M1 macrophage targeting polypeptides and uses thereof

By designing and synthesizing the M1 macrophage targeting peptides M1pep1 and M1pep2, the problem of the lack of M1 macrophage targeting peptides in the existing technology was solved, and specific binding to M1 macrophages was achieved, which has good application prospects in the diagnosis and treatment of inflammatory diseases, metabolic diseases and tumors.

CN116554273BActive Publication Date: 2025-10-10FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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Patent Information

Application Number
CN202310464016.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-04-26
Publication Date
2025-10-10
Estimated Expiration
2043-04-26

AI Technical Summary

Technical Problem

The existing technology lacks high-affinity and high-specificity molecular detection methods for M1 macrophages. The application of targeting peptides in M2 macrophages has been reported, but the research on M1 macrophage targeting peptides has not been reported.

Method used

Two M1 macrophage-targeting peptides, M1pep1 and M1pep2, were designed and synthesized, namely FSDDCYDCRIPR and VHAVPIRTIYYP, respectively. They were prepared by phage panning and chemical synthesis methods and used to prepare peptide-conjugated drugs and probes to achieve specific binding to M1 macrophages.

Benefits of technology

It achieves highly specific binding to M1 macrophages and has good application prospects in the diagnosis and treatment of inflammatory diseases, metabolic diseases and tumors.

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Abstract

The application discloses M1 type macrophage targeting polypeptides and application thereof, and belongs to the technical field of biological medicine. The application provides M1 type macrophage targeting polypeptides M1pep1 and M1pep2. Firstly, positive sequences are obtained through construction of a phage library and phage panning, polypeptides are obtained through a chemical synthesis method, and finally, the macrophage targeting polypeptides M1pep1 and M1pep2 are obtained through verification by flow cytometry and laser confocal experiments. The macrophage targeting polypeptides obtained by the application have small molecular weights, can be prepared into polypeptide coupled drugs or small molecule probes, and have good application prospects in the fields of diagnosis or treatment of diseases in which M1 type macrophages are widely involved, such as inflammatory diseases, metabolic diseases and tumors.
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