Apparatus for characterizing particles and method for characterizing particles
By performing one-dimensional particle tracking perpendicular to the expected flow direction of the sample, the problem of inaccurate particle displacement measurement caused by increased sample flow velocity and concentration in NTA is solved, and the accuracy of particle size measurement is improved.
CN120202400APending Publication Date: 2025-06-24PANALYTICAL BV
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Patent Information
- Application Number
- CN202380076673.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-11-02
- Filing Date
- 2023-10-31
- Publication Date
- 2025-06-24
AI Technical Summary
Technical Problem
During nanoparticle tracking analysis (NTA), it is difficult to accurately determine particle displacement as sample flow rate and concentration increases, resulting in a decrease in the accuracy of particle size measurement.
Method used
The method of performing one-dimensional particle tracking perpendicular to the expected flow direction of the sample is adopted to identify the nearest particles in subsequent frames of the video, reduce errors and improve the estimation accuracy of the sample flow rate.
Benefits of technology
It improves the accuracy of particle displacement, enhances the estimation of sample flow rate, and thus improves the accuracy of particle size measurement and improves the accuracy of particle size measurement.
✦ Generated by Eureka AI based on patent content.
Abstract
A device (10) for characterizing particles using nanoparticle tracking analysis (NTA) is provided. The device (10) comprises: a flow cell (101) for containing a sample comprising a plurality of particles suspended in a fluid; a pump (102) configured to provide a flow of the sample through the flow cell (101); a light source (103) configured to illuminate the sample; an imaging system (104) configured to collect light scattered or fluoresced by particles moving within the flow cell (101) and within a detection zone of the imaging system (102) and capture a video of the particles moving within the detection zone; and a computer (105) configured to process the video. The computer (105) is configured to determine an estimated flow rate of the sample through the flow cell (101). Determining the estimated flow rate includes performing one-dimensional particle tracking in a direction perpendicular to the expected flow direction of the sample.
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