Recombinant yeast cell expressing bacterial antigens intracellularly and on its extracellular surface and its vaccine application
A recombinant yeast cell expressing antigens intracellularly and extracellularly addresses the inefficiencies of existing vaccines by enhancing antigen production and immune response, offering effective protection against bacterial diseases in large livestock.
WO2025219478A1 Publication Date: 2025-10-23INST NAT DE RECH POUR LAGRICULTURE +1
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Patent Information
- Application Number
- PCT/EP2025/060561
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-04-18
- Filing Date
- 2025-04-16
- Publication Date
- 2025-10-23
AI Technical Summary
Technical Problem
Existing yeast-based vaccines struggle to effectively express sufficient amounts of antigens on the surface for large livestock, leading to inadequate immune responses and economic inefficiencies in vaccination processes against bacterial diseases.
Method used
A recombinant yeast cell expressing bacterial antigens both intracellularly and on its extracellular surface using a dual expression system with two different expression vectors, enhancing antigen production and immune response induction.
Benefits of technology
The dual expression strategy induces robust cell-mediated immune mechanisms in large animals, providing effective protection against bacterial infections with improved economic viability.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to a recombinant yeast cell genetically modified to express (i) at least one first bacterial antigen or an immunogenic fragment thereof intracellularly and (ii) at least one second bacterial antigen or an immunogenic fragment thereof on its extracellular surface, the at least one first bacterial antigen or an immunogenic fragment thereof being identical to or different from the at least one second bacterial antigen or an immunogenic fragment thereof. The present invention also concerns this recombinant yeast for use in vaccines and in treating or preventing bacteria-caused pathologies in livestock.
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