Disease Diagnosis TRIZ Cases

An automated evaluation system compares monocyte volume standard deviation and white blood cell count against specific thresholds to identify sepsis status.

Measuring GPC3-positive exosome levels diagnoses hepatocellular carcinoma with higher sensitivity than alpha-fetoprotein testing.

Segmenting blood proteome into organ groups enables detection of low abundance disease markers hidden by high abundance proteins.

Mitoferrofluor anchors to mitochondrial proteins via covalent bonds, enabling reliable iron detection when membrane potential collapses.

Multi-marker biomarker panel detects altered molecular levels to predict cardiotoxicity during drug development.

A lateral flow assay strip detects amniotic fluid proteins using monoclonal and polyclonal antibodies.

Combining catecholamine measurements via capillary electrophoresis resolves low sensitivity and specificity in early Alzheimer's disease detection.

Allogeneic leukemia-derived cell vaccine induces durable functional T cell responses to target residual cancer cells.

Procalcitonin concentration measurement in urine enables rapid urinary tract infection diagnosis, bypassing lengthy culture delays.

Surfactant and heat pretreatment separates thyroglobulin from interfering antibodies to improve immunoassay accuracy.

Measuring biochemical markers in red blood cell samples to assess post-transfusion survival and toxicity before transfusion.

Autoantibodies against aberrant peptides improve early-stage diagnosis reliability by bypassing low biomarker abundance constraints.

Extracting the midregional proadrenomedullin fragment reduces interference from binding proteins, ensuring reliable sepsis diagnosis.

NS1 protein immunoassay detects Zika-specific IgM and IgG antibodies, eliminating false positives from flavivirus cross-reactivity.

Analyzing circulating extracellular vesicles as surrogate indicators resolves the trade-off between invasive biopsy precision and patient convenience.

Segmenting detection into antiphospholipid screening and Borrelia confirmation resolves low sensitivity in early-stage Lyme disease diagnosis.

Segmenting breast epithelial cells by CD44 and CD24 expression overcomes the lack of reliable predictive markers for sporadic breast cancer.

Detecting CRELD2 and BiP proteins in urine samples enables early identification of endoplasmic reticulum stress.

A flexible display integrates M13 bacteriophage biosensors to detect volatile organic compounds through electrical resistance changes.

TG2-driven markers enable non-invasive endometriosis diagnosis, avoiding invasive laparoscopy risks while maintaining high sensitivity.