Thermodynamically stable form of sco-101, composition comprising the same and preparation process and use of the same
The development of a stable, non-hygroscopic crystal form I of SCO-101 addresses the instability issues of the existing polymorphic form, providing a more effective and safer form for cancer treatment therapies.
TWI933972BActive Publication Date: 2026-08-01RESISTANCE ONCOLOGY APS
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Patent Information
- Application Number
- TW111125562
- Authority / Receiving Office
- TW · TW
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2021-07-16
- Filing Date
- 2022-07-07
- Publication Date
- 2026-08-01
- Estimated Expiration
- 2042-07-06
AI Technical Summary
Technical Problem
The existing polymorphic form of SCO-101, as described in WO 2000/24707, is hygroscopic and metastable, leading to solvate formation and instability, which poses challenges for pharmaceutical development and patient safety.
Method used
Development of a thermodynamically stable, non-hygroscopic crystal form I of SCO-101, characterized by specific X-ray powder diffraction peaks, and processes to convert metastable forms into this stable form, including solvent mixing and temperature cycling.
Benefits of technology
Crystal form I of SCO-101 exhibits superior stability and non-hygroscopic properties, making it suitable for clinical development and enhancing the effectiveness of cancer treatment therapies.
✦ Generated by Eureka AI based on patent content.
Abstract
This invention relates to an improved crystal form of SCO-101, its preparation, and its uses. Furthermore, this invention relates to an intermediate crystal form of SCO-101 that can be converted into an improved crystal form of SCO-101.
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