Transferases TRIZ Cases
- Recombinant miRNA Plasmid Composition for Target Kinase Downregulation
Engineered plasmids boost miRNA production to degrade target kinase mRNA and reduce biomolecule bioavailability in disease treatment.
- Engineered Yeast Gene Duplications for Aerobic Xylose Fermentation
Gene duplications plus HOG1, ISU1, GRE3, and IRA2 deletions let engineered yeast ferment xylose to ethanol at practical rates.
- Recombinant miRNA Plasmid Composition for Kinase Overexpression
miRNA-encoding plasmids suppress overexpressed kinase mRNA through targeted degradation, helping restore cellular homeostasis in disease.
- Recombinant Microorganisms for Acetovanillone Phosphorylation
Engineered microbes use a mutant aromatic kinase to phosphorylate acetovanillone, improving lignin aromatic catabolism into useful chemicals.
- Engineered Methylobacteriaceae Fermentation of C1 Feedstocks to Glycolic Acid
Engineered Methylobacteriaceae uses glyoxylate reductase to turn methanol or formic acid into glycolic and lactic acid with less fossil reliance.
- ATP Regeneration Reaction pH Control Using Divalent Metal Bases
Using magnesium hydroxide or oxide to hold pH in coupled ATP regeneration and enzymatic reactions improves yield while cutting buffer load.
- Artificial circRNA Hybridization for Repeat Expansion mRNA Structures
Artificial circRNAs bind repeat-expanded mRNAs to disrupt pathological secondary structures, restore splicing, and directly target disease mechanisms.
- Engineered Prenyltransferases for Higher-Yield Cannabinoid Biosynthesis
Recombinant prenyltransferases with tuned amino acid sequences raise cannabinoid yield and product ratio while avoiding complex, high-impact synthesis.
- Engineered Transaminase Polypeptides for Stable Broad-Substrate Synthesis
Targeted residue changes improve transaminase stability, activity, and substrate scope for more efficient chiral amine synthesis.
- ATP Regeneration Reaction pH Control Without Buffer Overload
A divalent-metal basic compound maintains pH during ATP-coupled enzymatic synthesis, improving yield and productivity while easing purification.
- ClpB Chaperone Engineering for Higher PHA Productivity
ClpB chaperone expression helps PHA-producing microorganisms prevent protein aggregation and sustain higher polymer accumulation under stress.
- Plasma Kallikrein Antibody Dosing for Sustained HAE Control
Adaptive antibody dosing keeps plasma levels above 80 nM to sustain kallikrein inhibition in hereditary angioedema without dose-limiting toxicity.
- Oxide-Responsive Protein Nanocapsules for Reversible Cargo Release
Engineered AaLS protein cages use oxide-triggered open-close switching to load and release macromolecular cargo under mild physiological conditions.
- Recombinant Plasmid miRNA Composition for Kinase mRNA Silencing
Recombinant plasmids boost miRNA production to degrade kinase mRNA, lowering abnormal kinase expression and helping restore homeostasis.
- miRNA Plasmid Composition for Targeted Kinase Downregulation
Plasmid-encoded miRNA boosts intracellular silencing of kinase mRNA, improving control of disease-linked overexpression.