Organic Active Ingredients TRIZ Cases

This case shows how X-ray-defined Selinexor Forms A–D and phase conversion support stable, pure pharmaceutical manufacturing.

Granulation, limited disintegrant, and external lubrication enable 70%+ drug-load cores with hardness, low friability, and fast release.

A lipid-apolipoprotein nanocomplex uses a covalently linked RAGE-targeting peptide to deliver therapy to cerebrovascular lesions.

Benzodiazolium ENaC inhibitors aim to prolong lung action and limit hyperkalaemia.

Modified microRNAs replace selected uracils with 5-halouracil to improve cancer targeting, stability, and treatment resistance.

Specific lipid ratios and ammonium sulfate loading reduce leakage while supporting AUC, half-life, and antitumor activity.

This case combines PD-1 and CTLA-4 blockade in modified peptides to improve stability, binding, and immune response enhancement.

This case uses C24–C40 VLCPUFAs to improve retinal function by stabilizing highly curved membranes that EPA and DHA do not address.

This formulation uses segmented meloxicam microgranules and enteric coating to accelerate dissolution and support effective pain relief.

A PLGA-PEG-PLGA hydrogel gels at body temperature, retaining hydrophobic immunoadjuvants and enabling imaging-guided delivery.

Fused pyrrolinone compounds target selective HPK1 inhibition with stable metabolism.

Charged stabilizers reversibly protect RNA from hydrolysis while preserving encapsulation and transfection efficiency.

An enteric-coated C21 dosage form protects the compound from gastric fluids and supports stable delivery to the small intestine.

Formula I neuroactive steroids target GABAA receptors to expand CNS treatment options for depression, anxiety, and seizures.

This case uses agents that reduce BRG1 and BRM levels or activity to address metastasis and resistant cancers.

This case uses Formula 1 compounds to reduce OPN and RUNX2 expression, offering a drug approach to valvular calcification.

Medium- and macro-cyclic benzyl heterocycles target brain OX2R signaling to promote wakefulness and reduce cataplexy-like events.

This case uses bifunctional PROTAC molecules to recruit E3 ligases, degrade ENL, and suppress tumor growth.

This case uses deuterium substitution to improve ambroxol stability and prolong action despite greater manufacturing complexity.

This LB injectable depot uses surfactants, recrystallization, and micronization to limit aggregation and extend action.

Water-soluble polymers help arbekacin adhere to mucin, reach the conjunctiva, and stabilize the tear film.

This case uses 50–100 μm bupropion microparticles with cysteine and Carbopol 971P to improve dissolution, stability, and pharmacokinetics.

Amino acid-chelated zinc targets dendritic cell maturation with lower concentrations.

Tuned lipid ratios and PEG-ligand functionalization improve nucleic acid delivery specificity for lung and B-cell targets.

This case uses cationic-surface lipid nanoparticles to improve mucosal cell uptake, mRNA expression, and respiratory immunity.

This case uses PSMA ligands and chelators to deliver radioactive cargo by endocytosis for sustained cancer-cell retention.

A multi-screw extruder continuously mixes drug, lubricant, and carrier powders to reduce variability and improve aerosol performance.

Explore chemically modified mRNA 5′ end motifs that improve capping efficiency and stability while reducing immune-stimulatory by-products.

This case defines 0.001–0.01% eye drops, used once or twice daily, for effective intraocular pressure lowering.

An oral nanoparticle blend of Echinacea, zinc, and vitamin C supports URI recovery while avoiding unnecessary antibiotic use.

This case balances glycan release and bacterial viability through controlled reduction, neutralization, filtration, and concentration.

Vegetable oil-derived polyol hydrogels improve tumor targeting and cancer-cell apoptosis while preserving biocompatibility.

Novel octahydrofuro[3,4-b]pyrazines target oral GLP-1 activity while addressing peptide injection complexity and compliance.

Localized substituent changes tune JAK isoform binding, balancing therapeutic coverage with selectivity and side-effect risk.

Hydrolytic degradation and porous diffusion extend lipid nanoparticle release from days to weeks, limiting repeated injections.

Acidic buffering and mixed lipids improve nucleic acid encapsulation, serum stability, and intracellular delivery.

This case modifies 2C-X phenethylamines to improve bioavailability and brain penetration while reducing toxic metabolite formation.

This case examines an uridylic acid agent addressing limited memory enhancement research in healthy individuals.

This case uses heterocyclic compounds to inhibit Polθ-dependent MMEJ, targeting DNA repair vulnerabilities in HR-defective cancer cells.

This case examines oral cobicistat’s CYP3A and P-glycoprotein inhibition, direct SARS-CoV-2 activity, and synergy with remdesivir.

This case examines roluperidone's receptor pathway for treating negative symptoms while supporting BDNF, GDNF, and neuroprotection.

This case uses controlled in vivo conversion to ZMP to improve systemic bioavailability and AMP-activated protein kinase efficacy.

Two-phase separation and crystallization simplify orotic acid derivative production.

Targeted R1 and R2 substitutions retain the prostacyclin core while improving RVSP and Fulton index versus treprostinil.

Amide-linked benzoxazine STING agonists induce interferon-beta and tumor regression.

Water-soluble and pH-sensitive polymers help prevent recrystallization and support consistent API absorption across the GI tract.

A stable polycyclic crystal form supports selective OX2R action, addressing sleepiness and dual-antagonist treatment limits.

By inhibiting polysialic acid cleavage, the composition promotes neuron migration to injury sites while reducing surgical invasiveness.

A gene delivery vector modulates Wisper lncRNA in cardiac fibroblasts, reprogramming transcription to limit fibrosis and remodeling.

Phospholipid-flavagline conjugates exploit tumor lipid environments to improve uptake and limit toxicity to healthy cells.