoside, TEA-abietoyl hydrolyzed collagen, TEA-C12-14 alkyl phosphate, TEA-C10-15 alkyl sulfate, TEA-C11-15 alkyl sulfate, TEA-C12-13 alkyl sulfate, TEA-C12-14 alkyl sulfate, TEA-C12-15 alkyl sulfate, TEA C14-17 alkylsec sulfonate, TEA-canolate, cocamidodiacetate TEA, coconut fatty acid TEA, TEA-coco-sulfate, cocoyl alanine TEA, TEA-cocoyl glutamate, TEA-cocoyl glutamine, cocoyl glycine TEA, TEA-cocoyl hydrolyzed collagen, TEA-cocoyl hydrolyzed soy protein, cocoyl sarcosine TEA, TEA-dimethicone PEG-7 phosphate, TEA-dodecylbenzenesulfonate, TEA-hydrogenated cocoate,Hydrogenated taro glutamate TEA, TEA-isostearate, TEA-isostearoyl hydrolyzed collagen, TEA-lauraminopropionate, TEA laurate, (lauric acid / myristic acid) TEA, TEA laureth sulfate, TEA lauroyl collagen amino acid, TEA lauroyl glutamate, TEA-lauroyl hydrolyzed collagen, TEA-lauroyl keratin amino acid, TEA-lauroyl methylaminopropionic acid, TEA-lauroyl / myristoyl aspartate, TEA lauroyl sarcosinate, TEA-lauryl phosphate TEA-Lauryl Sulfate, TEA-Myristoyl Hydrolyzed Collagen, TEA-Oleate, TEA-Oleoyl Hydrolyzed Collagen, TEA-Oleoyl Sarcosinate, TEA-Oleyl Sulfate, TEA-Palmitate, TEA-Palm Kernel Sarcosinate, PEG-3 Cocamide Sulfate, TEA-Rosinate, TEA-Stearate, TEA-Talate, TEA-Tridecylbenzenesulfonate, TEA-Undecylenate, TEA-Undecylenol Hydrolyzed Collagen, Tetramethyldecine Diol, tetrasodium dicarboxyethyl stearyl sulfosuccinamate, TIPA laureth sulfate, TIPA-lauryl sulfate, TIPA myristate, TIPA-stearate, tocopheryl phosphate, trehalose undecylenate, TM-C12-15 pareth-2 phosphate, TM-C12-15 pareth-6 phosphate, TM-C12-15 pareth-8 phosphate, TM-C12-15 pareth-10 phosphate, trideceth-20, trideceth-50, trideceth-3 carboxylic acid, trideceth-4 carboxylic acid, trideceth-7 Carboxylic acid, trideceth-8 carboxylic acid, trideceth-15 carboxylic acid, trideceth-19 carboxylic acid, trideceth-10 phosphate, tridecylbenzenesulfonic acid, trilaureth-9 citrate, trimethylolpropane hydroxypropyl bis-hydroxyethylamine dendrimer, trisodium lauroampho-PG-acetate chloride phosphate, undecanoic acid, undeceth-5 carboxylic acid, undecylenamidopropylamine oxide, undecylenamidopropyl betaine, undecylenic acid, undecinoyl collagen amino acid,Undecinoyl glycine, undecylenoyl hydrolyzed collagen, undecinoyl wheat amino acids, undecyl glucoside, wheat germ oil fatty acids, wheat germ amidopropylamine oxide, wheat germ amidopropyl betaine, Yucca Schidigera leaf / root / stem extract, Yucca Schidigera stem extract, zinc coceth sulfate, and zinc cocosulfate.

[0272] Green and Synthetic Polymers: The compositions defined herein are advantageously combined with at least one green or synthetic polymer. Suitable cationic polymers include, for example, cationic cellulose derivatives, e.g., quaternated hydroxyethylcellulose available from Amerchol under the name Polymer JR 400®, cationic starch, diallylammonium salt and acrylamide copolymers, quaternated vinylpyrrolidone / vinylimidazole polymers, e.g., Luviquat® (BASF), polyglycol and amine condensation products, quaternated collagen polypeptides, e.g., lauryldimonium hydroxypropyl hydrolyzed collagen (Lamequat® L, Gruenau), quaternated wheat polypeptide, polyethyleneimine, cationic silicone polymers, e.g., amodimethicone, adipic acid and dimethylaminohydroxypropyl diethylenetriamine copolymer (Cartaretine®, Sandoz), acrylic acid and dimethyldiallylammonium chloride copolymer (Merquat® 5 These include polyaminopolyamides and their crosslinked water-soluble polymers, cationic chitin derivatives, for example, quaternary chitosans distributed optionally as microcrystalline, dihaloalkyls, for example, dibromobutan and bis-dialkylamines, for example, condensation products of bis-dimethylamino-1,3-propane, cationic guar gums, for example, Celanese's Jaguar® CBS, Jaguar® C-17, Jaguar® C-16, quaternary ammonium salt polymers, for example, Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol, and various types of polyquaternium (e.g., 6, 7, 32, or 37) found on the market under trade names such as Rheocare® CC or Ultragel® 300.Suitable anionic, amphoteric, amphoteric, and nonionic polymers include, for example, vinyl acetate / crotonic acid copolymer, vinylpyrrolidone / vinyl acrylate copolymer, vinyl acetate / butyl maleate / isobornyl acrylate copolymer, methyl vinyl ether / maleic anhydride copolymer and its esters, non-crosslinked and polyol-crosslinked polyacrylic acids, acrylamidopropyltrimethylammonium chloride / acrylate copolymer, octylacrylamide / methyl methacrylate / tert.-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymer, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymer, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinyl caprolactam terpolymer, and optionally derivatized cellulose ethers and silicones. In preferred variations, the compositions according to the present invention preferably include non-crosslinked or polyol-crosslinked polyacrylic acids as further polymer components.

[0273] Aromatic oils and / or fragrances: The compositions according to the present invention preferably comprise one or more aromatic oils and / or fragrances. Suitable aromatic oils are mixtures of natural and synthetic fragrances. Natural fragrances include extracts of flowers (lily, lavender, rose, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper), fruit peels (bergamot, lemon, orange), roots (nutmeg, angelica, celery, cardamom, costus, iris, calamus), woods (pinewood, sandalwood, guaiac, cedarwood, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, dwarf pine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal-derived ingredients, such as civet and beaver, may also be used. Typical synthetic fragrance compounds are ester, ether, aldehyde, ketone, alcohol, and hydrocarbon type products. Examples of ester-type fragrance compounds include benzyl acetate, phenoxyethyl isobutyrate, p-tert.butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethylphenylglycinate, allyl cyclohexylpropionate, styraryl propionate, and benzyl salicylate. Ethers include, for example, benzyl ethyl ether, while aldehydes include, for example, linear alcanals containing 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial, and bourgeois. Suitable examples of ketones are ionone, beta-isomethylionone, and methylcedyl ketone. Suitable alcohols are anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol, and terpineol. Hydrocarbons mainly consist of terpenes and balsams. However, it is preferable to use a mixture of different fragrance compounds that together produce a good aroma.Other suitable fragrance oils are relatively low-volatility essential oils, which are mostly used as aromatic components. Examples include sage oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, ladana oil, and lavandin oil. The following are preferably used individually or in mixture form: bergamot oil, dihydromyrcenolate, lilial, liral, citronellol, phenylethyl alcohol, hexyl cinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisanblenforte, ambroxan, indole, hedione, sandelice, citrus oil, mandarin oil, orange oil, allyl amyl glycolate, cyclobeltal, lavandin oil, sage oil, damascone, geranium oil bourbon, cyclohexyl salicylate, Belfixcool, Isoesuper, Fixolid NP, ebernyl, iraldine gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilat, irotyl and floramat.

[0274] Anti-cellulite agents: The compositions according to the present invention preferably comprise one or more anti-cellulite agents. The anti-cellulite agents and lipolytic agents are preferably selected from the group consisting of beta-adrenergic receptor agonists, such as synephrine and its derivatives, and cyclohexylcarbamates. The activators that enhance or amplify the activity of the anti-cellulite agents, particularly those that stimulate and / or depolarize C nerve fibers, are preferably selected from the group consisting of capsaicin and its derivatives, vanillyl nonylamide and its derivatives, L-carnitine, coenzyme A, isoflavonoids, soybean extract, pineapple extract, and conjugated linoleic acid.

[0275] Fat-enhancing agent: The composition according to the present invention preferably comprises one or more fat-enhancing agents and / or lipogenic agents, as well as an agent that enhances or amplifies the activity of the fat-enhancing agent. An example of a fat-enhancing agent is hydroxymethoxyphenylpropylmethylmethoxybenzofuran (trade name: Sym3D®).

[0276] Superfatty agents and / or viscosity factors: The compositions according to the present invention preferably comprise one or more superfatty agents and / or viscosity factors. Superfatty agents may be selected from, for example, lanolin and lecithin, as well as polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides, and fatty acid alkanolamides that also act as form stabilizers. The viscosity factors primarily used are aliphatic alcohols or hydroxyaliphatic alcohols containing 12 to 22 and preferably 16 to 18 carbon atoms, as well as partial glycerides, fatty acids, or hydroxy fatty acids. Combinations of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides and / or polyglycerol poly-12-hydroxystearate of the same chain length are preferably used.

[0277] Pearlescent waxes: The compositions according to the present invention preferably comprise one or more pearlescent waxes. Suitable pearlescent waxes include, for example, alkylene glycol esters, particularly ethylene glycol distearate; fatty acid alkanolamides, particularly coco-fatty acid diethanolamide; partially glycerides, particularly monoglyceride stearate; esters of polybasic, optionally hydroxysubstituted carboxylic acids and aliphatic alcohols containing 6 to 22 carbon atoms, particularly long-chain esters of tartaric acid; aliphatic compounds containing at least 24 carbon atoms in total, such as aliphatic alcohols, aliphatic ketones, aliphatic aldehydes, aliphatic ethers and aliphatic carbonates, particularly laurone and distearyl ethers; ring-opening products of olefin epoxides containing 12 to 22 carbon atoms having fatty acids, such as stearic acid, hydroxystearic acid or behenic acid, aliphatic alcohols containing 12 to 22 carbon atoms, and / or polyols containing 2 to 15 carbon atoms and 2 to 10 hydroxyl groups, and mixtures thereof.

[0278] Silicone: To provide a silky, easily spreadable, and luxurious texture, to make the appearance and feel of the skin smoother, and to further improve processability (defoaming), the compositions according to the present invention preferably contain one or more silicones or silicone derivatives. Suitable silicones include acetyl methylsilanol mannuronate, acetylmethionyl methylsilanol elastinate acrylate / behenyl, acrylate / dimethicone methacrylate copolymer, acrylate / behenyl methacrylate / dimethicone methacrylate copolymer, acrylate / bis-hydroxypropyl dimethicone crosslinked polymer, acrylate / dimethicone copolymer, acrylate / dimethicone methacrylate / ethylhexyl acrylate copolymer, acrylate / dimethiconol acrylate copolymer, acrylate / ethylhexyl acrylate / dimethicone methacrylate copolymer, acrylate / octylacrylamide / diphenylamodimethicone copolymer, acrylate / polytrimethylsiloxy methacrylate copolymer, acrylate / propyl trimethicone methacrylate copolymer, and acrylate / stearyl acrylate / dimethicone methacrylate copolymer. -, Acrylate / Tridecylacrylate / Triethoxysilylpropyl methacrylate / Dimethicone methacrylate copolymer, Acrylate / Trifluoropropyl methacrylate / Polytrimethylsiloxymethacrylate copolymer, Aminobispropyl dimethicone, Aminoethylaminopropyl dimethicone, Aminopropyl dimethicone, Aminopropyl phenyl trimethicone, Aminopropyl triethoxysilane, Ammonium dimethicone PEG-7 sulfate, Amodimethicone, Amodimethicone hydroxystearate, Amodimethicone / Silsesquioxane copolymer, Ascorbyl carboxydecyltrisiloxane, Ascorbyl methylsilanol pectinate, Behenoxydimethicone, Behentrimonium dimethicone PEG-8 phthalate, Behenyl dimethicone, Bis-amino PEG / PPG-41 / 3 aminoethyl PG-propyl dimethicone, Bis-aminopropyl / ethoxyaminopropyl dimethicone,Bis(butylbenzoate)diaminotriazineaminopropyltrisiloxane, bis-butyldimethicone polyglyceryl-3, bis-butyloxyamodimethicone / PEG-60 copolymer, bis(C13-15 alkoxy)hydroxybutamideamodimethicone, bis(C13-15 alkoxy)PG-amodimethicone, bis-(C1-8 alkyllauroyllysinedecylcarboxamide)dimethicone, bis-cetylcetyldimethicone, bis-cetyl / PEG-8 cetylPEG-8 dimethicone, bis-di Phenylethyldisiloxane, bis-ethylethylmethicone, bis-gluconamidoethylaminopropyldimethicone, bis-hydrogendimethicone, bis-hydroxyethoxypropyldimethicone, bis-hydroxylauryl, dimethicone / IPDI copolymer, bis-hydroxy / methoxyamodimethicone, bis-hydroxypropyldimethicone behenate, bis-hydroxypropyldimethicone / SMDI copolymer, bis-isobutylPEG-14 / amodimethicone copolymer, bis-isobutylPEG-1 5 / Amodimethicone Copolymer, Bis-Isobutyl PEG / PPG-20 / 35 / Amodimethicone Copolymer, Bis-Isobutyl PEG / PPG-10 / 7 / Dimethicone Copolymer, Bis-Isobutyl PEG-24 / PPG-7 / Dimethicone Copolymer, Bis-PEG-1 Dimethicone, Bis-PEG-4 Dimethicone, Bis-PEG-8 Dimethicone, Bis-PEG-12 Dimethicone, Bis-PEG-20 Dimethicone, Bis-PEG-12 Dimethicone Beeswax, Bis-PEG-12 Dimethicone Candelilla Bis-PEG-15 Dimethicone / IPDI Copolymer, Bis-PEG-15 Methyl Ether Dimethicone, Bis-PEG-18 Methyl Ether Dimethyl Silane, Bis-PEG / PPG-14 / 14 Dimethicone, Bis-PEG / PPG-15 / 5 Dimethicone, Bis-PEG / PPG-18 / 6 Dimethicone, Bis-PEG / PPG-20 / 20 Dimethicone, Bis-PEG / PPG-16 / 16 Dimethicone, Bis-PEG / PPG-20 / 5 Dimethicone, Bis-phenylhexamethicone, bis-phenylpropyl dimethicone, bis-polyethylene dimethicone, bis-(polyglyceryl-3 oxyphenylpropyl) dimethicone, bis-(polyglyceryl-7 oxyphenylpropyl) dimethicone, bis-PPG-15 dimethicone / IPDI copolymer, bis-(PPG-7 undeceneth-21) dimethicone, bis-stearyl dimethicone, bis-trimethoxysilylethyltetramethyldisiloxyethyl dimethicone, bis-vinyl dimethicone, bis-vinyl dimethicone / dimethicone copolymer, borage seed oil PEG-7 dimethicone ester, butyl acrylate / C6-14 perfluoroalkyl ethyl acrylate / mercaptopropyl dimeth...

Claims

1. (a1) an effective amount of 1,2-heptanediol, (b1) an effective amount of at least one antimicrobial component, and (c1) Optionally, a composition comprising or comprising at least one active substance and / or additive for a food, cosmetic or pharmaceutical composition or home care product, At least one antimicrobial component is caprylhydroxamic acid, o-cymen-5-ol, tropolone, 2-methyl-5-cyclohexylpentanol, sodium benzoate, potassium sorbate, benzyl salicylate, salicylic acid, farnesol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, glyceryl laurate, anisic acid and its salts, TEA salicylate, glyceryl caprate, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate A composition selected from the group consisting of lium, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, propanediol caprylate, crimbazole, thymol, 4-hydroxyacetophenone, sodium lactate, 1,3-propanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol (decylene glycol), 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and a mixture of two or more of the aforementioned antimicrobial components.

2. The composition according to claim 1, wherein at least one antimicrobial component is selected from the group consisting of caprylhydroxamic acid, o-cymen-5-ol, tropolone, 2-methyl-5-cyclohexylpentanol, sodium benzoate, benzyl salicylate, farnesol, glyceryl caprylate, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketal, anisic acid and its salts, tetrasodium glutamate diacetate, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, propanediol caprylate, crimbazole, thymol, 4-hydroxyacetophenone, 1,3-propanediol, 1,2-octanediol, 1,2-decanediol (decylene glycol), and mixtures of two or more of the aforementioned antimicrobial components.

3. (a1) is 1,2-heptanediol and 1,2-octanediol, or 1,2-heptanediol and 2,3-heptanediol The composition according to claim 1 or 2, comprising or consisting of the following.

4. A composition according to any one of claims 1 to 3, wherein at least one active substance and / or additive for a food, cosmetic, or pharmaceutical composition or home care product is selected from the group consisting of agents for skin aging, antioxidants, chelating agents, emulsifiers, surfactants, green and synthetic polymers, skin coolants, rheological additives, oils, fragrances or perfumes, polyols, and mixtures of two or more of the substances mentioned above.

5. The mixture further comprises at least one antimicrobial agent (b) different from the antimicrobial components, wherein the antimicrobial agent is 2-benzylheptanol, alkyl(C12-22)trimethylammonium bromide and chloride, ascorbic acid and its salts, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharate, benzethonium chloride, benzoic acid, camphor, cetylpyridinium chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol, cyclohexylglycerin, dimethylphenylbutanol, dimethylphenylbutanol, dimethylphenylbutanol, chlorocresol, chloroxyllenol, chloroxylglycerin, dimethylphenylbutanol, chloroxyl Tylphenylpropanol, ethanol, ethyl lauroyl alginate HCl, ethyl lauroyl alginate laurate, eucalyptol, gluconic acid and its salts, glycerin, hexamidine, hexamidine diisethionate, hexylglycerin, iodopropynyl butylcarbamate, jasmol, lauryl alcohol, mannitol, menthol, methyl salicylate, octenidine HCl, polyarginine, polyglyceryl-10 laurate, polyglyceryl-2 caprate, polyglyceryl-3 caprylate, polylysine, Salvia A composition according to any one of claims 1 to 4, selected from the group consisting of Officinalis (sage) oil, silver chloride, silver citrate, sodium caproyl lactylate, sodium caproyl / lauroyl lactylate, sodium lauroyl lactylate, sorbic acid, sorbitol, tetraselmis extract, triclocarban, triclosan, triethyl citrate, xylitol sesquicaprylate, zinc citrate, zinc pyrithione, zinc ricinoleate, and a mixture of two or more of the aforementioned antimicrobial agents.

6. 1,2-heptanediol is contained in an amount of 0.001 to 15.0% by weight of the composition, or the total weight of the final food, cosmetic or pharmaceutical preparation, or home care product, and / or The composition according to any one of claims 1 to 5, comprising at least one antimicrobial component (b1) in an amount of 0.01 to 25.0% by weight of the total weight of the composition.

7. A food, cosmetic, or pharmaceutical preparation comprising the composition described in any one of claims 1 to 6, i. In the form of a dispersion containing an oil component in an amount of ≥1% by weight, in the form of an emulsion, liquid, lotion, suspension, emulsion, ointment, paste, gel, cream, oil-based or liposome formulation selected from the group consisting of O / W emulsion, W / O emulsion, multiple emulsions, water-in-oil (W / O / W) or oil-in-water (O / W / O) emulsion, PIT emulsion, Pickering emulsion, or microemulsion; ii. In the form of a liquid surfactant formulation; iii. In the form of a solid surfactant formulation; iv. An aqueous or aqueous / alcoholic form selected from an aqueous / ethanolic solution or an aqueous / glycolic solution; Cosmetic or pharmaceutical preparations are cold-preserved preparations, including food, cosmetic, or pharmaceutical preparations.

8. Use of the composition according to any one of claims 1 to 6 for suppressing or inhibiting the growth of microorganisms in food, cosmetics, pharmaceuticals, or home care products, The microorganism used is selected from the group consisting of the genera Pseudomonas, Staphylococcus, Escherichia, Candida, Aspergillus, and combinations thereof.

9. Use of 1,2-heptanediol to enhance the efficacy of the antimicrobial component described in claim 1.

10. A method for inhibiting or suppressing the growth of microorganisms in food, cosmetics, pharmaceuticals, or home care products: - Steps to prepare food, cosmetic or pharmaceutical preparations, or home care products; A method comprising the step of incorporating an effective amount of the composition according to any one of claims 1 to 6.

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