Non-invasive analyte sensor for on-skin wearing
The non-invasive analyte sensor system addresses the challenge of slow glucose resorption by using an analyte-responsive layer and a conversion layer to maintain axial equilibrium, enabling accurate and continuous glucose monitoring on the skin.
Patent Information
- Application Number
- PCT/EP2024/075164
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-09-13
- Filing Date
- 2024-09-10
- Publication Date
- 2025-03-20
AI Technical Summary
Existing non-invasive analyte sensors for on-skin glucose monitoring face challenges such as slow glucose resorption by the skin, leading to accumulated glucose concentration readings that do not accurately reflect actual interstitial fluid glucose levels.
A non-invasive analyte sensor system comprising an analyte-responsive layer with a skin-contacting surface, a conversion layer, and an optional electron acceptor, which allows for precise and continuous monitoring of analyte concentrations by maintaining an axial equilibrium and using a glucose-responsive hydrogel layer that changes optical properties in response to analyte binding.
The system enables accurate and continuous monitoring of analyte concentrations, such as glucose, by ensuring that the glucose concentration within the detection volume corresponds to the bulk glucose concentration, thereby overcoming the limitations of slow glucose resorption and equilibrium sensors.