Transport peptide and application thereof

By developing a transport peptide that can bind to transferrin receptors, transcytosis uses transcytosis to transport drugs through the blood-brain barrier, solving the problem of drug difficulty in entering the brain and improving the treatment efficiency of central nervous system diseases.

CN120225539APending Publication Date: 2025-06-27VACINO BIOTECH CO LTD
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Patent Information

Application Number
CN202380079612.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-11-29
Filing Date
2023-11-06
Publication Date
2025-06-27

AI Technical Summary

Technical Problem

The blood-brain barrier limits the entry of drugs into the brain, resulting in inefficient treatment of central nervous system diseases.

Method used

A transport peptide is developed with binding affinity to transferrin receptors, transporting effectors through tissue barriers, especially blood-brain barriers, by inducing transcytosis.

Benefits of technology

It realizes the effective crossing of effectors through tissue barriers, especially the blood-brain barrier, improves the efficiency of drugs entering the brain, and has a wide range of clinical application value.

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Abstract

The present invention relates to a transporter peptide capable of binding to a transferrin receptor. The transporter peptide can be covalently or non-covalently conjugated with an effector to form a transporter peptide conjugate, or the transporter peptide and an effector form a recombinant transporter peptide conjugate in a manner that represents a nucleic acid encoding the transporter peptide and the effector. The transporter peptide and the recombinant transporter peptide transport the effector to a target by binding to a transferrin receptor. Binding of the transporter peptide to a transferrin receptor on a cell of a tissue barrier induces transendocytosis of the cell to transport the transporter peptide conjugate through the tissue barrier. The transport peptide can be used as a drug delivery system and can be used for related treatment of central nervous system (CNS) diseases.
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