Stabilisation and incorporation of membrane proteins in semi-permeable separation membranes using amphiphilic heteropolymers

Amphiphilic heteropolymers stabilize membrane proteins during membrane fabrication, enhancing performance by maintaining protein stability and functionality, resulting in improved water flux and selectivity.

WO2026082983A1 Publication Date: 2026-04-23E & J GALLO WINERY
6 Cites 1 Cited by

Patent Information

Application Number
PCT/EP2025/080220
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-10-18
Filing Date
2025-10-20
Publication Date
2026-04-23

AI Technical Summary

Technical Problem

Current methods for incorporating membrane proteins into semi-permeable separation membranes face challenges in maintaining protein stability and functionality, leading to suboptimal membrane performance and loss of integrity, particularly during processes like interfacial polymerization.

Method used

The use of amphiphilic heteropolymers to form a stable assembly with membrane proteins, which are then immobilized on a porous support through covalent linking and self-polymerization, ensuring the proteins remain functional during membrane fabrication, enhancing water permeability and selectivity.

Benefits of technology

The resulting semi-permeable membrane exhibits improved performance characteristics, including increased water flux, salt rejection, and ion selectivity, while maintaining protein integrity and functionality.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The present disclosure provides a semi-permeable membrane comprising an assembly comprising an amphiphilic heteropolymer, a membrane protein and a polyamide thin film composite layer at least partially on top of the amphiphilic heteropolymer-stabilized membrane protein. Methods of forming the semi-permeable membrane are also provided, including stabilizing a membrane protein with an amphiphilic heteropolymer and incorporating the resulting assembly onto a porous support. A polyamide layer may be formed on the membrane by interfacial polymerisation. The amphiphilic heteropolymer-stabilized membrane protein assembly may be immobilized on the support by intermediary of a polymer layer formed by a self-polymerizable compound.
Need to check novelty before this filing date? Find Prior Art