A microfluidic device for studying nanoparticle transport across membranes

By using microfluidic technology and ultraviolet curing technology to generate porous media, combined with sucrose aqueous solution and temperature control, the problem of observing nanoparticles in opaque porous media was solved, enabling low-cost visualization research.

CN117732523BActive Publication Date: 2026-08-28DALIAN UNIV OF TECH
6 Cites 0 Cited by

Patent Information

Application Number
CN202410025412.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-01-08
Publication Date
2026-08-28
Estimated Expiration
2044-01-08

AI Technical Summary

Technical Problem

Existing technologies make it difficult to directly observe and predict the transport patterns of nanoparticles in opaque porous media, and commonly used refractive index matching liquids are harmful to the human body, lacking a universal model.

Method used

Porous media were prepared using microfluidic technology, and opaque structures were generated by UV curing. Refractive index matching was performed using sucrose aqueous solution. Nanoparticle motion was measured by fluorescence microscopy and nanoparticle tracking technology, and a temperature control system was used to ensure temperature stability.

Benefits of technology

It enables the visual observation of nanoparticles in porous media, avoids media contamination, provides a low-cost method for studying nanoparticle transport, and is suitable for the visualization study of porous materials.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The application provides a microfluidic device for studying nanoparticle transmembrane transport, and belongs to the technical field of microfluidic chips. A porous medium film is generated in a non-contact manner inside a microfluidic channel by using ultraviolet light curing technology, the temperature of the microfluidic channel is controlled by using silver-containing epoxy resin, and the refractive index of the opaque porous medium is adjusted by using a sucrose aqueous solution. The diffusion movement of particles can be measured by a single particle tracking method of fluorescence microscopic imaging, and a particle movement trajectory image is obtained after processing. Compared with other devices, the application has the advantages of simple structure, low cost, convenient operation, and can be applied to oil exploitation, functional polymer membranes, basic biomedical research and clinical rapid detection and the like.
Need to check novelty before this filing date? Find Prior Art