A polyglycolated calixarene compound, and a preparation method and application thereof

Nanomicelles constructed by PEGylated calixarane compounds have solved the problems of long treatment cycles and poor water solubility of existing drugs in the treatment of inflammatory diseases. They have enabled precise loading and release of multiple drugs, enhanced anti-inflammatory effects, simplified the synthesis process, and improved biocompatibility and stability.

CN119875106BActive Publication Date: 2026-03-20CHINA PHARM UNIV
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Patent Information

Application Number
CN202510076363.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-17
Publication Date
2026-03-20
Estimated Expiration
2045-01-17

AI Technical Summary

Technical Problem

Existing drugs for treating inflammatory diseases have problems such as long treatment cycles, poor water solubility, gastrointestinal irritation, and osteoporosis side effects. In addition, the nitric oxide absorption system is relatively simple, making it difficult to achieve effective treatment results.

Method used

A polyethylene glycolated calixarene compound was developed, which was used to construct a macrocyclic carrier by linking azo bonds, combined with hydrophilic polyethylene glycol segments to form an amphiphilic molecule, which self-assembled into nanomicelles for regulating nitric oxide absorption under hypoxic conditions, and achieving precise drug release and nitric oxide absorption through the action of azo reductase.

Benefits of technology

It achieves precise loading and release of multiple drugs, enhances anti-inflammatory effects, simplifies the synthesis process, improves drug biocompatibility and stability, and synergistically treats inflammatory diseases.

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Abstract

The application discloses a kind of polyethylene glycol cupped aromatic compounds and its preparation method and application, the polyethylene glycol cupped aromatic compound is connected by diazotization reaction by skeleton molecule and the diamino benzoic acid with metaposition protection, and then by upper end free carboxyl modification hydrophilic polyethylene glycol molecule to construct amphiphilic molecule;The compound can prepare nanomicelle assembly by film dispersion method, and simultaneously in macrocyclic cavity, anti-inflammatory drug can be loaded by host-guest interaction;The compound can realize drug release and nitric oxide absorption in anoxic environment, as a kind of cupped aromatic nanodrug system, in drug loading and nitric oxide absorption synergistic treatment anoxic related inflammation has important application value.
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