Composition for alleviating neurological diseases comprising neural crest cell-derived exosomes containing nerve growth factor
Extracellular vesicles from neural crest cells with enhanced NGF expression address the limitations of stem cell therapies by providing effective neuroregenerative and anti-inflammatory treatment for neurological diseases.
Patent Information
- Application Number
- PCT/KR2025/014797
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-09-30
- Filing Date
- 2025-09-22
- Publication Date
- 2026-04-02
AI Technical Summary
Existing stem cell-based therapies for neurological diseases face challenges such as cell procurement, quality maintenance, and immune response induction, while the low yield of exosomes per nucleated cell limits their therapeutic application.
Development of extracellular vesicles derived from neural crest cells with enhanced nerve growth factor (NGF) expression, promoting neuronal differentiation, regulating inflammatory responses, and inhibiting apoptosis, manufactured through a method involving dedifferentiation of human induced pluripotent stem cells from urine cells and differentiation into neural crest cells, followed by NGF overexpression and vesicle secretion.
The extracellular vesicles effectively treat neurological diseases by inducing neuroprotective and regenerative effects, alleviating inflammation, and promoting nerve regeneration, offering a promising alternative to conventional cell therapies.