Composition for dental plaque color development, oral care product as well as preparation method and application of oral care product

Abstract

The invention relates to the technical field of oral care products, in particular to a composition for dental plaque color development, an oral care product and a preparation method and application of the oral care product. According to the scheme, the composition for dental plaque color development comprises the red pigment and the PVM / MA copolymer, the red pigment and the PVM / MA copolymer are combined to be used for preparing oral care products, and the dental plaque dyeing effect of toothpaste containing a color developing agent is improved in the aspect of dental plaque color development; the technical problem that in the prior art, an oral care product with an ideal dental plaque developing effect and an ideal cleaning effect is lacked is solved. The composition of the scheme is applied to oral care products including toothpaste, and the enrichment of the bacterial plaque developing pigment on the bacterial plaque can be promoted and the bacterial plaque developing effect can be enhanced through the operations of tooth brushing, mouth rinsing, tooth brushing and the like. The oral care product containing the composition disclosed by the invention not only can help a user to effectively clean the oral cavity, but also has enhanced effects of preventing and removing dental plaque, and has a good application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of oral care products, and specifically relates to a composition for dental plaque color development, an oral care product, and a preparation method and application thereof. Background Art

[0002] Dental plaque, as a bacterial community wrapped by a matrix, adheres tightly to the tooth surface, tooth gaps or restorations, forming a soft and unmineralized biofilm. This biofilm is not only difficult to remove by conventional rinsing or gargling, but also almost imperceptible to the naked eye due to its colorless property. If not removed in time, dental plaque gradually mineralizes under the action of saliva and finally forms dental calculus, becoming one of the main causes of periodontal diseases. Therefore, developing oral care products that can effectively identify and remove dental plaque has important market value and health significance.

[0003] Currently, the color development of dental plaque mainly relies on chemical staining methods, that is, using specific pigments to attach to the plaque for visual detection. Although dental clinics use professional plaque indicators or color development solutions for diagnosis, the proportion of people who regularly visit dentists is relatively low. If the dental plaque color development technology can be perfectly combined with daily-use toothpaste, it can not only expand the beneficiary population, but also significantly improve the cleaning efficiency of dental plaque. Ideally, such a product should allow users to observe the location of dental plaque by themselves, so as to clean it targeted.

[0004] However, most of the existing solutions stay on the basis of simply mixing color developers and toothpaste, which leads to problems of poor coloring effect and insufficient cleaning efficiency. The dental calculus staining agents currently available on the market, including iodine-containing liquid medicine, neutral red liquid, basic fuchsin liquid, malachite green liquid and fluorescein liquid that requires special light source irradiation to appear, as well as finished dental calculus display liquid and chewable tablets, although they provide certain help, have many inconveniences in actual application. The use of these products is often complex and requires professional guidance, and they do not fully meet the daily habits of consumers in terms of taste and easy cleaning, limiting their popularity. In addition, when providing oral hygiene guidance, dentists also tend to avoid using these products with single staining function and difficult to remove.

[0005] In view of the above situation, there is an urgent need to develop a new type of oral care product, which should have a significant color development effect, and at the same time be able to accurately locate and effectively remove dental plaque according to the color development result, providing users with a more convenient and efficient oral care experience. Summary of the Invention

[0006] The purpose of the present invention is to provide an oral care product for dental plaque color development, so as to solve the technical problem that there is a lack of oral care products with ideal dental plaque color development effect and cleaning effect in the prior art.

[0007] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] A composition for dental plaque coloring, comprising a red pigment and a PVM / MA copolymer.

[0009] In some embodiments, the red pigment is fluorescent pink or / and erythrosine.

[0010] In some embodiments, the proportion of the red pigment is 60-90%, and the remaining component is the PVM / MA copolymer.

[0011] This technical solution also provides an oral care product containing a composition for dental plaque coloring, and the oral care product includes toothpaste, mouthwash, dental powder, dental gel or chewing gum.

[0012] The using process of the toothpaste of this solution is as follows: First, use the toothpaste to smear the teeth. The dental plaque will be quickly stained. After smearing and rinsing with clear water, the stained dental plaque can be clearly shown (the staining substance in the toothpaste plays the role of marking the dental plaque). The user can perform the brushing operation according to the position where the dental plaque is colored, and focus on cleaning the position where the dental plaque is located. The toothpaste prepared with the specially made composition for dental plaque coloring of this solution has the following remarkable functions and optimized user experience:

[0013] Quick and accurate coloring: After the user smears the toothpaste and rinses with clear water, the dental plaque can be quickly stained and clearly shown. This characteristic enables the user to visually identify the specific position of the dental plaque, providing a clear guidance for subsequent cleaning.

[0014] Targeted cleaning: Based on the coloring result, the user can focus on brushing these areas according to the actual distribution of the dental plaque, ensuring key cleaning and improving the cleaning efficiency and effect.

[0015] Dual functions of indication and cleaning: The toothpaste of this solution not only plays the role of indicating the dental plaque, but also helps to further remove the identified dental plaque through its excellent cleaning performance. This dual-effect design aims to improve the user's oral hygiene level and prevent the occurrence of periodontal diseases.

[0016] Enhance self-care awareness: Through intuitive visual feedback, the user can more clearly understand their own oral health status, thereby promoting the formation of good oral care habits and encouraging regular and effective personal oral maintenance.

[0017] In summary, the toothpaste of this solution combines high-efficiency dental plaque coloring technology and excellent cleaning ability, providing an innovative and practical oral care tool for users, making the cleaning process more scientific and effective, and contributing to maintaining oral health in the long term.

[0018] In some embodiments, an oral care product comprises raw materials in the following parts by weight: 0.15 - 3 parts of a dental plaque chromogenic composition, 10 - 70 parts of a humectant, 0 - 60 parts of an abrasive, 0.1 - 10 parts of a thickener, 0.1 - 20 parts of a surfactant, 0.1 - 2 parts of a sweetener, and 0.1 - 5 parts of a flavor;

[0019] The dental plaque chromogenic composition comprises 0.1 - 2 parts of a red pigment and 0.05 - 1 part of a PVM / MA copolymer;

[0020] Preferably, the dental plaque chromogenic composition is 0.15 - 3 parts, the humectant is 20 - 60 parts, the abrasive is 10 - 50 parts, the thickener is 0.5 - 3 parts, the surfactant is 0.1 - 5 parts, the sweetener is 0.1 - 0.5 parts, and the flavor is 0.1 - 2 parts;

[0021] The dental plaque chromogenic composition comprises 0.1 - 1 part of a red pigment and 0.05 - 0.35 part of a PVM / MA copolymer.

[0022] With the above technical solution, the above formula is a formula for preparing toothpaste. Toothpaste is the most common and most frequently used oral cleaning product. Adding a plaque chromogenic composition to toothpaste can achieve better plaque chromogenic and tooth cleaning effects.

[0023] The plaque chromogenic composition of the red pigment and the PVM / MA copolymer can be added to oral care products to achieve dental plaque chromogenic while cleaning the oral cavity. According to the above formula, by selecting appropriate dosages of raw materials, products such as toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum, etc. can be prepared.

[0024] In some embodiments, the thickener comprises a first thickener and a second thickener; the first thickener comprises at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium polyacrylate, and carbomer; the second thickener is xanthan gum;

[0025] The mass ratio of the first thickener to the second thickener is 40 - 65:20 - 10, preferably 6:1.

[0026] With the above technical solution, hydroxyethyl cellulose, cellulose gum, carrageenan, sodium polyacrylate, and carbomer are thickeners that can be used in toothpaste. These thickeners need to be used in combination with xanthan gum to ensure the dispersion uniformity and stability of the plaque chromogenic composition in oral care products. Secondly, xanthan gum can also effectively maintain the stability of the paste.

[0027] In some embodiments, the humectant comprises a first humectant and a second humectant; the first humectant comprises at least one of glycerol, sorbitol, and propylene glycol; the second humectant is polyethylene glycol

[0028] The mass ratio of the first humectant to the second humectant is 5 - 50:5 - 20, preferably 40 - 50:20, and further preferably 4:1 - 5:1.

[0029] With the above technical solution, glycerol, sorbitol and propylene glycol are humectants that can be used in toothpaste, and polyethylene glycol as a humectant needs to be combined to ensure the stability of oral care products.

[0030] In some embodiments, the abrasive includes at least one of calcium carbonate, hydrated silica, dicalcium phosphate and calcium pyrophosphate; the surfactant includes at least one of anionic, cationic, amphoteric and nonionic surfactants; the sweetener includes at least one of sodium saccharin and sucralose.

[0031] The above abrasives, surfactants, etc. are commonly used substances in the prior art, with good safety and stability, low price and easy availability.

[0032] This technical solution also provides a preparation method of oral care products, including the following steps carried out in sequence:

[0033] S1: Mix the red pigment, PVM / MA copolymer and the second thickener to form mixture A;

[0034] S2: Disperse mixture A in part of polyethylene glycol A to form mixture B;

[0035] S3: Disperse the first thickener in part of polyethylene glycol B, and then add the first humectant, and after swelling, form mixture C;

[0036] S4: Add the sweetener, surfactant and water to mixture C, and after homogenization, obtain mixture D;

[0037] S5: Mix and stir mixture D and mixture B to form mixture E;

[0038] S6: Add the abrasive to mixture E and mix well to obtain mixture F;

[0039] S7: Add the essence to mixture F, homogenize, degas, and fill into a toothpaste tube;

[0040] Or include the following steps carried out in sequence:

[0041] S1: Mix the red pigment, PVM / MA copolymer and the second thickener, and then mix them with polyethylene glycol, starch and water in a ratio of 10 - 30:10 - 20:40 - 80:5 - 15 to make a 70 - 200 - mesh pill composition;

[0042] S2: Disperse the first thickening agent in the remaining polyethylene glycol, then add the first humectant, and form a first mixture after swelling.

[0043] S3: Add a sweetening agent, a surfactant, and the remaining water to the first mixture, and obtain a second mixture after homogenization.

[0044] S4: Mix and stir the second mixture and the ball composition to form a third mixture.

[0045] S5: Add an abrasive to the third mixture and mix evenly to obtain a fourth mixture.

[0046] S6: Add a flavor to the fourth mixture, homogenize, degas, and fill into a toothpaste tube.

[0047] Furthermore, the mass ratio of the polyethylene glycol A part to the polyethylene glycol B part is 10 - 30:40 - 60, preferably 20 - 30:40 - 55.

[0048] Adopting the above technical solution, the above preparation method is suitable for preparing toothpaste. During the preparation process, the red pigment, PVM / MA copolymer, and xanthan gum are fully dispersed in polyethylene glycol, so as to increase the full contact between the red pigment and the PVM / MA copolymer, improve the dispersion uniformity and stability of the plaque chromogenic composition, and form a stable framework structure for the toothpaste (representing oral care products). Secondly, the second thickening agent is fully contacted and mixed with polyethylene glycol and the humectant, and then fully dissolved with water. After mixing the two kinds of glue solutions, other components are added. In this way, the preparation process ensures the stability of the toothpaste (representing oral care products) and the plaque chromogenic effect of the red pigment.

[0049] In addition to toothpaste, the composition of this solution can also be used for the preparation of other oral cleaning products such as liquid toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum. The composition formed by the red pigment and the PVM / MA copolymer can be added to the corresponding products according to the conventional means of the existing technology.

[0050] In summary, the technical principle and beneficial effects of this technical solution are as follows:

[0051] A composition for tooth plaque chromogenic provided by this invention patent combines and adds the properties of two components, the coloring agent red pigment and the PVM / MA copolymer, to obtain a composition component that can promote the enhancement of the plaque chromogenic effect, helping users effectively clean tooth plaque and prevent periodontal diseases.

[0052] In this solution, red pigments (fluorescein and / or erythrosine) and PVM / MA copolymer are simultaneously used in the preparation of oral care products, and an ideal plaque color development effect can be obtained, further enhancing the effect of the red pigment as a colorant. The inventor analyzed the principle of the synergistic effect between the red pigment and PVM / MA copolymer: PVM / MA copolymer can effectively adhere to the tooth surface, and it can be fully mixed with the red pigment as a colorant, thereby enhancing the adsorption of the red pigment on dental plaque, especially strengthening the color development effect on invisible plaque, achieving the effects of preventing and timely removing dental plaque. More specifically, the inventor further analyzed the synergistic principle: In this invention, both fluorescein and erythrosine, the two red pigments, are organic edible synthetic pigments, and their molecular structures contain ester bonds (-COO-), carbonyl bonds (-CO-), ether bonds (-O-), carbon-halogen bonds (C-X), etc. As common colorants, they are not easily colored or the color development is not obvious on dental plaque due to the influence of other chemical substances. There are a large number of N-H bonds and C-H bonds in the molecular structure of PVM / MA copolymer. PVM / MA copolymer has good adsorption to organisms. A large number of N-H bonds and C-H bonds in the PVM / MA copolymer molecule can form intermolecular hydrogen bonds with fluorescein or erythrosine, increasing the adsorption rate and utilization rate of these two red pigments, enhancing the adhesion of fluorescein or erythrosine on teeth, and improving the plaque color development effect of these two pigments, especially the clarity and uniformity of plaque staining.

[0053] In addition to promoting dental plaque color development, the oral care products containing the composition of this solution also have good dental plaque cleaning effects. In addition to the conventional components in oral care products, the PVM / MA copolymer added in this formula has the properties of promoting dental plaque cleaning and oral cleaning. First, PVM / MA copolymer has a unique multi-carboxyl structure and excellent acid-base buffering ability, which can play a role in maintaining the relative stability of the pH value of the tooth surface and oral mucosa. Second, PVM / MA copolymer has extremely strong chelating ability, and its chelating ability is several times that of chelating agents such as sodium pyrophosphate and sodium phytate often used in toothpaste formulations. It can itself chelate some enzymes in the oral cavity, thereby inhibiting the formation of dental calculus. Third, PVM / MA copolymer forms a film on the oral mucosa and tooth surface, which helps to improve the residence of active substances on the tooth surface, solubilize poorly soluble components, and improve the bioavailability of active substances.

[0054] The inventors further applied the dental plaque coloring composition composed of PVM / MA copolymer, phloxine and / or erythrosine in toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum. In use, the two substances work synergistically to achieve the effect of enhancing the coloring of dental plaque, effectively overcoming the influence of surfactants or abrasives in toothpaste on the plaque coloring components. In summary, the beneficial effects of the plaque coloring composition composed of red pigment and PVM / MA copolymer are as follows:

[0055] (1) The PVM / MA copolymer has extremely strong chelating ability, and its chelating ability is several times that of chelating agents such as sodium pyrophosphate and sodium phytate often used in toothpaste formulations. Secondly, the PVM / MA copolymer forms a film on the oral mucosa and tooth surface, which helps to improve the residence of active substances on the tooth surface, solubilize poorly soluble components, and improve the bioavailability of active substances. When the PVM / MA copolymer is in full contact with phloxine or / and erythrosine red pigment, due to the molecular structure characteristics, hydrogen bonds can be formed between molecules, increasing the adhesion of these two red pigments to the tooth surface, and enhancing the plaque coloring effect even in the presence of surfactants or a large amount of abrasives.

[0056] (2) The toothpaste prepared with phloxine or / and erythrosine red pigment in the dental plaque coloring composition of the present invention can enhance the plaque coloring effect, help users effectively clean the oral cavity, and also has the enhanced efficacy of preventing and removing dental plaque. In addition, the applicant also found that thickeners containing xanthan gum and humectants using polyethylene glycol can improve the coloring effect and stability of toothpaste containing the dental plaque coloring composition. Detailed Description of the Invention

[0057] The present invention will be further described in detail below with reference to the embodiments, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the technical means used in the following embodiments and experimental examples are conventional means well known to those skilled in the art, and the materials, reagents, etc. used can all be obtained from commercial channels.

[0058] Overview of the composition, corresponding oral care products and preparation method:

[0059] (1) Composition

[0060] The composition for dental plaque coloring is composed of the following components by weight percentage: the red pigment accounts for 60-90%, and the remaining component is PVM / MA copolymer. The red pigment is one or both of phloxine or erythrosine.

[0061] Both the above-mentioned red pigment and PVM / MA copolymer can be commercially procured from suppliers. Among them, fluorescent pink and erythrosine were purchased from Beijing Orient Kyle Economic and Trade Co., Ltd., food grade. In this technical solution, the PVM / MA copolymer is a copolymer formed by maleic anhydride and methyl vinyl ether, and the molar ratio of maleic anhydride to methyl vinyl ether is 1:4 - 4:1. The specific viscosity value (defined as: using a capillary viscometer with an inner diameter of 0.63 mm to measure the viscosity values of water and a 1% sample respectively, and calculating the ratio of the viscosity value of the 1% sample to the viscosity value of water as the specific viscosity value) is 4 - 10. In subsequent specific experimental studies, the PVM / MA copolymer was purchased from Chongqing Maoye Chemical Reagent Co., Ltd., cosmetic grade; the PVM / MA copolymer is in the form of a molar ratio of maleic anhydride to methyl vinyl ether of 1:1, and the specific viscosity is 7 - 9.

[0062] (2) Toothpaste prepared from the composition

[0063] It is composed of a sweetening agent, a surfactant, other functional ingredients, a flavor, and water. The weight parts of each component are as follows: 0.15 - 3 parts of the dental plaque chromogenic composition (wherein, 0.1 - 2 parts of the red pigment, 0.05 - 1 part of the PVM / MA copolymer; preferably, 0.1 - 1.0 part of the red pigment, 0.05 - 0.35 part of the PVM / MA copolymer), 10 - 70 parts of a humectant (preferably 20 - 60 parts), 0 - 60 parts of an abrasive (preferably 10 - 50 parts), 0.1 - 10 parts of a thickener (preferably 0.5 - 3 parts), 0.1 - 20 parts of a surfactant (preferably 0.1 - 5 parts), 0.1 - 2 parts of a sweetening agent (preferably 0.1 - 0.5 parts), and 0.1 - 2 parts of a flavor.

[0064] Among them, the purity of the red pigment is ≥99.5%; the purity of the PVM / MA copolymer is ≥99.5%. The red pigment includes at least one of fluorescent pink and erythrosine. During the toothpaste formulation process, the total number of raw material parts is 100 parts, and deionized water is used to make up the remaining amount.

[0065] The content range of the thickener is preferably 0.5 - 3 parts. The thickener includes a first thickener and a second thickener; the first thickener is at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium polyacrylate, and carbomer; the second thickener is xanthan gum; the mass ratio of the first thickener to the second thickener is 40 - 65:20 - 10, preferably 6:1.

[0066] The content of the moisturizer is preferably in the range of 20-60 parts, and the moisturizer includes a first moisturizer and a second moisturizer; the first moisturizer includes at least one of glycerin, sorbitol, and propylene glycol; and the second moisturizer is polyethylene glycol. The mass ratio of the first moisturizer to the second moisturizer is 5-50:5-20, more preferably 40-50:10, and further preferably 4:1-5:1. In the present technical solution, the polyethylene glycol specifically uses polyethylene glycol 300.

[0067] The content of the friction agent is preferably in the range of 10-50 parts, including at least one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate.

[0068] The content of the surfactant is preferably in the range of 0.1-5 parts, including at least one of anionic, cationic, amphoteric and nonionic surfactants, such as sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium sulfonate or cocamidopropyl betaine.

[0069] The content of the sweetener is preferably in the range of 0.1-0.5 parts, including at least one of saccharin sodium and sucralose.

[0070] The content of the flavor is preferably in the range of 0.1-2 parts, including at least one of mint, spearmint oil, peppermint and anethole.

[0071] The preparation method of the toothpaste of this scheme is as follows (preparation method 1):

[0072] S1: Red pigment, PVM / MA copolymer and xanthan gum (second thickener) were mixed thoroughly to form mixture A (dry powder mixture).

[0073] S2: Mixture A is fully mixed and dispersed in part of polyethylene glycol (polyethylene glycol A part, polyethylene glycol is the second moisturizer) to form mixture B.

[0074] S3: Fully disperse the first thickener in the remaining polyethylene glycol (polyethylene glycol B part), then add the first humectant, and fully swell to form a mixture C. The mass ratio of polyethylene glycol part A to polyethylene glycol part B is 10-30:40-60, preferably 20-30:40-55. (Subsequent experimental studies use a ratio of polyethylene glycol part A to polyethylene glycol part B of 25:50).

[0075] S4: Add a sweetener, a surfactant and water to the mixture C, and homogenize to obtain a mixture D.

[0076] S5: Mixture D and mixture B are thoroughly stirred to form mixture E.

[0077] S6: Add the friction agent to the mixture E and mix thoroughly to obtain a mixture F.

[0078] S7: Add flavor to the mixture F, degas after homogenization, and then fill it into the toothpaste tube in a conventional manner.

[0079] The toothpaste of this solution can also adopt the following preparation method (Preparation Method 2):

[0080] If the pigment is directly dispersed in the paste, it will cause the paste color to be too dark and affect the consumer experience. Therefore, the inventor wraps the composition for tooth plaque color development in pills, and the pills are brushed open during brushing to promote plaque staining, which can greatly improve the appearance of the oral care product and enhance the consumer experience.

[0081] S1: Thoroughly mix the red pigment, PVM / MA copolymer, and the second thickener. For the mixture formed by the red pigment, PVM / MA copolymer, and the second thickener, mix it with the first polyethylene glycol (i.e., a part of the polyethylene glycol in the formula), starch, and an appropriate amount of water in a ratio of 10 - 30:10 - 20:40 - 80:5 - 15, and form a pill composition of 70 - 200 mesh through mixing, conventional pill making, and drying.

[0082] S2: Disperse the first thickener in the second polyethylene glycol (the remaining part of all the polyethylene glycol after removing the first polyethylene glycol added in the previous step), and then add the first humectant, and form the first mixture after swelling.

[0083] S3: Add the sweetener, surfactant, and the remaining water to the first mixture, and obtain the second mixture after homogenization.

[0084] S4: Mix and stir the second mixture and the pill composition to form the third mixture.

[0085] S5: Add the abrasive to the third mixture and mix well to obtain the fourth mixture.

[0086] S6: Add flavor to the fourth mixture, degas after homogenization, and fill it into the toothpaste tube.

[0087] Examples 1 - 6 show the composition of the tooth plaque color - developing composition, which is as follows:

[0088] Example 1: Tooth plaque color - developing composition for oral care products

[0089] The tooth plaque color - developing composition for oral care products is composed of the following components by weight percentage: 60% red pigment, 40% VM / MA copolymer.

[0090] Example 2: Tooth plaque color - developing composition for oral care products

[0091] A dental plaque chromogenic composition for oral care products, which consists of the following components in percentage by weight: 65% red pigment and 35% PVM / MA copolymer.

[0092] Example 3: A dental plaque chromogenic composition for oral care products

[0093] A dental plaque chromogenic composition for oral care products, which consists of the following components in percentage by weight: 70% red pigment and 30% PVM / MA copolymer.

[0094] Example 4: A dental plaque chromogenic composition for oral care products

[0095] A dental plaque chromogenic composition for oral care products, which consists of the following components in percentage by weight: 75% red pigment and 25% PVM / MA copolymer.

[0096] Example 5: A dental plaque chromogenic composition for oral care products

[0097] A dental plaque chromogenic composition for oral care products, which consists of the following components in percentage by weight: 80% red pigment and 20% PVM / MA copolymer.

[0098] Example 6: A dental plaque chromogenic composition for oral care products

[0099] A dental plaque chromogenic composition for oral care products, which consists of the following components in percentage by weight: 90% red pigment and 10% PVM / MA copolymer.

[0100] Examples 7 - 14 show the process of obtaining toothpaste containing the dental plaque chromogenic composition. For the specific toothpaste formula, please refer to Table 1.

[0101] The total mass fraction of the toothpaste is 100 parts, the sum of other toothpaste raw materials is less than 100 parts, and the balance is made up with water.

[0102] Table 1: Toothpaste formula for dental plaque chromogenic (unit: mass fraction)

[0103]

[0104]

[0105] Experimental Example 1: Stability evaluation and staining effect evaluation

[0106] To verify the stability and chromogenic effect of the toothpaste of the present invention, toothpaste without PVM / MA copolymer but only with red pigment (Group 1 in Table 2), toothpaste with red pigment and PVM / MA copolymer (Group 2 in Table 2), toothpaste without polyethylene glycol (Group 3 in Table 2), and toothpaste without xanthan gum (Group 4 in Table 2) were prepared.

[0107] The formula of group 2 is a specific form of the toothpaste formula (toothpaste containing a plaque coloring composition) of the present embodiment, and the preparation method is referred to the above (preparation method 1). PVM / MA copolymer is not added to group 1, and its preparation method is carried out according to the preparation method (preparation method 1) of the present embodiment, except that PVM / MA copolymer is not added to S1.

[0108] The toothpaste in group 3 does not contain polyethylene glycol, and the specific preparation method is as follows:

[0109] S1: Mix red pigment, PVM / MA copolymer and xanthan gum (second thickener) thoroughly to form mixture A.

[0110] S2: The first thickener (sodium carboxymethyl cellulose) is fully mixed with the humectant (glycerol) to form a mixture B after the mixture is fully swollen.

[0111] S3: Add a sweetener, a surfactant and water to mixture B, and homogenize to obtain mixture C.

[0112] S4: Mixture C and mixture A are fully stirred to form mixture D.

[0113] S5: Add the friction agent to the mixture D and mix thoroughly to obtain a mixture E.

[0114] S6: Add flavor to mixture E, homogenize and degas, and then pour into a toothpaste tube in a conventional manner.

[0115] The toothpaste in group 4 does not contain xanthan gum, and the specific preparation method is as follows: the original steps S1 and S2 are combined, specifically:

[0116] The red pigment and the PVM / MA copolymer are dispersed in a part of polyethylene glycol (polyethylene glycol A part, polyethylene glycol is the second moisturizer) to form a mixture B. The other operation steps are the same as the best embodiment of the preparation method 1.

[0117] The toothpaste in group 5 does not contain PVM / MA copolymer. The preparation method is the same as that of group 3, except that the step of adding PVM / MA copolymer is omitted. The red pigment and xanthan gum are mixed. No polyethylene glycol is added in group 5.

[0118] The remaining steps are carried out with reference to Group 2, that is, with reference to the aforementioned method for preparing a toothpaste containing a dental plaque coloring composition.

[0119] Table 2: Toothpaste formula (total weight parts: 100 parts, this experimental example uses fluorescent pink as an example for explanation, and the effect of using erythrosine is basically the same as that of fluorescent pink)

[0120]

[0121] (1) Stability evaluation

[0122] The inventor observed the stability of the toothpaste in accordance with GB / T 8372-2017. For each group, 2 tubes of sample toothpaste were taken. One tube of the sample was stored at room temperature, and the other was placed in a refrigerator at -8°C ± 1°C. After 8 hours, it was taken out and immediately placed in a constant temperature incubator at 45°C ± 1°C. After 8 hours, it was taken out and restored to room temperature, and then the stability was observed. The stability test results are shown in Table 2.

[0123] The stability test result being "stable" means that after opening the cap, the paste does not overflow from the nozzle; when the toothpaste tube is inverted, no liquid drips from the nozzle within 10 seconds; after the paste is extruded and compared with the sample stored at room temperature, its fragrance and color are normal, and the surface of the toothpaste paste has luster.

[0124] The stability test result being "unstable" means any of the following situations occur: after opening the cap, the paste overflows from the nozzle; when the toothpaste tube is inverted, liquid drips from the nozzle; after the paste is extruded and compared with the sample stored at room temperature, the fragrance and color change, and the surface of the toothpaste paste loses luster.

[0125] In Group 3, polyethylene glycol was not added, resulting in unsatisfactory overall stability of the toothpaste. This shows that polyethylene glycol is very important for maintaining the stability of the toothpaste system containing PVM / MA copolymer and red pigment. From the results of Group 3, it can be seen that when PVM / MA copolymer and red pigment appear together in the toothpaste system, there is a risk of causing instability of the toothpaste system. Comparing the results of Group 3 with those of Group 2, due to the addition of polyethylene glycol, the instability brought by the PVM / MA copolymer in Group 3 disappeared, indicating the role of polyethylene glycol in stabilizing the toothpaste system.

[0126] In Group 4, xanthan gum was not added, resulting in unsatisfactory overall stability of the toothpaste. This shows that xanthan gum plays an important role in the stability of the toothpaste system containing PVM / MA copolymer and red pigment. Comparing the results of Group 4 with those of Group 2, due to the addition of xanthan gum, the instability brought by the PVM / MA copolymer in Group 4 disappeared, indicating the role of xanthan gum in stabilizing the toothpaste system.

[0127] In Group 5, without adding the PVM / MA copolymer (only adding the red pigment), even without adding polyethylene glycol, the overall stability of the toothpaste system is still acceptable. Combining the experimental results of Groups 1 / 2 / 3, this indicates that the main reason for the instability of the system lies in the incompatibility between the PVM / MA copolymer and the specific toothpaste system of this solution. It can be seen that the role of polyethylene glycol is to increase the compatibility between the PVM / MA copolymer and the specific toothpaste system containing the red pigment of this solution, and polyethylene glycol plays a role in enhancing the stability of the specific toothpaste system of this solution, with a very significant effect. However, in other situations (without adding the PVM / MA copolymer), polyethylene glycol does not have an obvious effect on enhancing the stability of the toothpaste system. This further shows that the addition of polyethylene glycol is very crucial for maintaining the stability of the toothpaste system containing the PVM / MA copolymer and the red pigment. There is no relevant report in the prior art that polyethylene glycol has the above functions, which is unexpected by the inventor.

[0128] (2) Dyeing effect test

[0129] Moisten the oral cavity with clean water, squeeze out toothpaste about the size of a soybean (try to ensure that the toothpaste is about 1.375 g) onto a cotton swab dipped in water, apply the toothpaste on the front teeth, and rinse with clean water after 30 s. After sufficient color development, observe the color development effect, and the color development effect can be evaluated from aspects such as dyeing uniformity, dyeing clarity, and dyeing degree. After recording the normal situation of dental plaque, brush teeth and rinse with a toothbrush normally (each volunteer brushes teeth for 2 min and then rinses with a conventional brushing force) to remove the color-developing substance. In this experiment, 225 volunteer testers were randomly selected, aged 24 - 50 years old, with an average age of 30 years old, and randomly divided into 5 groups, with 45 people in each group.

[0130] Among them, the specific explanations of the evaluation indicators are as follows:

[0131] Uniform dyeing: Dental plaque at all positions in the oral cavity is successfully dyed, and the difference in dyeing depth is not significant.

[0132] Non-uniform dyeing: The dyeing degree of dental plaque at all positions in the oral cavity is uneven, with different depths.

[0133] Clear dyeing: The dyeing agent only makes the dental plaque show color and does not dye other parts such as soft tissues.

[0134] Unclear dyeing: The dyeing agent not only makes the dental plaque show color but also dyes other parts such as soft tissues.

[0135] Dyeing degree: The depth of the color of the dental plaque in the oral cavity after dyeing.

[0136] Residue after brushing: After color development, brush teeth and rinse, and observe whether the colored substance still exists on the tooth surface.

[0137] The experimental results are shown in Table 3. The volunteers applied the toothpaste to their teeth, and the coloring effect can be evaluated from aspects such as coloring time, dyeing uniformity, dyeing clarity, and dyeing degree. The experimental results found that the toothpaste of the present invention has a short action time, fast coloring, uniform and clear dyeing, moderate depth, good coloring effect, and no residue in the oral cavity. Compared with the control group, the effect is more excellent.

[0138] Table 3: Experimental results of the dyeing effect of the five groups of toothpastes shown in Table 2 (for each group of 45 subjects, if more than 80% of the subjects showed uniform dyeing, "uniform" was recorded in the table, otherwise it was recorded as "non-uniform"; for each group of 45 subjects, if more than 80% of the subjects showed clear dyeing, "clear" was recorded in the table, otherwise it was recorded as "unclear"; for each group of 45 subjects, if more than 80% of the subjects showed too light dyeing degree, "too light" was recorded in the table; for each group of 45 subjects, if more than 80% of the subjects showed moderate dyeing degree, "moderate" was recorded in the table)

[0139] Group Group 1 Group 2 Group 3 Group 4 Group 5 Dyeing uniformity Non-uniform Uniform Non-uniform Non-uniform Non-uniform Dyeing clarity Unclear Clear Unclear Unclear Unclear Degree of dyeing Too light Moderate Moderate Too light Too light Residue after brushing teeth Yes No No No Yes

[0140] The above experimental results are summarized as follows:

[0141] Toothpaste of Group 1: Red pigment used alone

[0142] The toothpaste of Group 1 only added red pigment and did not contain PVM / MA copolymer. This design led to several deficiencies in the dyeing process:

[0143] Poor dyeing effect: The dyeing uniformity was poor, the dyeing depth was too light, and the clarity was not ideal, affecting the effective identification of dental plaque.

[0144] Non-specific dyeing: It also dyed other parts such as soft tissues, reducing the specificity of the product and the user experience.

[0145] Pigment residue problem: There was still pigment residue on the teeth after brushing, and it was not thoroughly cleaned.

[0146] These drawbacks indicate that using red pigment alone cannot meet the requirements of efficiently detecting and removing dental plaque. This solution aims to make dental plaque easier to detect through an efficient dyeing mechanism, so that targeted cleaning can be carried out after confirming the location, ensuring that dental plaque can be easily removed by mechanical brushing. Obviously, the combined use of PVM / MA copolymer and red pigment is the key to achieving this goal. In addition, Group 5 also did not add PVM / MA copolymer and showed similar results to Group 1.

[0147] Toothpaste of Group 2: PVM / MA copolymer combined with red pigment

[0148] Group 2 toothpaste contains both PVM / MA copolymer and red pigment, which gives the product the following advantages:

[0149] Precise staining: The staining is uniform and does not cause unnecessary staining of other parts such as soft tissues, facilitating user observation.

[0150] Easy to remove: The staining substance can be effectively removed after brushing, maintaining oral hygiene.

[0151] Therefore, the addition of PVM / MA copolymer significantly improves the staining effect of the red pigment and ensures the easy removability of the staining substance.

[0152] Group 3 toothpaste: lacks polyethylene glycol

[0153] Compared with Group 2, Group 3 toothpaste does not contain polyethylene glycol, which results in less-than-expected staining uniformity and unclear staining (there is staining on other parts such as soft tissues). The experimental results prove that in the formulation containing PVM / MA copolymer and red pigment, polyethylene glycol not only helps maintain the paste stability of the toothpaste but also has a positive impact on the staining uniformity, enhancing the overall staining effect.

[0154] Group 4 toothpaste: lacks xanthan gum

[0155] Compared with Group 2, Group 4 toothpaste lacks xanthan gum, which causes several problems:

[0156] Poor staining uniformity: The staining is light and uneven.

[0157] Non-specific staining: There is staining on other parts such as soft tissues.

[0158] It can be seen that the addition of xanthan gum is crucial for ensuring the ideal color development effect and cleaning efficiency of toothpaste containing PVM / MA copolymer and red pigment, improving the staining uniformity and depth.

[0159] In summary, the synergistic effect between components is crucial for developing highly efficient, precise, and easily removable dental plaque showing toothpaste. By reasonably combining PVM / MA copolymer, red pigment, polyethylene glycol, and xanthan gum, the performance of the toothpaste can be significantly improved to meet users' higher requirements for oral health.

[0160] (3) Test of dental plaque removal effect

[0161] Subject information: 225 volunteer testers were randomly selected, aged 24 - 50 years old, with an average age of 30 years old. They were randomly divided into 5 groups, with 45 people in each group, namely Group 1, Group 2, Group 3, Group 4, and Group 5. There were no significant differences in age and gender among the groups. They brushed their teeth once in the morning and once in the evening every day (using toothpaste with the formulas of Group 1, Group 2, Group 3, Group 4, and Group 5 in Table 2 respectively) for 4 weeks.

[0162] The method for detecting dental plaque is as follows:

[0163] The plaque index (PLI) was proposed by Silness and Loe in 1964. It is scored according to the thickness of plaque on the tooth surface rather than the coverage area of plaque. It is used to evaluate oral hygiene status and measure the prevention and treatment effect of periodontal diseases. The characteristic of PLI is that it is scored based on the thickness of plaque rather than the range of the tooth surface covered by plaque. The scoring criteria for the plaque index are as follows:

[0164] 0: There is no plaque in the area near the gingiva;

[0165] 1: There is no visible plaque on the tooth surface in the area near the gingiva when visually inspected, but plaque can be scraped out when the tip of the probe passes;

[0166] 2: There is a moderate amount of plaque on the gingival margin or adjacent tooth surfaces;

[0167] 3: There is a large amount of plaque in the gingival sulcus and / or on the gingival margin and adjacent tooth surfaces.

[0168] The instrument for checking the plaque index is a sickle-shaped dental probe. Before the examination, rinse the mouth with clean water and dry the tooth surface. Check 4 surfaces of all teeth or select teeth numbered 16, 12, 24, 32, 36, 44 (the positioning identification of teeth according to the Fédération Dentaire Internationale (FDI) tooth numbering system (ISO 3950 standard)), namely the mesial, distal, buccal (labial), and lingual surfaces. Record the average value of the scores according to the scoring criteria. The score of each person is the average value of the scores of all the examined teeth. The index is calculated by dividing the total score of the 4 surfaces by 4 to obtain the plaque index of the tooth.

[0169] Before the start of the experiment, dental plaque was detected in the volunteers, and the plaque index was recorded. After the last use, the plaque index of the volunteers was detected and recorded. All data were statistically analyzed by software. Each group was expressed as mean ± standard deviation. Analysis of variance was used to compare whether there were statistical differences between the experimental group and the control group. After analysis of variance, for variables with statistical significance, the LSD method was used for pairwise comparison. Statistically significant differences were considered when the two-sided P ≤ 0.05 after statistical analysis.

[0170] The results showed that before use, there was no significant difference in PLI among the groups. After use, the data before and after use were comparable among the groups, and the trend of decrease in groups 2, 3 and 4 was more obvious, and the trend of decrease was more significant compared with groups 1 and 5, with statistical difference (see Table 4).

[0171] Table 4: Changes in PLI before and after use

[0172] Group Group 1 Group 2 Group 3 Group 4 Group 5 Before use 2.79±0.31 2.80±0.22 2.72±0.40 2.83±0.34 2.81±0.39 After use 0.88±0.13 0.31±0.17 0.50±0.08 0.56±0.20 0.95±0.11

[0173] In addition, it should be further emphasized that this experimental example uses the method related to "Preparation Method One" to prepare toothpaste (no ball composition is prepared), so the overall appearance color of the toothpaste is darker. If the toothpaste preparation process of "Preparation Method Two" is adopted, the overall appearance color of the toothpaste will become lighter, but the overall efficacy is basically the same as that of Group 2. In addition, for the toothpaste obtained by "Preparation Method Two", the red pigment and PVM / MA copolymer are used in combination to ensure the uniformity, clarity and moderate degree of dyeing; the addition of polyethylene glycol can ensure the stability of the paste and the uniformity of dyeing; the addition of xanthan gum can ensure the stability of the paste, and can ensure the uniformity, clarity and moderate degree of dyeing. That is, due to the use of a consistent formula, the toothpaste obtained by "Preparation Method Two" shows a similar pattern to the toothpaste obtained by "Preparation Method One", and the combination of red pigment and PVM / MA copolymer, the addition of polyethylene glycol and the addition of xanthan gum are very critical to achieve accurate marking of dental plaque by toothpaste, and to achieve rapid dental plaque cleaning.

[0174] Comparative Example 1

[0175] This comparative example is basically the same as Group 2 in Table 2, except that the preparation method is as follows:

[0176] S1: Disperse red pigment and PVM / MA copolymer in part of polyethylene glycol (polyethylene glycol A part, polyethylene glycol is the second moisturizer) to form mixture A.

[0177] S2: Fully disperse the first thickener (sodium carboxymethyl cellulose) and the second thickener (xanthan gum) in the remaining polyethylene glycol (polyethylene glycol B part), then add the first humectant, and form a mixture B after full swelling.

[0178] S3: Add a sweetener, a surfactant and water to mixture B, and homogenize to obtain mixture C.

[0179] S4: Mixture C and mixture A are fully stirred to form mixture D.

[0180] S5: Add the friction agent to the mixture D and mix thoroughly to obtain a mixture E.

[0181] S7: Add essence to the mixture E, degas after homogenization, and then fill it into the toothpaste tube in a conventional manner.

[0182] In the process steps of this comparative example, xanthan gum was not first mixed with the plaque chromogenic composition, and the plaque chromogenic composition was directly dispersed in polyethylene glycol.

[0183] Refer to the stability evaluation method in Experimental Example 1 to evaluate the stability of the toothpaste obtained in this comparative example. It was found that after the toothpaste prepared according to this scheme was placed in an oven at 45 °C for 8 h, the surface of the toothpaste was not shiny and the stability was abnormal.

[0184] Refer to the staining effect evaluation method in Experimental Example 1 to evaluate the staining effect of the toothpaste obtained in this comparative example. It was found that the toothpaste prepared according to this scheme showed uneven staining, unclear staining, and too light staining in terms of the staining effect.

[0185] Comparative Example 2

[0186] This comparative example is basically the same as Group 2 in Table 2, and the difference lies in the preparation method, which is as follows:

[0187] S1: Thoroughly mix the red pigment, PVM / MA copolymer, and xanthan gum (the second thickener) to form mixture A.

[0188] S2: Thoroughly disperse the first thickener in polyethylene glycol (the second humectant), and then add the first humectant. After sufficient swelling, mixture B is formed.

[0189] S3: Add the sweetener, surfactant, and water to mixture B, and obtain mixture C after homogenization.

[0190] S4: Add mixture A to mixture C and mix well to obtain mixture D.

[0191] S5: Add the abrasive to mixture D and mix well to obtain mixture E.

[0192] S6: Add essence to mixture E, degas after homogenization, and then fill it into the toothpaste tube in a conventional manner.

[0193] In the process steps of this comparative example, the mixture formed by the red pigment, PVM / MA copolymer, and xanthan gum was not directly dispersed using polyethylene glycol. Instead, after mixing polyethylene glycol with the first thickener, the first humectant, the sweetener, the surfactant, and water, the mixture formed by the red pigment, PVM / MA copolymer, and xanthan gum was added.

[0194] The stability of the toothpaste obtained in this comparative example was evaluated with reference to the stability evaluation method of Experimental Example 1. It was found that the stability of the toothpaste prepared according to this scheme was abnormal. After opening the cap, the paste overflowed from the nozzle; when the toothpaste tube was inverted, liquid dripped from the nozzle.

[0195] The staining effect of the toothpaste obtained in this comparative example was evaluated with reference to the staining effect evaluation method of Experimental Example 1. It was found that the toothpaste prepared according to this scheme showed uneven staining in terms of the staining effect.

[0196] Comparative Example 3

[0197] This comparative example was basically the same as Group 2 in Table 2, with the difference being the preparation method, which is as follows:

[0198] S1: The thickeners (sodium carboxymethylcellulose and xanthan gum) were fully dispersed in polyethylene glycol (the second humectant), and then the first humectant (glycerol) was added. After full swelling, a mixture A was formed.

[0199] S2: Red pigment, PVM / MA copolymer, sweetener, surfactant and water were added to the mixture A. After homogenization, a mixture B was obtained.

[0200] S3: Abrasive was added to the mixture B and thoroughly mixed to obtain a mixture C.

[0201] S4: Flavor was added to the mixture C, and after homogenization and degassing, it was filled into a toothpaste tube in a conventional manner.

[0202] This comparative example adopted a conventional toothpaste preparation method, and the dental plaque chromogenic composition was added together with other conventional components in Step S2.

[0203] The stability of the toothpaste obtained in this comparative example was evaluated with reference to the stability evaluation method of Experimental Example 1. It was found that the stability of the toothpaste prepared according to this scheme was not ideal. Specifically, after opening the cap, the paste overflowed from the nozzle; when the toothpaste tube was inverted, liquid dripped from the nozzle; after the paste was extruded and compared with the sample stored at room temperature, the fragrance and color changed, and the surface of the toothpaste paste became dull.

[0204] The staining effect of the toothpaste obtained in this comparative example was evaluated with reference to the staining effect evaluation method of Experimental Example 1. It was found that the toothpaste prepared according to this scheme was abnormal in terms of the staining effect, with uneven staining, unclear staining, and light staining.

[0205] Comparative Examples 1-3 were various attempts before the establishment of "Preparation Method 1". The process steps of "Preparation Method 1" (the mixing method of raw materials, the addition process sites of polyethylene glycol and xanthan gum) are very crucial for ensuring the stability of the paste and the dyeing effect. For "Preparation Method 2", its process also shows a similar pattern. Xanthan gum and polyethylene glycol need to be added to the ball composition. The inventor once tried to omit the second thickener (xanthan gum) in Step S1 in the previously described "Preparation Method 2" and add it in Step S2 (directly mixed and added with the first thickener), with other process steps remaining unchanged. The inventor also tried to use all the polyethylene glycol added in Step S1 for the addition in Step S2 (with other process steps remaining unchanged). The toothpastes obtained according to the above two process methods both showed unsatisfactory paste stability. Specifically, referring to the stability evaluation method in Experimental Example 1 to evaluate the stability of the toothpaste, it was found that when comparing the treated toothpaste with the sample stored at room temperature, the surface of the toothpaste paste appeared dull.

[0206] The above are only examples of the present invention. Common knowledge such as the specific structures and characteristics known in the art are not described in detail here. It should be noted that for those skilled in the art, without departing from the structure of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the implementation effect of the present invention and the practicality of the patent. The protection scope required by this application should be based on the content of its claims, and the specific implementation manners described in the specification can be used to explain the content of the claims.

Claims

1. A composition for developing dental plaque, characterized in that: Includes red pigment and PVM / MA copolymer.

2. A composition for developing dental plaque according to claim 1, characterized in that: The red pigment is fluorescent pink and / or erythrosine.

3. A composition for developing dental plaque according to claim 2, characterized in that: The red pigment accounts for 60-90%, and the remaining component is PVM / MA copolymer.

4. An oral care product containing the composition for developing dental plaque according to any one of claims 1 to 3, characterized in that: The oral care products include toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.

5. The oral care product according to claim 3, characterized in that: The invention comprises the following raw materials in parts by weight: 0.15-3 parts of dental plaque coloring composition, 10-70 parts of moisturizing agent, 0-60 parts of abrasive agent, 0.1-10 parts of thickener, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of flavor; The dental plaque coloring composition includes 0.1-2 parts of red pigment and 0.05-1 parts of PVM / MA copolymer; Preferably, the dental plaque coloring composition comprises 0.15-3 parts, a moisturizer 20-60 parts, an abrasive 10-50 parts, a thickener 0.5-3 parts, a surfactant 0.1-5 parts, a sweetener 0.1-0.5 parts, and a flavor 0.1-2 parts; The dental plaque coloring composition comprises 0.1-1 part of red pigment and 0.05-0.35 part of PVM / MA copolymer.

6. The oral care product according to claim 5, characterized in that: The thickener includes a first thickener and a second thickener; the first thickener includes at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium polyacrylate and carbomer; the second thickener is xanthan gum; The mass ratio of the first thickener to the second thickener is 40-65:20-10, preferably 6:

1.

7. The oral care product according to claim 5, characterized in that: The moisturizer includes a first moisturizer and a second moisturizer; the first moisturizer includes at least one of glycerin, sorbitol, and propylene glycol; the second moisturizer is polyethylene glycol The mass ratio of the first moisturizing agent to the second moisturizing agent is 5-50:5-20, preferably 40-50:20, and more preferably 4:1-5:

1.

8. The oral care product according to claim 7, characterized in that: The abrasive includes at least one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate; the surfactant includes at least one of anionic, cationic, amphoteric and nonionic surfactants; and the sweetener includes at least one of saccharin sodium and sucralose.

9. The method for preparing the oral care product according to any one of claims 5 to 8, characterized in that: The method includes the following steps in sequence: S1: mixing red pigment, PVM / MA copolymer and second thickener to form mixture A; S2: dispersing mixture A in the polyethylene glycol part A to form mixture B; S3: dispersing the first thickener in the polyethylene glycol B part, and then adding the first humectant to form a mixture C after swelling; S4: adding a sweetener, a surfactant and water to the mixture C, and homogenizing to obtain a mixture D; S5: Mixing the mixture D and the mixture B and stirring to form a mixture E; S6: adding a friction agent to the mixture E and mixing well to obtain a mixture F; S7: Add flavor to the mixture F, homogenize and degas, and pour into the toothpaste tube; Or include the following steps in order: S1: Mix red pigment, PVM / MA copolymer and second thickener, and then mix with polyethylene glycol, starch and water in a ratio of 10-30:10-20:40-80:5-15 to prepare a 70-200 mesh pellet composition; S2: dispersing the first thickener in the remaining polyethylene glycol, and then adding the first humectant to form a first mixture after swelling; S3: adding a sweetener, a surfactant and a balance of water to the first mixture, and homogenizing to obtain a second mixture; S4: mixing the second mixture and the ball composition to form a third mixture; S5: adding a friction agent to the third mixture and mixing well to obtain a fourth mixture; S6: Add essence to the fourth mixture, homogenize and degas, and pour into the toothpaste tube.

10. The method for preparing the oral care product according to claim 9, characterized in that: The mass ratio of the polyethylene glycol A part to the polyethylene glycol B part is 10-30:40-60, preferably 20-30:40-55.

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