Methods for treating leakage from a gastrointestinal site

The method addresses the challenge of gastrointestinal leakage by using a delivery matrix sealant with ciprofloxacin and ibuprofen to sustainably address infection and ischemia, improving surgical outcomes and reducing complications.

WO2025068904A1 Publication Date: 2025-04-03ETHICON INC
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Patent Information

Application Number
PCT/IB2024/059346
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-09-28
Filing Date
2024-09-25
Publication Date
2025-04-03

AI Technical Summary

Technical Problem

Current methods fail to effectively prevent and treat leakage from gastrointestinal sites, particularly anastomotic leaks, which are a significant complication in colorectal surgeries and have not seen significant improvement in leak rates over the past 40 years.

Method used

A method involving a delivery matrix sealant that combines ciprofloxacin and ibuprofen, delivered via a biologic or synthetic hydrogel, to address infection and ischemia at the gastrointestinal site, providing sustained release of the pharmacological agents for up to two weeks.

Benefits of technology

The method effectively prevents and treats leakage from gastrointestinal sites by providing sustained release of antibiotics and anti-inflammatory agents, reducing infection and ischemia, and improving patient outcomes by reducing hospital stay, mortality, and reoperation rates.

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Abstract

Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
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