Early diagnosis system for cervical cancer lesion caused by HPVE6 / E7 and application

Through multi-dimensional analysis of HPVE6/E7 protein and telomerase activity detection modules, combined with data and diagnostic modules, early diagnosis and risk assessment of cervical precancerous lesions are achieved, solving the screening difficulties in resource-poor areas and improving diagnostic accuracy and support for personalized treatment.

CN120629570APending Publication Date: 2025-09-12TIANJIN CENT OBSTETRICS & GYNECOLOGY HOSPITAL
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Patent Information

Application Number
CN202510768754.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-10
Publication Date
2025-09-12

AI Technical Summary

Technical Problem

Existing technologies consume enormous manpower, material and financial resources when conducting HPV-related cervical cancer screening in resource-poor areas, making it difficult to achieve effective early diagnosis and prevention.

Method used

The HPVE6/E7 protein detection module and the telomerase activity detection module are used, combined with the data analysis module and the joint diagnosis module, to perform multi-dimensional correlation analysis on cervical exfoliated cells, determine the diagnostic threshold, and achieve early diagnosis and risk assessment.

Benefits of technology

It provides a simple method for early diagnosis of cervical precancerous lesions, improves diagnostic accuracy, reduces the screening burden in resource-poor areas, can assess the risk of lesion progression and the possibility of recurrence after treatment, and supports personalized treatment plans.

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Abstract

The invention discloses an HPVE6 / E7-caused cervical cancer lesion early diagnosis system and application, and relates to the technical field of medical treatment, the system comprises an HPVE6 / E7 protein detection module used for quantitatively detecting the HPVE6 / E7 protein level in cervical exfoliated cells of a target object to obtain a detection result of the HPVE6 / E7 protein level; the telomerase activity detection module is used for detecting the activity of single-cell telomerase in the cervical exfoliated cells to obtain a detection result of the activity of the single-cell telomerase; the diagnosis threshold determination module is used for determining a diagnosis threshold of the HPVE6 / E7 protein level and a diagnosis threshold of the single cell telomerase activity based on the first correlation analysis result, the second correlation analysis result and the third correlation analysis result; the combined diagnosis module is used for carrying out early diagnosis on the precancerous lesion of the cervical cancer on the target object; and the risk assessment module is used for assessing the progress risk of the cervical lesion of the target object and the possibility of relapse after treatment according to the early diagnosis result of the cervical precancerous lesion.
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