Integration and validation of workflows for flow cytometry

The integration system addresses fragmented flow cytometry workflows by automating data exchange and quality control, enhancing efficiency and consistency across instruments.

WO2025217394A1 Publication Date: 2025-10-16BECKMAN COULTER INC
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Patent Information

Application Number
PCT/US2025/024050
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-10
Filing Date
2025-04-10
Publication Date
2025-10-16

AI Technical Summary

Technical Problem

Flow cytometry assay workflows are fragmented due to a lack of automation and integration, leading to manual data reentry, limited data visualization, and inefficient quality control, with current solutions failing to seamlessly connect flow cytometers to downstream analysis platforms and lacking tools for assay validation and quality control guidance.

Method used

An integration system that automates and integrates flow cytometry workflows, enabling seamless data exchange and quality control across instruments, including sample preparation, flow cytometry, and liquid handling, with tools for workflow management, validation, and quality control.

Benefits of technology

Enhances workflow efficiency by reducing manual data entry, improving data visualization, and providing automated quality control, ensuring consistent instrument performance, and facilitating integrated assay validation.

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Abstract

A system for integrating flow cytometry workflows. The system builds a worklist by adding task groups for single or multiple tube panels for analyzing one or more samples. The system instructs instruments to perform tasks in the task groups added to the worklist. The system exchanges data between the instruments. The data exchanged between the instruments being related to performance of the tasks in the task groups. The worklist can include a first task group for instrument quality control, a second task group for assay quality control, and a third task group for compensation and standardization verification.
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