A fermentation medium for producing mupirocin and a method for producing mupirocin

By optimizing the composition of the fermentation medium and temperature control, and combining it with a batch feeding method, the problem of unsatisfactory potency in mupirocin fermentation production was solved, achieving efficient and low-cost mupirocin fermentation production.

CN115820763BActive Publication Date: 2026-07-21ZHEJIANG HISUN PHARMA CO LTD
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Patent Information

Application Number
CN202211744274.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-11-01
Publication Date
2026-07-21
Estimated Expiration
2042-11-01

AI Technical Summary

Technical Problem

The existing mupirocin fermentation production process has problems such as unsatisfactory potency, high cost, and complicated operation.

Method used

Mupirocin was produced in a fermentation medium using Pseudomonas fluorescens HS-PF20-62, with optimized fermentation medium composition and temperature control, combined with a fed-batch method. The fermentation medium consisted of glucose, soybean meal, cottonseed meal, and ammonium sulfate. The fermentation temperature was 21-23℃, and glucose solution was added in batches over 48-96 hours.

Benefits of technology

It significantly improved the fermentation potency of mupirocin to over 12000 mg/L, reduced production costs, simplified the operation process, and is suitable for industrial production.

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Abstract

The present application relates to a kind of fermentation medium of mupirocin and the production method of mupirocin.The present application improves fermentation medium and the production method of mupirocin, significantly improves the fermentation level of mupirocin, and when fermenting 5-7 days, the fermentation titer reaches 12000mg / L or more.The whole production process is cheap and easy to obtain, and the fermentation process is simple and easy to operate, which is beneficial to industrial production.
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