COMBINED TREATMENT WITH A SIRPalpha-4-1BBL FUSION PROTEIN FOR CANCER

The SIRPa-4-1BBL fusion protein, combined with PD1-PD-L1 and VEGFR-VEGF inhibitors or Trifluridine/Tipiracil, addresses the limitations of current cancer therapies by enhancing immune response and targeting cancer cells for effective treatment.

WO2025181803A1 Publication Date: 2025-09-04KAHR MEDICAL LTD
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Patent Information

Application Number
PCT/IL2025/050192
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-28
Filing Date
2025-02-26
Publication Date
2025-09-04

AI Technical Summary

Technical Problem

Current cancer therapies, including immune checkpoint inhibitors, do not effectively target all patients, necessitating additional therapeutic options to enhance treatment efficacy and reduce side effects.

Method used

A combination treatment involving a SIRPa-4-1BBL fusion protein, which binds CD47 and 4-1BB, alongside agents that inhibit PD1-PD-L1, VEGFR-VEGF, or Trifluridine/Tipiracil, to target and treat cancer cells.

Benefits of technology

The combination treatment enhances adaptive immunity at tumor sites, increasing phagocytosis and reducing tumor survival, thereby effectively treating cancer with improved efficacy.

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Abstract

Combined treatment with a SIRPα-4-lBBL fusion protein for cancer is provided. Accordingly, there is provided a combination of a SIRPa-4-lBBL fusion protein and at least two agents selected from the group consisting of an agent which inhibits activity or expression of a receptor-ligand combination PD1-PD-L1, an agent which inhibits activity or expression of a receptor-ligand combination VEGFR-VEGF, and Trifluridine / Tipiracil, for use in treating cancer in a subject in need thereof. Also provided a combination of a SIRPa-4-lBBL fusion protein and agent which inhibits a receptor tyrosine kinase signaling pathway, for use in treating cancer in a subject in need thereof.
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