Application of Gal-9 + Th cell and / or Gal-9 + Treg as AIH detection target

By detecting the ratio of Gal-9+Th cells and/or Gal-9+Treg+Treg cells and using flow cytometry technology, the uncertainty problem of AIH detection targets was solved, accurate monitoring of the AIH course and evaluation of treatment effects were achieved, and the precision and effectiveness of treatment were improved.

CN120685907APending Publication Date: 2025-09-23HANGZHOU FIRST PEOPLES HOSPITAL
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Patent Information

Application Number
CN202510858528.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-25
Publication Date
2025-09-23

AI Technical Summary

Technical Problem

The pathogenesis of autoimmune hepatitis (AIH) is unclear in existing technologies, research results on the role of Treg cells are inconsistent, and there is a lack of effective detection targets and methods to accurately evaluate disease progression and treatment effects.

Method used

By detecting the proportion of Gal-9+Th cells and/or Gal-9+Treg cells, using flow cytometry (FACS) technology and using specific antibodies to label cell surface molecules, quantitative analysis of Gal-9+Th cells can be achieved as detection targets for AIH, simplifying the detection process and reflecting the disease status.

Benefits of technology

It provides more accurate monitoring of AIH disease progression, helps evaluate disease progression, monitor treatment effects and predict the risk of disease recurrence, provides a basis for individualized treatment plans, and improves the accuracy and effectiveness of treatment.

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Abstract

The invention discloses an application of a Gal-9 + Th cell and / or Gal-9 + Treg as an AIH detection target spot. Researches find that compared with a healthy control group, the peripheral blood Gal-9 + Treg cell proportion and Gal-9 + Th cell proportion of an AIH patient baseline group are remarkably increased, and after ALT of a patient in a treatment group returns to normal, the Gal-9 + Treg cell proportion and the Gal-9 + Th cell proportion are both decreased compared with those before treatment, and it is indicated that the Gal-9 + Treg cell proportion and the Gal-9 + Th cell proportion are effective indexes for monitoring disease improvement. However, the AIH is a chronic disease process, even if the ALT level returns to normal, Gal-9 + Treg cells and Gal-9 + Th cells still do not return to the level of a healthy control group, the Gal-9 + Th cells are taken as detection targets, the progress of the AIH disease course can be monitored more accurately, and disease repetition and biochemical rebounding caused by premature drug withdrawal are prevented.
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