Universal tissue fabrication techniques for self-assembled organ production and regenerative medicine applications

Advanced bioprinting and cell culture techniques address the challenges of creating functional tissues/organs by producing highly relevant 3D models with layered or branched structures, facilitating large-scale manufacturing and implantation.

WO2026060262A1 Publication Date: 2026-03-19FRONTIER BIO CORP +5
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Patent Information

Application Number
PCT/US2025/046182
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-07-25
Filing Date
2025-09-12
Publication Date
2026-03-19

AI Technical Summary

Technical Problem

Current methods for creating functional human tissues and organs face challenges such as organ shortages, immune rejection, high costs, and difficulty in reproducing complex tissue architectures, necessitating improved bioprinting and cell culture techniques.

Method used

Advanced bioprinting technologies and specialized bioinks, combined with optimized cell culture modalities, enable the creation of highly functional 3D lung models and other tissues/organs with layered or branched structures, utilizing proprietary culture systems and bioprinters for precise deposition and assembly.

Benefits of technology

The methods provide superior physiological relevancy and applicability, enabling large-scale manufacturing of various tissues/organs, studying disease mechanisms, and facilitating engineered implantation, with improved viability and reproducibility.

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Abstract

Methods and systems are described for a high-level approach to organ generation by self-assembly using bioprinting, overcoming longstanding challenges in replicating the intricate architecture and function of complex organs. In some embodiments, these methods are used to produce lung tissues and microtissues, demonstrating how mini-lung constructs can be produced on a small scale through specialized processes and media. In such embodiments, methods and systems for generating bioprinted lung tissues and microtissues are provided, as are tissues made by such methods. The tissues find use in implantation, drug discovery, personalized medicine, and other applications. Methods for the large-scale manufacturing of lung epithelial stem cells are also provided.
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