Maintaining diethylcarbamazine in an extruded daily ration animal feed product

WO2025029582A3 Publication Date: 2025-03-27RUBICON SCI LLC
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Patent Information

Application Number
PCT/US2024/039553
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-08-01
Filing Date
2024-07-25
Publication Date
2025-03-27

AI Technical Summary

Technical Problem

Existing methods for maintaining therapeutic levels of diethylcarbamazine in animal feed products are inefficient, as they require periodic dosing and can lead to degradation of the active ingredient, especially when stored at ambient temperatures.

Method used

A method involving the incorporation of diethylcarbamazine and a preservative containing a water-soluble antioxidant into an extruded daily ration feed product, which is then extruded to maintain a therapeutically effective concentration of diethylcarbamazine between 200 mg/kg to 2,000 mg/kg, while ensuring stability for extended storage periods.

Benefits of technology

The method effectively maintains at least 95% of the original diethylcarbamazine concentration for up to 8 months at ambient temperatures and up to 40°C and 75% relative humidity, providing a stable and effective therapeutic feed product.

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Abstract

A method is disclosed for maintaining a therapeutically effective amount of diethylcarbamazine in an extruded daily ration feed product for animals. The diethylcarbamazine is introduced and mixed into a feed mixture upstream of an extruder die. Additionally, a preservative is introduced and mixed into the feed mixture upstream of the extruder die. The preservative comprises an antioxidant system having a water-soluble antioxidant. The feed mixture is then extruded to form the extruded daily ration feed product having a concentration of diethylcarbamazine that is between 200 milligrams per kilogram to 2,000 milligrams per kilogram. This method ensures stabilization of diethylcarbamazine in the extruded daily ration feed product stored at ambient conditions over a shelf-life period. An effective amount of the therapeutic compound can be delivered to animals as part of their daily ration.
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