Biological Material Analysis TRIZ Cases

A separable core-shell template forms sensor substrate pores without damaging components, improving small extracellular vesicle detection.

Apo-A1 serum screening improves early SARS-CoV-2 detection accuracy while reducing reliance on slower RT-PCR testing.

Humanized anti-CD3epsilon antibodies preserve CD3 binding and immunosuppressive activity while reducing cytokine storm and immunogenicity.

Combining spike-binding antibodies across distinct epitopes helps maintain potent neutralization against SARS-CoV-2 variants for prophylaxis and treatment.

Thioflavin T fluorescence decay fitting separates lifetime components to identify amyloid polymorphs faster than cryo-EM or solid-state NMR.

Specific VH and VL framework substitutions improve PD-1 scFv stability and solubility while preserving high-affinity binding.

Protease digestion with LC-MS resolves co-eluting antibodies and improves PTM quantitation in co-formulated antibody samples.

Using albumin-binding markers and test strips, this case enables rapid point-of-care assessment of functional albumin without complex lab analysis.

Non-natural MUC1 glycopeptides on gold nanoparticles improve anti-MUC1 antibody detection for earlier pancreatic cancer diagnosis.

Gene copy numbers and an Exp(-k) model predict Klebsiella meropenem sensitivity faster than culture-based MIC testing.

Antibodies targeting VISTA block tumor-mediated immune suppression and strengthen anti-tumor immune responses for cancer therapy.

AC-driven DNA-barcoded nano-oscillators enable multiplex binding-kinetics detection with low sample use and label-free plasmonic readout.

Measures antigen-stimulated cytokines such as CXCL9, CXCL10, and IFN-γ to simplify precise cellular immune response testing.

Polycrystalline nanoparticle detection lines boost SERS or PEF signals in lateral flow strips for sensitive multiplex on-site diagnosis.

Fluorescent antibody panels enable flow cytometry immunophenotyping from 50-100 µl mouse blood while resolving over 30 immune subpopulations.

Anti-hPG antibodies detect progastrin in biological samples, enabling faster, less invasive, and cost-effective gastric cancer diagnosis.

Vapor-deposited self-assembled monolayers replace liquid surface treatment to improve antibody uniformity and trace-target detection sensitivity.

A widened sample port and controlled strip flow extend nitrous acid extraction, improving sugar chain antigen sensitivity and specificity.

Optimized CDR sequences raise PD-1 binding affinity and slow dissociation, improving PD-L1 blockade and T cell proliferation against tumors.

MIP and NIP sensor layers turn trace allergen binding into resistance changes, enabling fast point-of-consumption food checks.

Short cyclic peptides bind and internalize into EGFR and mutant EGFR cells, enabling targeted drug delivery against resistant NSCLC tumors.

Epitope-specific hCG aptamers replace thermosensitive antibodies to detect hCG variants, including hCGβcf, with higher accuracy in urine samples.