Disease Diagnosis TRIZ Cases

Measuring proBNP and NDKA levels in blood samples enables rapid stroke detection, resolving low sensitivity of existing imaging methods.

Lectin probes detect altered mammaglobin-A glycan structures, resolving low specificity in conventional CEA and CA15-3 diagnostic methods.

Combining an EZH2 inhibitor with an immune checkpoint inhibitor modulates tumor cell proliferation and immune evasion pathways.

A lentiviral shRNA vector enables precise frataxin knockdown in transduced myoblasts to create a viable disease model.

Measuring VEGFR1+ HPCs and VEGFR2+ EPCs levels identifies surges indicating increased risk of breast cancer progression or relapse.

A homogeneous immunoassay detects chromatin fragments and nucleosomes via antibody-mediated agglutination without separation steps.

A biomarker panel detects cardiac injury using antibody assays and mass spectrometry.

NMR spectroscopy quantifies albumin and amino acids to detect anemia risk before symptoms appear.

Chemical sensors detect volatile organic compounds in breath to identify infections, replacing invasive swabs and improving diagnostic reliability.

A cell-based biosensor measures transendothelial electrical resistance to detect pathogenic amyloid-beta oligomers.

Measuring urine proteins A1BG, ORM1, IGLC2, and TF diagnoses IgA nephropathy without invasive kidney biopsies.

Measures specific salivary components to overcome the low predictive accuracy of traditional bacterial counts.

Analyzing plasma MR-pro-ADM concentrations enables early cancer risk stratification, resolving the bottleneck of delayed preventive intervention.

A multiplexed immunoassay kit measures bilirubin, ammonia, and hepatitis biomarkers in patient samples.

EV-MASP2 biomarkers enable real-time treatment adjustments via feedback, resolving reliability gaps in pancreatic cancer care.

A chemiluminescent enzyme immunoassay detects human sCD14-ST in whole blood samples using specific antibodies.

Measuring histone and proADM levels in blood samples predicts mortality, replacing time-consuming severity scores.

A hydrophobic porous membrane with localized hydrophilic zones enables capillary-driven sample transport for rapid in vitro erythrocytic antigen detection.

A single-chain variable fragment panel detects specific protein variants to resolve diagnostic complexity and precision trade-offs.

Applying predetermined endocan thresholds to blood samples predicts respiratory, renal, and thrombocytopenia risks within 48-72 hours of ICU admission.

Protein microarray immobilizes SARS-CoV-2 spike domains on a substrate to detect immune responses.

Specific blocking treatments address elevated cytokines in CAR-T therapy.

Comparing subject plasma metabolite profiles against normal baselines detects preclinical Alzheimer's risk without invasive procedures.

Detect distinct polypeptide isoforms to monitor engraftment without invasive procedures or false positives from dead cell debris.

Stable isotope labelled histamine enables precise pathway differentiation through hydrophilic interaction chromatography and mass spectrometry.

Composite urinary IGFBP7 and TIMP-2 concentrations resolve low sensitivity in acute kidney injury prediction.

Modified vitamin D receptor ligand-binding domain enables fluorescence resonance energy transfer detection.

The Serum Enhanced Binding test measures serum albumin ligand binding capacities to identify liver dysfunction.

Digital seed amplification assays compartmentalize biofluid samples into microwells to detect pathological protein aggregates.

Antibodies bind proteolysis-resistant gluten peptides in feces to monitor dietary compliance and assess therapy effectiveness.

CD32 surface markers identify infected lymphocytes, resolving persistent viral reservoirs that cause rebound after treatment cessation.

Flow cytometry detects and quantifies labeled M and N alleles on erythrocyte surfaces using fluorescent antibodies.

Dual binding molecules form a complex for beta-1,3-1,6-glucan quantification, preventing false positives from plant-derived glucans.

Designed ankyrin repeat proteins dissociate allergen-specific IgE from cell receptors, enabling accurate local testing without painful skin prick risks.

Measures CD4+CD57+ T cell levels using multiparameter flow cytometry to predict costimulation blockade resistant rejection risk.

Molecular typing identifies epithelial ovarian cancer tissue types using specific protein expression profiles.