Liquid-phase nucleic acid nanoparticles and their use
WO2025029730A3 Publication Date: 2025-04-03RGT UNIV OF CALIFORNIA
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Patent Information
- Application Number
- PCT/US2024/040032
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-08-02
- Filing Date
- 2024-07-29
- Publication Date
- 2025-04-03
AI Technical Summary
Technical Problem
Current technologies lack effective methods for controlling the size and preventing adhesion of biomolecular condensates to hydrophobic surfaces, which limits their use as bioreactors and drug delivery systems.
Method used
A liquid-liquid phase separation system comprising nanostar droplets coated with a nucleic acid surfactant, which forms a shell around the nanostar condensates, preventing adhesion to hydrophobic surfaces and allowing tunable droplet sizes by adjusting the nanostar to nucleic acid surfactant ratio.
Benefits of technology
The system enables the production of nanostar droplets with radii ranging from 30 nm to 10 μm, preventing adhesion to hydrophobic surfaces and offering potential applications in drug delivery and bioreactor systems.
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Abstract
A liquid-liquid phase separation system comprising nanostar droplets comprising nanostar condensates coated with a nucleic acid surfactant is provided. The nucleic acid surfactant forms a shell around the nanostar condensates, which prevents the nanostar condensates from adhering to hydrophobic surfaces. The size of the nanostar droplets is tunable simply by adjusting the nanostar: nucleic acid surfactant ratio to allow production of nanostar droplets having a radius in a range from about 30 nm to about 10 μm. Methods of using such nanostar condensates encapsulated with nucleic acid surfactants for delivery of a payload such as a drug, protein, nucleic acid, gene therapy agent, gene editing agent, or other molecule of interest are also provided.
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