Microfluidic device for optimization of nanoparticle synthesis of poorly soluble drugs
The microfluidic device addresses aggregation issues in solid lipid nanoparticle production by using heaters and temperature control to maintain the organic material above its melting point, achieving stable and uniform nanoparticle synthesis.
KR103000082B1Active Publication Date: 2026-08-03DANKOOK UNIV CHEONAN CAMPUS IND ACADEMIC COOP FOUND
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Patent Information
- Application Number
- KR1020240176928
- Authority / Receiving Office
- KR · KR
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2024-12-02
- Publication Date
- 2026-08-03
- Estimated Expiration
- 2044-12-02
AI Technical Summary
Technical Problem
Existing microfluidic devices struggle to stably produce solid lipid nanoparticles for poorly soluble drugs due to aggregation issues when temperature is not maintained above the melting point of lipids, preventing uniform particle size production.
Method used
A microfluidic device with heaters and temperature control modules to maintain the organic material above its melting point, ensuring stable and uniform production of solid lipid nanoparticles by homogeneously mixing organic and aqueous phases.
Benefits of technology
The device enables stable, uniform, and reproducible production of solid lipid nanoparticles, preventing aggregation and ensuring consistent particle size, with improved polydispersity and encapsulation efficiency.
✦ Generated by Eureka AI based on patent content.
Abstract
The present disclosure relates to a microfluidic device for optimizing nanoparticle synthesis of poorly soluble drugs, capable of stably generating solid lipid nanoparticles, and may include: a first storage container in which an organic phase material is stored; a second storage container in which an aqueous phase material is stored; a microfluidic chip; a first pump connected to a first inlet port of the first storage container and the microfluidic chip; a second pump connected to a second inlet port of the second storage container and the microfluidic chip; a third storage container connected to an outlet port of the microfluidic chip; and a heater disposed in at least one of the first storage container, the microfluidic chip and the first pump.
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