Diclofenac sodium pellet and preparation method thereof
By using purified water and specific auxiliary materials, the safety hazards and hygroscopic problems of flammable solvents in the production of diclofenac sodium micropills are solved, a safer and more economical production process is achieved, and the stability and release efficiency of the drug are improved.
CN119700714APending Publication Date: 2025-03-28ZHEJIANG LIBERI BIOPHARMACEUTICAL CO LTD
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Patent Information
- Application Number
- CN202510237240.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-02
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
When producing diclofenac sodium micropellets, the use of flammable organic solvents poses safety risks, and the hygroscopicity of diclofenac sodium in high humidity environments will lead to increased production costs and reduced drug stability.
Method used
Purified water is used as a binder, combined with microcrystalline cellulose and colloidal silica and other auxiliary materials, and the hygroscopicity of diclofenac sodium is reduced through the mechanism of physical adsorption and forming a physical barrier, and the production process is simplified.
Benefits of technology
It significantly reduces safety risks and costs in the production process, and at the same time improves the stability and release efficiency of diclofenac sodium micropellets.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the field of pharmaceutical preparations, in particular to a diclofenac sodium pellet and a preparation method thereof, and the diclofenac sodium pellet comprises a pellet core, a diclofenac sodium medicine layer and a coating layer from inside to outside; wherein the diclofenac sodium medicine layer comprises 35%-50% of diclofenac sodium, 15%-30% of microcrystalline cellulose, 0.2%-2% of PVP (Polyvinyl Pyrrolidone) and 0.2%-2% of colloidal silicon dioxide. According to the diclofenac sodium pellet disclosed by the invention, organic solvents such as isopropanol, ethanol and the like are abandoned in the preparation process, the formula is more environment-friendly, the process is simpler, and more importantly, the technical threshold and the process requirements in the production process are remarkably reduced.
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