Method of manufacturing free-standing organic-inorganic complex 3D printing structure

The method for manufacturing self-supporting organic-inorganic composite 3D printed structures addresses the need for supports and chemical crosslinking agent risks by using a coagulation bath with collagen and inorganic materials, enabling efficient and safe production of structures with overhang features for hard tissue regeneration.

KR103001546B1Active Publication Date: 2026-08-05KOREA INST OF MATERIALS SCI
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Patent Information

Application Number
KR1020230167344
Authority / Receiving Office
KR · KR
Patent Type
Patents
Current Assignee / Owner
Filing Date
2023-11-27
Publication Date
2026-08-05
Estimated Expiration
2043-11-27

AI Technical Summary

Technical Problem

Existing methods for manufacturing 3D printed structures for hard tissue regeneration face challenges such as the need for supports, which increase production time and cost, and the use of chemical crosslinking agents that pose health risks.

Method used

A method for manufacturing a self-supporting organic-inorganic composite 3D printed structure using a coagulation bath containing collagen, inorganic materials, ethanol, and a pH adjuster to induce collagen hardening, allowing for the formation of structures without supports and avoiding chemical crosslinking agents.

Benefits of technology

The method enables the production of self-supporting structures with overhang features, reducing production time and costs, and eliminates the risks associated with chemical crosslinking agents, while maintaining excellent bone differentiation gene expression.

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Abstract

The present invention relates to a method for manufacturing a self-supporting organic-inorganic composite 3D printed structure, specifically comprising the steps of: 3D printing a paste containing printing inorganic powder and a collagen solution in a coagulation bath to form a molded body; a step of primary curing in the coagulation bath; and a step of secondary curing the molded body; wherein the coagulation bath is a hydrogel containing a gelling agent, ethanol, and a pH adjuster.
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