Polynucleotide encoding virus-derived protein

Abstract

The purpose of the present invention is to provide a novel polynucleotide that efficiently expresses the HIV Tat protein or an antigenic fragment thereof and has an excellent ability to induce an anti-Tat antibody, and to provide a pharmaceutical composition containing the polynucleotide. Disclosed is a novel polynucleotide encoding a polypeptide comprising: (a) the HIV Tat protein or an antigenic fragment thereof; and (b) a signal peptide. The pharmaceutical composition containing the polynucleotide can be used for the treatment and / or prevention of HIV-related diseases.