New insulin formulations for use in insulin pumps

Incorporating antimicrobial excipients into insulin formulations addresses the issue of bacterial colonization in insulin pumps, enhancing catheter longevity and safety by inhibiting bacterial growth and biofilm formation, thus improving patient care and reducing costs.

WO2025245624A1 Publication Date: 2025-12-04SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA ET HUMAINES S E C
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Patent Information

Application Number
PCT/CA2025/050740
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-28
Filing Date
2025-05-28
Publication Date
2025-12-04

AI Technical Summary

Technical Problem

Current insulin pumps face challenges with frequent catheter replacement due to bacterial colonization and infections, which are costly, unpleasant, and increase the risk of adverse events, while antibiotics are not viable for long-term use due to toxicity and antibiotic resistance.

Method used

Incorporation of antimicrobial excipients, such as metals (copper, zinc, nickel, and antioxidants like N-acetylcysteine) into insulin formulations to inhibit bacterial growth and biofilm formation on catheters, extending their use beyond the typical 2-3 days.

Benefits of technology

The antimicrobial excipients effectively prevent bacterial colonization and biofilm formation on catheters, potentially extending their use, improving patient safety, reducing costs, and minimizing environmental impact.

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Abstract

It is provided an insulin formulation comprising insulin and antimicrobial excipients for use in insulin pumps, connected to subcutaneous tissue via a catheter, a method also known as continuous subcutaneous insulin infusion, wherein the antimicrobial excipient inhibits growth of bacteria in insulin formulations and biofilm bacterial population formation on the internal surfaces of a catheter, allowing extending the time of use of the catheter.
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