Bioreactor system

The bioreactor vessel platform addresses the challenge of maintaining oxygen and nutrient levels in conventional bioreactor systems by promoting fluid flow and circulation, thereby enhancing cell culture growth and development across different stages.

WO2025072826A1 Publication Date: 2025-04-03THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
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Patent Information

Application Number
PCT/US2024/049060
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-09-29
Filing Date
2024-09-27
Publication Date
2025-04-03

AI Technical Summary

Technical Problem

Conventional bioreactor systems face challenges in maintaining oxygen and nutrient levels for cell cultures, leading to hypoxia and apoptosis, especially as the culture medium stagnates and nutrients become depleted.

Method used

The bioreactor vessel platform is designed to be installed in conventional petri dishes, featuring a structural framework that promotes fluid flow and circulation, ensuring continuous exposure of cell cultures to freshly oxygenated culture medium. This platform can be configured in multiple stages to accommodate different growth phases of cell cultures, from early development to maturation.

Benefits of technology

The bioreactor vessel platform effectively prevents stagnation and depletion of oxygen and nutrients, enhancing cell culture growth and development by maintaining a consistent supply of nutrients and preventing physical disruption during maturation stages.

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Abstract

A bioreactor vessel platform for submersion in a bioreactor vessel or petri dish may have different versions for initial and later stage development of cell cultures. The initial stage platform can include a center platform hub and an outer circumferential rim creating a central reservoir and a plurality of culture reservoirs. A magnetic stir bar can be rotated in the central reservoir to direct oxygenated culture medium to cell cultures in the culture reservoirs. The second stage platform has a multi-well configuration with a plurality of culture wells separated by distribution channels and may be made of a porous hydrogel.
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