An HSV-1 type nanoparticle vaccine, its preparation method and application
By mutating specific amino acids in the HSV-1 Pre-F gB protein and fusing it with ferritin, a nanoparticle vaccine was prepared, which solved the problems of insufficient stability and immunogenicity in the prevention and treatment of HSV-1 virus in the existing technology and achieved effective immune protection.
CN119978075BActive Publication Date: 2026-06-30BEIJING GENEVAX BIOTECHNOLOGY CO LTD +1
2 Cites 0 Cited by
Patent Information
- Application Number
- CN202411975612.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2026-06-30
- Estimated Expiration
- 2044-12-30
AI Technical Summary
Technical Problem
Current technologies lack effective methods for preventing or treating HSV-1 herpes simplex virus, especially for infections of the oral mucosa, face, and other sites caused by it, and existing vaccines lack stability and sufficient immunogenicity.
Method used
By mutating specific amino acids in the HSV-1 Pre-F gB protein to form a Pre-F gB mutant protein, and fusing it with ferritin, the protein is displayed on the surface of nanoparticles to prepare an HSV-1 nanoparticle vaccine, thereby enhancing the stability and immunogenicity of the protein.
Benefits of technology
It enhances the binding activity of HSV-1 virus antibodies, enabling effective cellular immune responses to be elicited at low doses, providing immune protection against HSV-1 virus.
✦ Generated by Eureka AI based on patent content.
Abstract
This invention relates to an HSV-1 nanoparticle vaccine, its preparation method, and its application. The nanoparticles comprise HSV-1 PreF gB mutant protein and ferritin. After assembly, multiple PreF gB mutant proteins are concentrated and displayed on the surface, forming ferritin-PreF gB nanoparticles. The mutation of PreF gB enhances the stability and effective immunogenicity of the gB protein, and its display on the nanoparticle surface further enhances immunogenicity, effectively stimulating the body's cellular immune mechanism, thus becoming an effective vaccine for preventing HSV infection.
Need to check novelty before this filing date? Find Prior Art