Control of cell production in a bioreactor

Abstract

The invention relates to a method, implemented by a control system, for controlling cell production in a bioreactor. The bioreactor comprises a cell culture vessel containing a culture medium and microcarriers, on the surface of which the cells grow. The method comprises dynamic adjustment of parameters during production. The dynamically-adjusted parameters include at least a temperature of the culture medium, a pH of the culture medium, a concentration of oxygen dissolved in the culture medium, and a quantity of microcarriers present in the vessel. The method improves the quality and quantity of the biomass produced in the bioreactor.