Immunological Disorders TRIZ Cases

Non-covalent Siglec-binding nanoparticles improve ligand stability and enable receptor-mediated delivery of therapeutic agents to target cells.

Controlled aqueous extraction and phytochemical markers make Astragalus preparations more consistent for immune modulation with lower inflammation and oxidative stress.

A water-based blend of tannic acid, surfactants, and essential oils denatures airborne allergens without flammable alcohol risks.

Selective spirocyclohexane Mcl-1 inhibitors strengthen target binding and restore apoptosis in cancers and other diseases with deregulated cell survival.

Sequence-specific siRNA duplexes degrade CFB mRNA to lower CFB protein levels and modulate complement-driven disease pathways.

Intermediate 2′FL and LNnT levels in infant formula reduce allergic sensitization while avoiding excessive HMO dosing and added formulation complexity.

See how intermediate 2'FL and LNnT concentrations in infant formula target allergic sensitisation while avoiding excessive HMO levels.

This case tunes 2′FL and LNnT concentrations to support immune development and reduce allergic responses without excessive formulation complexity.

Ginger-root polysaccharide extraction and purification concentrate active components for immune-cell viability, NO, phagocytosis, and cytokine responses.

This case combines eight herbal components to improve immune cell function, reduce viral loads, and mitigate symptoms without side effects.

This case uses SAR and parameter changes to tune immune modulators for selective IL-17 or TNF receptor signaling.

A method loads Cyclosporine A into liposomes using a pH gradient incubation step.

Combining EZH2 inhibitors with retinoic acid opens condensed chromatin, allowing transcription factors to access DNA and drive terminal differentiation.

Salting out furostanol saponins from Tribulus terrestris extract followed by alcohol washing.

siRNA nanoparticles target pulmonary inflammatory receptors to silence specific genes and reduce acute respiratory distress syndrome symptoms.

pH-sensitive polymer coatings dissolve at low acidity to ensure immediate drug release while maintaining taste masking properties.

Adding sterically hindered nitroxides to culture media scavenges radicals, mitigating oxidative stress that limits high-density cultivation productivity.

A herbal powder formulation using inulin as a natural carrier enhances immune function without added excipients.

Mangosteen rind extract treats atopic dermatitis by inhibiting immunomodulatory hormones to provide prolonged relief without steroid side effects.

Incorporating Toll-like receptor-modulating sequences into the AAV backbone reduces inflammatory responses while maintaining transgene delivery efficiency.

A Her2/neu fusion peptide vaccine elicits a stronger immune response through unified epitope presentation.

Fusing a bacterial tetramerization domain to p53 creates stable homo-tetramers that resist dominant negative inhibition from mutant proteins.

A vegetable-based dietary regimen with specific macronutrient ranges reduces glucose and insulin levels to stimulate anticancer responses.

Daphnoretin targets dendritic cell maturation parameters to prevent acute rejection while avoiding the chronic toxicity of broad immunosuppressants.

Modified peptide ligands resolve side effects in multiple sclerosis treatment by diverting immune responses from Th1 to Th2 profiles.

Calcium stearate prevents particle adhesion during compression, resolving manufacturing stickiness while maintaining teriflunomide stability.

Potato protein nutritional compositions reduce viscosity during spray drying to resolve allergenicity trade-offs in cow's milk allergy treatments.

MK2 activators with molecular weight below 1000 Da bind the C-lobe domain to trigger HSP-27 phosphorylation, restoring barrier integrity in ARDS.

Aquaporin protein vaccines induce protective immune responses, reducing tick infestations and disease transmission despite pesticide resistance.

Androgen receptor antagonists inhibit signaling pathways to reduce inflammatory gene expression in respiratory tissues.

Modifying endotoxin structure via phosphate addition to reduce toxicity while maintaining TLR-4 receptor agonist activity.

Ellagic acid derivatives modulate regulatory T cells to prevent organ rejection while avoiding the toxicity of conventional immunosuppressants.

Formula I compound extracts natural immune components to inhibit allergic pathways without side effects like palpitation.

Administering TH dsRNA to shrimps inhibits tyrosine hydroxylase activity, raising haemocyte counts and lowering bacterial mortality rates.

Segmented PEG-bl-PPS micelles target activated immune cells to accelerate chloroquine efficacy in autoimmunity while reducing systemic toxicity.

Combining HDAC and DNMT inhibitors upregulates innate immunity to reduce infections without triggering inflammation or antimicrobial resistance.

tRNA fragments activate toll-like receptors to stimulate immune responses while reducing cellular toxicity associated with synthetic compounds.

Lipidic particles incorporating phosphatidylserine mask immunogenic epitopes, reducing antibody formation against protein therapeutics.