Special Delivery TRIZ Cases
- Galactose-Targeted Nano Micelle for Liver Co-Delivery
A copolymer nano micelle system co-delivers genes and drugs to liver cells using galactose targeting ligands.
- Ultrasound-Driven Nanomotor Intracellular Delivery
A functionalized nanomotor converts ultrasound energy into mechanical motion to propel through biological media and penetrate living cells.
- dsRNA iRNA Compositions Targeting Complement C5
iRNA compositions direct the RNA-induced silencing complex to degrade C5 mRNA, resolving inadequate reduction of pathological effects in disease models.
- Programmable Cond-siRNA for Conditional Gene Silencing
Segmented cond-sirna strands suppress background activity while maintaining high potency through preliminary duplex assembly.
- CFTR Gene Editing via RNA-Guided Endonuclease and Donor Template
Segmented delivery of guide RNAs and donor DNA templates restores CFTR function by correcting 99% of non-responsive alleles.
- Engineered Extracellular Vesicles for Consistent Therapeutic Efficacy
Engineered extracellular vesicles loaded with specific microRNA cargo resolve potency variability to deliver consistent therapeutic efficacy.
- Retinoid Liposome Carrier for Myelofibrosis Treatment
Retinoid liposomes transport siRNA to bone marrow fibroblasts, suppressing HSP47 gene expression and extracellular matrix production to treat myelofibrosis.
- Magnetic Nanoparticle Delivery for CRISPR Stem Cell Editing
Magnetic core-shell nanoparticles guide CRISPR-Cas9 components into stem cells via magnetofection, bypassing viral vector immunogenicity and mutagenesis risks.
- shRNA Vector Inhibits Intravitreal Neovascularization in Retinopathy of Prematurity
A shRNA vector targets STAT3 mRNA to inhibit intravitreal neovascularization.
- Phosphate Oligomeric Compounds for Targeted Gene Delivery
Phosphate-based oligomeric compounds bind therapeutic agents and penetrate cellular membranes to enable intracellular transport.
- Peptide-Nucleic Acid Complexes for Cellular Delivery
Peptide-anionic substance complexes overcome endosomal retention barriers by facilitating direct cytoplasmic delivery of nucleic acids.
- Internalizing Nucleic Acid Molecule Targeting Cancer Cells
Internalizing nucleic acid molecules bind to cancer cell surface markers and mediate cellular uptake via endocytosis, reducing systemic side effects.
- DNAzyme Nanomotor MicroRNA Activation Intracellular
An RNA bridge activates a DNAzyme motor via microRNAs, enabling intracellular movement without external energy.
- Protease-Resistant VLP Capsids for Nucleic Acid Purification
Protease-resistant virus-like particles protect nucleic acid cargo from degradation during purification, enabling high-efficiency separation of siRNA and mRNA.
- Nanopore Lipid Bilayer Sequencing Speed
Lipid bilayer nanopores detect nucleic acid subunits via electrical current changes.
- Exonuclease-Resistant Polynucleotide Blocker Domain Design
Segmenting the polynucleotide with a localized blocker domain protects against exonuclease degradation, enabling controlled therapeutic cargo release.
- RNA Aptamers Targeting Mitochondrial HSP70 for Pancreatic Cancer Delivery
Nucleic acid compositions bind cell surface mitochondrial HSP70 to internalize therapeutic agents into cancer cells.
- MAGE-A3 Aptamer Specificity via SELEX and Conjugation
SELEX optimization and chemical conjugation enhance binding specificity for MAGE-A3 peptides, addressing insufficient affinity of existing aptamers.