Anti-PRLR chimeric antigen receptor switches

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A switchable CAR-T cell therapy with an anti-PRLR Fab molecule addresses the limitations of CAR-T cell treatments for breast cancer by controlling cell activity and reducing adverse effects, achieving safer and more effective tumor targeting.

WO2026132572A1PCT designated stage Publication Date: 2026-06-25ABBVIE GLOBAL ENTERPRISES LTD +2

Patent Timeline

19 Dec 2025

Application

25 Jun 2026

Publication

WO2026132572A1

IPC: C07K16/28; A61K40/11; A61K40/31; A61K40/42; A61P35/00; A61K39/395; A61K40/44

CPC: C07K16/2869; C07K2317/622; C07K2319/03; A61K40/11; A61K40/31; A61P35/00; C07K2317/21; A61K40/4202

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The present disclosure provides anti-PRLR antibodies and chimeric antigen receptor switches comprising the same.

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