Method for producing aromatic β-hydroxy acid
A method using a strong base and aliphatic thiols introduces carboxyl groups into aromatic compounds at atmospheric pressure, addressing the limitations of high-pressure methods and enabling efficient, low-cost production of aromatic β-hydroxy acids suitable for industrial scale.
Patent Information
- Application Number
- PCT/JP2025/035635
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-10-09
- Filing Date
- 2025-10-08
- Publication Date
- 2026-04-16
AI Technical Summary
Existing methods for producing aromatic β-hydroxy acids, such as the Kolbe-Schmitt reaction, require high-pressure carbon dioxide, posing safety risks and being unsuitable for large-scale industrial implementation due to the need for expensive reagents and complex purification processes.
A method involving the use of a strong base and an aliphatic thiol compound to introduce a carboxyl group into an aromatic compound without high-pressure carbon dioxide, utilizing aliphatic thiols to form thiocarbonate anions that react with carbon dioxide at atmospheric pressure, allowing for efficient production of aromatic β-hydroxy acids.
Enables large-scale, cost-effective production of aromatic β-hydroxy acids by eliminating the need for high-pressure equipment and simplifying purification, using relatively inexpensive reagents and avoiding hazardous conditions.