An oral suspension of sodium zirconium cyclosilicate and its preparation method
Through the combination of xanthan gum and locust bean gum and cellulose, the problem of sedimentation of sodium zirconium silicate oral powder in water is solved, stability and rapid disintegration are achieved, and patients' medication compliance and efficacy are improved. It is suitable for patients with hyperkalemia.
Patent Information
- Application Number
- CN202310554196.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-05-17
- Publication Date
- 2025-07-25
- Estimated Expiration
- 2043-05-17
AI Technical Summary
The existing oral powders of sodium zirconium silicate are easily settled in water, resulting in patients not being able to take them completely, and there is a sense of gravel, which affects compliance and efficacy, especially in children, and the existing suspension potassium ion exchange capacity or the use of a large number of suspensions makes it viscous and difficult to fill.
A mixture of xanthan gum and locust bean gum is used as a suspension agent, combined with cellulose and an appropriate amount of flavoring agent, a zirconium silicate oral suspension is prepared, and the suspension is controlled between 0.01 and 0.30%, and by controlling the particle size and viscosity, the suspension is stable and rapidly disintegrating in long-term storage.
It has achieved good dispersion stability and rapid disintegration of the cyclic zirconium silicate suspension, improved the patient's medication compliance, ensured that the efficacy of the drug is not affected, and was suitable for patients with hyperkalemia, especially children, and reduced the difficulty of production and filling.