Dapagliflozin targets SGLT2 to improve diastolic function, reduce fibrosis, and lower HFpEF hospitalization and cardiovascular risk.
Combining RXFP1 modulators with SGLT2 inhibitors extends therapeutic action and supports treatment of hypertension, heart failure, and CKD.
Combining a BET bromodomain inhibitor with an SGLT2 inhibitor addresses recurrent MACE risk after ACS, especially in type 2 diabetes.
Pairing zibotentan with dapagliflozin offsets fluid retention and hemoconcentration while improving CKD renal protection.