Application of plasmacytoid dendritic cells as a marker in pediatric sepsis prognostic products

By detecting the pDC level in the peripheral blood of children with sepsis, determining the cutoff value using ROC curves, and combining dynamic monitoring, this method solves the problem of the inability to accurately assess the immune status of children with sepsis in existing technologies. It achieves highly specific and sensitive prognostic assessment and guides personalized treatment.

CN119716052BActive Publication Date: 2025-11-28CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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Patent Information

Application Number
CN202510045631.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-10
Publication Date
2025-11-28
Estimated Expiration
2045-01-10

AI Technical Summary

Technical Problem

Existing methods for assessing the prognosis of sepsis mainly rely on organ function scoring systems, which lack timely reflection of the state of the immune system. In particular, they cannot effectively identify immune imbalances in the early stages, making it difficult to accurately predict the prognosis of children with sepsis.

Method used

The level of plasmacytoid dendritic cells (pDCs) in the peripheral blood of patients was detected by flow cytometry. The optimal cutoff value of 0.96% was determined by ROC curve. A value higher than this indicates a higher risk of death. The dynamic monitoring of pDC changes guides personalized treatment.

Benefits of technology

It enables early identification of high-risk sepsis patients, improves the specificity and sensitivity of prognostic assessment, allows for timely adjustment of treatment strategies, and reduces mortality.

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Abstract

The present application relates to the technical field of medical immunology, and particularly relates to application of plasma cell-like dendritic cells as a marker in a prognosis product for children sepsis. The present application detects the pDC level in the peripheral blood of a patient based on flow cytometry, and evaluates the prognosis of the patient based on the expression level. The pDC expression level is significantly positively correlated with the children sepsis score (Phoenix and pSOFA score), and is positively correlated with the mortality rate of children with sepsis. When the expression of pDC is higher than 0.96%, it indicates that the patient has a higher risk of death. The method of the present application can provide accurate prognosis evaluation in the early screening of children sepsis, has high specificity and sensitivity, helps doctors to timely adjust the treatment scheme, optimizes personalized treatment, and has good practical application value.
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